ChemistrySelect
·
2024
·Vol. 9
·期 3
·e202304182
·
IF 1.9
Yiguo He,Mengxiang Li,Liming Peng,Tong Yang,Dong Zhang,Yadong Zhang
Graphical Atorvastatin calcium is a pivotal pharmaceutical for the treatment of primary hypercholesterolemia, with the reaction between isobutyl acetate and aniline being a crucial step. By employing continuous flow synthesis technology, we achieved a yield of 94 % within a residence time of 15 minutes. Simultaneously, kinetic studies and CFD calculations were conducted. Subsequently, we conducted further reaction investigations and designed a continuous system. 4-methyl-3-oxo-n-phenyl-pentanamide, as a crucial component of atorvastatin calcium, often generates a large amount of by-products in conventional synthesis. Here, we first developed a continuous microflow system for the continuous flow synthesis of 4-methyl-3-oxo-n-phenyl-pentanamide. Compared to traditional batch reactors, the reaction time was reduced by 1/12 in the microreactor. Using this device, the kinetic parameters of the reaction were determined, and a reaction kinetics model was established to investigate the effects of channel geometry and material inlet velocity on the entire reaction system. Furthermore, we studied the subsequent reactions and successfully established a fully continuous synthesis device, where the two-step continuous flow chemical reactions were achieved at 40 minutes and a total yield of 32 %.
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Cell Metabolism
·
2025
·
IF 30.9
Jie Jiang,Yuqing Gao,Jiang Wang,Yan Huang,Rong Yang,Yongxin Zhang,Yuandi Ma,Yingquan Wen,Gongkai Luo,Shurui Zhang,Yutang Cao,Minjun Yu,Qinxue Wang,Shulei Hu,Kanglong Wang,Xiaozhen Guo,Frank J. Gonzalez,Yameng Liu,Hong Liu,Qing Xie,Cen Xie
Metabolic-dysfunction-associated steatohepatitis (MASH) remains a major health challenge. Herein, we identify sphingomyelin phosphodiesterase 3 (SMPD3) as a key driver of hepatic ceramide accumulation through increasing sphingomyelin hydrolysis at the cell membrane. Hepatocyte-specific Smpd3 gene disruption or pharmacological inhibition of SMPD3 alleviates MASH, whereas reintroducing SMPD3 reverses the resolution of MASH. Although healthy livers express low-level SMPD3, lipotoxicity-induced DNA damage suppresses sirtuin 1 (SIRT1), triggering an upregulation of SMPD3 during MASH. This disrupts membrane sphingomyelin-ceramide balance and promotes disease progression by enhancing caveolae-dependent lipid uptake and extracellular vesicle secretion from steatotic hepatocytes to exacerbate inflammation and fibrosis. Consequently, SMPD3 acts as a central hub integrating key MASH hallmarks. Notably, we discovered a bifunctional agent that simultaneously activates SIRT1 and inhibits SMPD3, which shows significant therapeutic potential in MASH treatment. These findings suggest that inhibition of hepatic SMPD3 restores membrane sphingolipid metabolism and holds great promise for developing novel MASH therapies.
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PubMed
高影响因子
CRYSTENGCOMM
·
2024
·Vol. 26
·期 29
·3948-3953
·
IF 2.6
Xinyue Wang,Dandan Wang,Yujie Liu,Jinhui Wang
Cyanurate or isocyanurate compounds containing plane π-conjugated groups usually have giant optical anisotropy, which are promising candidates for optoelectronic functional materials. In this work, a new alkali-metal isocyanurate was successfully synthesized by a hydrothermal method, namely Cs3(H2C3N3O3)3(H3C3N3O3)·3H2O, belonging to the triclinic crystal and P space group. The compound has two-dimensional layers constructed with (H2C3N3O3)− and (H3C3N3O3) six-membered rings extending along the ab plane. The characterization results show that it exhibits a wide band gap (5.03 eV) and a large birefringence (0.23 at 1064 nm). In addition, in order to evaluate the relationship between the crystal structure and its optical properties, the first-principles calculation was also carried out. This work provided a possible candidate for anisotropic optical crystals applied in the ultraviolet region.
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IEEE SENSORS JOURNAL
·
2024
·Vol. 24
·期 6
·7530-7536
·
IF 4.3
Zhihao Zhou,Wei Tan,Jun Cai,Yujiang Wu,Ping-An Yang,Xin Huang,Wenjing Fan,Litao Bai,Rui Li
Wearable electrical textiles are of great value for future personalized healthcare applications. Herein, we report a 3-D meshed textile pressure sensor, using a facile dip coating strategy, that combing the sensitive 2-D Ti3C2Tx MXene nanolayer with woven textile fibers. Based on the sensitive 3-D cross-connected conductive network, the textile sensor achieves simultaneously a high sensitivity of up to 81.9 kPa−1 and a fast response time of 30 ms in a wide pressure detection range (0–19 kPa) as well as prominent durability of more than 5000 cycles. Benefiting from superior performances, the textile sensor can be applied for real-time human physiological signals monitoring from pulse waves to human joint motion. This work represents a solid step toward personalized healthcare and clinical diagnosis.
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BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
·
2025
·Vol. 116
·期 1
·10
·
IF 2.2
Huang Junyun,Liu Boying,Yuan Sijia,Zhou Haiyun,Bao Jian,Tu Yong,Wang Zunyao,Wang Weixia
The UV filter benzophenone-3 (BP-3) is a prevalent environmental pollutant due to its extensive use in personal care products, raising concerns about its ecological risks. This study investigated the pH-dependent oxidative stress effects of benzophenone-3 (BP-3) on Carassius auratus by measuring four key biomarkers—superoxide dismutase, catalase, glutathione, and malonaldehyde in liver tissue. The results demonstrated that BP-3 exposure led to significant oxidative stress, as evidenced by altered antioxidant levels and increased lipid peroxidation. The integrated biomarker response indicated that stress was more pronounced at higher BP-3 concentrations and varied with pH, being greatest under acidic conditions. These findings demonstrate that the toxicity of BP-3 is strongly influenced by environmental pH, highlighting the necessity of incorporating pH variations into ecological risk assessments of ionizable organic pollutants.
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BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
·
2025
·Vol. 116
·期 1
·9
·
IF 2.2
Huang Junyun,Liu Boying,Yuan Sijia,Zhou Haiyun,Bao Jian,Tu Yong,Wang Zunyao,Wang Weixia
Benzophenone-3 (BP-3), a widely used ultraviolet filter in personal care products, has been extensively detected in aquatic environments and poses potential ecological risks. This study innovatively investigated the pH-dependent acute toxicity of BP-3 to three model aquatic organisms— Daphnia magna , Photobacterium phosphoreum , and Danio rerio —by determining the EC 50 and LC 50 values across a pH range of 5.0 to 9.0. Our results revealed that BP-3 exerted greater acute toxicity on all three tested aquatic organisms under acidic conditions (pH 5.0) than under alkaline conditions (pH 9.0). The increased toxicity with lower pH was attributed to the predominance of the more lipophilic molecular form of BP-3, emphasizing the significant influence of environmental pH on BP-3 toxicity. These findings provide essential toxicological data for assessing the ecological risks of BP-3 in diverse aquatic environments, highlighting the necessity of considering BP-3 concentration, environmental pH and exposed species in ecological risk assessments.
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PubMed
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RUSSIAN JOURNAL OF GENERAL CHEMISTRY
·
2025
·Vol. 95
·期 10
·2966-2979
·
IF 0.8
Li D. H.,Hou L. M.,Lin Q.,Lin Y.,Ma Y. K.,Bu M.
Lupeol is a natural pentacyclic triterpenoid with a wide range of biological activities. In view of its good biological activity base, to further enhance the anti-tumor activity, the researchers designed and synthesized 15 lupeol-3-indazole derivatives. All synthesized compounds were tested for their in vitro antiproliferative activity by MTT against the human lung cancer cell line (A549), human liver cancer cell line (HepG2), and human breast cancer cell line (MCF-7). Structure–activity relationship (SAR) analysis indicated that lupeol-4-[(5-bromo-1 H -indazol-3-yl)methyl]piperazine-1-carboxylate exhibited the most potent antiproliferative activity against MCF-7 cells (IC 50 = 4.53 μM), which was 13.69-fold higher than that of parent lupeol (IC 50 = 61.89 μM). In vitro anticancer mechanisms reveal that lupeol-4-[(5-bromo-1 H -indazol-3-yl)methyl]piperazine-1-carboxylate increased intracellular reactive oxygen species (ROS) levels, reduced mitochondrial membrane potential, and modulated the expression of apoptotic proteins in a dose-dependent manner, thereby inducing apoptosis in MCF-7 cells. Collectively, these findings demonstrated that the introduction of an indazole substituent at the C 3 position of lupeol significantly enhanced the anticancer activity of the compound, thereby laying a theoretical foundation for the development of novel triterpenoid-based anticancer agents.
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PHARMAZIE
·
2018
·Vol. 73
·期 8
·465-468
·
IF 1.016
Ma Wenxue,Yao Yawen,Gu Yuyan,Li Fang,Cai Jiaxuan,He Baozhu,Chen Qiuyan,Fang Jian,Ouyang Zizhang
Acute phase protein pentraxin 3 (PTX3) is increased in patients with atherosclerotic cardiovascular diseases, such as acute coronary syndrome and coronary artery vulnerability, thereby serving as an important biomarker for the prognosis of cardiovascular diseases. This study was designed
to evaluate the effects of statins on the expression of PTX3 in human endothelial cells. We observed that PTX3 is a TNFα inducible protein in human endothelial cells. In contrast, treatment with simvastatin reduces basal as well as TNFα induced gene and protein expression of PTX3
in a dose- and time-dependent manner. Our study suggests that reducing PTX3 expression by statins could contribute to its protective effects against endothelial dysfunction and coronary artery plaque destabilization.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2018
·
IF 5.091
Xuemei Li,Shijian Wang,Xiao Tang,Rui Zang,Peng Li,Pengxin Li,Zengming Man,Cong Li,Shuaishuai Liu,Yuhan Wu,Guoxiu Wang
Sodium super-ionic conductor (NASICON) structured Na 3 V 2 (PO 4 ) 3 (NVP), a promising cathode material for sodium-ion batteries (SIBs), benefits by its unique three-dimensional (3D) channel structure. However, the inherent characteristics of NVP (such as low electrical conductivity) usually lead to inferior rate and long-cycling performance, which miss the requirements of practical application in electrical energy storage systems (ESSs). Herein, we propose the synthesis of porous high-crystalline Na 3 V 2 (PO 4 ) 3 /C nanoplates (NVP/C-P) via hydrothermal method and post-calcination. The porous nanoplate structure provides increased specific surface area and shortened diffusion pathway for ion/electron transport. Consequently, NVP/C-P cathodes exhibit a high specific capacity (117 mAh g −1 , 0.2 C), exceptional rate performance (76.5 mAh g −1 , 100 C) and long cyclic stability (10,000 cycles).
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POLYMER TESTING
·
2021
·
IF 4.282
Haochuan Luo
An effective method to prepare crosslinked polybenzimidazole (PBI) via [2 + 3] Huisgen cycloadditions has been proposed. Propargyl modified PBI (PBI-PG) has been synthesized firstly. In the presence of diazido crosslinkers, PBI-PG can be thermally crosslinked by [2 + 3] Huisgen cycloadditions. Evidences from 1 H NMR and ATR spectra imply a small amount of grafting alkenyl structures on PBI-PG. The grafting alkenyl structures provide another crosslinking mechanism named as alkyne-alkene crosslink. The alkyne-alkene crosslink is highly efficient under heat to form crosslinking networks which display toughness, low tensile strengths, and large swelling ratios in phosphoric acid (PA) solutions. Influences of rigidities and chain lengths of crosslinkers on performances of crosslinked PBIs have been investigated. PBIs crosslinked by rigid crosslinkers behave as brittle materials while that crosslinked by flexible crosslinkers behave as tough materials. Addition of crosslinkers leads to decreased gel fractions but improved tensile strengths, which is attributed to competition results of crosslinking and plasticizing effects. PBI-R2-20, which is crosslinked by a long rigid crosslinker, exhibits the highest tensile strength of 102.33 MPa, which is 66.34 MPa higher than that of PBI-PG. With even lower PA uptakes, PBIs crosslinked by rigid crosslinkers display more thermally stable and higher conductivities than that crosslinked by flexible crosslinkers. After doping in 12 mol/L PA solution, PBI-R2-20, with an acid uptake of 163 wt%, displays the highest tensile strength of 8.1 MPa and the most thermally stable and the highest conductivity which reaches a maximum of 2.30 × 10 −2 S cm −1 at 188 °C among all crosslinked membranes.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2019
·Vol. 30
·期 7
·6760-6767
·
IF 2.195
Bao Runxi,Li Mingyu,Shen Meng,Liu Huan,Zhang Guangzu,Zeng Yike,Jiang Shenglin
Ceramic-polymer pyroelectric composite materials with favorable flexibility hold great potential for wearable sensors and energy harvesters, and the further improvement in pyroelectric properties would push them closer to practical application. In this work, an uniaxial stretching method was proposed to optimize the performance of lead zirconate titanate nanowires (PZT NWs)/polyvinylidene fluoride (PVDF) 1–3 composites. With just one stretching treatment, the pyroelectric coefficient of the composite was enhanced by inducing more β phase in PVDF matrix, and the permittivity was decreased by reorientation of PZT NWs to the strain direction in the meantime. As a result of the incorporated effects, the figure of merit of the stretched composite with orientated PZT NWs increases to the value of 2.18 × 10 −10 C cm −2 K −1 , which is 619% higher than that of untreated samples at 35 °C. This work could provide an efficient approach to fabricate high-performance ceramic-polymer pyroelectric composite materials.
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JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2021
·Vol. 104
·期 6
·2721-2729
·
IF 3.784
Xianju Zhou,Jie Zhang,Lingni Chen,Yanhong Li,Guotao Xiang,Sha Jiang,Li Li,Xiao Tang,Zhongmin Cao,Guangxin Xie
A series of novel red emission phosphors Sr 3 Lu 1- x (VO 4 ) 3 : x Eu 3+ ( x = 0.007, 0.009, 0.02, 0.04, 0.06) were synthesized successfully by traditional high-temperature solid-state reaction. The results of X-ray diffraction (XRD) reveal the doped Eu 3+ ions have replaced the lattice sites of Lu 3+ ions. The diffuse reflectance spectra illustrate the energy gap of Sr 3 Lu(VO 4 ) 3 host is 3.61 eV. The room-temperature steady-state fluorescence spectra show that these phosphors can be effectively pumped by the charge-transfer band (CTB) of the host in near ultraviolet (NUV) spectral region and then produce strong and pure red emission at 615 nm originated from 5 D 0 → 7 F 2 electric dipole transition of Eu 3+ . The Commission Internationale de L’Eclairage (CIE) coordinates of Sr 3 Lu 0.96 (VO 4 ) 3 :0.04Eu 3+ are (x = 0.65, y = 0.35), which are very close to the red standard of National Television Standards Committee NTSC (0.67, 0.33). The fabricated warm white-light-emitting diodes (LED) demonstrate high color-rendering index Ra as 93. The results imply the red-emitting Sr 3 Lu(VO 4 ) 3 :Eu 3+ phosphors could be potentially utilized in the fields of solid-state lighting.
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