Journal of Materials Chemistry B
·
2017
·Vol. 5
·期 30
·6138-6146
·
IF 4.543
Lijuan Zhang,Junmei Sun,Yunshan Zhou,Yuxu Zhong,Ying Ying,Yanqin Li,Yanqin Liu,Zareen Zuhra,Chunqian Huang
Cu3(BTC)2 (H3BTC = 1,3,5-benzenetricarboxylic acid) was anchored onto the surface of carboxymethylated chitosan non-woven fabrics by a controllable layer-by-layer technique in alternating solution baths of Cu(OAc)2·H2O and H3BTC solutions, and the resulting [Cu3(BTC)2]n@chitosan non-woven fabric composite materials (n = number of alternate deposition cycles) were thoroughly characterized. The results showed that the composite materials not only exhibited excellent decontamination ability against sulfur mustard (HD), with an enhanced degradation rate of HD with increasing n, but also possessed remarkable haemostasis performance. The degradation efficiency of sulfur mustard by [Cu3(BTC)2]4@chitosan was found to be much higher than that of pristine [Cu3(BTC)2]4. The inherent haemostatic capabilities of the chitosan non-woven fabrics were not affected by the growth of Cu3(BTC)2 on the surface of chitosan. Oral and histological toxicity examinations of the pristine Cu3(BTC)2 sample showed that damage and toxicity in the viscera of mice was very low, even if the intra-gastric administration dose of Cu3(BTC)2 reached a very high level (50 mg of Cu3(BTC)2 per kg of mouse). The results have shown that the as-prepared composite can be used safely as a promising haemostatic decontaminant with good recyclability against sulfur mustard.
研究领域:
材料科学
·
生物医学工程
·
化学
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高影响因子
Journal of Biobased Materials and Bioenergy
·
2016
·Vol. 10
·期 5
·378-384
·
IF 0.635
Chen Wei,Jiang Yetao,Sun Yong,Wang Yanjun,Li Zheng,Wang Xiaoyu,Zeng Xianhai,Liu Shijie,Lin Lu
5-Dimethylaminomethyl-2-Furanmethanol (DMMF) is an essential precursor for the production of ranitidine, a drug for gastropathy. Herein a facile pathway to the value-added pharmaceutical intermediate DMMF from carbohydrates, such as glucose and fructose, was developed for the first
time. The reaction was carried out under catalyst-free conditions using N, N-dimethyl formamide (DMF) as the amine donor in formic acid (FA). A plausible reaction mechanism from carbohydrates to DMMF was also proposed.
研究领域:
有机化学
·
药物化学
·
生物转化
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DOI
高影响因子
Reaction Chemistry & Engineering
·
2025
·
IF 3.1
Xue Luo,Jiahui Liu,Danhui Li,Lili Zhao,Hualiang An
Cyclopentanone self-condensation to 2-cyclopentylidenecyclopentanone is one of the key steps in synthesizing high-density fuels. In this study, MgAl-LDO(NO3−) catalysts, prepared via coprecipitation, demonstrated good catalytic performance. Meanwhile, Mg2Al-LDO(NO3−) catalysts with different Mg/Al ratios were explored. Characterization by XRD, NH3-TPD and CO2-TPD revealed that Mg2Al-LDO(NO3−) possessed appropriate acid–base active sites, correlating with its enhanced catalytic performance. Under optimized reaction conditions, cyclopentanone conversion reached 85.9% with 98.8% selectivity toward 2-cyclopentylidenecyclopentanone. Furthermore, the reusability of the catalyst was investigated. XRD, SEM, and N2 adsorption–desorption analyses indicated that structural changes in the Mg2Al-LDO(NO3−) catalyst led to its deactivation. GC-MS analysis of the reaction system identified the primary by-product as 2,5-dicyclopentylidenecyclopentanone. Based on these findings, a plausible reaction network is proposed.
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高影响因子
TALANTA
·
2022
·
IF 6.556
Bin Yang,Xiaowei Zeng,Jin Zhang,Jilie Kong,Xueen Fang
Delta (B.1.617.2), a highly infectious variant of SARS-CoV-2, has been sweeping the world, and threatening the safety of human life seriously. It is urgent to develop a highly selective and sensitive assay to accurately identify the SARS-CoV-2 variant Delta. In this work, we constructed a graphene/CRISPR-dCas9 electrochemical biosensor to accurately identify SARS-CoV-2 variant Delta, where the signal was further amplified by embedded electrochemical probe [Ru(phen) 2 dppz]BF 4 . This detection assay could be finished within 47 min totally, with the detection limit of 1.2 pM and good reproducibility with a C·V.% of 2.48% (n = 5). And the biosensor could selectively identify Delta among SARS-CoV-2 and other variants, including Alpha, Beta, Gamma. This assay was further validated by 26 real clinical samples, showing 100% clinical sensitivity and 100% clinical specificity, which provides a new direction for identifying other SARS-CoV-2 variants in the future.
研究领域:
生物技术
·
电化学
·
分子生物学
·
病毒学
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DOI
PubMed
高影响因子
JOURNAL OF ELASTOMERS AND PLASTICS
·
2013
·
IF 0.623
Aijie Ma,Qiuyu Zhang,Hepeng Zhang,Youqiang Shi,Yu Liu
2-Phenylimidazole (2-PZ) and polymethyl acrylic glycidyl ester (PGMA) are performed to fabricate a novel microcapsule latent curing agent of 2-PZ/PGMA by solvent evaporation method with 2-PZ as the core material and PGMA as the shell material. A novel single-component 2-PZ/PGMA/epoxy adhesive is also prepared by mixing 2-PZ/PGMA with epoxy resin matrix. The 2-PZ/PGMA microcapsules are characterized using scanning electron microscopy and granulometer. The curing kinetics and thermal properties of 2-PZ/PGMA/epoxy resin system are also investigated using differential scanning calorimeter, Fourier transform infrared spectrometer, and thermogravimetric analysis. Results show that 2-PZ/PGMA has good sphericity and narrow diameter distribution. The curing process of the 2-PZ/PGMA/epoxy resin system contains autocatalytic mechanism. Compared with that of pure epoxy, the presence of the 2-PZ/PGMA has little effect on thermal stability for the epoxy.
研究领域:
材料科学
·
化学工程
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DOI
高影响因子
JOURNAL OF ECONOMIC ENTOMOLOGY
·
2021
·Vol. 114
·期 2
·979-987
·
IF 2.381
Cui Kaidi,He Leiming,Cui Guangrui,Zhang Tao,Chen Yue,Zhang Tao,Mu Wei,Liu Feng
Grain commodities in postharvest storage often deteriorate because of fungal and insect attacks. With the green consumption requirements of consumers, ecofriendly and safe pesticides are needed for grain storage. The current study investigated the efficacy of the plant volatile compound trans-2-hexenal against the storage insect pest Tribolium castaneum (Herbst) and three commonly occurring storage fungi, viz., Fusarium graminearum, Aspergillus flavus, and Aspergillus niger, to recommend its application as a botanical fumigant for grain commodities. trans-2-Hexenal weakly repels T. castaneum but has favorable insecticidal activity against multiple developmental stages of T. castaneum, ranging in sensitivity as follows: eggs (LC50 = 14.3 µl/l) > adults (31.6 µl/l) > young larvae (42.1 µl/l) > mature larvae (64.5 µl/l) > pupae (70.5 µl/l). Moreover, trans-2-hexenal caused a high malformation rate and high mortality in adults developed from fumigated pupae. In a 7-d grain, trans-2-hexenal at 0.8 µl/ml provided an appreciable efficacy (81.3%), and concentrations ≥ 0.1 µl/ml completely inhibited the offspring of T. castaneum. trans-2-Hexenal was nonphytotoxic to the seed germination and seedling growth of wheat seeds. Furthermore, trans-2-hexenal completely inhibited the growth of A. flavus, F. graminearum, and A. niger at 5, 10, and 10 µl/l, respectively. The favorable biological activity of trans-2-hexenal against T. castaneum and three frequently occurring mycotoxigenic storage fungi indicated the potential of trans-2-hexenal for simultaneously controlling pests and pathogens, which could reduce its application frequency in grains and decrease pesticide resistance risks.
研究领域:
昆虫学
·
植物化学
·
食品科学
·
真菌学
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DOI
高影响因子
Cell Regeneration
·
2023
·Vol. 12
·期 1
·1-18
·
IF 0
Liu WenYe,Lin ShuHui,Li LingYa,Tai ZhiPeng,Liu Jing-Xia
EAF1 and EAF2, the eleven-nineteen lysine-rich leukemia (ELL)-associated factors which can assemble to the super elongation complex (AFF1/4, AF9/ENL, ELL, and P-TEFb), are reported to participate in RNA polymerase II to actively regulate a variety of biological processes, including leukemia and embryogenesis, but whether and how EAF1/2 function in hematopoietic system related hypoxia tolerance during embryogenesis remains unclear. Here, we unveiled that deletion of EAF1/2 (eaf1−/− and eaf2−/−) caused reduction in hypoxia tolerance in zebrafish, leading to reduced erythropoiesis during hematopoietic processes. Meanwhile, eaf1−/− and eaf2−/− mutants showed significant reduction in the expression of key transcriptional regulators scl, lmo2, and gata1a in erythropoiesis at both 24 h post fertilization (hpf) and 72 hpf, with gata1a downregulated while scl and lmo2 upregulated at 14 hpf. Mechanistically, eaf1−/− and eaf2−/− mutants exhibited significant changes in the expression of epigenetic modified histones, with a significant increase in the binding enrichment of modified histone H3K27me3 in gata1a promoter rather than scl and lmo2 promoters. Additionally, eaf1−/− and eaf2−/− mutants exhibited a dynamic expression of canonical WNT/β-catenin signaling during erythropoiesis, with significant reduction in p-β-Catenin level and in the binding enrichment of both scl and lmo2 promoters with the WNT transcriptional factor TCF4 at 24 hpf. These findings demonstrate an important role of Eaf1/2 in erythropoiesis in zebrafish and may have shed some light on regeneration medicine for anemia and related diseases and on molecular basis for fish economic or productive traits, such as growth, disease resistance, hypoxia tolerance, and so on.
研究领域:
发育生物学
·
血液学
·
分子生物学
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DOI
Nature Communications
·
2021
·Vol. 12
·期 1
·1-7
·
IF 14.919
Liu Yanting,Wang Ran,Qi Haifeng,Liu Xiao Yan,Li Guangyi,Wang Aiqin,Wang Xiaodong,Cong Yu,Zhang Tao,Li Ning
The exploration of highly efficient processes to convert renewable biomass to fuels and value-added chemicals is stimulated by the energy and environment problems. Herein, we describe an innovative route for the production of methylcyclopentadiene (MCPD) with cellulose, involving the transformation of cellulose into 3-methylcyclopent-2-enone (MCP) and subsequent selective hydrodeoxygenation to MCPD over a zinc-molybdenum oxide catalyst. The excellent performance of the zinc-molybdenum oxide catalyst is attributed to the formation of ZnMoO 3 species during the reduction of ZnMoO 4 . Experiments reveal that preferential interaction of ZnMoO 3 sites with the C=O bond instead of C=C bond in vapor-phase hydrodeoxygenation of MCP leads to highly selective formations of MCPD (with a carbon yield of 70%).
研究领域:
能源与环境科学
·
催化化学
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DOI
高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2019
·
IF 4.978
Ting Wang,Junnan Wei,Huai Liu,Yunchao Feng,Xing Tang,Xianhai Zeng,Yong Sun,Tingzhou Lei,Lu Lin
2, 5-Bishydroxymethylfuran (BHMF) has been currently emerged as a promising biomass-derived monomer . It is highly desirable to proceed a chemical process at a high substrate concentration, by which a facile and cost-effective separation of products can be expected. Herein, we report for the first time on the hydrogenation of highly concentrated 5-hydroxymethylfurfural (HMF) in deep eutectic solvents (DESs), giving a near quantitative selectivity towards BHMF in ChCl-glycerol DES at 25 °C in 3 h using NaBH 4 as the H-donor. DES is hailed as a new class of green solvent, in which HMF/BHMF could be stabilized by the strong hydrogen-bond interaction, and allowed the selective hydrogenation of HMF at high concentration up to 40 wt%. Notably, the resulting BHMF could be facilely separated by extraction with ethyl acetate, and then high purity of BHMF with a desirable isolated yield around 80% was obtained after removing of ethyl acetate. Additionally, the reaction efficiency of HMF hydrogenation in DESs was verified to be strongly associated with the viscosity of DESs and the p K a value of hydrogen-bonding donor.
研究领域:
化学工程
·
绿色化学
·
生物质转化
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DOI
高影响因子
LIQUID CRYSTALS
·
2013
·
IF 1.959
Lina Zhang,Xinbing Chen,Fengqi Zhao,Xuezhong Fan,Pei Chen,Zhongwei An
Three series of 2-(4′-alkoxybiphenyl-4-yl)-1H-benzimidazole derivatives (nM-x), which possessed 5-nitrobenzimidazole (nM-N series), benzimidazole (nM-H series) or 5-methylbenzimidazole (nM-M series) units at the end of the molecule, were synthesised and characterised by infrared, 1H- and 13C-nuclear magnetic resonance spectra, electrospray ionisation-mass spectrometry and elemental analysis. Their phase transition behaviour was investigated by differential scanning calorimetry, polarising optical microscopy and X-ray diffraction. All the compounds exhibited enantiotropic smectic mesophases with wide temperature domains for a carbon number in the alkoxy chain from 6 to 16, where the mesophase ranges were 14–91°C and 17–99°C during heating and cooling processes for the nM-N compounds, 7–25°C and 8–49°C for the nM-H compounds and 48–81°C and 52–85°C for the nM-M compounds, respectively. The effect of the length of alkoxy chain on mesomorphic properties was discussed. The nM-N and nM-M exhibited a much wider mesophase range whether during heating or cooling process than the corresponding nM-H series, especially for the longer terminal chain (n > 8), which indicated that the substituent in the benzimidazole moiety was helpful in increasing the mesophase stability.
研究领域:
有机化学
·
材料科学
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DOI
高影响因子
Scientific Reports
·
2026
·
IF 3.9
Liao Xuemei,Zhuang Ruirong,Zhuang Tangting,Xie Meijiao,Zhou Beidou
In this study, 45 2-benzylidene-1-indolone compounds were synthesized and their antitumor activities were evaluated. Experimental results demonstrated that these compounds exhibited varying degrees of inhibition against cancer cell proliferation. Notably, compound 20 showed significant activity against HGC-27 gastric cancer cells, with a half-maximal inhibitory concentration (IC 50 ) as low as 2.57 µM. Finally, the antitumor mechanism of compound 20 was investigated through network pharmacology and molecular docking, and 12 key genes and 21 related tumor signaling pathways were obtained. These findings suggest that compound 20 , as a potential lead compound, may provide a new direction for the development of antitumor drugs after structural optimization.
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF THERMOPHYSICS
·
2026
·Vol. 47
·期 8
·141
·
IF 3.6
Li Yan,Tian Lantu,Wang Shuo,Zhu Qunzhi
As the key heat storage and transfer medium in concentrated solar power (CSP) systems, molten salts’ thermophysical properties, such as thermal conductivity, specific heat capacity, and thermal stability, critically determine the systems energy conversion efficiency and economic viability. However, conventional molten salts suffer from low thermal conductivity and limited energy storage density, restricting their application in high-temperature thermal energy storage. Recent advances show that doping with nanoparticles, such as Al 2 O 3 , CuO, and SiO 2 , can significantly improve these properties. Nevertheless, systematic studies on quaternary molten salt systems remain scarce. In this work, we focus on the quaternary eutectic salt H15 (15 wt% Ca(NO 3 ) 2 –5.95 wt% NaNO 3 –45.05 wt% KNO 3 –34 wt% NaNO 2 ), which demonstrates a high decomposition temperature of 597.4 °C alongside a relatively low melting point of 84.4 °C and high thermal energy storage density of 1052.41 kJ/kg. To overcome its thermal performance limitations, Al 2 O 3 nanoparticles (0.1 wt% to 3 wt%) were introduced to form a nanocomposite molten salt. The influence of varying nanoparticle loadings was assessed via DSC, HotDisk, SEM, and XRD to examine corresponding changes in phase transition behavior, thermal conductivity, viscosity, and material microstructure. This study provides theoretical and experimental support for developing high-performance, wide temperature-range thermal energy storage materials for advanced CSP systems.
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高影响因子
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