INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Ye-Fei Ruan,Jin-Hui Wang,Wen-Da Zhong,Lin Qiu
Targeting mitochondrial dysfunction in inflamed lung vessels addresses a key challenge in acute lung injury treatment, where current therapies lack precision and efficacy. • We develop smart nanoparticles that actively seek out injured blood vessels and release medicine only where oxidative stress is high, enabling enhanced mitochondrial repair. • This strategy markedly improves lung function and survival in mice with acute lung injury, demonstrating a promising approach for treating severe pulmonary inflammation. Acute lung injury (ALI) is a life-threatening condition with complex pathogenesis. Mitochondrial dysfunction in pulmonary vascular endothelial cells serves as a central hub, driving oxidative stress, inflammation, and barrier disruption. Existing treatments are limited by poor targeting and insufficient efficacy. To address this, we engineered a novel dual-targeting nanoplatform, P-selectin-directed and ROS-responsive fucoidan micelles loaded with the mitochondrial modulator Mitochonic Acid 5 (Fuc-TP@MA-5). Here we show that this system actively homes to inflamed lung endothelium via fucoidan-P-selectin binding and selectively releases MA-5 within the high-ROS microenvironment via thioketal linker cleavage. This enhanced delivery potently restores mitochondrial membrane potential and ATP production, scavenges excess ROS, and inhibits endothelial apoptosis. Consequently, Fuc-TP@MA-5 significantly attenuates pulmonary edema, vascular hyperpermeability, and inflammatory cytokine storm in a murine model of LPS-induced ALI, outperforming free MA-5. Our work establishes a targeted mitochondrial functional improvement strategy, offering a promising and intelligent nanotherapeutic paradigm for treating ALI and other vascular inflammatory disorders. Download: Download high-res image (166KB) Download: Download full-size image
✓ 已验证
DOI
PubMed
高影响因子
Nano-Micro Letters
·
2026
·
IF 38.5
Yuxuan Jiang,Bingxin Sun,Mohsen Shakouri,Bin He,Wang Zhang,Ran Wang,Tianxiao Sun,Huan Pang
Aqueous zinc-iodine batteries (AZIBs) show promise for grid-scale energy storage, but they are hampered by polyiodide shuttling, sluggish iodine redox kinetics, and irreversible active-site poisoning caused by uncontrolled adsorption. We provide a comprehensive screening of M 1 (M 1 = P, S, B) heteroatom dopants, and P is identified as the best candidate for achieving coordination-tuned, moderate adsorption that balances adsorption and catalytic activity while mitigating site poisoning. Using phytic acid as both the P source and an etchant, we create a universal in situ approach to core–shell single-atom catalysts (M 2 -P-CSNC, M 2 = Fe, Co, Ni). The unique core–shell structure achieves stable confinement of polyiodides, rapid ion transport, and protection of active sites, while in situ P doping precisely regulates the local electronic environment and d -band center of the Fe–N x active centers. In situ characterization confirms that Fe–P-CSNC has a strong reversible anchoring ability for polyiodides, which can significantly accelerate redox kinetics. The optimized Fe–P-CSNC/I 2 exhibits almost no capacity decay after 20,000 cycles at a current density of 2 A g −1 . This work’s facile heteroatom doping strategy for electronic modulation offers a reference for high-performance catalyst design in conversion-type energy storage systems. Kindly check and confirm the edit made in the title.1. We have checked and confirmed the edited title.2. We found some issues with Figure 3d and have uploaded the revised image as an attachment.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FUEL
·
2025
·
IF 7.5
Balamurali Ravichandran,Naresh Narayanan,Huiyuan Liu,Weiqi Zhang,Narayanamoorthy Bhuvanendran,Huaneng Su
Intensified electrochemical corrosion under high-temperature and phosphoric acid conditions poses a significant challenge to the catalysts in high-temperature proton exchange membrane fuel cells (HT-PEMFCs). Herein, a S, P-doped hierarchical porous carbon nitride (S, P-HCN) supported PtCo alloy catalyst was developed to address this issue. The multilayered porous structure of S, P-HCN ensures high metal dispersion, a large specific surface area, and enhanced mass transfer. The PtCo/S, P-HCN catalyst exhibits remarkable performance, with specific activity (1.27 mA cm Pt -2 at 0.80 V), mass activity (0.51 mA µg Pt -1 at 0.80 V), and electrochemical active surface area (ECSA) (39.9 m 2 g -1 Pt ), surpassing commercial 20 % Pt/C by 2–3 times. Durability tests over 5000 potential cycles reveal excellent retention of mass activity (84 %) and specific activity (83.2 %) at 0.80 V, with only a minor 14 mV shift in half-wave potential. This enhancement stems from the synergistic effects between PtCo alloy nanoparticles and S, P-HCN, which modulate Pt- electronic structure, strengthen metal-support interactions, and boost catalytic efficiency. Single-cell HT-PEMFC studies demonstrate a peak power density of 377.4 mW cm −2 for PtCo/S, P-HCN, comparable to commercial Pt/C (398 mW cm −2 ), with reduced voltage degradation at low current densities. This work presents a promising approach for improving cathode materials and advancing HT-PEMFC performance.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Bioresources and Bioproducts
·
2026
·
IF 13
Fengzhi Tan,Feifan Lu,Jiali Wei,Xing Wang,Jinghui Zhou,Jingyu Xu
The widespread deployment of renewable energy sources worldwide, such as wind power and photovoltaics, has created an urgent need for efficient energy storage systems. Biomass-derived carbon aerogels, due to their environmentally friendly and sustainable properties, have emerged as ideal precursor materials for advanced energy storage applications, particularly in supercapacitors. This study developed a method to prepare phytate-induced phosphorus/sulfur (P/S) co-doped magnesium lignosulfonate-based carbon aerogels (LCAs). Phytate induction facilitated the formation of regular spherical structures while simultaneously optimizing surface morphology and enabling efficient and uniform doping of P and S heteroatoms. The optimized sample, LCA-2-700, the lignin-based carbon aerogel that was prepared with the magnesium lignosulfonate (LS)꞉sodium alginate (SA)꞉phytic acid (PA) mass ratio of 5꞉5꞉2 and carbonized at 700 °C, exhibited a specific capacitance of 362 F/g at the current density of 0.5 A/g, with the assembled device achieving an energy density of 40.1 W·h/kg at a power density of 700 W/kg. After 20 000 cycles, the capacitance retention rate remained at 82.5%, demonstrating excellent electrochemical durability. The high performance was attributed to the synergistic effects of its spherical structure, high specific surface area, and P/S dual-heteroatom doping. This study provides an effective approach for synergistic structure-doping regulation of lignin-based carbon aerogels and provides a potential pathway for practical applications in high-performance supercapacitors.
✓ 已验证
DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2023
·Vol. 11
·期 6
·111477
·
IF 7.7
Siyi Zhou,Fang Zhu,Hao Cheng,Sridhar Komarneni,Jianfeng Ma
In this study, Ni 3 S 2 @Mo 2 S 3 composites were grown on the surface of molybdenum-nickel (Mo-Ni) foam in situ by a one-step hydrothermal method . With p-nitrophenol (PNP) as the target pollutant, the catalyst can produce a good synergistic effect with ozone, and the degradation rate of PNP is more than 96%. Even after five cycles, Ni 3 S 2 @Mo 2 S 3 -NF/O 3 was able to degrade PNP efficiently and stably. In addition, the unique three-dimensional structure of Ni 3 S 2 @Mo 2 S 3 -NF solves the separation and recycling problem of traditional powder catalysts by maintaining the structural stability during the use process and thus, may reduce the cost of water treatment. The degradation process is mainly dominated by non-radical pathways, and the radical pathway, which work synergistically. This work reveals the influencing factors and degradation mechanism of Ni 3 S 2 @Mo 2 S 3 -NF/O 3 system for PNP degradation, which provides a new idea for water treatment and broadens its potential application.
✓ 已验证
DOI
高影响因子
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
·
2016
·Vol. 105
·期 6
·1369-1378
·
IF 2.881
Bing Wang,Jun Dong,Lijing Niu,Wenyan Chen,Dongliang Chen,Chengyi Shen,Jiang Zhu,Xiaoming Zhang
Electrospun membranes of poly(p-dioxanone-co- l -phenylalanine) (PDPA) hold potential as an anti-adhesion material. Since adjustable degradation properties are important for anti-adhesion materials, in this study, the in vitro and in vivo degradation processes of PDPA electrospun membranes were investigated in detail. The morphological analysis of these membranes revealed the main degradation conditions of PDPA membranes. The weight remaining and molecular weight variation showed that the overall degradation rate of the membranes could be adjusted by modulating the molecular structure of the PDPAs. Especially, α-chymotrypsin could catalyze the degradation process of PDPAs. Based on these results, the in vitro degradation mechanism was demonstrated, and confirmed by 1 H NMR of the hydrolysis products. Finally, the in vivo degradation and biocompatibility of different PDPAs were investigated. The kinetic study showed that the in vitro and in vivo molecular weight loss of PDPAs have the first-order characteristics. The in vivo degradation rate of the most Phe-containing PDPA-3 is the slowest, and this result relates to the biocompatibilities of PDPAs. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1369–1378, 2017.
研究领域:
生物材料学
·
组织工程
·
高分子科学
·
生物医学工程
·
药物递送
·
再生医学
·
生物降解
✓ 已验证
DOI
高影响因子
FLUID PHASE EQUILIBRIA
·
2012
·
IF 2.139
Jian Cao,Chuan Wu,Hong Dong,Dahai Cheng,Yindi Zhang,Xia Wu
Vapor pressures, vaporization enthalpies and acentric factors for new compounds, diethoxy(methyl)( o -tolyl)silane, diethoxy(methyl)( m -tolyl)silane and diethoxy(methyl)( p -tolyl)silane were reported. The saturated temperature was measured using the inclined ebulliometer in the pressure range from 2000 to 61,000 Pa and the normal boiling point was measured according to the Siwoloboff method. The standard vaporization enthalpy was derived from the temperature dependence of vapor pressure data. The critical parameters were estimated by an improved group contribution method and the acentric factors have been estimated from the Antoine equation and the experimental normal boiling points.
研究领域:
热力学
·
物理化学
·
化学工程
✓ 已验证
DOI
高影响因子
Nanoscale
·
2023
·Vol. 15
·期 17
·7803-7811
·
IF 6.7
Tian Sun,Tong Chen,Jiahao Chen,Qiang Lou,Zihao Liang,Guijun Li,Xiaoyun Lin,Guoshen Yang,Hang Zhou
Despite the impressive developments in perovskite optoelectronic devices, their long-term stability remains a major challenge. Chemical reactions and ion exchange at the metal/perovskite contact interface are two significant factors that lead to the failure of perovskite devices. To address this issue, a titanium nitride (TiN) layer is introduced as a robust corrosion-resistant coating between perovskite films and metal electrodes. By introducing TiN layer, a perovskite photodiode with dark current down to 3.25 × 10−11 A cm−2 is realized. Consequently, the TiN-based perovskite photodiode shows a specific detectivity of 1.21 × 1014 cm W−1 Hz1/2, which is approximately two orders of magnitude higher than that of the control device without a TiN layer. Under continuous illumination of a 520 nm green light for 576 000 cycles, the responsivity of the TiN-based photodetector remains at 94.27% of its initial value. The TiN-based photodetector exhibits superior stability under thermal stress. After aging at 85 °C for 572 h, the TiN-based photodetector retains 72% of its initial responsivity. Using the TiN-based photodiode, a perovskite image sensor containing 64 × 64 pixelated perovskite photodiodes is constructed over an amorphous silicon thin-film transistor (TFT) backplane. The perovskite image sensor exhibits real-time imaging capability and long-term stability for over 6 months. This study highlights the importance of using metallic nitrides to achieve high-performance and air-stable perovskite devices for optoelectronic applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Cleaner Production
·
2023
·
IF 11.1
Shuangying Li,Qingxiang Zhou,Zhi Li,Menghua Liu,Yanhui Li,Chunmao Chen
In this work, an effective fluorescent probe for analysis of p-aminoazobenzene (p-AZO) was established with carbon dots (CDs) and magnetic molecularly imprinted nanomaterial , in which CDs and the magnetic nanomaterial were simultaneously derived from prussian blue (PB) by one-pot hydrothermal method . The sensitivity of the constructed probe is greatly improved owing to the introduction of magnetic solid phase extraction. Factors affecting the enrichment efficiency and detection performance of p-AZO were optimized. Under optimal conditions, the probe exhibited good selectivity and sensitivity for p-AZO. Good linearity was achieved in the range of 2–600 nmol L −1 . Low detection limit for p-AZO was 1 nmol L −1 . Satisfactory recoveries in the range of 95.8–98.7% were obtained at two spiked concentrations of 0.02 and 0.1 μmol L −1 , indicating that the probe established with CDs and MMIPs based MSPE was reliable and robust for determination of p-AZO in real water samples.
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Linghui Cao,Haoye Wang,Bowen Chen,Shixin Jiang,Zilong Su,Kaixuan Chen,Jiajun Wang,Aijuan Xie,Shiping Luo
Using metal–organic frameworks (MOFs) as the precursor and carbon spheres as the template, LaFe x Ni (1-x) O 3 (x = 1, 0.8, 0.6, 0.4, 0.2, 0) perovskite-type oxides were synthesized. The structure, morphology and valence state of as-prepared perovskite-type oxides were characterized by X-ray diffraction, scanning electron microscope, transmission electron microscopy, and X-ray photoelectron spectroscopy. Cyclic voltammetry and electrochemical impedance techniques were used to study the effect of Ni-doping ratios on the electrocatalytic performance of perovskite. The differential pulse voltammetry was used to measure the content of p-aminophenol (PAP) and paracetamol (PAT) through the LaFe 0.6 Ni 0.4 O 3 modified glassy carbon electrode. The experiment shows that among LaFe x Ni (1-x) O 3 (x = 1, 0.8, 0.6, 0.4, 0.2, 0) perovskite-type oxides, LaFe 0.6 Ni 0.4 O 3 was best electrode material due to its low charge transfer resistance and high electrochemical active surface area. The linear ranges of PAP and PAT were both 1.0–100.0 μM under optimized conditions, while the detection limits were 0.111 and 0.162 μM (S/N = 3), respectively. The practicality of the suggested sensor was explored through the simultaneous detection of PAP and PAT in real samples, and satisfactory findings in acetaminophen pills were obtained.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Chengming Wu,Quan Wang,Jifan Li,Chun-Ling Liu,Wen-Sheng Dong
Catalytic conversion of biomass-derived platform chemicals into bulk chemicals p -xylene (PX) is appealing yet challenging due to low catalytic efficiency and severe reaction conditions. In this work, we fabricated a series of phosphate-modified ZrO 2 /SBA-15 ( x P-Zr/SBA-15) via adjusting the addition of phosphoric acid, and used them for the catalytic conversion biomass-derived 2,5-dimethylfuran (DMF) and ethylene to PX. Because of the enhanced adsorption capability for the reactant molecules (DMF and ethylene) and the good synergistic effect between Brønsted acid sites (P-OH) and Lewis acid sites (Zr 4+ ), 30P-Zr/SBA-15 revealed an excellent catalytic performance in the selective conversion of DMF into PX. The DMF conversion was 98.5%, PX yield was 92.0% at 250 °C for 12 h, and the corresponding PX productivity was upto 50.5 mmol PX ·g cat −1 ·h −1 . The results are far superior to those obtained on most previously reported catalysts in the literature under similar reaction conditions. The kinetic study revealed that 30P-Zr/SBA-15 has a lower apparent activation energy for the tandem reaction including the Diels-Alder reaction (57.0 kJ·mo −1 ) and dehydration reaction (37.7 kJ·mo −1 ). Moreover, the 30P-Zr/SBA-15 catalyst exhibited the excellent recyclability and could be recycled at least six times without a significant loss of activity. On the basis of the temperature-programmed surface reaction of DMF and ethylene, a reasonable reaction mechanism was proposed.
✓ 已验证
产品关联
DOI
高影响因子
DIAMOND AND RELATED MATERIALS
·
2023
·
IF 4.1
Baijian Feng,Zihao Chen,Na Li,Yongguang Bi,Fansheng Kong,Zhong Wang,Shaofan Tan
In this work, for the first time, biomass-derived carbon dots (AMP-CDs) with strong water solubility, antioxidant activity and good biocompatibility were synthesized by a one-step microwave method using Allium macrostemon Bunge polysaccharides (AMP) as the main carbon source, L-cysteine as the nitrogen and sulfur source, and phosphoric acid as the phosphorus source. The results showed that sphere-like AMP-CDs with an average particle size of about 2.34 ± 0.49 nm were successfully prepared, with good resistance to salt and photobleaching, and maintained high fluorescence intensity under normal pH conditions in human body. AMP-CDs were highly resistant to 2,2-diphenyl-1-pycrylhydrazyl (DPPH), 2,2′-Azinobis- (3-ethylbenzthiazoline-6-sulphonate) (ABTS) and hydroxyl radical (·OH) with significantly higher scavenging ability than AMP , with IC 50 (μg/mL) of 10.240, 7.265, and 574.730, respectively. In addition, AMP-CDs can be selectively used for the sensitive detection of Cr 6+ with the limit of detection was 5.25 μM, and satisfactory results were obtained for the Cr 6+ recovery experiments of actual environmental samples. In vitro cytotoxicity and hemolytic activity assays showed that AMP-CDs have good biocompatibility and can smoothly enter cells for clear imaging. Therefore, AMP-CDs are likely expected to be applied as a potential antioxidant and metal ion detection probe in the field of drug and food, environmental and biological scenario samples for metal ion detection analysis.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）