ADVANCED FUNCTIONAL MATERIALS
·
2023
·Vol. 33
·期 30
·2214619
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IF 19
Xiang Sun,Mengshi Wei,Xin Pang,Lin Lin,Qiang Gao,Lichao Su,Ting Liu,Youliang Yao,Jibin Song,Wei Wang,Xiaohui Yan
Sonodynamic bacterial inactivation, a reactive oxygen species (ROS)-empowered approach featuring high penetration depth and low health risk, is explored for antibiotic-free antibacterial treatment. However, the low yield and insufficient diffusion of ROS negatively affect the antibacterial efficacy of sonodynamic treatment, thus hindering its further development. Here an actuator-integrated mechanism is proposed for enhancing the sonodynamic efficacy of loaded sonosensitizers through motion-induced hydrodynamic effects, demonstrated by a porphyrin-decorated gold nanomotor, which can produce ROS for bacterial inactivation while performing multimodal motion via actuation using low-frequency ultrasound. Corroborated by numerical simulation, the experimental results show that the motor's stirring motion significantly increases the yield and diffusion of ROS through fluid flow and frequent interactions between the motor and bacterial targets, resulting in doubled antibacterial efficiency in comparison to a stationary motor. Furthermore, the flow-induced shear forces combined with the frequent interactions constitute a source of mechanical damage and can form a synergy with the antibacterial properties of ROS, enabling an efficient biofilm eradication that is inaccessible by freely suspended porphyrin. In conclusion, this study reports a motion-based strategy to enhance sonodynamic efficacy and provides proof of concept using a sonodynamic gold nanomotor powered by ultrasound.
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CHEMICAL PAPERS
·
2018
·Vol. 72
·期 6
·1525-1534
·
IF 0.963
Shi Xiang,Shi Hong-Xin,Wu Hong-Ke,Shen Hai-Min,Cao Peng
A novel environmentally friendly fluorinated diamine N-[2-[(2-aminoethyl) amino]ethyl]-perfluoro-2,5-dimethyl-3,6-dioxa-nonanamide(FDETA) was synthesized for the first time based on diethylenetriamine and ethyl perfluoro-2,5-dimethyl-3,6-dioxa-nonanoate (FEt). It was characterized by means of Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR) and mass spectroscopy (MS). Subsequently, fluorinated polyurethanes (FPUs) containing various amounts of FDETA were then synthesized using hexamethylene diisocyanate (HDI), poly(tetramethylene oxide glycol) (PTMG), FDETA and 1,4-butanediol (BDO) as the main starting materials. Results of proton 1 H NMR and FTIR had verified successful incorporation of the FDETA chain extenders into FPU backbones. The surface properties of FPUs were detected by contact angle measurement, scanning electron microscope (SEM), and energy-dispersive X-ray spectroscopy (EDX). The thermal property of FPUs was also investigated by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). Results from EDX, SEM and contact angle studies indicated that fluorinated side chains in the hard segments had indeed migrated onto the surface. Results from DSC and TGA studies indicated that the thermal stability and the degree of phase separation were also improved.
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JOURNAL OF NANOPARTICLE RESEARCH
·
2018
·Vol. 20
·期 2
·1-12
·
IF 2.127
Yang Dong,Zou Xiaoyan,Tong Zhenwei,Nan Yanhu,Ding Fei,Jiang Zhongyi
One-dimensional nanotubes have attracted enormous attention due to their specific structure and excellent performance since the carbon nanotube was prepared. In this study, the open-ended SrTiO 3 nanotubes (STNTs) have been fabricated for the first time via an isomorphic conversion strategy using the protonated titanate nanotubes (HTNTs) as the precursor and template under the hydrothermal treatment. The as-prepared STNTs consist of uniform and continuous multilayers, having inner and outer diameters about 8.0 and 13 nm. The STNT formation involves the exchange of Sr 2+ ions with H + ions in HTNTs and then in situ growth of cubic SrTiO 3 crystals by the templating of HTNT frameworks. It is found that the diffusion process of Sr 2+ ions plays a critical role in controlling the nanotube morphology of SrTiO 3 crystals. In addition, the SrTiO 3 nanotubes exhibit high photocatalytic activity for the Cr(VI) reduction, which can reduce nearly 100% Cr(VI) within 6 h under simulated sunlight irradiation. The current strategy may be broadly applicable for fabricating the nanotubes from raw materials without 2D layered nanostructure.
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ChemCatChem
·
2018
·Vol. 10
·期 14
·3040-3048
·
IF 4.674
Tingxia Hu,Haiping Li,Na Du,Wanguo Hou
Graphical Iron rules : Fe-doped Bi 2 WO 6 exhibits a much higher photoactivity than Bi 2 WO 6 because of the introduction of the dopant and defect energy levels. The metal-doping of Bi-based oxide photocatalysts to enhance the photocatalytic performance has been a research hotspot in recent years, but the research on the mechanism of doping-induced photoactivity improvement is still incomplete. To illustrate the mechanism completely and clearly, Fe-doped Bi 2 WO 6 , as an example, was synthesized by a facile hydrothermal route. Fe-doped Bi 2 WO 6 exhibits a much higher photoactivity than pure Bi 2 WO 6 in the degradation of Rhodamine B (RhB) and salicylic acid (SA). By replacing W 6+ , the Fe 3+ doping narrows the energy band gap and generates many oxygen vacancies, which can increase the adsorption of both RhB and SA, and the introduced defect and Fe-doping energy levels in the band gap of Bi 2 WO 6 increase the separation efficiency of photoinduced charge carriers significantly. These lead to the considerable photoactivity enhancement of Fe-doped Bi 2 WO 6 . The photoactivity of Fe-doped Bi 2 WO 6 is stable and superior to that of most reported modified Bi 2 WO 6 photocatalysts. This work illustrates in detail the mechanism for the photoactivity improvement of Fe-doped Bi 2 WO 6 , which benefits the research of other metal-doped photocatalysts.
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JOURNAL OF BIOMATERIALS APPLICATIONS
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2018
·
IF 2.082
Lei Xu,Shuo Wu,Xiaoqiu Zhou
Drug-loaded nanoparticles have been widely researched in the antitumor. However, some of them are unsatisfactory in the long blood circulation and controlled drug release. Red blood cell (RBC) membrane vesicles (RV)-coated nanoparticles have gained more and more attention in drug delivery for their many unique advantages, such as excellent stability, long blood circulation, and reduced the macrophage cells uptake. Herein, by utilizing the advantages of RV, we fabricated RV-coated poly(lactide-co-glycolide) (PLGA)–docetaxel (RV/PLGA/DTX) nanoparticles to enhance the antitumor efficiency in vivo. The RV/PLGA/DTX showed spherical morphology with particle size of about 100 nm and zeta potential at −12.63 mV, which could maintain stability for a long time. The RV/PLGA/DTX significantly enhanced cellular uptake of DTX compared to PLGA/DTX in HepG2 cells. Moreover, RV/PLGA/DTX showed the strongest antitumor effect in vitro. Prolonged blood circulation and enhanced DTX accumulation at the tumor site through enhanced permeability and retention (EPR) effect were achieved by RV/PLGA/DTX, which eventually obtained satisfactory antitumor effect and depressed system toxicity on mice bearing HepG2 xenografts mouse models when compared with free DTX. The hematoxylin and eosin (H&E) and immunofluorescence assays further proved the advantages of RV/PLGA/DTX in vivo antitumor. These RV-coated nanoparticles provide a mimetic therapy, completely inhibited the growth of the HepG2 cells, and with simple compositions, suggesting it to be an ideal strategy for improving the antitumor effect of drug-loaded nanoparticles.
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ACS Synthetic Biology
·
2018
·
IF 5.316
Xianglai Li,Zhenya Chen,Yifei Wu,Yajun Yan,Xinxiao Sun,Qipeng Yuan
Hydroxytyrosol (HT) is a valuable natural phenolic compound with strong antioxidant activity and various physiological and pharmaceutical functions. In this study, we established an artificial pathway for HT biosynthesis. First, efficient enzymes were selected to construct a tyrosol biosynthetic pathway. Aro10 from Saccharomyces cerevisiae was shown to be a better ketoacid decarboxylase than Kivd from Lactococcus lactis for tyrosol production. While knockout of feaB significantly decreased accumulation of the byproduct 4-hydroxyphenylacetic acid, overexpression of alcohol dehydrogenase ADH6 further improved tyrosol production. The titers of tyrosol reached 1469 ± 56 mg/L from tyrosine and 620 ± 23 mg/L from simple carbon sources, respectively. The pathway was further extended for HT production by overexpressing Escherichia coli native hydroxylase HpaBC. To enhance transamination of tyrosine to 4-hydroxyphenylpyruvate, NH4Cl was removed from the culture media. To decrease oxidation of HT, ascorbic acid was added to the cell culture. To reduce the toxicity of HT, 1-dodecanol was selected as the extractant for in situ removal of HT. These efforts led to an additive increase in HT titer to 1243 ± 165 mg/L in the feeding experiment. Assembly of the full pathway resulted in 647 ± 35 mg/L of HT from simple carbon sources. This work provides a promising alternative for sustainable production of HT, which shows scale-up potential.
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ACS Applied Materials & Interfaces
·
2018
·
IF 8.097
Ao Zhuang,Yongjun Bian,Jianwei Zhou,Suna Fan,Huili Shao,Xuechao Hu,Bo Zhu,Yaopeng Zhang
Various attractive materials are being used in bioelectronics recently. In this paper, hydroxymethyl-3,4-ethylenedioxythiophene (EDOT-OH) has been in situ integrated and polymerized on the surface of the regenerated silk fibroin (RSF) film to construct a biocompatible electrode. In order to improve the efficiency of in situ polymerization, sodium dodecyl sulfate (SDS) was adopted as surfactant to construct a well-organized and stable poly(hydroxymethyl-3,4-ethylenedioxythiophene) (PEDOT-OH) coating, whereas ammonium persulfate was used as oxidant. The effects of dosages of surfactant and oxidant, initial pH value, and monomer concentration on the polymerization were studied. Under the optimal conditions, the RSF/PEDOT-OH film exhibited a square resistance of 3.28 × 105 Ω corresponding to a conductance of 6.1 × 10–3 S/cm. Scanning electron microscope images indicated that PEDOT-OH was deposited uniformly on the surface of the RSF film with SDS. Furthermore, Fourier transform infrared spectroscopy confirmed that interactions existed between the peptide linkages of silk fibroin (SF) macromolecules and PEDOT-OH. The RSF/PEDOT-OH film displayed favorable electrochemical stability, biocompatibility, and fastness. This study provides a feasible method to endow conductivity to RSF materials in various forms. In addition, the conductive layer and biocompatible silk substrate make the RSF/PEDOT-OH biomaterial highly suitable for potential applications in bioelectric devices, sensors, and tissue engineering.
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BIOTECHNOLOGY LETTERS
·
2018
·Vol. 40
·期 7
·1049-1055
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IF 1.846
Zhao Weirui,Ding Huanru,Hu Sheng,Huang Jun,Lv Changjiang,Mei Jiaqi,Jin Zhihua,Yao Shanjing,Mei Lehe
Objective To develop a new and efficient biocatalytic synthesis method of imidazole-4-acetic acid (IAA) from l -histidine ( l -His). Results l -His was converted to imidazole-4-pyruvic acid (IPA) by an Escherichia coli whole-cell biocatalyst expressing membrane-bound l -amino acid deaminase (m l -AAD) from Proteus vulgaris firstly. The obtained IPA was subsequently decarboxylated to IAA under the action of H 2 O 2 . Under optimum conditions, 34.97 mM IAA can be produced from 50 mM l -His, with a yield of 69.9%. Conclusions Compared to the traditional chemical synthesis, this biocatalytic method for IAA production is not only environmentally friendly, but also more cost effective, thus being promising for industrial IAA production.
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Journal of Materials Chemistry A
·
2018
·Vol. 6
·期 40
·19743-19749
·
IF 9.931
Chengcheng Yan,Long Lin,Dunfeng Gao,Guoxiong Wang,Xinhe Bao
The electrochemical CO2 reduction reaction (CO2RR) powered by renewable electricity has emerged as a promising approach to alleviate global warming and energy depletion simultaneously. Notably, efficient catalysts containing Earth-abundant elements to achieve high CO2RR performance are in great demand for future applications. Herein, carbon-supported gallia gel nanoparticles were synthesized by precipitating gallium nitrate on carbon black in an ethanolic ammonia solution. Nano-sized gallia nanoparticles uniformly dispersed on the carbon support achieved a maximum CO faradaic efficiency of 77.0% at −0.71 V vs. the reversible hydrogen electrode (RHE) in CO2-saturated 0.1 M KHCO3 solution, showing a dramatic improvement compared to a bulk Ga electrode with only 24.2% CO faradaic efficiency at −0.80 V vs. RHE. X-ray photoelectron spectroscopy measurements revealed that surface Ga3+ species were reduced to metallic Ga when subjected to a negative potential during the CO2RR, indicative of the formation of oxide-derived active gallium sites. Control experiments further highlighted the necessity of close coalescence between the nano-sized gallia particles and the conductive carbon support. The present study underscores the feasibility of improving the CO2RR performance of Ga-related materials through nanostructuring of oxide-derived gallium catalysts.
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COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
·
2017
·
IF 4.075
Lin Zhang,Hongqiang Li,Xuejun Lai,Xiaofeng Liao,Jing Wang,Xiaojing Su,Heng Liu,Wenjian Wu,Xingrong Zeng
To improve the thermo-oxidative aging resistance of natural rubber , a kind of functionalized graphene (FGE) was prepared by grafting 2- tert -butyl-6-(3-tertbutyl-2-hydroxy-5-methylphenyl) methyl-4-methylp-henyl acrylate (GM) onto graphene oxide (GO) using (3-mercaptopropyl) trimethoxysilane as bridging agent. In comparison to GO, FGE appeared more curled surface and reached the higher water contact angle of 134°. By latex-mixing method, the uniformly dispersed FGE endowed NR vulcanizates with obviously improved thermal stability. Importantly, the NR/FGE nanocomposites exhibitd excellent thermo-oxidative aging resistance, which was attributed to not only the synergistic antioxidative effect of hindered phenol groups and thioether bonds, but also the barrier role of graphene sheets to oxygen. Our findings provide a new strategy to prepare functionalized graphene as effective antioxidant for rubber and other polymer materials.
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Journal of Materials Chemistry C
·
2017
·Vol. 6
·期 2
·388-392
·
IF 5.256
Yaoguo Shen,Sangen Zhao,Chenxi Wang,Zujian Wang,Jianghe Feng,Maochun Hong,Junhua Luo
Bistable compounds have attracted intensive interest because of their great potential to realize seamless integration of multifunctional switches in one device. However, previous studies are mainly limited to organic–inorganic hybrid compounds, which have relatively low phase-transition temperature and thermal stability. Here, we report a new pure inorganic compound CsCdPO4, which undergoes a high-temperature phase transition at 447 K. Correspondingly, CsCdPO4 simultaneously shows an interesting duple bistability of nonlinear optical and dielectric properties. Furthermore, it shows an extremely high thermal stability up to 1418 K, which is significantly higher than those of organic–inorganic bistable compounds. This work will open up a new avenue to develop multifunctional materials that remain stable even under extreme operating conditions (e.g. extremes of temperature).
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Nature Communications
·
2022
·Vol. 13
·期 1
·1-9
·
IF 17.694
Huang Lei,Wei Min,Qi Ruijuan,Dong Chung-Li,Dang Dai,Yang Cheng-Chieh,Xia Chenfeng,Chen Chao,Zaman Shahid,Li Fu-Min,You Bo,Xia Bao Yu
Efficient and robust platinum-carbon electrocatalysts are of great significance for the long-term service of high-performance fuel cells. Here, we report a Pt alloy integrated in a cobalt-nitrogen-nanocarbon matrix by a multiscale design principle for efficient oxygen reduction reaction. This Pt integrated catalyst demonstrates an increased mass activity, 11.7 times higher than that of commercial Pt catalyst, and retains a stability of 98.7% after 30,000 potential cycles. Additionally, this integrated catalyst delivers a current density of 1.50 A cm −2 at 0.6 V in the hydrogen-air fuel cell and achieves a power density of 980 mW cm −2 . Comprehensive investigations demonstrate that the synergistic contribution of components and structure in the platinum-carbon integrated catalyst is responsible for the high-efficiency ORR in fuel cells.
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