CHEMICAL ENGINEERING SCIENCE
·
2024
·
IF 4.1
Yanlin Wang,Xi Wang,Jingjing Mu,Hairong Yu,Xingbin Lv,Ting Liang,Changjing Cheng
Barium ions (Ba 2+ ) contamination is a serious environmental problem worldwide. The currently existing Ba 2+ -detection techniques are generally expensive, time-consuming, and complicated. Therefore, the development of a simple, inexpensive, rapid, and effective strategy to detect Ba 2+ in water is of great importance. Herein, we first report a smart photonic crystal hydrogel (PCH) sensor for simple, highly selective, and naked-eye detection of Ba 2+ in water based on 18-crown-6/Ba 2+ host–guest interactions. This sensor was composed of a poly(benzo-18-crown-6-acrylamide- co - N -isopropylacrylamide- co -acrylamide) (PBCNA) intelligent hydrogel with embedding Fe 3 O 4 @SiO 2 colloidal photonic crystals (CPCs). The prepared PBCNA PCH sensor demonstrated pH and temperature-dependent Ba 2+ -detection performances. Besides, the Ba 2+ -responded PCH sensor could be easily regenerated via simple washing using hot/cold water at least 20 times without compromising its detection performance. Such a PCH sensor with obvious advantages of portability, ease of operation, cost-effectiveness, high selectivity and excellent regenerability, provides a simple and effective strategy to monitor Ba 2+ in contaminated water.
研究领域:
环境科学
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材料科学
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化学传感器
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产品关联
DOI
高影响因子
Nanomaterials
·
2019
·Vol. 10
·期 1
·53
·
IF 4.034
Yuanyuan Li,Xiaofang Tian,Yaoqiong Wang,Qimei Yang,Yue Diao,Bin Zhang,Dingfeng Yang
Using solar energy to remove antibiotics from aqueous environments via photocatalysis is highly desirable. In this work, a novel type-II heterojunction photocatalyst, MgSn(OH)6/SnO2,was successfully prepared via a facile one-pot in situ hydrothermal method at 220 °C for 24 h. The obtained heterojunctions were characterized via powder X-ray diffraction, Fourier-transform infrared spectroscopy, transmission electron microscopy, and ultraviolet-visible diffuse reflectance spectroscopy. The photocatalytic performance was evaluated for photodegradation of tetracycline solution under ultraviolet irradiation. The initial concentration of tetracycline solution was set to be 20 mg/L. The prepared heterojunctions exhibited superior photocatalytic activity compared with the parent MgSn(OH)6and SnO2compounds. Among them, the obtained MgSn(OH)6/SnO2heterojunction with MgCl2·6H2O:SnCl4·5H2O = 4:5.2 (mmol) displayed the highest photocatalytic performance and the photodegradation efficiency conversion of 91% could be reached after 60 min under ultraviolet irradiation. The prepared heterojunction maintained its performance after four successive cycles of use. Active species trapping experiments demonstrated that holes were the dominant active species. Hydroxyl radicals and superoxide ions had minor effects on the photocatalytic oxidation of tetracycline. Photoelectrochemical measurements were used to investigate the photocatalytic mechanism. The enhancement of photocatalytic activity could be assigned to the formation of a type-II junction photocatalytic system, which was beneficial for efficient transfer and separation of photogenerated electrons and holes. This research provides an in situ growth strategy for the design of highly efficient photocatalysts for environmental restoration.
研究领域:
材料科学
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环境催化
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光催化
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水处理
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纳米材料
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DOI
高影响因子
MEDICINAL CHEMISTRY RESEARCH
·
2015
·Vol. 24
·期 8
·3327-3333
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IF 1.402
Ye Lianbao,Wu Jie,Yang Jiebo,Chen Weiqiang,Luo Yan,Zhang Yanmei
Abstract HGF/c-Met signaling pathway has come into the spotlight as a promising therapeutic target for inhibiting tumor growth and has become one of the leading molecular targets in cancer. Various strategies are currently in development to disrupt the HGF–Met signal transduction pathway, in which small molecular inhibitors have been a particularly active field. On the basis of the structures of two c-Met inhibitors, PF-04217903 and JNJ-38877605, some novel 7-[(quinolin-6-yl)methyl] purines ( 4a – 4e ) were rationally designed on the principle of bioisosterism strategy. These compounds were synthesized and evaluated as novel c-Met inhibitors. Molecular docking experiments analyzed the results and explained the molecular mechanism of eminent activities to c-Met. The results showed that all the title compounds were active against c-Met enzyme to some extent. Though these compounds did not demonstrate inhibition as we expected, this study provided important information for building diversification of chemical library and molecular docking experiment supplied the basis for further research works. Graphical Abstract Some novel
7-[(quinolin-6-yl)methyl] purines as potential c-Met inhibitors have been designed and prepared. Their synthesis and spectral characterization are reported here.
研究领域:
癌症研究
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药物化学
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分子生物学
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产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL SCIENCES
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2020
·Vol. 132
·期 1
·1-14
·
IF 1.406
Cheng Si Yuan,Yang Xi Nan,Tao Zhu,Wei Lian Tong,Zhao Wei Wei,Jiang Dao Fa,Jin Yan Mei,Gao Jie,Ma Pei Hua
Abstract The host–guest binding characteristics of cyclopentanocucurbit[6]uril (CyP 6 Q[6]) and cyanine dye trans -4-[4-(dimethylamino)styryl]-1-methylpyridinium iodide ( t -DSMI) have been studied. The results show that CyP 6 Q[6] and t -DSMI form a 1:1 inclusion system, generating strong fluorescence. On this basis, the fluorescent probe t -DSMI@CyP 6 Q[6] has been constructed, and its anion recognition ability has been investigated. In a neutral environment, BF 4 − , H 2 PO 4 − , and I − elicit obvious specific responses from the probe, since they have stronger binding forces. This probe shows greater sensitivity than the previously reported probe t -DSMI@HMeQ[6]. Graphic abstract Since the complex formed by CyP 6 Q[6] and t -DSMI can produce strong fluorescence at pH > 4.6, t -DSMI@CyP 6 Q[6] was constructed to recognize the anions at pH ≅ 5. The results show that in a near neutral environment, BF 4 − , H 2 PO 4 − , and I − elicit obvious specific responses from the probe.
研究领域:
分析化学
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材料科学
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化学传感器
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DOI
高影响因子
Nature Biomedical Engineering
·
2023
·Vol. 7
·期 9
·1129-1141
·
IF 28.1
Li Xianlei,Gong Ningqiang,Tian Falin,Zhang Shangkun,Zhang Yuxuan,Wang Yufei,Qing Guangchao,Wang Yongchao,Li Fangzhou,Xu Yihui,Zhang Linlin,Wang Jinjin,Ni Qiankun,Gan Yaling,Gu Chaojiang,Jiang Huaidong,Huang Xingxu,Shi Xinghua,Zhang Tongcun,Wu Yan,Liang Xing-Jie
The infusion of chimaeric antigen receptor (CAR) T cells can trigger the release of life-threatening supraphysiological levels of pro-inflammatory cytokines. However, uncertainty regarding the timing and severity of such cytokine release syndrome (CRS) demands careful monitoring of the conditions required for the administration of neutralizing antibodies. Here we show that a temperature-sensitive hydrogel conjugated with antibodies for the pro-inflammatory cytokine interleukin-6 (IL-6) and subcutaneously injected before the infusion of CAR-T cells substantially reduces the levels of IL-6 during CRS while maintaining the therapy’s antitumour efficacy. In immunodeficient mice and in mice with transplanted human haematopoietic stem cells, the subcutaneous IL-6-adsorbing hydrogel largely suppressed CAR-T-cell-induced CRS, substantially improving the animals’ survival and alleviating their levels of fever, hypotension and weight loss relative to the administration of free IL-6 antibodies. The implanted hydrogel, which can be easily removed with a syringe following a cooling-induced gel–sol transition, may allow for a shift in the management of CRS, from monitoring to prevention.
研究领域:
肿瘤学
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免疫治疗
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生物医学工程
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药理学
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DOI
PubMed
高影响因子
Nanoscale
·
2018
·Vol. 10
·期 45
·21284-21291
·
IF 7.233
Jiguo Tu,Haiping Lei,Mingyong Wang,Zhijing Yu,Shuqiang Jiao
The electrochemical behaviors of the ultrashort nickel phosphite nanorods supported on reduced graphene oxide (Ni11(HPO3)8(OH)6/rGO nanorods), as a candidate for cathodic applications in aluminum-ion batteries, are firstly investigated. Ni11(HPO3)8(OH)6/rGO nanorods are synthesized by a facile solvothermal process. Ni11(HPO3)8(OH)6 and Ni11(HPO3)8(OH)6/rGO cathodes both possess very high initial discharge capacities of 132.4 and 182.0 mA h g−1 at a current density of 200 mA g−1, respectively. In addition, the long-term cycling stability of the Ni11(HPO3)8(OH)6/rGO cathode is further evaluated, exhibiting a discharge capacity of 49.2 mA h g−1 even over 1500 cycles. More importantly, the redox reaction mechanism of the Ni11(HPO3)8(OH)6 cathode for aluminum-ion batteries revealed that Ni11(HPO3)8(OH)6 is partially substituted with Al3+ to form AlmNin(HPO3)8(OH)6 and metallic Ni in the nanorod-like Ni11(HPO3)8(OH)6 cathodes during the discharge process. These findings are of great significance for the further development of novel materials for aluminum-ion batteries.
研究领域:
材料科学
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电化学
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能源存储
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DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2016
·
IF 4.836
Xiaming Feng,Xin Wang,Wei Cai,Ningning Hong,Yuan Hu,Kim Meow Liew
A novel strategy of using supramolecular self-assembly for preparing sandwich-like melamine cyanurate/MoS 2 sheets as the hybrid flame retardants for polyamide 6 (PA6) is reported for the first time. The introduction of MoS 2 sheets function not only as a template to induce the formation of two-dimensional melamine cyanurate capping layers but also as a synergist to generate integrated flame-retarding effect of hybrid sheets, as well as a high-performance smoke suppressor to reduce fire hazards of PA6 materials. Once incorporating this well-designed structures (4 wt%) into PA6 matrix, there resulted in a remarkable drop (40%) in the peak heat release rate and a 25% reduction in total heat release. Moreover, the smoke production and pyrolysis gaseous products were efficiently suppressed by the addition of sandwich-like hybrid sheets. The integrated functions consisting of inherent flame retarding effect, physical barrier performance and catalytic activity are believed to the crucial guarantee for the reduced fire hazards of PA6 nanocomposites. Furthermore, this novel strategy with facile and scalable features may provide reference for developing various kinds of MoS 2 based hybrid sheets for diverse applications.
研究领域:
材料科学
·
高分子化学
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火灾安全工程
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产品关联
DOI
PubMed
高影响因子
BIOTECHNOLOGY AND BIOENGINEERING
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2024
·
IF 3.5
Han-Yu Liu,Pan Ning,Feng Qian,Yao-Wu Wang,Hai-Min Zhang,Pu Wang
Flavin-dependent halogenase (FDH) is highly prized in pharmaceutical and chemical industries for its exceptional capacity to produce halogenated aromatic compounds with precise regioselectivity. This study has devised a multi-enzyme self-assembly strategy to construct an effective and reliable in vitro coenzyme cycling system tailored for FDHs. Initially, tri-enzyme self-assembling nanoclusters (TESNCs) were developed, comprising glucose dehydrogenase (GDH), flavin reductase (FR) and FDH. The TESNCs exhibited enhanced thermal stability and conversion efficiency compared to free triple enzyme mixtures during the conversion of L -Trp to 6-Cl- L -Trp, resulting in a 2.1-fold increase in yield. Subsequently, an ordered co-immobilization of GDH, FR, and FDH was established, further amplifying the stability and catalytic efficiency of the FDH coenzyme cycle system. Compared to the free TESNCs, the immobilized TESNCs demonstrated a 4.2-fold increase in catalytic efficiency in a 5 mL reaction system. This research provides an effective strategy for developing a robust and efficient coenzyme recycling system for FDHs.
研究领域:
生物化学
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合成生物学
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酶工程
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产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Mengyi Ba,Yanli Song,Wen Li,Yuanyuan Zhang,Haixin Liu,Xiang Xu,Zhiqiang Cai,Shaoqiang Hu,Tao Sun
In this work, a novel pillar[6]arene bonded with octyl-imidazolium ionic liquids (IMP6A-C4) as a stationary phase for gas chromatographic (GC) separations was designed, synthesized, and characterized. The IMP6A-C4 capillary column, prepared by the static coating method, had medium polarity (1 3 3) and relatively high column efficiency of 4982 plates/m determined by n-dodecane at 120 ℃. As demonstrated, through the separation of the mixture of 17 aliphatic analytes and the mixture of 20 analytes with different polarities, the IMP6A-C4 column exhibited privileged retention and high resolving capacity for H-bonded and aromatic analytes, suggesting advantages over the P6A-C4 column and common polysiloxane HP-5 and HP-35 columns. Strikingly, it implemented high resolutions with good peak shapes for isomer mixtures of phenols , anilines, and benzaldehydes . These findings demonstrated that the excellent resolving performance of the IMP6A-C4 column can be attributed to the comprehensive interactions of its rigid 3D aromatic cavities and polar imidazolium ionic liquids, including π-π, ion-π, H-bonding, dipole–dipole interactions. On the other hand, the IMP6A-C4 capillary column exhibited good repeatability and reproducibility with the RSD% values in the range of 0.01–0.03% for run-to-run, 0.09–0.32% for day-to-day, and 2.72–5.23% for column-to-column. The satisfactory separation performance reveals the promising prospects of the IMP6A-C4 stationary phase in separation science .
研究领域:
分析化学
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分离科学
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材料科学
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化学工程
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产品关联
DOI
高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2025
·
IF 4.7
Zongpeng Liu,Shaojian Hu,Qingquan Hao,Rui Ma,Yuning Zhang,Bencheng Wu,Jianhua Zhu
Nowadays, heterogeneous catalytic esterification for synthetic esters production is believed more compatible with the postulates of green chemistry and sustainability goals. In this work, we developed hydrophobic stannous oxide supported on mesoporous silica KIT-6 materials (SnO/KIT-6) via a feasible synthesis and post-grafting modification approach, which served as solid heterogeneous catalysts and then tested in the synthesis of complex polyolester (CPE). The catalytic behaviour of as-prepared catalysts was also systematically investigated and the highest carboxyl conversion ( ca. 95.6%) could be achieved under the optimal preparation conditions within the studied range. The obtained results revealed that Lewis acidity of the tin-based catalysts played a crucial role in esterification conversion efficiency, which varied depending upon the dispersion of different SnO loading. Furthermore, the reusability of the catalyst was evaluated and demonstrated relatively stable catalytic activity for up to five consecutive cycles. Additionally, the possible esterification reaction mechanism of CPE over the modified S-SnO/KIT-6 was also elucidated. The resultant catalysts leveraged full advantage of the unique textural properties and adequate surface hydrophobicity, intensively facilitating the diffusion of large polar molecules and resisting to deactivation from generated water. Collectively, the findings of present study may provide some valuable insights for adopting productive and environmentally benign catalytic processes to synthesize ester-based lubricants in the future.
研究领域:
催化
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绿色化学
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材料科学
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化学工程
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2025
·
IF 3.8
Chen Lifang,Chen Jiaqi,Lei Ying,Lin Pengcheng,Cao Donglin,Xiao Wei,Hu Liangshan
Interleukin-6 (IL-6) is an acute phase response protein. Its level rapidly increases in infection, trauma, and acute inflammatory states. It usually appears earlier than other inflammatory markers such as C-reactive protein and procalcitonin. Therefore, detecting abnormal IL-6 levels (The clinical reference range is greater than 7 pg mL −1 ) faster can help humans receive timely treatment and recover their health. This article successfully synthesized a medium-entropy oxide nanoenzyme. It does not require the involvement of hydrogen peroxide and has a low Michaelis constant of 0.101 mM. Based on the interaction between La-based medium-entropy oxide (MEO-La) nanoenzyme and secondary antibody, specific detection of IL-6 in enzyme-linked immunosorbent assay is achieved. The concentration of IL-6 in human serum can be qualitatively detected. The detection limit and linear range are 0.03 pg mL −1 and 5–1000 pg mL −1 , respectively. This work not only is of great significance for better understanding the unique properties of medium-entropy nanoenzymes but also has enormous potential for biochemical sensing of human health. Graphical This work develops a medium entropy oxide nanoenzyme for ultrasensitive IL-6 detection, achieving a detection limit of 0.03 pg mL −1 . The hydrogen peroxide free system has shown great potential in early disease diagnosis and biochemical sensing applications.
研究领域:
生物化学
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纳米技术
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免疫学
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医学诊断
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2025
·Vol. 15
·期 14
·10862-10872
·
IF 4.6
Muneera Alrasheedi,Salah M. El-Bahy,Refat El-Sayed,Khaled F. Debbabi,Alaa S. Amin
Although modern reported methods, such as AAS, ICP-AES, ICP-MS, have good sensitivity, the high cost of equipment, the need for sophisticated instruments, separation and preconcentration steps and experienced technicians along with lack of precise methods make them cumbersome. Solid phase extraction (SPE) emerges as an attractive technique that reduces solvent consumption, minimizes exposure, shortens extraction time, and lowers disposal costs. Herein, a pioneering methodology for the quantification of minute amounts of silver is introduced, using 2-nitro-6-(thiazol-2-yl-diazenyl)phenol (NTDP) as a complexing agent and Triton X-100 as a nonionic surfactant within a ternary surfactant system at a pH of 5.3. This novel extraction strategy demonstrated selective preconcentration. The enriched solution was subjected to spectrophotometric analysis for the quantification of the analyte. After refining extraction and complexation parameters, a remarkable 250-fold increase in the enrichment factor was attained, highlighting a sensitivity boost of 509 times compared with traditional extraction approaches relying solely on nonionic surfactants. The key parameters of molar absorptivity and Sandell sensitivity were determined to be 6.04 × 106 L mol−1 cm−1 and 0.0018 ng cm−2, respectively. The calibration plot was observed from 5.0–175 ng mL−1, whereas Ringbom optimum concentrations ranged from 15–160 ng mL−1. The detection and quantification limits were 1.63 and 4.95 ng mL−1, respectively. The relative standard deviation (RSD) of the complex was 2.27. The suggested method was efficiently utilized for assessing the Ag+ concentration in real samples, producing acceptable outcomes.
研究领域:
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）