Polymers
·
2019
·Vol. 11
·期 9
·1396
·
IF 3.164
Shuang Gao,Jing-Yu Jiang,Yan-Yan Liu,Ying Fu,Li-Xia Zhao,Chun-Yan Li,Fei Ye
The herbicide diuron is hardly soluble in water and most organic solvents and is usually made into a wettable powder or mixed with soil when used, which causes environmental risk and a reduction in herbicidal efficacy. In this study, the physicochemical properties were changed by usingβ-cyclodextrin (β-CD) to encapsulate diuron to form an inclusion complex. Some key technologies, including X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and nuclear magnetic resonance (1H NMR), were used to characterize the inclusion complex. The stoichiometry of the inclusion complex was determined by recording the1H NMR spectrum or by using a diagram of inclusion ratios. A phase solubility study proved that the formed inclusion complex exhibited higher water solubility. Thermogravimetric analysis (TGA) demonstrated that the formed inclusion complex exhibited better thermal stability. Biological activity studies indicated that the herbicidal activity, in terms of herbicide removal, of the formed inclusion complex was higher than that of the original diuron. In general, the formation of the inclusion complex could reduce the environmental damage caused by diuron and enhance its herbicidal activity, providing an environmentally friendly method for using diuron.
研究领域:
环境科学
·
植物保护
·
农业化学
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DOI
高影响因子
Molecular Catalysis
·
2024
·
IF 3.9
Xiangyu Zheng,Zhe Dou,Wenqiang Xiang,Wen Zhang,Ye Ni,Guochao Xu
N -substituted β-amino esters as an important class of chiral amines, are widely used as building blocks in pharmaceuticals. A novel imine reductase Sv IRED was identified through gene mining from Streptomyces viridochromogenes with high enantioselectivity of > 99 % ee (1 R , 2 S ), 95 % de ( cis:trans ), towards 2-oxocyclohexane-1-carboxylate and cyclopropylamine. Sv IRED exhibited the highest activity at pH 7.0 and 40 °C. A variety of amine donors could be used by Sv IRED and produce chiral N -substituted β-amino esters with different enantioselectivity. Employing methylamine ( i ) and pyrrolidine ( n ) as amine donors, Sv IRED exhibited reversed enantioselectivity of 23 % ee (1 S , 2 R ) and 79 % ee (1 S , 2 R ) respectively. Through alanine scanning, M183 and H244 were identified with remarkable roles in governing enantioselectivity towards i and n . Compared with WT Sv IRED, the enantioselectivity of M183A was inverted to ee value of >99 % (1 R , 2 S ) and de value of >99 % ( cis:trans ) towards i , and the enantioselectivity of H244A was inverted to ee value of 88 % (1 R , 2 S ) and de value of >99 % ( cis:trans ) towards n . Interaction analysis indicated the orientation of ester group was vital for manipulation of enantioselectivity. This study provides novel Imine reductase mutants for enantioselective synthesis of N -substituted β -amino esters with different amine donors.
研究领域:
生物化学
·
生物催化
·
酶工程
·
手性合成
·
药物化学
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DOI
高影响因子
JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2022
·Vol. 30
·期 11
·4863-4876
·
IF 4.705
Fan Yajun,Shen Dianling,Yan Yu,Hu Xiaopeng,Guo Yaping,Zhong Yujun,Li Zhiyang,Xie Lianwu
To achieve efficient adsorption and recycling of Cu 2+ in wastewater, using Cu 2+ as template ion, glutaraldehyde as crosslinker, three sodium alginate hydrogel beads including SA, SAC, and SAB beads were prepared by imprinting sol–gel method using sodium alginate (SA) with carboxymethyl cellulose (CMC) and β -cyclodextrin ( β -CD) as different precursors, respectively. Scanning electron microscopy and Fourier transform infrared spectroscopy were used to characterize and analyze morphology and composition change of the hydrogel beads, respectively. When the mass ratio of SA to CMC or SA to β -CD reach 1:1, the SAC beads or SAB beads are nearly homogeneous sphere. Then the effects of pH, adsorption time, initial concentration of Cu 2+ , adsorbent dosage, and coexisting ions on the adsorption efficiency of three hydrogel beads were investigated. The results indicated that adding carboxymethyl cellulose and β -cyclodextrin into skeleton of beads increased the toughness of the beads and improved the adsorption capacity of Cu 2+ . Compared to the saturated adsorption capacity 510 mg/g of Cu 2+ on SA, the saturated adsorption capacity of Cu 2+ on SAB and SAC reached 817 mg/g and 822 mg/g, respectively. And their adsorption efficiency for Cu 2+ are over 95% at 25 °C with pH of 7, contact time within 350 min, adsorbent dosage of 4 mg/50 mL, and initial concentration of 5 mg/L. Thus, SAC and SAB beads could be used as adsorption material for detecting and removing Cu 2+ from wastewater.
研究领域:
环境科学
·
材料科学
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DOI
高影响因子
CHINESE JOURNAL OF CHEMISTRY
·
2015
·Vol. 33
·期 2
·185-191
·
IF 1.578
Lin Tan,Guo Wang,Nali Chen,Jianqiang Zhang,Huixia Feng
Graphene/mono-(6-amino-6-deoxy)- β -cyclodextrin multilayer films composed of graphene sheet (GS) and mono-(6-amino-6-deoxy)- β -cyclodextrin (NH 2 - β -CD) were fabricated easily by two steps. First, negatively charged graphene oxide (GO) and positively charged mono-(6-amino-6-deoxy)- β -cyclodextrin (NH 2 - β -CD) were layer-by-layer (LBL) self-assembled on glassy carbon electrode (GCE) modified with a layer of poly(diallyldimethylammonium chloride) (PDDA). Then graphene/mono-(6-amino-6-deoxy)- β -cyclodextrin (GS/NH 2 - β -CD) multilayer films were built up by electrochemical reduction of graphene oxide/mono-(6-amino-6-deoxy)- β -cyclodextrin (GO/NH 2 - β -CD). Combining the high surface area of GS and the active recognition sites on β -cyclodextrin ( β -CD), the GS/NH 2 - β -CD multilayer films show excellent electrochemical sensing performance for the detection of DA with an extraordinary broad linear range from 2.53 to 980.05 µmol·L −1 . This study offers a simple route to the controllable formation of graphene-based electrochemical sensor for the detection of DA.
研究领域:
材料科学
·
分析化学
·
生物医学工程
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DOI
高影响因子
JOURNAL OF FOOD SCIENCE
·
2025
·Vol. 90
·期 3
·e70154
·
IF 3.4
Jianhua Yuan,Ying Wu,Yucong Shi,Lei Zhou,Yanjun Zhang,Chengmei Liu,Junzhen Zhong
In this study, a series of characterizations and analyses of fibrous β-lactoglobulin self-assembly (FBS) and worm-like β-lactoglobulin self-assembly (WBS) were carried out to investigate the key factors for the formation of self-assemblies of β-lactoglobulin under two different induced conditions. Compared with natural β-lactoglobulin, FBS was always positively charged, increasing to 9.69 mV when heated for 10 h, whereas WBS was always negatively charged, decreasing to −20.73 mV when heated for 20 min. Electrostatic interactions play a crucial role in the formation of both FBS and WBS. The free sulfhydryl content decreased by 10.4% at 20 min of heating compared with that at 1 min of heating. β-Lactoglobulin converted the exposed free sulfhydryl groups to disulfide bonds when heated under neutral conditions, and disulfide bonds played a key role in the formation of WBS. The surface hydrophobicity of FBS reached its maximum at 1 h of heating, while that of WBS reached its maximum at 15 min of heating. The hydrophobic interactions played an extremely important role in the formation of the two self-assemblies. The investigation of the formation mechanism of FBS and WBS is of great significance for the preparation of β-lactoglobulin self-assembled gels. Practical Application Probing the formation mechanism of β-lactoglobulin self-assemblies provides new methods and ideas for the preparation of β-lactoglobulin gels, which is important for improving the structure and properties of gel carriers prepared from bio-based materials.
研究领域:
食品科学
·
蛋白质化学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2025
·
IF 4.7
Jin Han,Fang Chen,Weipeng Qin,Lei Wang,Dan Wu,Kun Shen,Xiaoxue Yin,Qingquan Xue
The practical application of tea tree oil (TTO) as a natural broad-spectrum antimicrobial agent is limited by high volatility, chemical instability, and compatibility challenges with conventional polymer matrices. In this study, an antimicrobial thermosetting system with controlled hydrolysis was constructed. The N,N,N′,N″,N″-pentamethyldipropylenetriamine (PMD) cured samples exhibited superior mechanical and thermal properties in comparison to the N,N,N′,N′-tetramethyl-1,6-hexanediamine (TMHDA) or N,N,N′,N′-tetramethyl-1,3-propanediamine (TMPDA) cured samples. The TTO-loaded β-cyclodextrin (β-CD) was cross-linked by a rapid quaternization reaction to give the thermoset with quaternary ammonium contact-mode antimicrobial and TTO pharmaceutical antimicrobial properties. The remaining tertiary amine groups in the system provide a weakly alkaline environment, while the quaternary ammonium ester (Quat Ester) groups undergo weak base accelerated hydrolysis. The tensile strength of the cured system reached 23.69 MPa, and the antimicrobial activity against Escherichia coli and Staphylococcus aureus reached 95.27 and 95.63%, respectively; the antimicrobial performance could be further enhanced when long-chain cetyl chloroacetate (CCA) was involved in the curing (the antimicrobial activity reached 98.33 and 98.07%, respectively). The antimicrobial and pH-responsive degradation properties provide ideas for the development of degradable and antimicrobial materials for three-dimensional (3D) printing, solid disinfectants and so on.
研究领域:
高分子材料科学
·
生物医学工程
·
抗菌材料
·
药物递送
·
可降解材料
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2021
·Vol. 56
·期 23
·13043-13055
·
IF 4.22
Zhu Yao,Rong Jian,Mao Kaili,Yang Dongya,Zhang Tao,Qiu Fengxian,Pan Jianming,Pu Zhilong
Polymer of cyclodextrin (CD) is still of great sustainable interest in the scientific research attributing to its excellent physicochemical properties. Owing to its water solubility and superior binding capacity, CD is usually modified through various strategies to exploit its application area. Herein, for the first time, magnetic β-cyclodextrin (β-CD) polymer is endowed with boronate affinity property via mild chemical modifications to specifically separate natural drug raw material shikimic acid (SA). The uniform morphology, magnetic response ability and composition analysis of the porous adsorbent were highly supported by the characterizations. The capture process towards SA depending on the pH value is explored in detail by adsorption kinetics, equilibrium, selectivity and reusability. It is found that specific recognition sites decorated on the surface of magnetic β-CD provides strength support for selective adsorption and separation of shikimic acid. The prepared adsorbent shows high adsorption quantity ( Q , mg g −1 ) of 31.60 mg g −1 at 25 °C, high specific recognition and good adsorption capacity (above 83.7%) and stability after five cycles. This study gives a new sight on the utilization of porous β-CD-based material by grafting functional boric acid group for specific capture of natural cis-diol-containing compounds.
研究领域:
材料科学
·
药物化学
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2019
·
IF 6.393
Lan Guo,Yuan Liu,Rongmei Kong,Guang Chen,Hao Wang,Xiuli Wang,Lian Xia,Fengli Qu
β-Glucuronidase (β-GCU) is closely related to the occurrence of multiple diseases, and it has been applied as a biomarker and therapeutic target in clinical diagnosis. However, reliable methods with high selectivity and sensitivity for monitoring β-GCU are still lacked. Herein, we designed a novel fluorescent nanoprobe, rhodamine B encapsulated MOF-5 (RhB@MOF-5) for the first time, to detect β-GCU through the synergistic effect of inner filter effect (IFE) and static quenching effect (SQE) by employing 4-nitrophenyl-β-D-glucuronide (PNPG) as the substrate. After encapsulating into MOF-5, the fluorescence emission of RhB at 550 nm excited by 320 nm was greatly enhanced. The major overlap between the fluorescence excitation spectrum of RhB@MOF-5 (about 320 nm) and the ultraviolet absorption spectrum of PNPG (about 310 nm) lead to PNPG being a good IFE absorber in this sensing system. Under the optimized conditions, the excitation spectrum of the RhB@MOF-5 could be absorbed by PNPG, resulting in the dramatically decrease of fluorescence emission. After adding β-GCU into the system, the substrate of PNPG would be enzymatic hydrolyzed to p -nitrophenol (PNP) and glucose, then the IFE disappearance and the fluorescence recovered. The current sensing platform was interference-free and exhibited a broad linearity relationship for β-GCU range of 0.1–10 U L −1 (R 2 = 0.9957) with a limit of detection as low as 0.03 U L −1 , which was reduced by more than one orders compared with the reported methods. Moreover, the encapsulation of dyes using porous nanoparticles to achieve some tailor-made characteristics will enrich experimental design inspiration.
研究领域:
生物化学
·
医学诊断
·
材料科学
✓ 已验证
DOI
高影响因子
International Journal of Biological Sciences
·
2024
·
IF 8.2
Zuodong Xuan,Chen Chen,Huimin Sun,Kunao Yang,Jinxin Li,Meilin Fu,Yang Bai,Zeyuan Zheng,Yue Zhao,Chunlan Xu,Bin Liu,Tian Li,Chen Shao
Background: Prostate cancer progression hinges on β-catenin's stability and activity, a key factor in epithelial-mesenchymal transition (EMT) and metastasis. This study delves into NDR1-dependent phosphorylation's impact on β-catenin via FBXO11, an E3 ubiquitin ligase, in prostate cancer cells. Methods: Human prostate cancer cell lines underwent various in vitro assays, including real-time PCR, Western blotting, immunoprecipitation, immunofluorescence, and protein stability assays, to explore β-catenin's interactions and post-translational modifications. NDR1 modulation's in vivo efficacy was assessed using a nude mice lung metastasis model. Small-molecule screening identified a potential NDR1 activator, aNDR1, tested for its effects on metastasis via in vitro and in vivo assays. Results: NDR1 phosphorylated β-catenin at Ser33/37, facilitating its interaction with FBXO11. This led to FBXO11-mediated ubiquitination and cytoplasmic degradation of β-catenin, while the NDR1-FBXO11 complex impeded β-catenin nuclear translocation by inducing JNK2 ubiquitination. Thus, NDR1 and FBXO11 jointly regulate β-catenin activity in prostate cancer cells through dual phosphorylation-driven ubiquitination, potentially suppressing EMT. Reduced NDR1 expression inhibited FBXO11 and β-catenin phosphorylation, diminishing β-catenin and JNK2 ubiquitination, promoting EMT and enhancing prostate cancer cell metastasis. The inhibitory effects of aNDR1 on prostate cancer metastasis were validated. Conclusion: The NDR1/FBXO11 axis outlines a non-canonical β-catenin degradation pathway crucial in regulating EMT and prostate cancer cell metastasis. NDR1 activation, particularly with aNDR1, could offer a promising therapeutic avenue against prostate cancer metastasis.
研究领域:
癌症生物学
·
分子生物学
·
细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
KOREAN JOURNAL OF CHEMICAL ENGINEERING
·
2024
·
IF 2.9
Wen Jie,Lyu Yanjun,Zhang Lianhong,Ma Yuling,Huang Xia,Zhu Wanyu
A novel method was developed to introduce β-cyclodextrin (β-CD) cage-like macromolecules into acrylic ester resin using metal oxides as a medium, resulting in high-oil-absorption resin composites. β-CD was first grafted onto the surface of cobalt-aluminum bimetallic oxide (CoAl-LDO) via a facile hydrothermal method in an alkaline environment, generating more pore structures. To enhance the hydrophobic properties of β-CD-grafted CoAl-LDO nanoparticles, KH-570 was employed as a modifier to modify nanoparticles. Finally, the β-CD-grafted CoAl-LDO/acrylic ester resin composite was successfully synthesized by suspension polymerization method. The oil absorption performance of the resin composite was evaluated using various solvents. Its saturated capacity reached 18.62 g/g for cyclohexane, 19.92 g/g for toluene, and a remarkable 31.42 g/g for trichloromethane. Even for diesel, a challenging oil due to its viscosity, the absorption reached a noteworthy 16.17 g/g. Further demonstrating its selectivity, the composite strictly adsorbed oil while repelling water. Notably, the impressive capacity remained largely unchanged after eight regeneration cycles.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ORGANIC CHEMISTRY
·
2024
·
IF 3.3
Jin Yan,Suijie Zhong,Xu Chen,Yihuan Luo,Hua Cao,Xiang Liu,Limin Zhao
Here, we report controlled and site-selective C–H alkenylation and dialkenylation of indolizines and pyrrolo[1,2-a]quinolines with β-alkoxyvinyl trifluoromethylketones under simple and practical conditions. Moreover, this direct C–H alkenylation strategy can also be extended to imidazo[1,2-a]pyridines. Notably, without a transition metal and external oxidant, efficient dehydrogenative β-alkenylation of tertiary amines with β-alkoxyvinyl trifluoromethylketones is presented.
研究领域:
有机化学
·
合成化学
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DOI
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2019
·Vol. 166
·期 6
·B388
·
IF 3.12
Jingdang Chai,Jie Zhang,Yangping Wen,Lie Zou,Xinxin Zhang,Xing Xin,Muhan Zhou,Jingkun Xu,Ge Zhang
An electrochemical sensor based on PEDOT:PSS-β-CD-SWCNT-COOH/GCE for highly sensitive analysis of shikonin (SHI) in PBS buffer solution was reported. PEDOT:PSS-β-CD-SWCNT-COOH composite was obtained by using poly(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate) (PEDOT:PSS), β-Cyclodextrin (β-CD) and carboxylated single-walled carbon nanotube (SWCNT-COOH) to modify glassy carbon electrode (GCE) and characterized by scanning electron microscopy and electrochemical impedance spectroscopies. In optimized conditions, PEDOT:PSS-β-CD-SWCNT-COOH had a high sensitivity to SHI and it could detect SHI in linear ranges 6 nM to 30 μM with a low detection limit of 1.8 nM. And a series of experiments showed that the modified electrode exhibited good repeatability, reproducibility, and selectivity to electrochemical determination of SHI.
研究领域:
分析化学
·
生物医学工程
·
材料科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）