Journal for ImmunoTherapy of Cancer
·
2025
·Vol. 13
·期 6
·e011472
·
IF 10.6
Hong Yang,Boshao Deng,Xiao Han,Lulu Wang,Jing Zhao,Yunpei Zhao,Zihan Sun,Siyi Wang,Guokang Liu,Yuzhang Wu,Jian Chen
Background Breast cancer is the most diagnosed malignancy and a leading cause of cancer-related deaths among women globally. Cuproptosis plays a significant role in tumor progression and therapeutic response. Increasing studies suggest that targeting cuproptosis presents a promising strategy for cancer therapy, such as through the development of copper nanoparticles as therapeutic agents. However, resistance to cuproptosis has emerged as a critical hallmark of cancer. Therefore, it is essential to further investigate the mechanisms underlying cuproptosis resistance to enhance its therapy effect. Methods The relationship between breast cancer progression and the C5a/C5aR pathway or cuproptosis was determined by single-cell RNA sequencing analyses, RNA-sequence analyses, bioinformatic analyses, survival analyses and immunohistochemistry. The antitumor effects of CuS nanoparticles and C5a receptor antagonists (C5aRA) were assessed by in vitro and in vivo strategies including cell counting kit-8, colony formation assay, relative reactive oxygen species level assay, western blots, real-time quantitative PCR, immunohistochemistry, immunofluorescence assay, flow cytometry and the xenograft mice models. Complement system activation by CuS nanoparticles was tested by ELISA. Results Our results indicated that activation of the C5a/C5aR pathway contributes to cuproptosis resistance by upregulating ATP7B expression via the Wnt/β-catenin pathway. Consequently, combining CuS nanoparticles with lazer treatment and C5aRA markedly enhanced the antitumor efficacy of CuS nanoparticles by overcoming cuproptosis resistance, leading to a synergistic effect in cancer therapy that included cuproptosis-targeting therapy, immunotherapy, and photothermal therapy. Conclusions This study reports, for the first time, proved C5a/C5aR pathway-mediated cuproptosis resistance in cancer cells, and combining CuS nanoparticles and C5aRA offers a superior and novel therapeutic strategy for cancer.
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PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2026
·
IF 6.9
Chao Liu,Shangshang Wang,Jingting Sun,Zhuangzhi Yu,Yuxi Song,Qinfang Zhang,Zhigang Zou
Photocatalytic oxygen reduction reaction (ORR) in seawater provides an efficient, cost-effective and sustainable pathway for hydrogen peroxide (H 2 O 2 ) production. However, developing the stable and high-efficiency seawater photocatalysts remains a crucial challenge due to the high concentration of Cl − and rapid charge carrier recombination rate. Here we fabricated 2D/2D CuS/CaIn 2 S 4 (CuS/CIS) heterostructured photocatalysts for visible-light-driven H 2 O 2 photosynthesis from seawater and O 2 under ambient condition. The introduction of CuS in CuS/CIS composites benefited superior light harvesting and the charge carrier separation. The optimized 5-CuS/CIS had an exceptional H 2 O 2 photosynthesis rate of 1194.0 μmol∙g −1 ∙h −1 with stable reusability in seawater, outperforming their counterparts. Additionally, 5-CuS/CIS possesses the higher H 2 O 2 photosynthesis rate in seawater and single salt-based solutions than that in deionized water. The corresponding enhancement mechanism of H 2 O 2 photosynthesis in seawater was discussed in depth. Thorough experimental analysis and theoretical calculations corroborate the two-step one-electron ORR path for H 2 O 2 photosynthesis. Through systematic characterization, we pinpoint the photo-reduction active sites governing H 2 O 2 formation and reveal optimized interfacial charge transfer pathways. This study offers new insights into designing stable heterostructured photocatalysts to facilitate charge carrier separation and achieve high-efficiency for H 2 O 2 photosynthesis from seawater.
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2016
·Vol. 28
·期 6
·4669-4675
·
IF 1.798
Zhang Xiufang,Mei Jie,Wang Song,Zheng Yingying,Cui Can,Pan Jiaqi,Li Chaorong
The cotton cellulose nanofibers(CCNFs)/ZnO/CuS nanocomposites have been successfully fabricated by the electrospun-hydrothermal method and successive ionic layer adsorption. The results of XRD, SEM and TEM indicate that the CuS are successfully combined with the ZnO. The photocatalytic activity of the CCNFs/ZnO/CuS nanocomposites is investigated by the degradation of methylene blue under visible light irradiation, and it is demonstrated to be significantly enhanced after the CuS is introduced. Furthermore, the direct interfacial charge transfer of the ZnO/CuS is considered as the main reason for the enhancement.
研究领域:
材料科学
·
纳米技术
·
光催化
·
环境工程
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DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2023
·
IF 7.2
Xueying Du,Jiaxin Hu,Qihang Sun,Hongquan Fu,Juan Zhang,Jinming Chang,Hejun Gao,Yunwen Liao
Low-cost transition metal sulfides have been shown to be ideal candidates for photocatalytic hydrogen evolution . However, most preparation processes have long reaction times and high energy consumption. In this work, CuS/ZnCdS heterojunction was prepared by a rapid and energy-saving microwave method . It was characterized by SEM, TEM, XRD , XPS , and photoelectrochemical tests. The results showed that CuS was successfully loaded with ZnCdS and did not alter the intrinsic structure of ZnCdS. It not only improved the light absorption efficiency, but lowered the position of the conduction band and reduced the forbidden band width. The optimum photocatalytic hydrogen evolution rate of CuS/ZnCdS could get 7.58 mmol g −1 h −1 and the AQE was 10.07% at 420 nm. The enhanced photocatalytic activity can be attributed to the construction of Z-scheme heterojunction to promote the separation and transfer of photogenerated charges. This work provides a valuable route to explore high quality ZnCdS based photocatalysts using a fast, low-cost microwave technique.
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高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Jiayao Wang,Jingguo Li,Shaokui Cao,Yingliang Liu,Jun Shi
In recent years, the remotely multi-responsive chitosan (CS) hydrogel has been garnering extensive attention owing to its remarkable potential in biomedical applications. Meanwhile, it presents a wide range of uses in the realm of controlled drug delivery and photothermal chemical combination therapy. In this paper, the CS/β-glycerophosphate disodium salt (β-GP) physical crosslinked network was employed as the framework to encapsulate near-infrared (NIR) responsive hollow copper sulfide (CuS)/polydopamine (PDA) nanoparticles, and the NIR/pH synergistic responsive CS/CuS/PDA hydrogel was fabricated. The negatively charged β-GP, along with the hollow CuS/PDA nanoparticles, played a key role in promoting the creation of abundant electronegative cavities. As a result, the hybrid hydrogel achieved an impressively high DOX loading rate, reaching up to 95.5%. The CS/CuS/PDA hydrogel exhibits excellent pH responsiveness, which could be attributed to the disintegration of the CS/β-GP network under acidic buffer solution. In addition, hollow CuS/PDA nanoparticles embedded in the hydrogel endow the hydrogel with excellent NIR photothermal responsiveness, which significantly promotes the release of DOX. Consequently, the CS/CuS/PDA hydrogel reveals excellent synergistically enhanced NIR, pH, and thermal triple-responsiveness, indicating its tremendous promise in the field of controlled drug release.
研究领域:
生物医学工程
·
材料科学
·
药学
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高影响因子
Advanced Materials Technologies
·
2025
·
IF 6.2
Li Mi,Qian Yang,Qindong Pu,Yicheng Jiang,Adric Ru Khiing Hii,Zhenghong Wu,Xiaole Qi
Diabetic wounds, a common complication of diabetes, pose significant challenges in clinical management. Proactively targeting bacterial biofilms in chronic wounds can enhance anti-inflammatory efficacy, accelerate the transition from inflammation to tissue proliferation, and promote more efficient healing. In this study, a bilayer hydrogel patch (NIM@UP/CuS@BT gel) is developed for diabetic wound management. This innovative system comprises a glucose-responsive bottom layer containing copper sulfide (CuS) to deliver transient antibacterial and antibiofilm activity during the initial infection phase, and a stable upper layer incorporating nimesulide (NIM) to provide sustained anti-inflammatory effects throughout the subsequent healing phase. This results demonstrate that the upper layer of the hydrogel patch exhibits enhanced mechanical strength of 146.3 ± 18.9 kPa, offering robust physical protection similar to a plaster. Additionally, the patch exhibits satisfied antibacterial performance, achieving over 95% bactericidal efficacy against both Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ), with an in vivo bactericidal rate of 78.7%. Furthermore, the downregulation of pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) and the upregulation of the anti-inflammatory cytokine interleukin-10 (IL-10) confirms its potent anti-inflammatory properties. In summary, the bilayer hydrogel system exhibits high biocompatibility, antibacterial and anti-inflammatory capabilities, addressing the distinct needs of different stages in the wound healing process.
研究领域:
生物医学工程
·
药剂学
·
伤口愈合
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材料科学
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传染病
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DOI
高影响因子
CHEMISTRY OF MATERIALS
·
2020
·
IF 9.567
Xiaowen Zhang,Simin Liu,Dezhi Tan,Yuehui Xian,Duoduo Zhang,Zuxing Zhang,Yi Liu,Xiaofeng Liu,Jianrong Qiu
Establishing a new photonic material with large optical nonlinearity in the near-infrared regime is significant for ultrafast optical science and devices. In this paper, we developed a facile photochemical approach to fabricate covellite CuS plasmonic nanocrystals (NCs) with high chemical stability and strong oxidation resistance under ambient conditions. The photochemically derived CuS NCs possess strong absorption in the visible-to-near-infrared optical range caused by the localized surface plasmon resonance effect (LSPR). We further demonstrate superior saturable absorption behavior of CuS NCs with a large modulation depth and a high damage threshold. Using CuS as an optical switch, a highly stable mode-locked pulsed laser operating in the telecommunication band with a signal-to-noise ratio over 70 dB and a pulse duration of 1.57 ps has been achieved. Our results suggest that the photochemical method is an effective technique to fabricate plasmonic NCs, which can be developed as an excellent candidate for ultrafast photonic devices in the visible-to-near-infrared region.
研究领域:
光学材料
·
超快光子学
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纳米技术
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高影响因子
ADVANCED MATERIALS
·
2013
·Vol. 25
·期 32
·4452-4458
·
IF 14.829
Kai Dong,Zhen Liu,Zhenhua Li,Jinsong Ren,Xiaogang Qu
Graphical A novel 980 nm laser-driven hydrophobic anticancer drug-delivery platform based on hollow CuS nanoparticles is constructed in this work. The excellent synergistic therapy combining drug treatment and photothermal ablation of cancer cells both in vitro and in vivo is demonstrated, which opens up new opportunities for biological and medical applications.
研究领域:
生物医学工程
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肿瘤学
·
纳米医学
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PubMed
高影响因子
INORGANIC CHEMISTRY
·
2025
·
IF 4.7
Xin Wan,Wensong Wang,Enze Tian,Jun Zhou,Congqiang Long,Fan Liu,Qiao Zhang,Jinxuan Fan,Feipeng Du,Bin Li,Si Chen
Nanomaterials offer enhanced stability and functionality for photothermal agents; however, their efficacy is often limited by suboptimal cellular internalization and photothermal conversion efficiency. To address these challenges, we designed a multicomponent inorganic–organic hybrid photothermal agent that integrates a virus-mimicking morphology and stimuli-responsive components. Gold nanostars (GNS) were functionalized with a pH-responsive epigallocatechin gallate (EGCG) polyphenol network, followed by in situ growth of CuS, yielding star-shaped GEC nanoassemblies with a rough surface. This biomimetic design leverages (i) the plasmonic photothermal properties of the GNS core, (ii) the acid-triggered disassembly of the EGCG network (mimicking viral protein shells), and (iii) the in situ synthesized CuS layer exhibiting a virus-mimetic rough surface and targeting capability, which enhances near-infrared light absorption and promotes endocytosis by the target cells. The synergistic integration of GNS and CuS significantly enhanced the photothermal conversion efficiency. Under tumor acidic conditions, the EGCG network disintegrated, leading to the shedding of the CuS shell and a reduction in overall size, which facilitated deep tissue penetration. Structural characterization confirmed the hierarchical architecture and pH-responsive size transition. Compared to unmodified GNS, the cellular uptake of GEC by 4T1 cells was approximately 4.5-fold higher, attributable to its virus-like rough surface, acid-responsive disintegration, and targeting ability. This work demonstrates a rational biomimetic strategy for engineering stimuli-responsive inorganic–organic hybrids with optimized photothermal performance through biomimetic component engineering.
研究领域:
纳米医学
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光热治疗
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生物材料
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癌症纳米技术
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刺激响应材料
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PubMed
高影响因子
DENTAL MATERIALS
·
2025
·
IF 6.3
Xue Yang,Yadong Chen,Yifan Chen,Jiajia Xu,Honghai Yan,Qiaojie Luo,Wei Yao,Xiaodong Li
Objective To develop a multifunctional strategy based on in-situ copper sulfide (CuS) nanoparticle deposition, aiming to simultaneously mitigate interface-confined water to improve adhesive infiltration, suppress enzymatic degradation, and prevent bacterial colonization. Methods Demineralized dentin matrices (DDM) were sequentially treated with CuSO₄ and Na₂S solutions at three concentrations (0.0015, 0.015, 0.15 mol/L), with conventional wet-bonding as a control. Nanoparticle distribution, matrix dehydration, matrix metalloproteinase (MMP) activity, antibacterial efficacy ( Streptococcus mutans , Staphylococcus aureus and Escherichia coli ), and bonding performance (nanoleakage, microtensile bonding strength) were systematically evaluated. Results Uniform CuS deposition significantly reduced DDM hydration to release the interface-confined water. The 0.015 and 0.15 groups showed enhanced mechanical properties. Moreover, all concentrations of CuS deposition inhibited MMP and showed antibacterial effect. As a result, the 0.015 and 0.15 groups showed improved adhesive infiltration, reduced nanoleakage ( p < 0.05) and increased both immediate and aged microtensile bonding strength ( p < 0.01). Conclusion In-situ CuS nanoparticle deposition synergistically enhances bond durability, through DDM dehydration, MMP inhibition, and antibacterial action. This approach effectively minimizes hybrid layer defects and collectively prolongs bonding longevity. Clinical significance The Cu-assisted bonding technique provides a clinically feasible solution to address multifactorial failure modes in dentin bonding, leveraging nanomaterial synergy for durable adhesive restorations.
研究领域:
口腔材料学
·
纳米牙科
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粘接牙科学
·
口腔生物学
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PubMed
高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2020
·Vol. 20
·期 4
·2365-2371
·
IF 1.134
Zeng Bin,Zeng Wujun
A novel reduced graphene oxide graphene-CdS/CuS nanoplate (G-CdS/CuS NP) was fabricated using a microwave method of loading CdS nanoplates onto graphene sheets (G-CdS NP) and subsequent cation exchange between G-CdS NP and Cu(NO3)2. The prepared G-CdS/CuS NP exhibited
excellent photocatalytic activity which was attributed to the synergy between graphene and CdS/CuS NP. The heterostructure in the CdS/CuS NP lead to an efficient charge transport across the interface. Graphene facilitated the transformation of electrons and reduced the recombination of electron–hole
pairs. These results provide a fabrication method for highly active photocatalysts and will lead to future rational design of photocatalytic materials.
研究领域:
材料科学
·
纳米技术
·
光催化
·
能源材料
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DOI
高影响因子
ORGANIC ELECTRONICS
·
2015
·
IF 3.827
Hongwei Lei,Pingli Qin,Weijun Ke,Yaxiong Guo,Xin Dai,Zhao Chen,Haoning Wang,Borui Li,Qiao Zheng,Guojia Fang
In this paper, a thin layer of high work function CuS was introduced to the interface between the anode and hole transporting layer (HTL) to modify the indium tin oxide (ITO) anode. Modified ITO substrates possess a higher work function, a lower sheet resistance and a negligible loss in transparency. More importantly, a thin layer of CuS can also benefit for the hole transporting of the device. Polymer solar cells (PSCs) utilizing modified ITO anodes exhibit a significant enhancement in power conversion efficiency ( PCE ) and air stability compared to devices with normal ITO anodes. This anode modification strategy applies to different active layer systems. Anode-modified devices with poly (3-hexylthiophene) (P3HT) and [6,6]-phenyl-C61-butyric acid methyl ester (PC 61 BM) as the active layer exhibit a PCE of 3.5%, while poly(4,8-bis(5-(2-ethyl-hexyl)-thiophene-2-yl)-benzo[l,2-b:4,5-b′] dithiophene-alt-alkylcarbonyl-thieno[3,4-b]thiophene) (PBDTTT-C-T) and [6,6]-phenyl-C71-butyric acid methyl ester (PC 71 BM) system shows a PCE of 7.4%. As a result, this work provides a good compatibility for modification of ITO by a thin layer of CuS in PSCs to achieve better performance.
研究领域:
材料科学
·
光伏技术
·
有机电子学
·
纳米材料
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DOI
高影响因子
危险品化学品经营许可证（带存储）