SENSORS AND ACTUATORS B-CHEMICAL
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2026
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IF 8.3
Xudong Liang,Yuchen Duan,Xiangyu Li,Fujia Zhao,Yunwei Li,Yiming Jian,Lei Shi,Jiayu Li,Guo-Dong Li
Detection of 3-hydroxy-2-butanone (acetoin), a characteristic volatile metabolite of Listeria monocytogenes (LM) , represents a promising non-invasive strategy for monitoring contamination levels of foodborne pathogens in food. However, current sensing materials suffer from poor selectivity and insufficient sensitivity at trace concentrations. Herein, a series of Pd-loaded Cd 2 GeO 4 (Pd/CGO) chemiresistive gas sensors that achieves highly selective and sensitive acetoin detection was reported. Among them, the 0.5 wt% Pd/CGO-based sensor exhibits a high response, with an ultrafast response time and a detection limit as low as 10 ppb. The sensor also demonstrates excellent selectivity over common interfering gases, good reproducibility, and robust long-term stability. Mechanistic investigations combining O 2 -TPD, XPS, and DFT calculations reveal that Pd loading not only increases the proportion of chemisorbed oxygen species on the CGO surface, which enhances the overall sensing response, but also serves as new active sites. This work demonstrates that rational Pd modification combined with dual-site engineering offers a promising paradigm for designing high-performance metal oxide gas sensors for pathogen biomarker detection in food.
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CHEMICAL ENGINEERING JOURNAL
·
2026
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IF 12.5
Yu Liu,Changting Chen,Chengzuo Liu,Jianan Zeng,Jianqiang Luo,Xiaolan Tong,Xuejiao Peng,Shujuan Liu,Jianguo Ma
Constructed a type-II CoNC@CdS heterojunction for PEC reduction of U(VI). • PEC reaction rate was 12.8 times that of photocatalysis alone. • Built-in electric field and bias synergistically promoted charge separation. • Soluble U(VI) was efficiently converted to insoluble UO 2 precipitate. Photoelectrocatalytic (PEC) reduction of U(VI) is an effective strategy for treating uranium contamination in water. Herein, a CoNC@CdS type-II heterojunction electrode was designed for the efficient reduction of U(VI) via a PEC process. Under optimized conditions, the fabricated electrode delivers an outstanding U(VI) removal efficiency of 97.8%, accompanied by a pseudo-first-order kinetic rate constant of 0.0349 min −1 . The PEC reaction rate of CoNC@CdS is 20.1 and 12.8 times higher than that of single electrocatalysis and photocatalysis systems, respectively. Stability evaluation reveals that even after six successive cyclic tests, the U(VI) removal efficiency remains above 80%, demonstrating robust cycling durability. Mechanism characterizations elucidate that CoNC improves electrode conductivity and light absorption capability, while layered CdS shortens charge migration distance and restrains carrier recombination. The built-in electric field of type-II heterojunction combined with external bias drives spatial separation and directional transport of photogenerated charge carriers, thereby efficiently converting soluble U(VI) into insoluble UO 2 precipitates. This work provides a promising strategy for uranium recovery and remediation in complex aqueous matrices.
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Communications Earth & Environment
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2026
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IF 9.3
Yang Ning,Wang Xiaofei,Wang Junfeng,Deng Junjun,Wei Zhenwei,Fu Pingqing
The high electric field at the microdroplet interface plays a crucial role in regulating aqueous aerosol chemistry. However, the impact of charge at the air-water interface on sulfur-containing aerosols remains unclear. Here we show, using various microdroplet systems, how interfacial reactions of sulfur-containing aerosols proceed under different charge conditions. Field observations were also conducted across multiple regions to characterize the molecular composition of aqueous sulfur-containing aerosols. In small negatively charged droplets, sulfite is spontaneously oxidized to sulfate, with an estimated rate comparable to reported rates of sulfite oxidation by common atmospheric oxidants. Meanwhile, sulfur radicals like sulfate radicals are generated, leading to the rapid formation of organosulfates. In large positively charged droplets, sulfate is spontaneously reduced to sulfite radicals and sulfite, promoting the formation of organosulfonates. These results provide key insights into how charge at the air–water interface affects sulfur aerosols and contribute to our understanding of air pollution.
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Nature Communications
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2026
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IF 18.1
Zuo Shulin,Lin Muke,Xu Guizhi,Huang Jiahao,Zhang Rumeng,Mei Ji,Fang Jingyun,Xia Dehua
Conventional catalytic ozonation of electron-rich sulfur-containing pollutants shows limited efficiency due to nonselective oxidation of hydroxyl radicals ( • OH) and sulfate-induced deactivation of active metal sites. Here, we synthesized a high-entropy spinel, (CuNiMnCo)Fe 2 O 4 , featuring sublattice-resolved electronic reconstruction that enables selective ozone activation and suppresses sulfur poisoning. The catalyst achieves 99% removal of methyl mercaptan (CH 3 SH), significantly outperforming 51% of CoFe 2 O 4 . Spectroscopic analyses and density functional theory calculations reveal that high-entropy doping induces lattice distortion and local coordination disorder, which strengthen A–O–B covalency and inter-site electronic communication. This structural perturbation further drives a sublattice-resolved electronic reconstruction, enriching Co/Mn sites while depleting Fe/Cu/Ni sites. This electronic differentiation promotes cooperative dual-end activation of O 3 on Fe–Co/Mn motifs and preferential CH 3 SH adsorption on Cu/Ni sites. Orbital modulation of Co t 2g and Fe e g states near the Fermi level balances interfacial charge transfer, favoring formation of a surface-bound *O 3 species over conventional O–O bond cleavage. The resulting spatially separated activation and oxidation sites enable CH 3 SH mineralization via an electron transfer process while suppressing • OH generation and minimizing sulfate accumulation. This spatially differentiated reaction environment ensures durable performance under humid conditions. These findings establish sublattice-engineered electronic asymmetry as a strategy for selective catalytic ozonation.
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Nature Communications
·
2026
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IF 18.1
Liu Xu,Cao Miao,Jia Feiyue,Jia Hongbao,Li Zonglin,Guo Xueping,Zhang Junrong,Hua Weijie,Li Lina,Wu Qian,Zhao Hongying
Antibiotic-resistant bacteria (ARB) and their genes (ARGs) pose a significant risk to public health and the ecosystem. Conventional water disinfection efficiently eliminates pathogens, however, it requires intensive chemical consumption but inefficiently removes ARGs. Herein, we propose an on-demand electrochemical platform that simultaneously eliminate both ARB and ARGs with in-situ generated hydroxyl radicals (·OH) without additional chemical inputs. Single-atom copper catalysts with CuN 4 coordination structure (SA-CuN 4 /NC) are precisely tuned to directly convert oxygen into controllable ·OH via three-electron oxygen reduction reaction (3e⁻ ORR). Operando X-ray adsorption near-edge spectroscopy reveals a potential-driven self-reconstruction of single-atom Cu sites to optimize ·OH concentration. Specially, the preferentially adsorbed H + onto the adjacent N atoms promotes the breaking of Cu-N bonds to form stable Cu 2 -CuN 2 cluster as a genuine active site. As expected, the SA-CuN 4 /NC with moderate ·OH (~11.5 μM) exhibits ultra-fast degradation of E. coli HT115 , accomplishing an ~ 8 log removal within 1 min and a complete elimination of ARGs in 30 min. Excess ·OH (~47.9 μM) triggers bacterial aggregation which compromises bacterial inactivation. These findings demonstrate that 3e⁻ ORR is a sustainable and effective strategy to obtain fast and complete water disinfection, preventing environmental spread of ARGs.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2026
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IF 4.1
Xue Jun-Chang,Jiang Yue,Xia Huan,Hou Lu,Li Heng-Ye,Wang Zhong-Xia,Kong Fen-Ying,Wang Wei
An electrochemical sensor was developed for the sensitive voltammetric determination of 4-nitrophenol (4-NP) by integrating an in situ grown nanocomposite of amino-functionalized carbon nanotubes (NH 2 -CNTs) and a zinc porphyrin-tetrathiafulvalene covalent organic framework (TTCOF-Zn). This hybrid design strategically couples the electron donor–acceptor (D-A) architecture of TTCOF-Zn, featuring pre-engineered electron transport channels, with the exceptional electrical conductivity of NH 2 -CNTs via covalent bonding, synergistically enhancing charge transfer efficiency. Leveraging the high conductivity, abundant active sites, and hierarchical porosity of the TTCOF-Zn/NH 2 -CNTs nanocomposite, the modified electrode achieves an exceptional detection limit of 17 nM (linear range, 50 nM–1 mM) using differential pulse voltammetry, surpassing most reported sensors. The sensor also demonstrates excellent reproducibility, long-term stability, and strong anti-interference capability against common co-existing species. Its practical applicability was demonstrated through quantitative analysis of 4-NP in real lake water samples, with results validated by the HPLC method, underscoring the potential of D-A COF/CNT covalent hybrids for high-performance environmental monitoring. Graphic
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2026
·Vol. 37
·期 22
·1766
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IF 3.2
Wang Dingqin,Fei Zihao,Zheng Deyi
Perovskite-structured Li 0.33 La 0.56 TiO 3 (LLTO) ceramic fillers are widely used for their low cost and environmental friendliness, yet their poor uniform dispersion in polymer matrices and inadequate interfacial compatibility between phases still limit performance. This study fabricated PDA@LLTO/PVDF-HFP composite electrolytes via solution casting, by modifying LLTO with a biodegradable polydopamine (PDA) coating. Dopamine undergoes oxidative self-polymerization on LLTO surfaces to form a PDA layer, whose excellent adhesion ensures firm binding to the LLTO surfaces, reducing filler surface energy and promoting uniform dispersion. Meanwhile, PDA’s phenolic hydroxyl and amino groups interact with PVDF-HFP’s fluorine and carbonyl groups via hydrogen bonding, electrostatic interactions, and physical entanglement, forming a strong interface. PDA reduces interfacial gaps and defects by acting as a “molecular bridge” to improve adhesion between the two phases. Results show the 2.4 wt%-PDA@LLTO/PVDF-HFP composite exhibits well-balanced electrochemical performance: an ionic conductivity of 2.37 × 10 −4 S cm −1 at 25 °C, an interfacial impedance reduced from 367 to 167 Ω, a lithium-ion migration number of 0.81, and an electrochemical stability window expanded to 4.88 V, The critical current density reaches 2.297 mA/cm 2 . The assembled solid-state full batteries deliver an initial discharge capacity of 168.59 mAh/g at 0.5 C, retaining 148.80 mAh/g (88.3% capacity retention) after 180 cycles, with Coulombic efficiency stabilized at 99.6% and significantly improved thermal stability. This work provides new insights for developing high-performance all-solid-state electrolytes, which hold promising applications.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2026
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IF 4.1
Wei Ruxia,Sheng Wei,Chen Shengyu,Zheng Yiwei,Li Xu,Feng Na,Luo Yanni,Tan Xuecai,Huang Ke-Jing
The development of highly sensitive and selective platforms for trace Zn 2+ detection is crucial for environmental monitoring and biomedical diagnostics. Herein, a photoelectrochemical (PEC) sensor was constructed using an L-cysteine (L-Cys)-functionalized BiOBr composite, in which surface-interface engineering was adopted to enrich available recognition sites and modulate the interfacial PEC response. Compared with pristine BiOBr, the incorporation of L-Cys introduces abundant Zn 2+ binding functional groups and modifies the local surface environment of BiOBr, thereby enhancing the photocurrent response and enabling the selective recognition of Zn 2+ . The sensor operates through a signal-off mechanism, in which the coordination of Zn 2+ with surface-bound L-Cys forms an interfacial coordination layer that partially hinders mass transport and interfacial charge transfer, resulting in a decrease in photocurrent. Under optimized conditions, the platform exhibits a wide linear response ranging from 0.5 to 40 nmol/L, with a low detection limit of 2.69 nmol/L ( S / N = 3). Furthermore, the applicability of the sensor is validated in real-world scenarios, demonstrating excellent recoveries in tap water, lake water, and complex biological matrices such as HepG2 cell lysates (recoveries, 96.3–108.5%). This work provides a robust strategy for engineering bio-semiconductor interfaces for the detection of essential metal ions in complicated samples.
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ACS Sensors
·
2026
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IF 10.9
Weizhuo Gao,Chuanyu Zhang,Hongcheng Xu,Xifeng Sun,Xiaoke Lu,Jing Zhang,Wanheng Zhou,Kun Wei,Hao Sun,Weixuan Jing,Zhuangde Jiang,Xueyong Wei
Biomolecular point-of-care monitoring in saliva, urine, and sweat pioneers the real-time and noninvasive biochemical analysis for personalized healthcare and precision disease therapeutics. However, the adoption of these technologies still faces challenges due to the hardly detectable targets with weak redox activity, extremely low analyte concentration, operational instability of sensors, and low scalability of the fabrication process. To address these issues, we proposed a novel core-shell multifunctional particle for the light-enhanced detection of testosterone at the nanomolar level. The particle comprises a ZnIn2S4/SiC core and a targeted molecularly imprinted polymer shell, achieving multifunctions, including visible light sensitivity, testosterone recognition, and redox activity. The printable ability of the multifunctional particle leads to inkjet-printed testosterone sensors with stable (over 50 days), reproducible, and outstanding light-promoted sensing performance (limit of detection 0.01 nM (S/N = 3) and linear range from 0.01 to 1000 nM). The effectiveness of the testosterone sensors was validated in saliva and urine lateral flow electrochemical testing strips and wearable sweat testosterone sensors, achieving testosterone point-of-care testing in multiple human biofluids. These offer great opportunities for the noninvasive biomolecular profiling, further promoting personalized healthcare and precision disease therapeutics.
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MOLECULAR PHARMACEUTICS
·
2026
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IF 4.9
Xiaoqian Liu,Weitao Fang,Ruijie Zhang,Wuheng Yue,Zhiwei Xiong,Baimin Niu,Huizhen Sun,Jiaxin Chen,Jue Wang,Jiawei Han
Some drugs undergo gelation during the formulation development process, which not only poses significant challenges to the manufacturing process of solid dosage forms but also significantly restricts the drug dissolution and absorption. Could such gelation be utilized by designing the prescription to overcome the adverse effects and water solubility defect of drugs? Herein, this study attempted to design the self-gelation tablets of indomethacin (IND) by introducing small-molecule ligands and to explore the self-gelation mechanism. As a result, the designed tablets occurred to have spontaneous gelation with a typical 3D structure and viscoelasticity upon contact with a small amount of water, accompanied by amorphization transformation. Such a self-gelation behavior was significantly influenced by the composition ratios, storage temperatures, and medium pH values. In comparison to pure IND tablet, the designed IND-ligand tablets performed significantly increased apparent solubility (>200-fold) and intrinsic dissolution rate (>6000-fold) and maintained the long-term supersaturated dissolution with acid–base interactions, which was revealed by nucleation inhibition, fluorescence quenching, and phase solubility tests. Moreover, the self-gelled tablets significantly enhanced the membrane permeability of IND, demonstrating the potential for promoting oral absorption. Thus, this study revealed the self-gelation mechanism of the tablet combination and confirmed such prescription design involving self-gelation as an efficient solubilization strategy.
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ACS Applied Materials & Interfaces
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2026
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IF 7.8
Peixin Zhang,Luoxing Xiang,Junghye Lee,Zhengkai Chen,Lin Huang,Liang Feng
Developing advanced adsorbents with both high selectivity and low regeneration energy remains a central challenge in realizing energy-efficient CO2 capture technologies. In this work, we report an ultramicroporous metal–organic framework, PCP-IPAN, designed with CO2-philic electrostatic cavities to promote strong yet thermally tunable interactions with CO2 molecules. Notably, the framework exhibits highly temperature-sensitive adsorption profiles, characterized by a sharp reduction in CO2 uptake within a narrow temperature range (273–323 K). This significant thermal sensitivity enables a large working capacity and ensures facile desorption at mild temperatures, which is a key requirement for reducing the energy penalty in pressure- and temperature-swing adsorption (P/TSA) processes. Single-component adsorption measurements reveal that PCP-IPAN-Co achieves high CO2 capacities of 4.60 and 3.32 mmol g–1 at 273 and 298 K (1.0 bar), respectively. Furthermore, it delivers CO2/N2 (15/85) IAST selectivities of 71.6 and 99.3, alongside CO2/CH4 (50/50) IAST selectivities of 39.8 and 19.6 at these temperatures. Dynamic column breakthrough experiments for CO2/N2 and CO2/CH4 binary mixtures confirm the material’s excellent separation selectivity, and vacuum pressure swing adsorption (VPSA) simulations demonstrate its efficient separation energy consumption during cyclic operation. These findings highlight PCP-IPAN as an efficient platform for carbon capture.
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RSC Advances
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2026
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IF 6.1
Zhenhua Zeng,Ayang Wu,Haimin Gao,Yanping Zheng,Huicong Yang,Xiaojie Yao,Zhongjie Yang
MicroRNAs (miRNAs) are important liquid biopsy biomarkers, and their multiplex detection is highly important for the early screening of hepatocellular carcinoma. This work developed a CRISPR/Cas13a biosensing platform based on near-infrared (NIR) light and glutathione (GSH) dual activation for highly sensitive and specific determination of miRNA-21, miRNA-155, and miRNA-224. The advantages of this platform lie in the introduction of GSH-responsive mesoporous silica carriers and photolytic linkers (pc-linkers), which transform the sensing process from “passive triggering” to “controllable activation”, effectively suppressing nonspecific signals. Specifically, GSH can degrade mSiO 2 with tetrasulfide bonds, thereby degrading the carrier. It will release the CRISPR/Cas13a system loaded on the carrier, thereby achieving specific recognition and cleavage of miRNA-21/155; at the same time, 808 nm NIR light excites upconversion nanoparticles (UCNPs) to generate ultraviolet light, which cleaves the pc-linker to activate the detection of miRNA-224. The detection limits of the developed assay for detecting miRNA-21, miRNA-155, and miRNA-224 were 4.2 pM, 5.7 pM, and 0.205 nM, respectively. The recoveries in the serum spiked experiments were 98.97–109.24%, with a relative standard deviation of less than 4.613%, indicating that the method has good accuracy and reliability. This work proposes a novel and reliable strategy for detecting multiple miRNAs in complex biological samples. MicroRNAs (miRNAs) are important liquid biopsy biomarkers, and their multiplex detection is highly important for the early screening of hepatocellular carcinoma.
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PubMed
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