Innovative Food Science & Emerging Technologies
·
2026
·
IF 6.9
Haoran Li,Yongsheng Ni,Yumeng Li,Baocai Xu
Photodynamic inactivation (PDI) is a promising non-thermal antimicrobial technology. However, its practical application is constrained by the low-light utilization efficiency and poor adhesion of photosensitizers. To address these limitations, we developed a curcumin/octyl gallate/chitosan (COS) coating. COS was prepared via a two-stage self-assembly process by incorporating a curcumin/octyl gallate (CUR/OG) assembly into a chitosan (CS) matrix. The CUR/OG, characterized by a band gap of 2.3 eV, imparted visible-light activity to the COS. Furthermore, the COS exhibited good adhesion, storage stability, and photostability. Compared to pristine CS, the COS exhibited a 1.3-fold enhancement in adhesion strength. Upon visible-light irradiation, it achieved up to a 6.5-log CFU reduction in the population of four representative foodborne bacteria ( Pseudomonas fragi , Brochothrix thermosphacta , Escherichia coli O157:H7, and Staphylococcus aureus ). Biochemical analyses indicated that COS-mediated PDI was associated with the disruption of bacterial cell membrane integrity, impairment of energy metabolism, and induction of oxidative stress. Under visible light, the COS extended the refrigerated shelf-life of prepared mutton to 1.5 times that of the untreated control. Moreover, the COS-mediated PDI maintained approximately 99.99% reduction in bacterial counts after three consecutive reuse cycles on food contact surfaces. This study provided an effective approach for enhancing the bactericidal activity and adhesion of photodynamic coatings, offering a promising solution for preservation of prepared mutton.
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Small
·
2026
·
IF 11.8
Yitian Zhang,Dianji Li,Minhao Liu,Ziqing Tang,Hui Yu,Min You,Qiang Chen,Xi Ding
Highly wet, dynamic, inflammatory, and fouling environments were significant challenges in the healing of diabetic oral ulcers. Inspired by the oral mucosa, a wet-adhesion Janus hydrogel (WAJH) with asymmetric bifunctionalities of antifouling/antioxidant was proposed for diabetic oral ulcer treatment. In the WAJH, the antifouling layer was composed of the agar/polyacrylamide double-network (Agar/PAAm DN) hydrogel, and the wet-adhesive layer was constructed by the poly(acrylic acid-co-2-phenoxyethyl acrylate)/tannic acid (PAEA/TA) hydrogel. The antifouling layer mimicked the oral epithelium to prevent pollutant invasion, and the adhesive layer imitated the basement membrane of oral mucosa to adhere firmly to wet diabetic oral ulcers. Importantly, the adhesion energies of the two layers were distinctly different, measuring 15 J m −2 for the antifouling layer and 316 J m −2 for the adhesive layer, respectively. Notably, TA not only significantly enhanced the toughness and wet adhesion but also endowed the WAJH with reactive oxygen species (ROS) scavenging and antioxidant capabilities. The WAJH remarkably accelerated the healing of oral ulcer by inhibiting inflammation at the ulcer, promoting angiogenesis, and promoting re-epithelialization in vivo. Consequently, the WAJH with antifouling and antioxidant exhibited promising prospects in the clinical treatment of diabetic oral ulcer.
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Lidong Wang,Yongyan Sun,Yuting Sun,Changbin Zhang,Guixi Wang,Junnan He,Yan Zhao,Ming Li
Photodynamic therapy (PDT) holds promise for oral squamous cell carcinoma (OSCC) but is limited by the tumor microenvironment─specifically hypoxia, elevated glutathione (GSH), and the lack of tumor-selective photosensitizer activation. To overcome these barriers, we developed a GSH-activated nanoplatform Cu-TCPP(Zn)/Ti3C2Tx for fluorescence imaging-guided synergistic photodynamic/chemodynamic therapy (PDT/CDT). The system is constructed from two-dimensional Cu-TCPP(Zn) MOF nanosheets, where Cu2+ and Zn2+ completely quench the fluorescence and PDT activity of TCPP and surface-anchored Ti3C2Tx MXene. In the TME, overexpressed GSH reduces Cu2+ to Cu+ and abstracts Zn from the Zn–N4 complex, triggering nanocomposite disintegration to restore fluorescence, activate PDT, and simultaneously deplete GSH to reduce antioxidant defense. The resulting Cu+ catalyzes a Fenton-like reaction with endogenous H2O2 to generate •OH for CDT, while Ti3C2Tx acts as a catalase-like nanozyme, decomposing H2O2 into O2 to alleviate hypoxia, promote charge transfer, improve the utilization efficiency of photogenerated electrons, and enhance PDT efficacy. In vitro, the platform showed excellent biocompatibility and GSH-responsive activation, inducing 41.21% apoptosis in CAL-27 cells under 660 nm laser irradiation, significantly outperforming controls. In vivo, the nanocomposite accumulated efficiently in tumors via the EPR effect, suppressed tumor growth, and exhibited no observable systemic toxicity. This work provides a TME-responsive theranostic platform that integrates tumor-specific activation, GSH depletion, hypoxia alleviation, and enhanced ROS generation for precise and effective OSCC treatment.
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Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 2
·122009
·
IF 7.5
Xingyu Guo,Haiyan Song
Photocatalytic H 2 O 2 production from O 2 using covalent organic frameworks (COFs) is a promising solar-to-chemical energy conversion route. However, existing design strategies for COF-based photocatalysts are constrained by various issues, making it difficult to achieve synergistic optimization of both photogenerated charge separation efficiency and catalytic activity. In addition, compared with pure water medium, achieving efficient H 2 O 2 production in alcohols is of great significance for alcohol-mediated organic synthesis and direct alcohol fuel cells. Herein, two amide-linked COFs were fabricated via site-specific benzene ring functionalization, focusing on precise amino group incorporation. Aligned with recent advances in photocatalytic structure property relationships, amino group introduction induces significant charge density differentials in COFs, modulating donor acceptor interactions and efficiently promoting photogenerated charge separation/transport. Consequently, the 2-aminoterephthalic acid-based COF (PPTD-COF) exhibits superior photocatalytic H 2 O 2 production performance. PPTD-COF achieves a H 2 O 2 productivity of 16.23 mmol h −1 g −1 in ethanol within 0.5 h, 16-fold higher than the unmodified terephthalic acid-based COF (PTA-COF). Ethanol acts as an efficient electron-proton donor, supplying abundant H + for the oxygen reduction reaction (ORR) and facilitating proton-coupled electron transfer (PCET) for efficient H 2 O 2 generation. This work develops a site-specific functionalization strategy to tune COF electronic structures, optimize donor-acceptor interactions, and enhanced charge dynamics, highlighting potential applications in sustainable energy and environmental remediation.
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JOURNAL OF MEMBRANE SCIENCE
·
2026
·
IF 8.8
Yingnan Ma,Zhen Xu,Yulu Zhang,Zixuan Guo,Juan Chen,Panliang Zhang,Kewen Tang
This study innovatively proposed an in-situ confined polymerization strategy of trimesoyl chloride (TMC) and piperazine (PIP) within MOFs nanosheets, successfully constructing a thin film nanocomposite (TFN) separation membrane with excellent interfacial compatibility. The method employed MOFs nanosheets as confined templates to achieve bottom-up in-situ construction of a continuous and dense polyamide matrix. By precisely controlling the number of polymerization cycles, the MOFs content in the functional layer was effectively regulated from 83.3 wt% to 42.6 wt%. Benefiting from the molecular-level interfacial compatibility between MOFs and the polymer phase, as well as the synergistic effect of efficient solution diffusion and fine molecular sieving mechanisms, the TFN membranes demonstrated significantly enhanced CO 2 separation performance, CO 2 permeance reached 1688.3 GPU with selectivities of 36.4 for CO 2 /N 2 and 38.9 for CO 2 /CH 4 , which surpassed the Upper bound (2008 and 2019). The TFN membranes exhibited outstanding long-term operational stability (selectivity fluctuation <3.6%) under rigorous conditions including prolonged 14-day continuous testing and variable temperature (35-75 °C) and pressure (0.1-0.5 MPa) conditions. This work provided a new paradigm for the precise design and scalable fabrication of gas separation membranes, opening new avenues for the development of high-performance separation membranes.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Jian Duan,Kun Wang,Xiaoqiang Shu,Lianhao Zhao,Changhui Chen,Shifang Fei,Min Xi,Xiang Chen,Diankai Wang,Kaihuan Zhang,Sijia Xie,Bo Liu,Chang Chen,Zheng Deng
Rapid and timely nucleic acid detection through polymerase chain reaction (PCR) is an urgent demand in epidemic prevention and control. However, conventional Peltier-based PCR instruments are too slow to meet this requirement. Herein, an ultra-fast photothermal real-time quantitative PCR (qPCR) system that integrates a metal-organic framework (MOF)-based photothermal membrane with a silicon-based microfluidic chip is constructed for rapid SARS-CoV-2 detection. After optimization of the synthesis temperature of zirconium-ferrocenyl (Zr-Fc) MOFs and the thickness of Zr-Fc MOF/SWCNTs (ZFC) membranes, the resultant ZFC-22 membrane exhibits excellent and robust photothermal performance with an ultra-fast heating rate of 60.3 °C/s, enabling a rapid heat generation rate. Subsequently, the ZFC-22 membrane is integrated into a custom-designed silicon-based microfluidic chip that not only enhances heat conduction but also effectively confines heat in the PCR microchannel via thermal-isolation grooves, thereby reducing heat loss. Finally, a photothermal real-time qPCR system consisting of photothermal modules, microfluidic chips, control modules, and fluorescence imaging modules is constructed, which completes 40 nucleic acid amplification cycles within 10 min with an excellent amplification efficiency (98.6%), a low limit of detection (10 copies/μL), and an extremely low average optical power (1 W/well).
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RSC Advances
·
2026
·Vol. 16
·期 12
·11158
·
IF 6.1
Wenli Qin,Xinyi Zhang,Gaofeng Chen,Zhaoting Ji,Zengling Ma
The increasing influx of nutrients ( e.g. , nitrogen and phosphorus) into freshwater systems is exacerbating eutrophication in natural waterways. To address this issue, a novel magnetic photocatalyst composed of a carbon nanotube core and a titanium dioxide coating (denoted as C–TiO 2 –Fe 3 O 4 and C–TiFe 2 O 4 ) is successfully synthesized. Microcystis aeruginosa and microcystin-LR (MC-LR) in eutrophicated water can be efficiently inactivated by the composite via visible light photocatalysis. The incorporation of magnetic Fe significantly enhances cyanobacteria capture and improves the photocatalytic efficiency for algal inactivation and MC-LR breakdown. C–TiFe 2 O 4 exhibits the highest adsorption-photocatalysis performance with an inactivation efficiency of 77.9% after 7 hours. Under optimal conditions (7 h of reaction time, a catalyst dosage of 0.39 g L −1 , and an initial algae density of 1 × 10 6 cells per mL), the MC-LR removal rate is 89.1%. Notably, C–TiFe 2 O 4 maintains exceptional stability and reusability even after five cycles. The composite demonstrates promising potential for treating harmful algal blooms (HABs) across diverse environmental conditions. These findings highlight the viability of C–TiFe 2 O 4 as a sustainable and scalable technology to mitigate HABs and degrade MC-LR in contaminated water systems. The prepared magnetic photocatalysts, C–TiO 2 –Fe 3 O 4 and C–TiFe 2 O 4 , are sustainable and scalable technologies to mitigate HABs and degrade MC-LR in contaminated water systems.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Jingxian Wang,Xueyang Liu,Yixuan Lin,Junjie Wang,Hanwen Zhang,Luoxin Wang,Hua Wang,Siwei Xiong
The integration of ceramic fillers with high thermal conductivity into polymer fiber insulating paper enhances both thermal conductivity and dielectric strength. Nonetheless, elevated filler loadings augment the filler-matrix interface, thereby intensifying phonon scattering. Additionally, filler agglomeration, driven by van der Waals forces, impedes the formation of a continuous thermal network and introduces defects that facilitate electrical treeing. This research draws inspiration from “brick-and-mortar” architectures, employing high-surface-area thermotropic liquid crystal polyarylate (PAR) nanofibers as the continuous mortar and surface-modified hexagonal boron nitride (TMS@h-BN) nanoplates as the bricks. A scalable papermaking process is employed to fabricate high-thermal-conductivity insulating paper with a high filler content. The three-dimensional network structure of PAR nanofibers spatially confines the h-BN nanoplates, effectively preventing their agglomeration. Furthermore, π-π conjugation between the aromatic structures of PAR and the benzene rings of h-BN enhances interfacial bonding by facilitating the diffusion and entanglement of PAR molecular chains during thermal pressing. This results in a dense interfacial structure that provides an efficient pathway for phonon transport, thereby enhancing thermal conductivity and minimizing electrical distortion. At a filler loading of 70 wt%, the TMS@h-BN/PAR nanocomposite paper exhibits superior mechanical performance and flexibility, achieving an in-plane thermal conductivity of 14.19 W·m −1 ·K −1 and a breakdown field strength of 111.17 kV/mm, which represent significant improvements over commercial insulating paper. Additionally, it demonstrates exceptional thermal stability and flame retardancy, with minimal dimensional changes following heat treatment.
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ACS Applied Bio Materials
·
2026
·
IF 5.6
Yingze Li,Jibin Zheng,Chang Chen,Zhenguang Li,Yu Cheng
Successful tissue remodeling following biomaterial implantation requires adequate tissue integration, which is often compromised by macrophage-mediated foreign body responses and persistent inflammation. Developing biomaterials that actively modulate macrophage behavior via biophysical and biochemical cues holds significant promise for tissue engineering. Here, we present a magneto-actuated polyelectrolyte scaffold platform, where antioxidative lignin@Fe3O4 nanoclusters are noncovalently anchored onto chitosan/chondroitin sulfate scaffolds. Upon exposure to a dynamic magnetic field, the nanoclusters generate interfacial microvibrations, delivering dynamic mechanical stimuli to macrophages while simultaneously scavenging reactive oxygen species via their intrinsic antioxidative activity. This mechano-chemo coordinated modulation effectively induces macrophage polarization from the M1 to M2 phenotype, as evidenced by significantly downregulated pro-inflammatory markers and upregulated anti-inflammatory markers in vitro. As a proof of concept, the subcutaneous implantation of scaffolds under the dynamic magnetomechanical actuation demonstrates improved tissue integration, characterized by reduced inflammation and enhanced extracellular matrix deposition. This platform offers an approach for promoting biomaterial adoption and tissue remodeling through spatiotemporally coordinated mechano-chemo modulation.
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ACS Applied Materials & Interfaces
·
2026
·Vol. 18
·期 35
·48113-48123
·
IF 7.8
Kong Yong,Lai Zhengbo,Dai Xiaolei,Xu Fuhao,Shen Xiaodong
Polymer-based aerogels exhibit high thermal management performance including insulation and passive radiative cooling. However, the lack of elasticity limits their application. Herein, we developed an elastic poly(vinylidene fluoride- co -hexafluoropropylene) (PVDF-HFP)-based aerogel (PFHS) for efficient thermal management. PFHS achieves a low thermal conductivity of 0.035 W/(m·K), a high solar reflectance of 98.18%, and a mid-infrared emissivity of 96.85%, as well as high hydrophobicity with a water contact angle of 140 ° . PFHS exhibits a high temperature reduction of 9.8 ° C and an outdoor daytime cooling power of 116.68 W/m 2 under an average solar irradiance of 821.14 W/m 2 . It also has superior thermal insulation performance under cold (−20 ° C) and hot (60 ° C) conditions. Moreover, PFHS has excellent weather resistance and thermal stability. These attributes establish PFHS as a promising prospect for the efficient thermal and environmental management of buildings and outdoor facilities, offering a new strategy for the development of multifunctional polymer aerogels.
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ACS Applied Materials & Interfaces
·
2026
·Vol. 18
·期 35
·47481-47493
·
IF 7.8
Xu Jiayu,Zhou Shenyue,Wu Wen,Wen Yuxing,Tang Yingying,Miao Lili,Yu Yuanyuan,Zhang Wanjun,You Zhengyao,Chen Mengxi,Li Xiaowei,Zhou Shoujun,Wang Weipeng,Zhang Haiyang
Extracellular vesicles (EVs) are lipid bilayer nanovesicles that mediate intercellular communication and hold significant potential for clinical applications. Although material-based isolation strategies offer promising alternatives to conventional methods, their relative performances have not been systematically evaluated. In this study, we conducted a comparative assessment of magnetic nanomaterials with distinct surface functionalities, including metal oxides (TiO 2 ), metal–organic frameworks (UiO-66), biopolymeric materials (chitosan), and lipid probes (DSPE-PEG, DOPE-PEG, and CLS-PEG). A comprehensive evaluation across multiple dimensions including capture capacity, capture rate, sample volume, and product purity reveals that the bifunctional magnetic nanomaterial Fe 3 O 4 @UiO-66@DSPE material exhibits superior EV capture performance. This material enables the efficient and stable enrichment of high-purity EVs by synergizing Zr 4+ -phosphate coordination with lipid bilayer anchoring, and preserves EV biological integrity and activity. Meanwhile, this method could be highly compatible with proteomics, and over 1000 proteins are identified by proteomic analysis of urinary EVs, while 34 proteins are upregulated and 25 proteins are downregulated in prostate cancer patients relative to healthy donors. Notably, the differentially expressed proteins, such as AGT, ITIH4, and PGLYRP2, are associated with disease progression. Overall, this work highlights the superior performance of the Fe 3 O 4 @UiO-66@DSPE material for efficient and selective EV isolation. It provides a powerful tool for clinical liquid biopsy and proteomic biomarker discovery, enabling early diagnosis, prognostic evaluation, and precision therapy.
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LANGMUIR
·
2026
·Vol. 42
·期 34
·25009-25021
·
IF 4.4
Liu Changlong,Zhang Yunpeng,Liu Fengming,Gao Shang,Zhang Liping,Mu Mei,Huang Jun
To address the trade-off between friction reduction and
proppant
suspension in conventional fluids, an aqueous two-phase system comprising
nanoparticle-reinforced biopolysaccharideand zwitterionic gel was
developed for deep offshore reservoir stimulation. Specifically, xanthan
gum (XG) serves as the dispersed phase, while a rehydratable sulfobetaine-type
zwitterionic cross-linked gel (poly(sulfobetaine methacrylate)- co -poly(ethylene glycol) diacrylate, PSBMA–PEGDA)
synthesized via UV-initiated free radical polymerization followed
by lyophilization and ball milling acts as the continuous phase. Silica
nanoparticles are subsequently incorporated as a physical cross-linking
reinforcing phase to ultimately yield a stable aqueous two-phase system.
Comprehensive rheological, ball-on-disk tribological, and static proppant
suspension characterizations reveal that the optimized system achieves
an interfacial friction reduction efficiency of 82%, outperforming
its single-phase counterpart by 41.3%. Furthermore, it exhibits a
static proppant suspension duration exceeding 36 h, substantially
outperforming that of conventional single-phase XG system (∼5.8
h). The friction reduction mechanism is primarily governed by the
synergistic effect between the elastic kinetic energy dissipation
of the semirigid XG network and the zwitterionic hydration lubrication
layer. This robust proppant suspension capacity is attributed to the
high-yield-stress 3D hybrid network, which is formed through the spatial
interpenetration of the XG double-helical scaffold and PSBMA–PEGDA
microdomains, and further fortified by silica nanoparticles acting
as physical cross-linking nodes. Consequently, this aqueous two-phase
system emerges as a highly functional fracturing fluid material, integrating
superior friction reduction and proppant suspension properties for
the reservoir stimulation of deep offshore oilfields.
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