JOURNAL OF APPLIED MICROBIOLOGY
·
2025
·Vol. 136
·期 9
·
IF 3.2
Song Kangjia,Liu Jie,Zhou Wenqi,Zhang Feifei,Fan Lei,Zhu Deyi,Zhang Xuanhui,Wang Zhi,Sun Jiazhen
AimsThis research aims to screen and identify a microbial strain capable of efficiently degrading waterborne polyurethane used in the biomedical field. Furthermore, the research seeks to enhance the strain’s degradation capability through ultraviolet mutagenesis and elucidate its enzymatic degradation mechanism.Methods and resultsWe successfully isolated the target strain from the soil sample and identified it as Bacillus sp. J-11. Under optimized culture conditions (substrate concentration of 0.4%, temperature of 30°C, and pH of 6.0), strain J-11 exhibited remarkable degradation capability towards biomedical-grade polyurethane emulsion (Baymedix® CD104), achieving a degradation efficiency of 78.2% within 4 days. Gel permeation chromatography (GPC) analysis demonstrated a progressive decrease in the molecular weight of the polyurethane film over time. Thermogravimetric analysis (TGA) further revealed a reduction in thermal stability, while extended depth field microscopy (EDFM) uncovered significant microscopic structural changes, including holes and collapse on the film surface. Additional degradation experiments conducted on commercial PU foam under co-carbon conditions showed that strain J-11 achieved a degradation rate of 37.6% within 30 days. Enzyme activity assays indicated that the hydrolytic and oxidative enzymes secreted by strain J-11 played a critical role in the degradation process.ConclusionsStrain J-11 exhibits highly efficient biodegradation potential through the secretion of hydrolases and oxidases, which break down the molecular chains of polyurethane. This study has elucidated its degradation pathway and provided a theoretical foundation for future mechanistic investigations and the management of biomedical material waste.
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DOI
PubMed
高影响因子
POLYMER BULLETIN
·
2022
·Vol. 80
·期 9
·9709-9726
·
IF 2.843
Wang Guoqiang,Zhang Li,Wang Jianyu,Hao Xingyu,Dong Yakun,Sun Rubo
Polylactic acid (PLA) is a kind of bio-based and biodegradable polyester and has shown promise in a variety of fields, but its wider application is limited due to its brittle property. Therefore, in order to improve the ductility of PLA, we synthesized bio-based and biodegradable poly(butylene adipate-copolybutylene furandicarboxylate) (PBAF70) and blended with PLA. The blend's structure, mechanical properties, thermal properties, crystallization properties, and rheological properties were characterized. The results reveal that when the amount of PBAF70 varies from 0 to 30 wt%, the elongation at break increases from 5.7 to 222%, indicating that PBAF70 enhanced the ductility of PLA. At the same time, XRD results showed that stretching-induced crystallization occurred in PBAF70 during the stretching process. The strongly electronegative oxygen atoms in the furan ring may increase the interaction and the compatibility between PBAF70 and PLA. Therefore, the glass transition temperature of PBAF70 is not obvious in the DSC curves of the blends, and the rheological results show that the complex viscosity of the blends is greater than that of PLA. Due to the addition of PBAF70, PLA can only crystallize at a higher temperature, and the addition of PBAF70 hinders the cold crystallization of PLA. It can be seen from SEM that the cross section of the blend is rough, while the PLA is smooth. When the amount of PBAF70 was the same as that of PBAT, the elongation at break of PLA/PBAF70 was better than PLA/PBAT.
研究领域:
材料科学
·
生物工程
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DOI
高影响因子
ACS Applied Polymer Materials
·
2024
·
IF 4.4
Dongguang Yan,Yingqiang Fan,Chengyu Gu,Bingbing Feng,Tianran Deng,Tianhao Li,Guanggui Cheng
With the rapid advancement of artificial intelligence, there has been a surge of enthusiasm for flexible ionic conductors suitable for use in human–computer interaction. Complex preparation processes, difficulties to being efficiently molded, and disability in rapid integration are the main challenges faced by flexible ionic conductors in practical application. In this study, a simple, facile, and environmentally friendly approach involving melt transesterification and melt blending has been developed to produce ultrastretchable, highly ionically conductive, and easily processable poly(butylene succinate)-block-polyethylene glycol/propylene carbonate/sodium thiocyanate (PBS-b-PEG/PC/NaSCN) blend-based ionic conductive thermoplastic elastomers (ICTEs). Differential scanning calorimetry (DSC), X-ray diffraction (XRD), and Fourier infrared spectroscopy (FTIR) revealed that the excellent ionic conductivity of the ICTE could be attributed to the synergistic effects of poly(butylene succinate) (PBS) segments and propylene carbonate (PC) in constructing ionic conductive channels in the ICTE. The ICTE exhibited a tensile strength of 8.3 MPa and an elongation of 1790%, making it suitable for use in wearable devices. Based on its outstanding processability, shape stability at high temperatures, thermal stability during processing, and constant sensing performance, an ICTE-based fabric sensor was successfully fabricated using the melt spinning and weaving technique. This fabric sensor effectively demonstrated its capability to monitor human activities.
研究领域:
材料科学
·
柔性电子
·
高分子化学
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DOI
高影响因子
JOURNAL OF BIOMATERIALS APPLICATIONS
·
2023
·
IF 2.9
Lihua Guan,Huijing Zhao,Kai Wang,Ke-qin Zhang,Kai Meng
Compliance mismatch between the artificial blood vessel and the host vessel leads to abnormal hemodynamics and is a major mechanical trigger of intimal hyperplasia. Efforts have been made to achieve higher compliance of artificial blood vessels. However, the preparation of artificial blood vessels with compliance matching to host vessels has not been realized. A bi-layered artificial blood vessel was successfully prepared by dip-coating and electrospinning composite method using poly(L-Lactide-co-caprolactone) (PLCL) and thermoplastic poly(ether urethane) (TPU). In the case of a certain wall thickness (200 μm), thickness ratios of the PLCL inner layer (dip-coating method) and TPU outer layer (electrospinning method) were controlled at 0:1, 1:9, 3:7, 5:5, 7:3, and 1:0 respectively and the compliance, radial tensile properties, burst pressure, and suture retention strength were investigated. Results showed compliance value of the artificial blood vessel decreased with the increase of the thickness ratio, which suggested the compliance of the bi-layered artificial blood vessel can be regulated by adjusting the ratio of the inner and outer layer thicknesses. In the six different artificial blood vessels, the one with thickness ratio of 1:9 not only had high compliance (8.768 ± 0.393%/100 mmHg) but also can guarantee the other mechanical properties, such as the radial breaking strength (6.333 ± 0.689 N/mm), burst pressure (534.473 ± 20.899 mmHg), and suture retention strength (300.773 ± 9.351 cN). The proposed artificial blood vessel preparation method is expected to achieve compliance matching with the host vessel. It is beneficial for eliminating abnormal hemodynamics and reducing intimal hyperplasia.
研究领域:
生物医学工程
·
材料科学
·
心血管外科
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DOI
PubMed
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2019
·Vol. 37
·期 11
·1119-1129
·
IF 2.804
Jia Han,Chang Kun,Gu Shu-Ying
A reversible disulfide bond-based self-healing polyurethane with triple shape memory properties was prepared by chain extending of random copolymer poly(lactide- co -caprolactone) (PCLA), hexamethylene diisocyanate (HDI), polytetrahydrofuran (PTMEG), and 4,4′-aminophenyl disulfide. The chemical structures were characterized using 1 H nuclear magnetic resonance ( 1 H-NMR) spectroscopy, Fourier transform infrared spectroscopy (FTIR), and gel permeation chromatography (GPC). The thermal properties, self-healing properties, triple-shape memory effect, and quantitative shape memory response were evaluated by differential scanning calorimetry (DSC), tensile tests, two-step programming process thermal mechanical experiments, and subsequent progressive thermal recovery. The self-healing mechanism and procedures were investigated using polarizing optical microscopy (POM) and an optical profiler. It was concluded that self-healing properties (up to 60%) and triple-shape memory properties around 35 and 50 °C (with shape fixation ratios of 94.3% and 98.3%, shape recovery ratios of 76.6% and 85.1%, respectively) were integrated to the shape memory polyurethane. As-prepared polyurethane is expected to have potential applications in multi-shape coatings, films, and step-by-step deploying structures.
研究领域:
材料科学
·
高分子化学
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DOI
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2018
·Vol. 410
·期 25
·6653-6661
·
IF 3.307
Zhang Wenjuan,Jiang Liyan,Wang Dongze,Jia Qiong
In this work, poly(glycidyl methacrylate-ethyleneglycol dimethacrylate) monolith functionalized with copper tetra(N-carbonylacrylic) aminephthalocyanine and iminodiacetic acid was successfully synthesized. Owing to hydrogen bonding and hydrophilic interactions, the monolith exhibited good performance for glycopeptide enrichment. When the tryptic digests of horseradish peroxidase were enriched by the developed monolith, a total of 20 glycopeptides could be captured and identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis with a detection limit as low as 0.5 fmol μL −1 . With the mixture of bovine serum albumin and horseradish peroxidase digests (200:1, m / m ) as the sample, 14 glycopeptides were identified after enrichment, showing the high selectivity of the monolith. Moreover, the functionalized monolith exhibited good stability and reproducibility. It was successfully applied to enrich glycopeptides from human serum, demonstrating its potential applications in selective and efficient capture of glycopeptides in complex biological samples.
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研究领域:
分析化学
·
蛋白质组学
·
生物医学工程
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DOI
PubMed
高影响因子
Gels
·
2025
·Vol. 11
·期 5
·370
·
IF 5.3
Fangyi Liu,Gaoyang Li,Zhenhui An,Sijia Wang,Shouhong Xu,Honglai Liu
Oxidative stress and chronic inflammation play pivotal roles in causing impaired tissue regeneration and delaying wound healing processes. Epigallocatechin gallate (EGCG) demonstrates robust anti-inflammatory and antioxidant characteristics, thereby emerging as a highly promising therapeutic substance for tissue repair applications. In order to counteract the pathological characteristics of the wound microenvironment, including increased levels of reactive oxygen species (ROS), low pH (weak acidic conditions), and elevated glucose concentrations, a hydrogel with pH/ROS/glucose-responsive properties was fabricated. This hydrogel was modified with phenylboronic acid (PBA) groups, which not only enhance its mechanical strength but also endow it with multi-stimuli responsiveness via dynamic boronate ester bonds. The impacts of grafting of PBA and loading of EGCG on the rheological and mechanical properties, as well as the network structure of the hydrogels, were systematically investigated. Moreover, in vitro experiments showed that the hydrogel could achieve excellent sustained and controlled release of both small-molecule and macromolecular drugs. Additionally, cell viability tests verified the hydrogel’s outstanding biocompatibility, and antioxidant experiments demonstrated its efficient ability to scavenge intracellular ROS. In conclusion, this injectable and biodegradable hydrogel possesses multi-stimuli responsiveness, controllable drug release behavior, and antioxidant capacity, presenting a promising approach to alleviate oxidative damage and promote tissue repair. This study offers valuable perspectives for the design of advanced hydrogel materials aimed at treating wound healing.
研究领域:
生物材料学
·
药剂学
·
组织工程学
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产品关联
DOI
PubMed
高影响因子
ChemCatChem
·
2025
·
IF 3.9
Yannan Han,Jilei Xu,Beizhan Li,Qingda An,Zuoyi Xiao,Jiahui Huang
Graphical In this study, we developed a new strategy for the synthesis of long-chain dicarboxylic acid ester precursors via the aldol condensation of 2,5-diformylfuran (DFF) and methyl levulinate (MLA) in the presence of protic ionic liquids. The reaction mechanism was further investigated using nuclear magnetic resonance (NMR) and Fourier transform infrared spectroscopy (FTIR). In this study, a series of long-chain dicarboxylic acid ester precursors were synthesized via aldol condensation reactions catalyzed by protic ionic liquids (PILs). When 2,5-diformylfuran (DFF) and methyl levulinate (MLA) were employed as substrates, the yield of long-chain dicarboxylic acid ester precursors reached 91.0% in the presence of pyrrolidine lactate. This preparation process eliminated the need for additional acids and bases, thereby minimizing the generation of waste salts, which was a common issue in base-catalyzed systems and biosynthesis methods. Nuclear magnetic resonance (NMR) characterization revealed that a strong interaction between the hydroxyl group of the catalyst and the carbonyl group of MLA facilitated the activation of the substrate for the aldol condensation reaction. Notably, the yield of dicarboxylic acid ester precursors remained stable even after five catalytic cycles, demonstrating the excellent reusability of the catalyst. Furthermore, pyrrolidine lactate exhibited broad applicability in both aldol condensation and Knoevenagel condensation reactions. This work presented a novel and sustainable strategy for the synthesis of long-chain dicarboxylic acid ester precursors.
研究领域:
化学工程
·
生物基材料合成
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产品关联
DOI
高影响因子
Advanced Materials Interfaces
·
2019
·Vol. 6
·期 13
·1900535
·
IF 4.713
Qingyi Xie,Haohang Zeng,Qingmei Peng,Christine Bressy,Chunfeng Ma,Guangzhao Zhang
Chemical immobilization of antifoulant groups to polymers is a promising approach to develop ecofriendly antifouling materials with static antifouling ability and a durable efficacy. In this work, telomer of dodecafluoroheptyl methacrylate (DFMA), triclosan acrylate (TA), and 3-mercaptopropyl trimethoxysilane (KH590) is grafted to bis-silanol terminated poly(dimethylsiloxane) (PDMS), yielding a novel self-stratifying silicone coating containing nonleaching antifoulants. X-ray photoelectron spectroscopy (XPS) analysis reveals that the antifoulant groups are enriched on the coating surface due to DFMA migration. Such a modified PDMS coating can significantly inhibit the growth of marine bacterial biofilm and the adhesion of diatoms owing to the nonleaching antifoulant groups. On the other hand, the coating exhibits a good fouling release performance since it inherits the low surface energy (≈20 mJ m −2 ) and low elastic modulus (<2 MPa) from PDMS forming a physically dynamic surface. Marine field tests demonstrate that the coating has excellent antifouling ability after immersion in natural seawater for more than 6 months.
研究领域:
材料科学
·
海洋生物学
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DOI
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
·
2019
·
IF 2.29
Junjie Chen,Bo Jin,Guan Luo,Huihui Liu,Qingchun Zhang,Qi Huang,Rufang Peng
The thermodynamics and kinetics of the curing reactions between polyglycidyl nitrate (PGN) and toluene diisocyanate, isophorone diisocyanate, and polyaryl polymethylene isocyanate (PAPI) were studied by microcalorimetry. The reaction rate between PGN and PAPI was the fastest among the three reactions above. Three thermodynamics ( i.e. , activation enthalpy, entropy, and free energy), rate constant, and three thermokinetic parameters ( i.e. , activation energy, pre-exponential constant, and reaction order) of the curing reactions were obtained by calculating the results of the reaction between PGN and PAPI at a series of temperature from 303.15 K to 318.15 K. The linear relationship between ln k and the mole ratio of the isocyanate and hydroxyl groups was observed. The corresponding kinetic equation describing the curing reaction between PGN and PAPI was d α /d t = 10 −3.83 (1 − α ) 3.04 at 318.15 K.
研究领域:
高分子化学
·
热力学
·
反应动力学
·
功能材料
·
含能材料
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2014
·Vol. 38
·期 6
·2348-2353
·
IF 3.159
Dehua Li,Meiduo Zhang,Guang Wang,Shuangxi Xing
Novel naphthopyran derivative based photochromic polymer nanoparticles are prepared via miniemulsion copolymerization with methyl methacrylate (MMA) and n-butyl methacrylate (BMA) monomers. The systematic modulation of the photochromic rate can be achieved via tuning the ratio of MMA and BMA monomers to lead the naphthopyrans to swing between rigid and soft surroundings. Transmission electron micrographs (TEM) and dynamic light scattering (DLS) images prove that the nanoparticles are discrete and smooth. The typical spectral characteristics of naphthopyran in the polymer nanoparticles indicate that the photochrome is incorporated into the nanoparticles successfully. In addition, the polymer nanoparticles exhibit good photochromic reversibility and stability upon UV irradiation and thermal back reaction.
研究领域:
高分子化学
·
光功能材料
·
纳米材料
·
有机光化学
·
智能响应材料
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DOI
高影响因子
CANADIAN JOURNAL OF CHEMICAL ENGINEERING
·
2015
·Vol. 94
·期 3
·424-429
·
IF 1.231
Xia Gui,Ying Ding,Zhi Yun
An integrated approach was developed for preparing epoxy fatty acid methyl esters (EFAMEs) from cottonseed using a two-phase solvent extraction (TPSE) process followed by sequential base-catalyzed transesterification and epoxidation reactions. The TPSE process was performed to achieve simultaneous production of high-quality crude cottonseed oil and nontoxic cottonseed meal. The base-catalyzed transesterification of the cottonseed oil proceeded smoothly at 30 °C over 2 h to provide a high yield of fatty acid methyl esters (FAMEs). Subsequent epoxidation of the unsaturated FAMEs using petroleum ether as a non-polar solvent, H 3 PO 4 as a catalyst, 0.3 g/g H 2 O 2 as an oxygen donor, and HCOOH as an oxygen carrier gave the corresponding EFAMEs with a conversion to oxirane of 0.85 g/g. The order of effectiveness of catalysts was found to be H 3 PO 4 > TiO 2 > H 2 SO 4 > strong-acid cation exchange resin. The bio-based integrated process and new methods for the preparation of modified EFAMEs show great promise for comprehensive development and commercial applications of cottonseed with fewer steps and lower cost.
研究领域:
应用化学
·
油脂化学
·
生物基材料
·
绿色化工
·
天然产物转化
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）