ENVIRONMENTAL POLLUTION
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2023
·
IF 8.9
Yingying Sun,Jie Chen,Wei Wang,Lizhong Zhu
Persistent organic pollutants (POPs) in agricultural soil often triggered metabolic alterations and phytotoxicity in plants, ultimately threatening crop quality. Unraveling the phytotoxic mechanisms of POPs in crops is critical for evaluating their environmental risks. Herein, the molecular mechanism of POP-induced phytotoxicity in rice ( Oryza sativa L.) was analyzed using metabolic profile, enzyme activity , and gene expression as linkages, including polycyclic aromatic hydrocarbons, polybrominated diphenyl ethers , polychlorinated biphenyls, and phthalate esters. Despite no observable changes in phenotypic traits (e.g., biomass and length of aboveground), the levels of reactive oxygen species (ROS) were promoted under stresses of the tested POPs, particularly 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47), dibutyl phthalate (DBP), and di(2-ethylhexyl) phthalate (DEHP). Metabolomics analysis revealed that ROS contents positively correlated with metabolic perturbation levels ( r = 0.83), among which the galactose metabolism was significantly inhibited when exposed to DBP, DEHP, or BDE-47. The α-Galactosidase (α-Gal) involved in galactose metabolism was targeted as the key enzyme for the phytotoxicity of DBP, DEHP, and BDE-47, which was revealed by the inhibition of saccharide levels (45.5−82.1%), the catalytic activity of α-Gal (18.5−24.3%), and the gene expression (28.5−34.5%). Molecular docking simulation suggested that the three POPs occupied the active sites of α-Gal and formed a stable protein-ligand complex, thus inhibiting the catalytic activity of α-Gal. Partial least-squares regression analysis indicated that α-Gal activity was negatively associated with hydrogen bond acceptor, rotatable bond, and topological polar surface area of POPs. The results offered novel insights into the molecular mechanisms of phytotoxicity of POPs and provided important information for evaluating the environmental risk of POPs.
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NATURE
·
2023
·Vol. 621
·期 7979
·511-515
·
IF 64.8
Yang Guangxu,Gong Zhenggang,Luo Xiaolin,Chen Lihui,Shuai Li
Plywood is widely used in construction, such as for flooring and interior walls, as well as in the manufacture of household items such as furniture and cabinets. Such items are made of wood veneers that are bonded together with adhesives such as urea–formaldehyde and phenol–formaldehyde resins 1 , 2 . Researchers in academia and industry have long aimed to synthesize lignin–phenol–formaldehyde resin adhesives using biomass-derived lignin, a phenolic polymer that can be used to substitute the petroleum-derived phenol 3 , 4 , 5 , 6 . However, lignin–phenol–formaldehyde resin adhesives are less attractive to plywood manufacturers than urea–formaldehyde and phenol–formaldehyde resins owing to their appearance and cost. Here we report a simple and practical strategy for preparing lignin-based wood adhesives from lignocellulosic biomass. Our strategy involves separation of uncondensed or slightly condensed lignins from biomass followed by direct application of a suspension of the lignin and water as an adhesive on wood veneers. Plywood products with superior performances could be prepared with such lignin adhesives at a wide range of hot-pressing temperatures, enabling the use of these adhesives as promising alternatives to traditional wood adhesives in different market segments. Mechanistic studies indicate that the adhesion mechanism of such lignin adhesives may involve softening of lignin by water, filling of vessels with softened lignin and crosslinking of lignins in adhesives with those in the cell wall.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-10
·
IF 16.6
Xue Tiantian,Zhu Chenyu,Yu Dingyi,Zhang Xu,Lai Feili,Zhang Longsheng,Zhang Chao,Fan Wei,Liu Tianxi
Polyimide aerogel fibers hold promise for intelligent thermal management fabrics, but their scalable production faces challenges due to the sluggish gelation kinetics and the weak backbone strength. Herein, a strategy is developed for fast and scalable fabrication of crosslinked polyimide (CPI) aerogel fibers by wet-spinning and ambient pressure drying via UV-enhanced dynamic gelation strategy. This strategy enables fast sol-gel transition of photosensitive polyimide, resulting in a strongly-crosslinked gel skeleton that effectively maintains the fiber shape and porous nanostructure. Continuous production of CPI aerogel fibers (length of hundreds of meters) with high specific modulus (390.9 kN m kg −1 ) can be achieved within 7 h, more efficiently than previous methods (>48 h). Moreover, the CPI aerogel fabric demonstrates almost the same thermal insulating performance as down, but is about 1/8 the thickness of down. The strategy opens a promisingly wide-space for fast and scalable fabrication of ultrathin fabrics for personal thermal management.
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Arabian Journal of Chemistry
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2023
·
IF 6
Yuan Lin,Yimin Zhang,Zhuang Xiong,Min Wu,Muling Zeng,Chuangnan Li,Fujin Liu,Yazhi Liao,Chunping Liu,Jing Chen
In this study, we successfully synthesized a novel glycyrrhetinic acid (GA) derivate compound as a liposomal carrier. Glycyrrhetinic acid-diaminododecane-cholesterol (GA-DA-CH) was synthesized from GA, diaminododecane, and cholesteryl hemisuccinate by two-step amidation under catalytic conditions. The chemical structures of GA-DA (glycyrrhetinic acid-diaminododecane) and GA-DA-CH were confirmed by Mass Spectrum (MS), Nuclear Magnetic Resonance (NMR) spectrometer, and analyzed by Fourier Transform Infrared spectroscopy (FTIR), High-Performance Liquid Chromatography (HPLC). Glycyrrhetinic acid ligand-modified liposomes (GA-DA-CH-Lips) were prepared, consisting of egg phosphatidylcholine, cholesterol and GA-DA-CH. GA-DA-CH was integrated into the liposomal capsule to promote hepatocellular carcinoma targeting. The particle size of GA-DA-CH-Lips was calculated to be between 122.87 and 133.30 nm, with an approximate polydispersity index (PDI) was 0.20, and a zeta potential was in the range of –32.50 to –26.53 mV. GA-DA-CH-Lips were constructed with more than 90% encapsulation efficient and drug loading efficiency of no<6.40%. In addition, environmental stability assays show that GA-DA-CH-Lips are sensitive to temperature, and thus should be preserved at low temperatures. Furthermore, in vitro cellular uptake from qualitative and quantitative analysis indicates that GA-DA-CH integrating into liposomes possess a specific target for hepatocellular carcinoma. Intracellular inhibition showed that GA-DA-CH-Lips effectively inhibited cell proliferation in dose-dependent features. Based on these results, we have reason to believe that GA-DA-CH-Lips could be a potential hepatic target drug delivery to improve the therapeutic effect of hepatic diseases.
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CHEMOSPHERE
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2023
·
IF 8.8
Hao Li,Canyuan Lin,Ruhui Ma,Yuancai Chen
In this study, the selective adsorption of aromatic compounds on mesoporous MIL-53(Al) was investigated, and followed the order: Biphenyl (Biph) > Triclosan (TCS) > Bisphenol A (BPA) > Pyrogallol (Pyro) > Catechol (Cate) > Phenol (Phen), and exhibited high selectivity toward TCS in binary compounds. In addition to hydrophobicity and hydrogen bonding, π–π interaction/stacking predominated, and more evidently with double benzene rings. TCS-containing halogens could increase π interaction on the benzene rings via forming Cl–π stacking with MIL-53(Al). Moreover, site energy distribution confirmed that complementary adsorption mainly occurred in the Phen/TCS system, as evidenced by Δ Q pri (the decreased solid-phase TCS concentration of the primary adsorbate) < Q sec (the solid-phase concentrations of the competitor (Phen)) . In contrast , competitive sorption occurred in the BPA/TCS and Biph/TCS systems within 30 min due to Δ Q pri = Q sec , followed by substitution adsorption in the BPA/TCS system, but not for the Biph/TCS system, likely attributed to the magnitude of energy gaps (E g ) and bond energy of TCS (1.80 eV, 362 kJ/mol) fallen between BPA (1.74 eV, 332 kJ/mol) and Biph (1.99 eV, 518 kJ/mol) according to the density-functional theory of Gaussian models. Biph with a more stable electronic homeostasis than TCS lead to the occurrence of substitution adsorption in the TCS/BPA system, but not in the TCS/Biph system. This study provides insight into the mechanisms of different aromatic compounds on MIL-53(Al).
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CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Wei Huang,Xiangyu Tang,Wuming Fan,Qianqian Sun,Yonggui Wang,Zefang Xiao,Yanjun Xie
The development of photothermal materials with high photothermal-conversion efficiencies is important in a range of applications, such as power generation, sterilization, desalination , and energy-production. To date, a few reports have been published related to improving the photothermal conversion performances of photothermal materials based on self-assembled nanolamellae. Herein, hybrid films of co -assembled stearoylated cellulose nanocrystals (SCNCs) and polymer-grafted graphene oxide (pGO)/polymer-grafted carbon nanotubes (pCNTs) were prepared. The chemical compositions , microstructures, and morphologies of these products were characterized, and it was found that the self-assembled SCNC structures exhibited numerous surface nanolamellae due to crystallization of the long alkyl chains. The hybrid films (i.e., SCNC/pGO and SCNC/pCNTs films) consisted of ordered nanoflake structures, confirming the co-assembly behavior of the SCNCs with pGO or pCNTs. The melting temperature (~65 °C) and latent heat of melting (87.87 J/g) of SCNC 1.07 indicate its potential to induce the formation of nanolamellar pGO or pCNTs. Under light irradiation (50–200 mW/cm 2 ), the pCNTs exhibited a higher light absorption capacity than pGO, and as a result, the SCNC/pCNTs film exhibited the best photothermal performance and electrical conversion, ultimately demonstrating its potential for use as a solar thermal device in practical applications.
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JOURNAL OF FOOD SAFETY
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2023
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IF 2.4
Shengjie Li,Feng Cheng,Xueqin Cao,Bakri Mahinur,Maitinuer Maiwulanjiang
As the interest in “natural” and “safe” products grows, the use of natural products instead of synthetic preservatives to combat food spoilage and poisoning caused by microorganisms during processing and storage has become a prioritized option. The present research evaluated the antibacterial activity of the Mentha longifolia L. essential oil (MLEO) against several pathogenic bacteria, and the mechanism of action against methicillin-resistant Staphylococcus aureus (MRSA). Gas Chromatography Quadrupole Time-of-Flight Mass Spectrometry (GC-Q-TOF MS) analysis suggested that main components of MLEO were carvone (47.39%) and limonene (12.48%). The oil showed considerable antibacterial activity with MIC values of 0.394–1.576 mg/mL, and could be a promising bactericide. Non-targeted metabolomics analysis based on GC-Q-TOF MS identified 66 different metabolites, and Kyoto Encyclopedia of Genes and Genomes enrichment analysis of these metabolites revealed that MLEO achieves the effects by affecting amino acid metabolism in MRSA.
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APPLIED SURFACE SCIENCE
·
2023
·
IF 6.7
Xinqi Liu,Huiling Yuan,Qian Zheng,Bingyuan Huang,Fang Liao,Hejun Gao,Hongquan Fu,Juan Zhang,Yunwen Liao
The effective capture and storage of radioactive iodine is of great significance to the safe use of nuclear energy. In this study, nitrogen- and oxygen-doped carbon nanotubes acted as effective iodine capture agents in a low concentration of iodine solution of approximately 100 mg L −1 . The iodine uptake capacity is proportionate to hydroxy-functional groups as oxygen species and graphitic nitrogen as nitrogen species, respectively, rather than defects and the specific surface area of carbon nanotubes. The essential adsorption activity of oxygen-doped carbon nanotubes is more than 2.5 times that of nitrogen-doped carbon nanotubes, indicating oxygen-doped carbon nanotubes as a potential carbon material in practical applications for the adsorption of iodine. Theoretical study further deepened the understanding of the iodine adsorption sites on carbon nanotubes. This work provided a new method for the design and synthesis of high-performance radioactive iodine solid adsorbents in the future.
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INDUSTRIAL CROPS AND PRODUCTS
·
2023
·
IF 5.9
Xuelian Wang,Xinping Li,Chandravati Yadav,Wu Lan,Linping Wang,Yasumitsu Uraki,Jia Kang,Hui Jie Zhang,Xiangyu You
Kraft lignin (KL) is an industrial byproduct of pulp preparation from woody biomass and is mainly burned for energy recovery. To explore value-added applications of KL, it was first acetylated, and acetylated lignin (AcL) was combined with poly( N,N -dimethylacrylamide) to prepare tough lignin hydrogels crosslinked by hydrophobic lignin domains via a simple solvent exchange method. The AcL hydrogels (AcLGs) with optimum mechanical properties have a high tensile strength of 1.7 MPa, large Young's modulus of 1 MPa, and super high fracture energy of ∼47600 J m −2 . The Young's modulus and tensile strength of AcLG are 60 and 6 times higher than those of the pristine KL based hydrogel, respectively. AcLG had a weak inhibitory effect on Chinese hamster lung cell proliferation . Owing to its good mechanical properties and noncytotoxicity, AcLG has excellent potential as a biomedical material .
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CHEMICAL ENGINEERING SCIENCE
·
2023
·
IF 4.7
Chuanqi Geng,Xiaojia Wu,Hui Yu,Xinyu Li,Chencan Du,Zhiyong Zhou,Zhongqi Ren
In this study, N-butylpyridinium tetrachloroferrate ([Bpy][FeCl 4 ]), a temperature-responsive solvent, was applied to achieve reversible phase-change extraction with simultaneous solvent recycling for the ethanol/heptane and toluene/heptane systems. The distribution and selectivity coefficients were 7.87 and 0.862, respectively, for ethanol in the 60 mass% ethanol/heptane system; the corresponding values for toluene in the 20 mass% toluene/heptane system were 1.34 and 44.3, respectively, which are significantly better than those for existing conventional solvents. [BPy][FeCl 4 ] was reused five times in each system, and the extraction efficiency remained stable at high values. The experimental results as a function of temperature and solvent:solute mass ratio showed that the reversible phase-change process by [BPy][FeCl 4 ] could be achieved under a range of conditions. This process achieves switchable phase-change extraction and simultaneous solvent recovery, thus offering the possibility of saving energy, reducing equipment requirements, and simplifying operations.
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MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Jie Yu,Zhonghang Chen,Jiefan Zhu,Viachaslau Zhylko,Liyan Dai
The aqueous two-phase extraction process (APTE) was utilized for the extraction of polysaccharides from the fruits of Ilex cornuta (Lindl. et Paxt.) (PFIC). After screening and selection of isopropanol/ammonium sulfate as the aqueous two-phase system, various parameters of crude extract amount, ultrasonic time, extraction temperature and extraction time on the extraction process was investigated in detail and optimized by response surface methodology (RSM). Under the optimal conditions in which crude extract amount was 2.23 g, ultrasonic time was 17.5 min, extraction temperature was 69 °C and extraction time was 1.55 h, the yield of polysaccharides reached 50.87% which was close to the predicted value of 50.78%. Structural features of PFIC were investigated by GPC, GC–MS and FT-IR analysis. And the results indicated that PFIC with a molecular weight of 3.89 kDa was composed of monosaccharides including rhamnose (1.83%), arabinose (11.70%), xylose (3.30%), mannose (3.55%), glucose (61.88%) and galactose (17.74%). The bioactivity experiments showed that PFIC had strong scavenging ability on DPPH radical, fine scavenging ability on hydroxyl radical and certain scavenging ability on superoxide anion radical. Overall, these results suggested that PFIC exhibiting fine to good antioxidant capacities could be potentially developed as a natural antioxidant.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2023
·Vol. 21
·期 1
·1-15
·
IF 10.2
Zhang Yipeng,Wang Liying,Wang Zi-Dan,Zhou Quan,Zhou Xuefei,Zhou Tianhua,Guan Yi-Xin,Liu Xiangrui
Colon-targeted oral drug delivery systems (CDDSs) are desirable for the treatment of ulcerative colitis (UC), which is a disease with high relapse and remission rates associated with immune system inflammation and dysregulation localized within the lining of the large bowel. However, the success of current available approaches used for colon-targeted therapy is limited. Budesonide (BUD) is a corticosteroid drug, and its rectal and oral formulations are used to treat UC, but the inconvenience of rectal administration and the systemic toxicity of oral administration restrict its long-term use. In this study, we designed and prepared colon-targeted solid lipid nanoparticles (SLNs) encapsulating BUD to treat UC by oral administration. A negatively charged surfactant (NaCS-C12) was synthesized to anchor cellulase-responsive layers consisting of polyelectrolyte complexes (PECs) formed by negatively charged NaCS and cationic chitosan onto the SLNs. The release rate and colon-specific release behavior of BUD could be easily modified by regulating the number of coated layers. We found that the two-layer BUD-loaded SLNs (SLN-BUD-2L) with a nanoscale particle size and negative zeta potential showed the designed colon-specific drug release profile in response to localized high cellulase activity. In addition, SLN-BUD-2L exhibited excellent anti-inflammatory activity in a dextran sulfate sodium (DSS)-induced colitis mouse model, suggesting its potential anti-UC applications.
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