CHEMOSPHERE
·
2017
·
IF 4.208
Xiaoxue Pan,Liqing Yan,Ruijuan Qu,Zunyao Wang
The goals of this study were to bring forward new data and insights into the effect of activation methods, operational variables and reaction pathways during sulfate radicals-based oxidation of benzophenone-3 (BP-3) in aqueous solution. Heat, transition metal ions (Fe 2+ , Cu 2+ , Co 2+ ), UV and visible light irradiation were used to activate persulfate (PS) to degrade BP-3. The results showed that these three activation methods can remarkably enhance BP-3 removal efficiency. Under the conditions of [BP-3] 0 : [PS] 0 = 1: 500, pH = 7.0, and 40 °C, complete removal of BP-3 (1.31 μM) was observed in 3 h. In the pH range of 3.0–9.0, the degradation of BP-3 decreased with increasing pH. Increasing the PS dosage accelerated the reaction, while the presence of humic acid (HA) significantly inhibited the efficiency of BP-3 removal. Based on electron paramagnetic resonance (EPR) and radical quenching studies, sulfate and hydroxyl radicals contributed to the oxidation process. According to the evolution of BP-3 and its 7 by-products, as well as frontier electron densities (FED) calculation, two routes were proposed involving hydroxylation, demethylation and direct oxidation. On the whole, this work is a unique contribution to the systematic elucidation of BP-3 removal by PS.
研究领域:
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2018
·Vol. 6
·期 22
·5908-5915
·
IF 5.976
Gaoliang Fang,Daqin Chen,Su Zhou,Xiao Chen,Lei Lei,Jiasong Zhong,Zhenguo Ji
Successful development of all-inorganic CsPbX3 (X = Cl, Br, or I) perovskite quantum dots (PQDs) has been witnessed due to their unique optical and electrical properties. However, the heavy usage of Pb element in PQDs has limited the commercial application of these PQDs, and the preparation of low-Pb or Pb-free PQDs is imperative. In this study, we report room-temperature reverse synthesis of CsPbxMn1−xCl3 PDQs from CsMnCl3 precursor nanocrystals through cation exchange. Interestingly, two-step phase transformation processes from hexagonal CsMnCl3 to rhombohedral Cs4PbxMn1−xCl6 and finally to cubic CsPbxMn1−xCl3 are evidenced. With an increase in the reaction time, Mn2+ ions in the PQD lattice are gradually replaced by Pb2+ ions. Notably, Mn2+ d → d broadband luminescence is not detected for the Cs4PbxMn1−xCl6 product, but it is intense for the CsPbxMn1−xCl3 sample owing to efficient energy transfer from CsPbCl3 to Mn2+. Moreover, it is found that the introduction of Br− into the reaction system will prohibit the complete phase transformation from rhombohedral Cs4PbxMn1−x(Cl/Br)6 to cubic CsPbxMn1−x(Cl/Br)3. By controlling the ratio between the CsMnCl3 precursor and PbBr2, tunable luminescence is easily achieved due to the combined emissions from both CsPb(Cl/Br)3 PQDs and Mn2+-emitting centers.
研究领域:
材料科学
·
纳米技术
·
光电
✓ 已验证
DOI
高影响因子
Food Analytical Methods
·
2015
·Vol. 9
·期 4
·845-855
·
IF 1.956
Li Chang,Jia Hanbing,Wang Yuting,Shen Mingyue,Nie Shaoping,Xie Mingyong
A gas chromatography mass spectrometry (GC-MS) method was developed and validated for the determination of the sum of 3-monochloropropane-1,2-diol (3-MCPD) esters in edible oils. Meanwhile, the measurement uncertainty was estimated. Testing sample preparation was optimized, and the optimal condition was attained. Good linearity was observed with the GC-MS method for the concentration range of 0.05–5.0 mg/kg ( R
2 = 0.9994). It was proved to be an accurate and precise method for the determination of 3-MCPD esters according to the validation results. The recovery range was 89.0–104.6 %, and the limits of detection (LOD) and the limits of quantification (LOQ) were 25 and 50 μg/kg, respectively. Satisfactory reproducibility was achieved with lower than 15 %. Repeatability was determined and expressed as relative standard deviation (RSD), with the value range of 3.9–12.0 %.The contents of 3-MCPD esters were determined in 12 kinds of oils using this method. Measurement uncertainties were calculated by applying bottom-up approach. The main dominant sources were identified and quantified, which were standard solutions preparation, recovery, and calibration curve. It reminds that the predominant uncertainty sources should be paid much more attention during preparing the testing samples in the future.
研究领域:
食品科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
THERMOCHIMICA ACTA
·
2014
·
IF 2.105
Xiang Liu,Mengmeng Liang,Yonghong Hu,Wenge Yang,Ying Shi,Jingjing Yin,Yan Liu
In this study, the solubility of 3-thiophenecarboxylic acid was measured in (water + acetic acid) binary solvent mixtures in the temperature ranging from 283.15 to 338.15 K by the analytical stirred-flask method under atmospheric pressure. The experimental data were well-correlated with the modified Apelblat equation and the λh equation. In addition, the calculated solubilities showed good agreement with the experimental results. It was found that the modified Apelblat equation could obtain the better correlation results than the λh equation. The experiment results indicated that the solubility of 3-thiophenecarboxylic acid in the binary solvents increased with increasing temperature, increases with increasing water contents, but the increments with temperature differed from different water contents. In addition, the thermodynamic properties of the solution process, including the Gibbs energy , enthalpy, and entropy were calculated by the van’t Hoff analysis. The experimental data and model parameters would be useful for optimizing the process of purification of 3-thiophenecarboxylic acid in industry.
研究领域:
化学工程
·
物理化学
✓ 已验证
产品关联
DOI
高影响因子
MEDICINAL CHEMISTRY RESEARCH
·
2018
·Vol. 28
·期 2
·133-142
·
IF 1.607
Feng Yu,Teng Xingxing,Gu Jinhua,Yu Bangwei,Luo Yan,Ye Lianbao
In the previous research, our group designed and synthesized 2,3,4,5-tetrahydro-1 H -pyrido-[4,3-b] indoles, which showed high anti-tumor activity. In this study, a series of novel 2,3,4,5-tetrahydro-1 H -pyrido-[4,3-b] indole derivatives were designed by introducing an alkyl or aralkyl and a sulfonyl group, which are considered as the pharmacophores of some antitumor drugs based on the combination principles, and synthesized. The antiproliferative activity of all the target compounds were evaluated against Hela, A549, HepG2, and MCF-7 cell lines using the MTT assay in vitro. The results were represented by IC 50 values. All compounds showed moderate to excellent antiproliferative activity with IC 50 values between 0 μM and 100 μM against cancer cells. The proliferations of Hela, A549, HepG2, and MCF-7 cell lines were inhibited in a dose-dependent manner, and the cytolytic activity was markedly inhibited at the same time. The IC 50 values of intermediate 3 inhibited against Hela, A549, HepG2, and MCF-7 cell lines were 52.75, 50.30, 60.31, and 54.39 μM, respectively, which were higher than the new compounds that we expected. The compounds 4a – 4d bearing sulfonyl, substituted by electron donating group, showed moderate to significant antiproliferative activity, in which compound 4c was the best with the IC 50 values of 13.71, 9.42, 15.06, and 14.77 μM, and these results suggested that the introduction of sulfonyl could increase the antiproliferative activity of 2,3,4,5-tetrahydro-1 H -pyrido-[4,3-b]indole. Compounds 4e – 4g bearing alkyl, phenyl, and arylated alkyl produced good antiproliferative activity and the IC 50 value of 4 g was lower than 30 μM. The target compounds were more potent against A549 compared to the other three cell lines. Molecular docking studies revealed the binding orientations of all the synthesized compounds in the active site of c-Met. Moreover, molecular dynamics simulations have been performed to evaluate the binding stabilities between the synthesized compounds and their receptors.
研究领域:
药物化学
·
肿瘤学
·
计算生物学
✓ 已验证
DOI
高影响因子
ORGANIC & BIOMOLECULAR CHEMISTRY
·
2019
·Vol. 17
·期 4
·930-938
·
IF 3.49
Yue-Wei Sun,Yue-Ming Bei,Lan-Zhi Wang
Various functional 3-acyl-1,5-benzodiazepines containing carboxyl, ester and acyl groups at the 2-position were synthesized via an efficient, sustainable and catalyst-free domino reaction. During the synthesis process, one new cycle and four new bonds (one C–C, two C–N and one CC) were constructed by the nucleophilic substitution, nucleophilic addition, dehydration and cyclization reaction by the H+ shift. Furthermore, a total of 26 examples were examined by reacting inexpensive starting materials of N,N-dimethylformamide dimethyl acetal, aromatic ketones, 1,2-phenylenediamine compounds and aldehyde derivatives. Therefore, it displayed a broad substrate scope, good functional group tolerance, high yields (77–97%) and the ease of obtaining target compounds without the involvement of toxic solvents and column chromatography, which provided a novel method for the synthesis of a wide variety of biologically relevant 1,5-benzodiazepines.
研究领域:
有机化学
·
药物化学
✓ 已验证
DOI
PubMed
高影响因子
MOLECULES
·
2013
·Vol. 18
·期 4
·4158-4169
·
IF 2.428
Luhui Ren,Xue Du,Mengnan Hu,Chaoqun Yan,Taigang Liang,Qingshan Li
An asymmetric synthesis of a series of novel 4-methyl-(3'S,4'S)-cis-khellactone derivatives3a–ois reported for the first time. Their structures were confirmed by1H-NMR,13C-NMR and MS. Their cytotoxic activity was evaluated by the MTT assay against three selected human cancer cell lines: HEPG-2 (human liver carcinoma), SGC-7901 (human gastric carcinoma), LS174T (human colon carcinoma). Some compounds showed high inhibitory activity against these human cancer cell lines. Among them, compound3aexhibited strong cytotoxicity, with IC50values ranging from 8.51 to 29.65 μM. The results showed that 4-methyl-cis-khellactone derivatives withS,Sconfiguration could be a potential antitumor agents.Keywords:4-methyl-(3'S,4'S)-cis-khellactone derivatives;asymmetric synthesis;antitumor activity
研究领域:
药物化学
·
肿瘤学
·
有机合成化学
✓ 已验证
DOI
PubMed
高影响因子
POSTHARVEST BIOLOGY AND TECHNOLOGY
·
2020
·
IF 4.303
Xueyin Ru,Ning Tao,Yanyan Feng,Qingqing Li,Qingguo Wang
Enzymatic browning is one of the essential issues affecting the quality of fresh-cut produce. In this study, we identified a novel, safe, and effective anti-browning agent, 3-mercapto-2-butanol, which can prevent fresh-cut potatoes from browning for 5 d under the concentration of 25 μL L −1 at 5 °C. The inhibitory effect of 3-mercapto-2-butanol was close to sodium bisulfite. 3-Mercapto-2-butanol was further identified as a competitive inhibitor which directly inhibited the activity of polyphenol oxidase (PPO) by enzyme kinetic analysis, and the expression levels of PPO-related genes ( POT32 and POT33 ) were decreased after 3-mercapto-2-butanol treatment. Besides, the concentration of enzymatic browning substrate tyrosine (Tyr) in the potato chips was found significantly higher in 3-mercapto-2-butanol treatment group than in the control group. We speculated that 3-mercapto-2-butanol could reduce the consumption of Tyr by inhibiting the activity of PPO. Our finding not only provided a novel and safe anti-browning agent candidate (3-mercapto-2-butanol) to efficiently solve the browning issue for fresh-cut food products, but also preliminarily revealed its mechanism in browning inhibition.
研究领域:
食品科学
·
植物生理学
✓ 已验证
DOI
高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 10
·1-9
·
IF 5.3
Cheng Ye,Tian Dong-Yang,Chen Cui-Li,Bao Ning,Wu Zeng-Qiang
Stainless steel sheets were coated with carbon ink to obtain disposable carbon electrodes, which were used as supports for moleculary imprinted polymer (MIP) electrochemical sensors by electropolymerizing o-phenylenediamine and o-aminophenol along with indole-3-acetic acid (IAA) as the template. After optimization, the MIP biosensors could be used for sensitive and selective detection of IAA with the limit of quantification of 0.1 µM. Our experimental results showed that stable and reproducible electrochemical responses could be achieved for the disposable MIP biosensors. This approach was successfully used for detection of IAA in different tissues of pea sprouts. This study reveals the potential of MIP electrochemical sensors in practical applications and shrinks the trench between the research and the real world. Graphical Abstract
研究领域:
分析化学
·
植物生理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Photonics
·
2017
·
IF 6.756
Haiting Zhang,Yating Zhang,Xiaoxian Song,Yu Yu,Mingxuan Cao,Yongli Che,Zhang Zhang,Haitao Dai,Junbo Yang,Guizhong Zhang,Jianquan Yao
We fabricated a vertical field effect phototransistor with Au/Ag nanowires as the transparent source electrode and with vertically stacked layers of poly(3-hexylthiophene) (120 nm) and lead sulfide quantum dots (380 nm), which formed heterojunctions. The built-in electric field in the layered heterojunction aids the separation of photoinduced excitons, while the short channel enables efficient carrier transport across the active region. Both of these benefits enable a high photoperformance and fast photoresponse. This vertical phototransistor can be operated at room temperature with a low operation voltage of −1 V and is therefore energy-efficient. Further, it has a wide response spectrum from 400 to 2100 nm, a high photoresponsivity of more than 9 × 104 AW–1, and a high detectivity of up to 2 × 1013 Jones (cm Hz1/2 W–1) under infrared illumination. Additionally, this vertical phototransistor had a response time of 9 ms, which is faster than a previously reported lateral field effect phototransistor based on poly(3-hexylthiophene)/lead sulfide quantum dots. The vertical architecture combined with the layered heterojunction approach provides a new, facile way of fabricating high performance devices.
研究领域:
材料科学
·
光电子学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2014
·
IF 4.908
Bingxin Huang,Qian Liu,Jürgen Caro,Aisheng Huang
Dense and phase-pure zeolite LTA membranes were hydrothermally synthesized on 3-aminopropyltriethoxysilane (APTES)-modified macroporous Al 2 O 3 tubes without seeding. Pervaporation experiments were conducted for the separation of liquid water/iso-butanol and water/ethanol mixtures to evaluate the separation performances of the zeolite LTA membranes. A water flux of 4.5 kg/m 2 h is obtained at 100 °C for the separation of a 95.0 wt% iso-butanol/5.0 wt% water mixture, and the separation factors of water/iso-butanol are found to be about 3000 for all temperatures and concentrations studied.
研究领域:
化学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
CRYSTENGCOMM
·
2014
·Vol. 16
·期 19
·4001-4007
·
IF 3.858
Qingshuang Liang,Lin Han,Xiaolong Deng,Chuangang Yao,Junling Meng,Xiaojuan Liu,Jian Meng
In this paper, we report a facile, low-cost synthesis of Cu2Sn(SxSe1−x)3 colloidal nanocrystals (NCs) by heating a mixture of metal salts, sulfur powder, selenium powder, oleylamine and dodecanethiol. The composition of the Cu2Sn(SxSe1−x)3 NCs could be tuned across the x range from 0 to 1 by modulating the molar ratio of the S/Se precursors. The lattice parameters (a and c) of the Cu2Sn(SxSe1−x)3 NCs, calculated from X-ray diffraction patterns, were consistent with Vegard's law, confirming the formation of homogeneous nanocrystals. The X-ray diffraction and transmission electron microscopy results indicated that the as-prepared Cu2Sn(SxSe1−x)3 NCs had a monoclinic structure. The UV-visible absorption spectra of the Cu2Sn(SxSe1−x)3 NCs revealed that the band gap of the nanocrystals could be tailored from 1.55 to 1.87 eV by decreasing the Se content. Additionally, compared with the more commonly used hot injection method, the procedure developed here is highly suitable for large-scale colloidal nanocrystal production, which we tested by performing a gram-scale synthesis.
研究领域:
材料科学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）