Scientific Reports
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2024
·Vol. 14
·期 1
·1-13
·
IF 3.8
Dezhakam Ehsan,Vayghan Roya Faraghi,Dehghani Sarina,Kafili-Hajlari Taha,Naseri Abdolhossein,Dadashpour Mehdi,Khalilzadeh Balal,Kanberoglu Gulsah Saydan
Nowadays, rapid and facile diagnosis of cancer using user friendly processes has attracted much attention. In this regard, an electrochemical (EC) biosensor with high sensitivity was fabricated by merging MIL156 MOF@COF nanocomposite with Au nanoparticles for the detection of CA15-3. Herein, metal clusters of MIL-156 as a Metal organic frameworks (MOF) were coated by a crystalline covalent organic frameworks (COF) through covalent bonding and created core-shell-like structures. The active part of the working electrode was modified in two consecutive steps. First, MIL-156 MOF@COF and then Au nanoparticles were electrodeposited on the glassy carbon electrode (GCE). The porosity of nanocomposite has significantly increased the surface area and improved the conductivity. Au nanoparticles also form an acceptable substrate for bonding antibodies due to their high affinity with amino groups. In addition, Au nanoparticles amplify the EC signal of the biosensor with their undeniable conductivity. Nanocomposite was characterized with XRD, SEM, and EDAX techniques. To investigate the proposed biosensor, differential pulse voltammetry (DPV) was used as an analytical technique. The CA15-3 calibration provided a linear range between concentrations of 30 and 100 nU/mL, thus expressing the powerful diagnostic potential of the designed biosensor. Furthermore, the suggested biosensor has been used in serum samples and discriminate breast cancer sufferers from healthy individuals with high confidence levels.
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ACS Nano
·
2025
·
IF 16
Yanhui Zhuang,Hao Yang,Yuhang Li,Yang Zhao,Huihua Min,Sheng Cui,Xiaodong Shen,Han-Yi Chen,Yifeng Wang,Jin Wang
Covalent organic frameworks (COFs) have shown promise as bifunctional catalysts to simultaneously mitigate shuttle effects and Li dendrite issues of lithium–sulfur (Li–S) batteries. However, the inherent low conductivity of the COFs has significantly limited their catalytic activity and stability. Herein, bifunctional catalytic activity and durability of the COF/MXene heterostructure are activated by tuning the surface curvatures of COFs interfaced with MXene. The increased curvature of COFs could induce enhanced electron delocalization and alter heterostructure geometry, which in turn strengthens lithium polysulfide adsorption, lowers energy barriers, and stabilizes catalytic sites to promote sulfur redox reactions. Concurrently, the hierarchical COF/MXene structure improves electrolyte penetration and wettability, facilitates rapid ion transport, and homogenizes the Li-ion flux distribution, thus achieving uniform lithium deposition. Consequently, the 1D-COF/MXene Li–S batteries demonstrate a high-rate capacity of 926 mA h g–1 at 4C, a stable cycling performance with a reversible capacity of 589 mA h g–1 at 3C after 500 cycles, and a high reversible capacity of 604 mA h cm–2 with a sulfur loading of 3.5 mg cm–2 under a low electrolyte-to-sulfur ratio of 10 μL mg–1. This work offers an efficacious approach to regulate catalytic activity and stability of catalysts.
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TALANTA
·
2025
·
IF 6.1
Yingfei Hui,Hao Guo,Mingyue Wang,Liping Peng,Borong Ren,Yanyan Ma,Wu Yang
Glutathione (GSH) levels have been linked to aging and the pathogenesis of various diseases, highlighting the necessity for the development of sensitive analytical methods for GSH to facilitate disease diagnosis and treatment. In this study, we synthesized a novel core-shell material, UiO@TBTA, by in-situ growing TFPB-TAPA COF on UiO-66-NH 2 through a Schiff base reaction. The resulting composite capitalize on the advantages of both materials, demonstrating excellent stability, large specific surface area, and abundant active functional groups while preserving superior crystallinity. Notably, this strategy effectively reduces the occurrence of aggregation-caused quenching (ACQ) in COFs. Due to the inner filter effect and hydrogen bonding interactions between UiO@TBTA and GSH, a specific ratiometric fluorescence detection of GSH was achieved in the range of 0.1–7 μM, with a limit of detection (LOD) of 0.0685 μM. In addition, due to the sensitive color change of the sensing material from orange to black caused by GSH, a proportional colorimetric sensing strategy has also been proposed, enabling the detection of GSH within the range of 1–200 μM. What's more, two intelligent artificial neural networks models were constructed with the help of machine learning that can quickly, accurately, and sensitively determine the concentration of GSH based on fluorescence images and color photographs respectively. Our work represents the first study utilizing MOF@COF composite for the multimodal detection of GSH, thus providing a novel strategy for the multimodal detection of the target analyte. Prospectively, the construction of the fluorescence/colorimetric dual-mode intelligent ratiometric sensing platform using deep machine learning holds great promise for real-time monitoring.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Tengfei Liu,Yuanshuang Liu,Dingrong Qu,Shougang Chen,Wenwu Chen,Lei Han,Zhigang Qiu,Linqi Zhu,Mindong Chen
COF LZU-1 has the characteristics of a porous structure, a large specific surface area , and good chemical stability. In recent decades, extensive research has been conducted on its use as a nanomaterial for drug loading and separation. Here, we report a new corrosion inhibitor encapsulated nanostructure (LZU-1 @BTA). We synthesized LZU-1 via a hydrothermal method and loaded benzotriazole (BTA) corrosion inhibitor into LZU-1. The results show that loaded BTA can achieve effective pH-responsive release under acidic and alkaline conditions. The amino group present in the LZU-1 molecule can cross-link with epoxy resin , and its compatibility allows for good dispersion in epoxy resin without any further modification. The LZU-1 @BTA modified epoxy coating has shown remarkable anti-corrosion properties and excellent self-healing capabilities, which have been evaluated through various techniques such as potentiodynamic polarization curves, electrochemical impedance spectroscopy (EIS), local electrochemical impedance spectroscopy (LEIS), scanning Kelvin probe (SKP) and salt spray testing. The high-quality dispersion of LZU-1 @BTA in the resin, the high cross-linking density, and the pH-responsive release of BTA in the epoxy resin are some of the key factors that contribute to the excellent anti-corrosion performance of the epoxy resin composite coating . This research has opened up new possibilities for designing anti-corrosion coatings with significantly better corrosion resistance .
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Journal of Future Foods
·
2025
·
IF 7.2
Pengfei Dong,Shuang Wu,Youfa Wang,Ning Yu,Vijaya Raghavan,Jin Wang
Sesame allergy has emerged as a public health issue due to its persistent occurrence, severe symptomatic manifestations, and widespread incidence globally. Among sesame allergens, 2S albumins (Ses i 2) is one of the widely recognized allergens, and its precise detection is urgently needed to prevent sesame-related allergies. In this work, a composite structure was designed and synthesized by combining metal ion self-assembled metal organic frameworks (MOFs) and imine constructed covalent organic frameworks (COFs) (represented by MOF@COF), which constructing a high-sensitivity sensing system for identification and detection of Ses i 2. A novel hybrid material, comprising a strategically assembled combination of UIO-66-NH 2 and TA-COF, was crafted to yield a functionalized UIO-66-NH 2 @TA-COF composite, demonstrating remarkable electrochemical performance. As a result, a significant quantity of aptamer strands can adhere to the UIO-66-NH 2 @TA-COF surface resulting from robust π-π stacking interactions. With the change in the relative concentration of Ses i 2 from 5 to 650 nM, the UIO-66-NH 2 @TA-COF sensor exhibited a low detection limit of 0.13 nM, which demonstrates its extremely high sensitivity. In addition, the UIO-66-NH 2 @TA-COF sensor exhibited excellent reproducibility, stability and specific recognition ability to Ses i 2. Therefore, this innovative sensor exhibits great potential for real-world applications in food safety.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
·
IF 9.4
Jinhong Bi,Zhangtong Zhang,Jinjin Tian,Guocheng Huang
Tetracycline (TC) antibiotics, extensively utilized in livestock farming and aquaculture, pose significant environmental challenges. Photocatalysis, leveraging renewable sunlight and reusable photocatalysts, offers a promising avenue for mitigating TC pollution. However, identifying robust photocatalysts remains a formidable challenge. This study introduces a novel hollow-flower-ball-like nanoheterojunction composed of a nitrogen-rich covalent organic framework (N-COF) coupled with BiOBr (BOB), a semiconductor with a higher Fermi level. The synthesized N-COF/BOB S-scheme nanoheterojunction features an expanded contact interface, strengthened chemical bonding, and unique band topologies. The N-COF/BOB composites showcased exceptional TC degradation performance, achieving an 81.2% removal of 60 mg/L TC within 2 h, markedly surpassing the individual efficiencies of N-COF and BOB by factors of 3.80 and 5.96, respectively. Furthermore, the total organic carbon (TOC) removal efficiency highlights a superior mineralization capacity in the N-COF/BOB composite compared to the individual components, N-COF and BOB. The toxicity assessment revealed that the degradation intermediates possess diminished environmental toxicity. This enhanced performance is ascribed to the robust S-scheme nanoheterojunction structure, which promotes efficient photoinduced electron transfer from BOB to N-COF. This process also augments the separation of photogenerated charge carriers, resulting in an increased yield of superoxide radicals (∙O 2 − ) and hydroxyl radicals (∙OH). These reactive species significantly contribute to the degradation and mineralization of TC. Consequently, this study introduces a sustainable approach for addressing emerging antibiotic contaminants, employing COF-based photocatalysts.
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INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
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2025
·
IF 2.5
Zongning Guo,Xuelin Huang,Zhiqiang Mai,Li Yang,Shaofeng Zheng,Jiaying Liao,Feng Gao,You Zhang,Zhe Jiao
The radioactive uranium element associated with rare earth minerals poses a significant threat to human health. Current detection of uranium relies on analysis in the lab, which cannot meet the demand for rapid on-site detection. We have developed a porphyrin-based covalent organic framework material, COF-MF, which exhibited specific fluorescent response to uranyl ion (UO22+). Based on the combination of the imino group of the hydrazone with the hexavalent uranium on the skeleton, it blocked intramolecular charge transfer, leading to fluorescence quenching, without interference from other coexisting metal cations. The fluorescence intensity of COF-MF at 680 nm gradually decreased with UO22+ concentrations ranging from 0.1 nM to 4.0 mm, and a linear relationship was observed in the concentration range from 0.1 nM to 10 nM. By integrating 3D printing technology, we developed a portable, rapid on-site detection device combined with smartphone-based app detection software. The response curve of UO22+ from 0.1 nM to 4.0 mm was studied, and the detection limit of the device for UO22+ was 0.05 nM, which was lower than the natural radioactivity limit value of non-ferrous metal mineral products. The analysis results of uranium in standard material (GWB04122) were consistent with ICP-MS. This study can be used for rapid on-site screening of uranium in imported ores by customs, providing important technical support for the quality control of imported ores.
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ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Juanjuan Li,Baohui Shi,Fei Gao,Hui Liu,Xuhan Zheng,Yan He,Qingyan Pan,Junqing Chen,Xueji Zhang,Lijun Qu,Chaoji Chen,Yingjie Zhao,Yuanyuan Shang
Covalent organic frameworks (COFs) are widely used due to their high structural order, tunable pore size, and large specific surface area. However, COFs are typically bulk solid microcrystalline powders that are insoluble and challenging to process, which significantly impacts their application prospects. We report a method for the in situ growth of COF-COOH on the surface of polyacrylonitrile (PAN) fibers by using electrospinning. COFs were synthesized via a solvothermal method suitable for most COF materials. Nitrogen atoms in the nitrile groups of the PAN macromolecular chain form hydrogen bonds with the hydrogen atoms of the monomer 2,5-diamino-terephthalic acid (DABDA). This interaction facilitates the effective mixing of PAN and DABDA, resulting in the uniform growth of COF-COOH, which adheres firmly to the fiber surface. The resulting PAN@COF-COOH fiber membrane exhibits remarkable structural stability. It has obvious adsorbability to chromium(VI) (Cr(VI)) in aqueous solution under acidic conditions and also for cationic dyes such as Rhodamine B and methylene blue. It is revealed that COF materials exhibit selective adsorption due to pore size limitations. The integration of the electrospinning method with COF materials allows for the large-scale production of COF fiber membranes, which holds significant importance and offers broad application prospects in this field.
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Journal of Physical Chemistry Letters
·
2023
·
IF 5.7
Yangyang Wan,Jiaojiao Zhang,Dayong Wang,Pengting Sun,Lebin Shi,Shun Li,Jianming Zhang,Xiaohong Yan,Xiaojun Wu
Two-dimensional (2D) covalent organic frameworks (COFs) with versatile structural and optoelectronic properties that can be tuned with building blocks and topological structures have received widespread attention for photocatalytic water splitting in recent years. However, few of these have been reported for overall water splitting under visible light. Here, we present a data-driven search of 2D COFs capable of visible-light-driven overall water splitting by combining high-throughput first-principles computations and experimental validations. Seven 2D COFs were identified to be capable of overall water splitting from the CoRE COF database, and their photocatalytic activities were further verified and optimized by our preliminary experiments. The production rates of H2 and O2 reached 80 and 32 μmol g–1 h–1, respectively, without using sacrificial agents. This work represents an attempt to explore 2D COFs for visible-light-driven overall water splitting with a data-driven approach that could accelerate the discovery and design of COFs toward photocatalytic overall water splitting.
研究领域:
材料科学
·
纳米技术
·
光催化
·
计算化学
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JOURNAL OF FOOD COMPOSITION AND ANALYSIS
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2025
·
IF 4.6
Qiao Yan,Pingping Zhang,Menglin Wang,Ling Ma,Ke Wang,Kaoqi Lian
This study aimed to synthesize a novel magnetic covalent organic framework (COF)-based material and establish an efficient magnetic solid-phase extraction (MSPE) method for the determination of benzimidazoles (BZDs) in honey. Given the abundant nitrogen atoms in BZDs, the target material (Fe₃O₄@SiO₂@MPA-TAPT-COF) was designed with Fe₃O₄ as the magnetic core and a COF shell polymerized from 5-bromobenzene-1,3-dicarbaldehyde (MPA) and 4,4',4''-(1,3,5-triazine-2,4,6-triyl) trianiline (TAPT). The synthesized Fe₃O₄@SiO₂@MPA-TAPT-COF exhibited considerable specific surface area, good magnetic responsiveness, and excellent reusability. An MSPE method using Fe₃O₄@SiO₂@MPA-TAPT-COF as the adsorbent was developed for the purification of BZDs in honey, followed by quantification via ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS). This method featured simple operation, high sensitivity, and good efficiency. Under optimized MSPE conditions, It showed good linearity for 17 BZDs in the concentration range of 0.2–100 μg/L, with correlation coefficients (R²) ≥ 0.9991. The limits of detection (LODs) for BZDs in honey were as low as 0.009–0.342 μg/kg. For spiked honey samples, the recoveries of the 17 target BZDs ranged from 61.44 % to 118.90 %.These results confirm that Fe₃O₄@SiO₂@MPA-TAPT-COF is a promising adsorbent for sample pretreatment, and the developed method provides a reliable tool for the sensitive and efficient analysis of BZDs in honey.
研究领域:
分析化学
·
食品安全
·
环境科学
·
材料科学
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Nanoscale
·
2025
·
IF 5.1
Xiangming Wang,Yang Zhao,Han Qin,Feng Yan,Tao An,Weimin Liu,Yu Su,Xianbo Yu
Magnesium batteries exhibit promising prospects owing to their high theoretical volumetric capacity, abundant natural reserves, and superior safety. However, their practical applications are hindered by the sluggish diffusion kinetics of Mg2+ in conventional cathode materials. This study innovatively proposes a strategy for the epitaxial growth of imine-linked covalent organic frameworks on the surface of carbon nanotubes (CNTs@COF), thereby effectively balancing electrode conductivity and the density of active sites through precise control of the COF layer thickness. This composite material not only facilitates the efficient diffusion of Mg2+ via axially aligned COF channels and continuous charge transport networks but also enhances electrical conductivity through the incorporation of CNTs, significantly improving the energy storage performance, cycling stability, and utilization efficiency of active sites in magnesium batteries. Furthermore, the Mg2+ storage mechanism in CNTs@COF is hypothesized to involve the storage of six electrons per CN bond within each COF unit. As a result, CNTs@COF exhibits superior discharge capacity, rate capabilities, and cycling performance (e.g., 191.7 mAh g−1 at 20 mA g−1 after 200 cycles and 107.6 mAh g−1 at 500 mA g−1 after 3000 cycles). The synthetic approach paves the way for constructing high-performance multivalent battery systems, bridging the gap from molecular design to macroscopic electrochemical performance.
研究领域:
材料化学
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电化学
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能源存储
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纳米材料
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电池技术
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功能材料
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SENSORS AND ACTUATORS B-CHEMICAL
·
2019
·
IF 6.393
Yufeng Sun,Jingbo He,Geoffrey I.N. Waterhouse,Longhua Xu,Hongyan Zhang,Xuguang Qiao,Zhixiang Xu
In this work, the development of a simple and sensitive electrochemical sensor for the simultaneous determination of sulfadiazine (SDZ) and acetaminophen (AP) is described. The sensor harnessed a molecularly imprinted polymer (MIP) for selective recognition of SDZ and AP, and a graphene [email protected] organic framework ( [email protected] ) nanocomposite for signal amplification. The [email protected] nanocomposite was first immobilized on a glassy carbon electrode (GCE), after which a polypyrrole MIP was electrodeposited on the modified electrode. The resulting electrochemical sensor (denoted as MIP/ [email protected] /GCE) showed a strong current response to both SDZ and AP in phosphate buffer at pH 7.0. Under optimal testing conditions, linear calibration curves were obtained over the concentration range 0.5–200 μM for SDZ and 0.05–20 μM for AP, with limits of detection being 0.16 μM and 0.032 μM, respectively. Beef and fodder samples spiked with SDZ and AP were extracted in ethyl acetate, then the SDZ and AP in the extracts quantified using the MIP/ [email protected] /GCE sensor. Recoveries were excellent, ranging from 82.0 to 108.0%. The same method was also employed to determine SDZ and AP residues in pork and chicken samples, with the results correlating well with those obtained using high-performance liquid chromatography.
研究领域:
分析化学
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电化学
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材料科学
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食品安全
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危险品化学品经营许可证（带存储）