CHEMICAL ENGINEERING JOURNAL
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2022
·
IF 16.744
Yaqian Dong,Zhi Fang,Deliu Ou,Qing Shi,Yu Ma,Weiyou Yang,Bin Tang,Qiao Liu
Constructing inexpensive, efficient, and stable pH-universal oxygen reduction electrocatalysts with controlled distribution of active species is of great importance for the exploration of green energy conversion devices. Herein, we demonstrated the rational preparation of S-modified Fe–N–C nanosheet catalysts with hierarchical porous architecture, large specific surface area (up to 1471 m 2 g −1 ) and controlled S doping (up to 12.3 at.%) by the co-pyrolysis of cysteine, FeCl 3 with Zn-mediated MgO template. Merited from rich and accessible active sites, the catalysts display outstanding oxygen reduction reaction (ORR) activity in terms of very small E j3 (potential@3 mA cm −2 , 0.87 V in 0.1 M KOH, 0.66 V in 0.1 M PBS (pH7.4) and 0.64 V in 0.5 M H 2 SO 4 ) and overwhelming diffusion-limited current density (9.8, 6.1, 10.3 mA cm −2 in alkaline, neutral, acidic media, respectively), along with extremely respectable stability (∼90% activity retention for 53200, 26728, 43200 s in alkaline, neutral, acidic media, respectively), which underscore comparable or even better overall performance than commercial Pt/C and advanced pH-universal ORR catalysts ever reported. The as-assembled primary alkaline zinc–air battery delivers considerately large peak power density of 205 mW cm −2 and energy density up to 990.6 Wh kg Zn −1 at 10 mA cm −2 (115 mW cm −2 and 676.7 Wh kg Zn −1 for Pt/C-based battery), implying its highly promising application in practical energy conversion devices.
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高影响因子
ChemMedChem
·
2017
·Vol. 12
·期 19
·1600-1609
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IF 3.225
Xinyu Hu,Yongmei Wang,Liangliang Zhang,Man Xu,Jianfa Zhang,Wei Dong
Graphical The power of attraction : Salecan-based composite hydrogels have magnetic-field-responsive properties due to the introduction of Fe 3 O 4 @SiO 2 nanoparticles into the hydrogel system. As a model anticancer drug, doxorubicin (DOX) was loaded into the composite hydrogels with high efficiency via strong electrostatic interactions between the amine group in DOX and carboxyl groups present in the hydrogels. These DOX-loaded salecan-g-PPH/Fe 3 O 4 @SiO 2 composite hydrogels show pH-responsive controlled drug release, and the liberated DOX can be effectively taken up by A549 cells. Salecan is a water-soluble extracellular β-glucan and has excellent physicochemical and biological properties for hydrogel preparation. In this study, a new pH/magnetic field dual-responsive hydrogel was prepared by the graft copolymerization of salecan with 4-pentenoic acid (PA) and N -hydroxyethylacrylamide (HEAA) in the presence of Fe 3 O 4 @SiO 2 nanoparticles for doxorubicin hydrochloride (DOX) release. Integration of Fe 3 O 4 @SiO 2 nanoparticles in salecan-g-poly(PA-co-HEAA) copolymers afforded magnetic sensitivity to the original material. DOX-loaded hydrogels exhibited a clear capacity for pH/magnetic field dual-responsive controlled drug release. Lowering the pH to acidic conditions or introducing an external magnetic field caused an enhancement in DOX release. This salecan-g-poly(PA-co-HEAA)/Fe 3 O 4 @SiO 2 composite hydrogel is a promising drug carrier for magnetically targeted drug delivery with enhanced DOX cytotoxicity against A549 cells.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
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IF 7.7
Chang Liu,Ning Li,Xinyu An,Xu Li,Zhiming Liu
The novel incorporation of dragon fruit peel extract (DE), rich in anthocyanins, Zn 2+ (from Zinc Alginate) and pectin was applied to create active and intelligent food packaging composite films. These films were characterized for their microstructure and properties. Various levels of anthocyanin extracts (1 %, 3 %, and 5 %) were evaluated for their impact on the films' physical and functional properties, incorporating microstructure, mechanical strength, barrier properties, pH sensitivity, and bacteriostatic effectiveness. The films exhibited a significant antibacterial rate of up to 99.99 % against common foodborne pathogens, enhanced flame retardancy with an enhancement of 32.7 %, and a broad pH sensitivity range, indicating their adaptability to various conditions. The results demonstrated that the prepared indicator film achieved a 50 % reduction in water vapor permeability. Additionally, the mechanical properties were enhanced, with only a slight decrease of 12.2 % in tensile strength and 14.0 % in elongation at break. In tests monitoring shrimp freshness, pectin/ZA/DE films showed notable color changes correlating with shrimp quality. These specific values highlight the pectin/ZA/DE films' potential for real-world applications, suggesting that they have potential applications as smart packaging materials in the food industry.
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PubMed
高影响因子
POLYMER
·
2024
·
IF 4.1
Yong Chen,An Liu
As a natural isoflavone compound, glabridin (GLD) has excellent skin-whitening properties, but its biomedical applications are greatly limited due to its poor water solubility and low skin permeability. In the current work, GLD was complexed with hydroxypropyl-β-cyclodextrin (HP-β-CD) to form a GLD/HP-β-CD inclusion complex that would improve the water solubility and skin permeability by changing the physicochemical properties of GLD, including the formation of intermolecular hydrogen bonds and amorphous transformation. The cytotoxicity of GLD/HP-β-CD on HaCaT keratinocytes is lower than that of GLD, while it has a more substantial inhibitory effect on melanin than GLD. Furthermore, a dual thermo- and pH-responsive hydrogel called PCG was established as the carrier of GLD/HP-β-CD. The PCG hydrogel presented a porous structure, biodegradability, and excellent biocompatibility. GLD had a dual thermo- and pH-responsive release behavior from the PCG hydrogel and displayed an accelerated release rate at weakly acidic pH conditions compared to the neutral pH environment. Moreover, GLD/HP-β-CD/PCG hydrogel can significantly inhibit melanin deposition in vivo . Taken together, this study provides a low toxicity and high efficiency new method for the application of GLD in biomedical fields, demonstrating its enormous potential in skin-whitening.
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NEW JOURNAL OF CHEMISTRY
·
2024
·
IF 2.7
Lihua Huang,Ying Luo,Yiyang Cong,Jia Liu,Caiyan Xu,Zhaoxiang Zeng,Yihua Yin,Hao Hong,Wenjin Xu
Metal–organic frameworks (MOFs) are unique coordination polymers that have emerged as important candidates for drug delivery in recent years. Herein, we designed a drug delivery system for multi-modal combination therapy (IR-820/DOX@MIL-101-PDA-PEG-F3, simplified as ID@MIL-PPF3). In this study, pH-sensitive nanocarriers MIL-101(Fe) were prepared and loaded with the effective chemotherapy agent doxorubicin (DOX) and the phototherapeutic reagent new indocyanine green (IR-820) using a physical adsorption method. Dopamine was spontaneously polymerized in alkaline solutions to form a hybrid coating on MIL-101(Fe) (denoted as ID@MIL-101-PDA). The surface of ID@MIL-101-PDA was functionalized by the synthesized polymer NH2-PEG-OCH3/F3 to obtain ID@MIL-PPF3. Characterization results show that ID@MIL-PPF3 has a good drug loading rate (27.7%) and photothermal conversion efficiency (28.89%). In addition, Fe3+ released from MIL-101(Fe) can engage in a Fenton-like reaction to generate hydroxyl radicals (˙OH) to realize chemodynamic therapy (CDT). ID@MIL-PPF3 not only demonstrates the ability to intelligently release drugs, but also realizes chemotherapy combined with PDT/PTT/CDT therapy for tumor cells, which was proved by in vitro evaluation. In conclusion, ID@MIL-PPF3 provides a new idea and method for building a multi-modal combination therapy targeted drug delivery platform.
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高影响因子
JOURNAL OF POLYMER RESEARCH
·
2024
·Vol. 31
·期 11
·1-15
·
IF 2.6
Ni Ruixuan,Yang Ziteng,Wang Li,Dai Shanshan,Lu Hongsheng
Hydrogel as a temporary plugging material provides an efficient strategy to replace locally damaged oil pipelines. However, the poor mechanical properties and incomplete gel-breaking severely limit the practical application of this strategy. Herein, a temperature and pH-responsive hydrogel P(ACG-co-AM)-MMT was prepared by copolymerizing a natural amino acid derivative monomer N-acryloyl glycine (ACG) and acrylamide (AM) with montmorillonite (MMT) as filling material. Hydrogen bonding is the main driving force in hydrogel formation, as confirmed by infrared spectroscopy. The introduction of MMT plays a key role in enhancing the mechanical properties of hydrogels. This successfully overcame the issues of inadequate mechanical properties-rapid degradation trade-off in hydrogel temporary plugging materials. The results show that the hydrogel can withstand the pipeline pressure up to 84 kPa and effectively plug the pipeline. Due to the reversibility of hydrogen bonds, the hydrogel can realize the transformation of sol-gel-sol under temperature stimulation. The plugged area of the pipeline is removed by injecting thermal-produced water. When the hot water temperature is 85 ℃, the pipeline changes to the dredging state only 21 min, dramatically simplifying the operation time. P(ACG-co-AM)-MMT hydrogel has great potential as a temporary plugging material in replacing partially damaged oil pipeline plugging operations. Graphical
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POWDER TECHNOLOGY
·
2025
·
IF 4.6
Menglu An,Weiying Wang,Jingguo Li,Shaokui Cao,Yingliang Liu,Jun Shi
MnO 2 nanosheets have attracted extensive attention in the field of photothermal therapy due to their excellent pH/glutathione (GSH) responsiveness. In this study, MoS 2 @gold nanorods (AuNRs)/polydopamine (PDA)@MnO 2 (400–500 nm) nanocomposites with controllable drug release property were prepared by covering MnO 2 nanosheets around near-infrared (NIR) responsive MoS 2 @AuNRs (100–200 nm) via in-situ redox reaction. The large surface area and strong negative charge of MnO 2 nanosheets ensured that MoS 2 @AuNRs/PDA@MnO 2 had a high loading efficiency of 92.44 % for doxorubicin hydrochloride (DOX). MoS 2 @AuNRs/PDA@MnO 2 revealed significant NIR/pH/GSH triple-responsive drug release properties owing to the synergistically enhanced NIR photothermal-response of MoS 2 @AuNRs (61.10 % of photothermal conversion efficiency) and the reaction between MnO 2 and GSH in weakly acidic media. In addition, in vitro cell viability results confirmed that MoS 2 @AuNRs/PDA@MnO 2 could efficiently kill tumor cells under the dual action of acidic media and NIR laser. This study develops a novel nanocarrier with NIR/pH/GSH triple-responsive drug delivery capability, which has broad applications in photothermal therapy and intelligent drug delivery.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Kaifang Yi,Wenjing Leng,Xiaoyuan Ma,Peiyi Liu,Zibo Li,Dandan He,Li Yuan,Gongzheng Hu,Yajun Zhai
Polyelectrolyte complexes (PECs) provided new opportunities for drug-controlled release systems and had the potential to address the challenges during the effective oral delivery of colistin and niclosamide. Here, an innovative pH-sensitive PEC for the oral co-delivery of colistin and niclosamide (CS/AL-PECs@COL/NIC) was developed, which was self-assembled through electrostatic interaction by an optimized double-emulsion method from two oppositely charged nanoparticles (chitosan-coated nanoparticles and alginate-coated nanoparticles). The CS/AL-PECs@COL/NIC exhibited pH sensitivity, formed a tight cross-linked structure in the gastric acid environment, effectively slowing down the release of the loaded drugs (colistin and niclosamide), and transformed into a loose structure in the neutral environment of the intestine, facilitating the stable release of the loaded drugs. Importantly, the CS/AL-PECs@COL/NIC had good in vivo antibacterial activity against E. coli infection and alleviated the inflammation and intestinal damage caused by bacterial infection in the mouse intestinal infection model. Both in vitro and in vivo studies indicated that the CS/AL-PECs@COL/NIC had good biocompatibility and good palatability. In particular, the oral administration of an effective dose of CS/AL-PECs@COL/NIC did not cause intestinal flora disorder, which had an advantage over colistin treatment. Thus, the prepared CS/AL-PECs@COL/NIC may contribute to treating colistin-resistant bacterial infections as a biocompatible oral administration.
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PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Jiaying Chen,Yilin Wang,Mingxia Pu,Shan He,Neethu Ninan,Ming Cheng
Soybean protein isolate (SPI) exhibits limited functional properties in processing applications due to environmental stressors such as pH, salt ion, and temperature. The present study was devoted to exploring the non-covalent assembly of SPI with chitosan (CS), glucan (GL) and sodium alginate (SA) under different pH conditions. At a fixed mixing ratio (1:1), the phase behavior, protein solubility, and surface hydrophobicity (H 0 ) of the resulting protein-polysaccharide complexes (PPCs) exhibited great differences due to the diversity of polysaccharide charge density and structure. Specifically, CS and SA primarily incorporated with SPI through electrostatic interactions, resulting in a pronounced enhancement of SPI solubility near the isoelectric point, with increases of 37.1 % and 51.6 %, respectively. In contrast, the combination of GL with SPI dominated by hydrophobic interactions and hydrogen bonds, yielding a similar protein solubility and H 0 to SPI itself under different pH. Further analysis in charge density indicates that heat treatment promotes the electrostatic complexation of proteins with polysaccharides, whereas an increase in ionic strength inhibits the non-covalent assembly, and this effect was pronounced in the anionic polysaccharide system. In addition, the formation of electrostatic complexes exerted a positive effect on the stability of the emulsions, while the co-soluble systems tended to produce emulsion particles with smaller particle sizes. In summary, the charged polysaccharides showed great potential to modulate protein structure and enhance the stability of protein emulsions compared with the nonionic polysaccharides.
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高影响因子
Journal of the Taiwan Institute of Chemical Engineers
·
2024
·
IF 5.5
Peng Xu,Jiawei Bao,Qun Li,Weishan Shi,Gang Xing,Zhaogang Teng
Background Smart pesticides, capable of responding to environmental stimuli, hold promise for achieving precise and on-demand release of pesticides, thereby reducing environmental risks and optimizing pesticide utilization. Methods Herein, we prepared a novel composite nanoparticle with a core-shell structure of poly(acrylic acid)-coated mesoporous silica by distillation precipitation polymerization method, which is simple and efficient. Then, abamectin was successfully loaded by impregnation adsorption, and a novel pH-responsive controlled-release pesticide formulation, Abamectin-MSN@PAA, was prepared. Significant Findings In this work, Abamectin-MSN@PAA exhibited a loading content of 23.79 % and an average particle size of approximately 272.1 nm. Notably, the formulation demonstrated acid-responsive release kinetics, with cumulative release percentages of 85.91 %, 69.03 %, and 53.44 % observed at pH values of 5, 7, and 9, respectively, after 96 h. Moreover, Abamectin-MSN@PAA effectively preserved abamectin from degradation under UV light exposure. In comparison with abamectin suspension, Abamectin-MSN@PAA exhibited superior adhesion to radish leaves and demonstrated increased aphid mortality in bioassay experiments. Following 7 days of drug spraying, the aphid survival rate was 26.67 % for Abamectin (40 mg L −1 ) and only 18.3 % for Abamectin-MSN@PAA (40 mg L −1 ). These findings underscore the potential of pH-responsive poly(acrylic acid)-coated mesoporous silica nanoparticles as a versatile platform for controlled pesticide delivery, thereby enhancing pesticide bioavailability and efficacy in agriculture.
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高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2024
·Vol. 26
·期 4
·1-18
·
IF 2.1
Lu Zhimeng,Yan Kun,Liu Chunlei,Wang Jiapeng,Yu Guiping,Zhang Hao
Tripterygium wilfordii Hook F, a traditional medicine in China has bioactive but toxic triptolide (TP, a diterpenoid triepoxide) as its main active constituents. The applications of TP are hampered by its prominent toxicity and low solubility in water. In this study, a safe pH-sensitive material [methoxy polyethylene glycol (mPEG)- adipic dihydrazide (ADH)] was synthesized and loaded with TP to form pH-sensitive polymeric micelles, thereby improving the safety and solubility of TP, as well as providing a theoretical basis for the wide application of TP. The mPEG-ADH/TP micelles were characterized by a series of indicators [namely entrapment efficiency (EE), critical micellar concentration (CMC), electrokinetic potential, stability, polydispersed index (PDI), and particle size]. Also, we ascertained the in vitro release of TP from mPEG-ADH/TP micelles along with pharmacokinetic investigations in vivo. Besides, we evaluated the cytotoxicity of mPEG-ADH/TP micelles against A549 cells, HCT116 cells, and HaCat cells and further conducted in vivo toxicity studies in rats. The TP-loaded mPEG-ADH micelles had smaller sized particles (48.3 nm), excellent PDI (0.142), stable property and higher EE (89.87%). Importantly, the TP in the mPEG-ADH/TP micelles was almost completely released at acidic pH (pH 5.0), while the drug was released slowly and sparingly at physiological pH (pH 7.4). The results suggest the release of TP from mPEG-ADH/TP micelles was sensitive to pH, which could facilitate targeting of the drug into intra-cellularly low pH endosomes and lysosomes as well as enhance cytotoxicity in cancer tissues. Moreover, mPEG-ADH/TP micelles exhibited excellent proliferation inhibition on tumor cells. In addition, the liver injury of rats in the 1 mg/kg dose of mPEG-ADH/TP micelles group was significantly reduced by Hematoxylin–eosin (HE) staining. Taken together, mPEG-ADH/TP micelles could act as a promising alternative to enhance the efficacy of oncologic treatments.
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高影响因子
JOURNAL OF POLYMER SCIENCE
·
2025
·
IF 3.6
Sunqi Yu,Siyuan Chen,Tianrui Tong,Yunfeng Yan,Qi Shuai
Micelle-based drug delivery systems (DDS) have emerged as a promising solution to address challenges associated with the in vivo delivery of hydrophobic anticancer chemotherapeutics. However, micelles still encounter issues such as drug pre-leakage and poor stability in physiological conditions. To overcome these limitations, we developed a core-cross-linking strategy utilizing amphiphilic copolymers, mPEG- b- P(AVL- co -LA) (mPPAL), functionalized with phenylboronic acid (PBA), and catechol by CuAAc “click” chemistry, respectively. These copolymers self-assembled into core-cross-linked micelles (CLMs), featuring boronic ester bonds, which were characterized through a series of evaluations. The CLMs exhibited a rational particle size, uniform morphology, low critical micelle concentration (CMC), high PTX loading capacity, and excellent stability. Two promising micelles, CLM1 and CLM3, were identified, and their responsiveness to acidic pH and elevated levels of ROS was confirmed to enable controlled PTX release. The results of MTT assay and hemolytic analysis demonstrated high biocompatibility and potential in vivo application of these selected CLMs. The anticancer efficacy of the selected PTX-CLMs was further validated through MTT assay and 3D tumor spheroid studies. Fluorescence microscopy and flow cytometry demonstrated rapid intracellular uptake of the CLMs. In vivo biodistribution studies demonstrated successful accumulation in the targeted tumor tissue. These findings suggest that the boronic ester-based CLMs developed in this study are a promising nanocarrier for effective PTX delivery. Graphical Phenylboronic acid (PBA) and catechol-modified amphiphilic copolymers (mPPAL@R) were synthesized via ring-opening polymerization followed by CuAAc click chemistry. These copolymers were employed to construct pH- and ROS-dual-responsive micelles with boronic ester core-crosslinking. A series of in vitro and in vivo experiments were conducted to evaluate PTX-loaded micelles, demonstrating their significant potential for effective PTX delivery.
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