TALANTA
·
2024
·
IF 5.6
Feifan Qi,Mengdie Wu,Simin Liu,Wendi Mu,Chunyan Wu,Xinshui Ren,Chuang Rui,Fangfang Wu,Dong Chang,Hongzhi Pan
Carbohydrate antigen 199 (CA199) is the most sensitive marker reported for pancreatic cancer, and it is a difficult task to develop a highly sensitive assay for CA199. During the experiment, a ratiometric electrochemical immunosensor for quantitative analysis of CA199 was prepared for NiCo@Fc-MWCNTs-LDH as the electrode sensing surface and 3D-rGOF@Ag/Au as the label of Ab 2 . NiCo@Fc-MWCNTs-LDH not only provide the required signal for the immunosensor, but also have a layered structure to obtain a large specific surface area, which can provide more sites for the placement of biological molecules. rGOF has the advantages of large specific surface area and high porosity, which can adsorb Ag electrochemical probe through redox reaction. The modification of gold nanoparticles can not only enhance the electrical conductivity of nano-composites, but also immobilize more biomolecules to improve the sensitivity of electrochemical sensors. With the beefing up of CA199 concentration, the oxidation peak current of Ag increases and the oxidation peak current of Fc-COOH decreases. The ratio (y = I Ag /I Fc-COOH ) of two different signals was linear with the logarithm of CA199 concentration in a certain value range. Under optimal conditions, the immunosensor showed excellent performance in the concentration range of 0.0001 U/mL to 10 U/mL, and the detection limit was 5.55 × 10 −4 U/mL. The strategy could clearly discriminate between matched and mismatched targets, demonstrating high specifificity. This approach further detects CA199 in human plasma to differentiate pancreatic cancer patients from healthy individuals with high accuracy. This method also provided a new idea for the ultrasensitive quantitative detection of other biomarkers.
研究领域:
生物医学工程
·
肿瘤标志物检测
·
纳米材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2021
·
IF 4.821
Ying Song,Jinlei Chen,Xiaobin Yang,De Zhang,Yanqiu Zou,Dejiang Ni,Jiaming Ye,Zhi Yu,Qiang Chen,Shangzhong Jin,Pei Liang
Fe 3 O 4 magnetic nanoparticles with a particle size of ∼ 250 nm were synthesized by the thermal solvent method, and then modified with polyethyleneimine (PEI) as the intermediate layer on the Fe 3 O 4 surface to form ultra-thin polymer interlayer to replace the traditional carbon shell and silicon shell interlayer. The seeding of Fe 3 O 4 magnetic particles was completed thanks to the strong positive charge of the amino group of PEI-adsorbed 3–5 nm colloidal gold on the surface of magnetic beads, and the addition of silver nitrate and reducing agent to the magnetic microsphere enabled the silver shell to be coated on the surface of the magnetic microspheres almost without affecting their magnetism. Moreover, the effects of the additive amount of colloidal gold, silver nitrate and ultrasonic time on the magnetic nanoparticles were systematically studied. Morphology and characterization analysis showed that the prepared Fe 3 O 4 @Ag magnetic nanoparticles (MNPs) had uniform particle size, good dispersibility, strong magnetic response, and powerful SERS performance. Furthermore, the SERS performance of the composite nanometer material was investigated by using 4-aminophenol and pesticide paraquat as active targets, with the molecular concentration down to 10 -8 M and 10 -10 M, respectively, confirming that the functional composite had a good SERS activity and Fe 3 O 4 magnetic core.
研究领域:
材料科学
·
环境科学
·
分析化学
✓ 已验证
DOI
高影响因子
RSC Advances
·
2021
·Vol. 11
·期 22
·13193-13200
·
IF 3.361
Nannan Zhang,Yuxi Meng,Yuxue Ning,Andrew E. H. Wheatley,Fang Chai
The enormous and urgent need to explore cost-effective catalysts with high efficiency has always been at the forefront of environmental protection and remediation research. This work develops a novel strategy for the fabrication of reusable CuO-based non-noble metal nanomaterials as high-efficiency catalysts. We report a facile and eco-friendly synthesis of CuO hexapods and CuO–Ag composite using uric acid as a reductant and protectant. Both exhibited high catalytic activity in the hydrogenation of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) by sodium borohydride (NaBH4), with the CuO–Ag composite showing superior catalytic performance. Notably, the highest turnover frequency of CuO–Ag reached 7.97 × 10−2 s−1, which was much higher than numerous noble-metal nanomaterials. In addition, CuO hexapods and CuO–Ag composite were also shown to act as highly efficient and recyclable catalysts in the degeneration of 4-NP. Both CuO hexapods and the CuO–Ag composite exhibited outstanding catalytic durability, with no significant loss of activity over more than 10 cycles in the hydrogenation of 4-NP.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
·
2024
·
IF 8.1
Yanzhi Cai,Dengpeng Chen,Laifei Cheng,Siyu Guo,Zhongyi Hu,Yuhan Wang,Haiming Yu,Yuan Zhou
The performance of sensors is often limited by the structural characteristics of the single form of conductive filler, making it difficult for sensors to simultaneously consider the broad sensing range and high sensitivity. How to achieve high sensitivity and broad working range of sensors through innovative sensing materials and sensor structure design remains a challenge. Here, a flexible sensor with multidimensional sensing materials and a double-layer structure is constructed. It consists of a high-performance CNTs@Ag-MXene-TPU sensing layer and a TPU flexible layer with significant deformability. Thanks to the synergistic effect of the double-layer structure and multidimensional sensing materials, this sensor has a high sensitivity of up to maximum gauge factor of 12216.3 and a wide sensing range of 300 %. Its response time and recovery time can reach 200 and 250 ms, respectively, and it also exhibits excellent cycling stability.
研究领域:
材料科学
·
传感器技术
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2014
·Vol. 38
·期 8
·3999-4006
·
IF 3.159
Zhenzhen Wang,Shangru Zhai,Bin Zhai,Zuoyi Xiao,Feng Zhang,Qingda An
Novel protocol towards multifunctional magnetic organic–inorganic core–shell nanostructured catalysts of Fe3O4@SN/HPW@CG–Ag with tailored properties are presented in this work. Such nanocomposites congregate the properties and functions of a single component into a whole. For instance, Fe3O4 cores protected by amino-functionalized SiO2 shell endowed the composites with superparamagnetism (28.6 emu g−1) and thereby facilitate the process of separation and recovery. Phosphotungstic acid, as a bridging agent, provided a strong interaction for the anchoring of glutaraldehyde cross-linked chitosan onto the surface of Fe3O4@SN. More interestingly, chitosan could simultaneously behave as a stabilizer and reductant for the in situ synthesis of “green” Ag NPs without addition of any other reducing agent or organic solvent, and Ag NPs provided the compounds with a catalytic performance. Further the size, loading of Ag NPs and the thickness of the chitosan layer were all controllable. Meaningfully, the as-synthesized catalyst Fe3O4@SN/HPW@CG–Ag exhibited an exceptional catalytic performance for the reduction of 4-nitrophenol in the presence of sodium borohydride (the reaction was accomplished within 7 min) and could be reused at least 10 times with good stability by means of convenient magnetic separation. Thence, the design philosophy of the multifunctional robust Ag-based nanocatalysts may pave the way for the synthesis of other catalyst systems with long-term stability.
研究领域:
材料科学
·
催化化学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Nanomedicine
·
2024
·
IF 6.6
Yaxu Feng,Qing Sun,Pei Liu,Wei Fan,Bing Fan
Background Enterococcus faecalis (E. faecalis) is one of the main pathogens responsible for refractory root canal infections in the teeth and shows resistance against various antibacterial managements. Effective control of E. faecalis infection is a prerequisite for successful treatment of refractory apical periodontitis. This study aimed to analyze the antibacterial activity and mechanisms of Au@Ag nanoparticles (NPs) combined with photothermal therapy (PTT) against the original and Ag+-resistant E. faecalis.Methods Au@AgNPs with optimal shell thicknesses were synthesized and characterized. The antibacterial activity of Au@AgNPs with PTT against the original or Ag+-resistant E. faecalis was evaluated, and the antibiofilm activity was tested on E. faecalis biofilm on the dentin of teeth. The potential antibacterial mechanisms of Au@AgNPs combined with PTT against E. faecalis have also been studied. Moreover, its influence on dentin microhardness and cytotoxicity was assessed.Results This study revealed that Au@AgNPs combined with PTT showed enhanced antibacterial and antibiofilm effects, no negative effects on dentin microhardness, and low cytotoxicity toward human periodontal ligament cells (hPDLCs). Moreover, Au@AgNPs combined with PTT effectively inhibited the growth of Ag+-resistant E. faecalis. Its antibacterial effects may be exerted through the release of silver ions (Ag+), destruction of the cell membrane, production of reactive oxygen species (ROS) and inhibition of adenosine triphosphate (ATP) production. Hyperthermia generated by Au@AgNPs with PTT reduced membrane fluidity and enhanced Ag+ sensitivity by downregulating fabF expression. The upregulated expression of heat shock genes demonstrated that the Ag+ released from Au@AgNPs compromised the heat adaptation of E. faecalis.Conclusion PTT significantly enhanced Ag+ sensitivity of the original and Ag+-resistant E. faecalis. Au@AgNPs combined with PTT may have the potential to be developed as a new antibacterial agent to control E. faecalis infections in teeth.
研究领域:
牙科学
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纳米医学
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Kai-hua Zhang,Ru-Yue Ding,Xin-Jie Zhao,Xiao-jing Wang,Yu-pei Li,Jun Zhao,Fa-tang Li
Sustained photocatalytic hydrogenation of CO 2 molecules is crucial for the CO 2 methanation reaction. Synchronizing directional photogenerated charge carriers and regulating the activation and hydrogenation process of CO 2 molecules are key to achieving the efficient photocatalytic methanation of CO 2 . Herein, Ag–Bi bimetallic sites were designed and anchored on the surface of TiO 2 via a one-step solution impregnation reduction and applied for the photocatalytic conversion of CO 2 to CH 4 . The optimum 5 %Ag 90 Bi 10 -TiO 2 composite exhibited excellent photocatalytic performance for the photoreduction of CO 2 into CH 4 . The product selectivity of CH 4 reached up to 97.2 %, at a rate of 58.9 μmol·g −1 ·h −1 . In situ Kelvin probe force microscopy and diffuse reflectance infrared Fourier transform spectroscopy attributed the high selectivity of CH 4 to the coexistence of metallic Ag and Bi sites, which induced directional photogenerated electrons and hole transfer. Moreover, the synergistic function of Ag–Bi bimetallic active sites on TiO 2 facilitated the hydrogenation of *CO 2 – to CH 4 . The proposed strategy provides insight into the design of highly selective photocatalysts for the reaction of photocatalytic methanation of CO 2 .
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Journal of Biomedical Nanotechnology
·
2022
·Vol. 18
·期 8
·2001-2009
·
IF 3.641
Ma Jun,Yu Da-Hai,Zhao Di,Huang Teng,Dong Min,Wang Ting,Yin Hai-Tao
Radiotherapy is an effective anti-cancer therapy for patients with non-small cell lung cancer (NSCLC), however, the prognosis is unsatisfactory owing to radio-resistance and toxicity. It is crucial to improve radiotherapy efficacy. Ag nanoparticles (NPs) and ginsenoside Rg3 (Rg3) exerted
antitumor and radio-sensitization effects. Therefore, we investigated whether poly-lactide-co-glycolide-polyethylene glycol (PLGA-PEG)-Rg3-Ag will function as a noninvasive, tracing, radiotherapy sensitizer. The morphology of NPs was visualized with transmission electron microscopy (TEM).
The drug loading content, encapsulation efficiency, and cumulative drug release of Rg3 was determined by HPLC. Cellular uptake of NPs in A549 and SPCA-1 was measured by immunostaining. The radio-sensitization effect of PLGA-PEG-Rg3-Ag in vitro was determined in A549 by detecting proliferation,
colony formation, and apoptosis with CCK-8, clonogenic survival assay, and flow cytometry, while in vivo was determined in nude mice by testing the body weight and tumor volume. PLGA-PEG-Rg3-Ag exerted radio-sensitization effect by reducing cell proliferation and colony formation while
enhancing cell apoptosis in A549; reduced tumor volume in nude mice. PLGA-PEG-Rg3-Ag exhibits radio-sensitization effects in NSCLC.
研究领域:
肿瘤学
·
药剂学
·
放射治疗学
✓ 已验证
DOI
高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Hangyu Luo,Xiaofeng Liu,Zhenbang Meng,Han Wang,Qi He,Ri Chen,Wenxia Wang
Antibacterial micromotors with intriguing properties have represented frontiers of research in the biomedical and environmental fields. While single-powered micromotors still encounter some challenges for efficient propulsion in an intricate biological environment, herein, dual-propelled Fe3O4/BiOI/Ag (FBA) micromotors with hollow structure were synthesized via two facile steps without involving any sophisticated equipment. In this unique design, efficient propulsion of an FBA micromotor powered by magnetic stimuli/visible light was demonstrated. Impressively, the micromotor was capable of flexible propulsion with a remarkable velocity of 119.2 ± 5.9 μm s–1 without addition of toxic fuel. Taking advantage of the locomotion, bacterial capture ability, and photocatalytic capacity, 1 × 107 CFU mL–1 Escherichia coli (E. coli) can be totally inactivated by hollow FBA micromotors. The ideal universality of FBA for antibacterial application toward Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) was confirmed. Besides, the FBA micromotors manifested antibiofilm capacity toward E. coli, methicillin-resistant S. aureus (MRSA), and P. aeruginosa. It is worth mentioning that they also displayed ideal biocompatibility and lower toxicity. More importantly, the FBA micromotors can effectively accelerate S. aureus-infected wound healing without causing adverse effects. This work offers an innovative strategy for facile design of dual-propelled micromotors for various environmental and biomedical applications.
研究领域:
生物医学工程
·
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry C
·
2024
·Vol. 12
·期 15
·5615-5622
·
IF 5.7
Qianrong Jin,Jinrong Shi,Jianwei Jin,Wenli Xu,Suqin Chen,Yuexiao Pan
Efficient and versatile materials that are both non-toxic and environmentally sustainable have become paramount in our pursuit of greener and more durable illumination solutions. In this study, we investigated the optical properties of rare-earth-based all-inorganic perovskite (AIP) crystal Cs2NaGdCl6 (CNGC) with various substitutions to explore its potential applications in lighting devices. The primitive crystal CNGC exhibits intrinsic blue emission due to its self-trapped excitons (STEs) but singly-doping with Bi3+ ions results in weak blue emission, indicating quenching of the STE emission. Alloying by introducing Ag+ ions into the CNGC:Bi3+ lattice, replacing the Na+ ions, caused the disruption of the crystal field symmetry, which lifts the parity-forbidden selection rule and allows for s–p transitions of the Bi3+ ions. Thus, the co-doping with Ag+ ions in addition to Bi3+ leads to intense broad-band warm white emission covering a wide spectral range of 470–800 nm, with a correlated color temperature (CCT) of 4512 K and a color rendering index (CRI) of 79. The findings from this study provide valuable insights for the development of efficient and high-quality lighting devices using a simple technique.
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
高影响因子
Reaction Kinetics Mechanisms and Catalysis
·
2024
·Vol. 137
·期 2
·1225-1238
·
IF 1.7
Wang Wanchun,Chi Yangxu,Sun Jiahong,Zhou Feng,Zhan Su
In this work, Ag/CuBi 2 O 4 composite photocatalyst films with excellent photocatalytic sterilization properties were prepared by photodeposition. The photocatalytic activity of silver-modified CuBi 2 O 4 (Ag/CuBi 2 O 4 ) under the photocatalytic-Fenton coupling system was verified by its inactivation rate of Escherichia coli in seawater. The results showed that the photocatalytic sterilizing performance of CuBi 2 O 4 loaded with Ag in the presence of trace amounts of H 2 O 2 was significantly improved. 15Ag/CuBi 2 O 4 possessed the optimal photocatalytic activity, and its sterilizing rate in 30 min could reach 96.6%. Its sterilization rate in 30 min could reach 96.6%, which is about 70% higher than that of pure CuBi 2 O 4 . Meanwhile, the mechanism of the enhanced sterilization performance of Ag/CuBi 2 O 4 in the photocatalytic-Fenton coupled system was investigated. Firstly, according to the electrochemical results, the loading of Ag can significantly improve the charge separation efficiency of CuBi 2 O 4 . And promotes the conversion of H 2 O 2 to hydroxyl radicals(·OH); Secondly, the valence band potential of 15Ag/CuBi 2 O 4 is more positive than that of CuBi 2 O 4 , which suggests that Ag loading can enhance the oxidation of CuBi 2 O 4 cavities. Comprehensive radical trapping experiments demonstrate that ·OH and holes (h + ) are the main active species for inactivating Escherichia coli (E. coli). In this work, effective conversion of H 2 O 2 to ·OH in a wide spectral range was achieved by loading Ag nanoparticles on the surface of CuBi 2 O 4 , which provides a new idea for the development of photocatalytic-Fenton coupling technology and ballast water treatment. Graphical abstract
研究领域:
环境科学
·
材料科学
·
光催化
·
微生物学
✓ 已验证
DOI
高影响因子
Nanomaterials
·
2025
·Vol. 15
·期 11
·778
·
IF 4.3
Weimin Ning,Mingxuan Li,Lei Jiang,Mei Yang,Maoyan Liu,Yong Liu
Bacterial leaf blight (BLB) is a destructive disease caused byXanthomonas oryzae pv. oryzae(Xoo). It has been proven that BLB adversely influences the growth and production of rice, resulting in substantial losses in yield. Nanoparticle–antimicrobial compounds possess excellent physicochemical properties, which have generated groundbreaking applications in protecting rice against BLB attacks. However, there is less research focused on the interaction between nanoparticles and the microbiome of BLB rice leaves, particularly the structure and function of endophytic bacteria, which are essential to plant health and pathogenesis. Therefore, the study explored how Cu-Ag nanoparticles influenced the endophytic bacteria’s composition and functions in healthy and BLB rice leaves. The data demonstrated that the relative abundance of beneficial bacteria,Burkholderiales,Micrococcales, andRhizobiales, increased after the introduction of Cu-Ag nanoparticles on the leaves of BLB rice. The examination of PAL activity demonstrated that nanoparticles limited the spread ofXooin rice leaves. Furthermore, endophytic community functional prediction demonstrated that nanoparticles may regulate the physiological process associated with potential stress resistance and growth-promoting function in the endophytic communities. This investigation may enhance the understanding of interactions between nanoparticles and the composition of rice endophytic microbiome, which can contribute to the exploration and application of nanomaterials in crop pathogen management.
研究领域:
植物病理学
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）