Journal of Materials Chemistry B
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2017
·Vol. 5
·期 7
·1454-1460
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IF 4.543
Zeying Zhang,Jin Xie,Jie Yu,Zhisong Lu,Yingshuai Liu
Although bioenzymes or artificial nanoenzymes-catalyzed reactions can efficiently amplify the detection signal in immunosorbent assays, the cascade reactions are sensitive to various conditions, including pH, temperature, time, and so on, resulting in poor reproducibility and dose-dependent response. In this work, a novel colorimetric immunoassay strategy was developed using an iron oxide magnetic nanoparticle (MNP) as a label for signal generation and amplification without the need for subsequent cascade reactions. The signal intensity is directly proportional to the level of targeting analytes, providing a more accurate quantification and a better reproducibility. The measurable color change results from the formation of a soluble red complex between bathophenanthrolinedisulfonic acid disodium salt (BPT) and Fe2+ released from dissolution of iron oxide MNP. The MNP, acting as an iron pool, provides a large amount of Fe2+ after its dissolution, thus promoting an efficient signal amplification. A qualitative evaluation is directly observed with the naked eye, while quantitative detection is achieved by measuring the absorbance of the colored solution using a UV-Vis spectrophotometer. Under optimal conditions, a limit of detection (LOD) at 3.6 pg mL−1 was achieved with a cancer biomarker carcinoembryonic antigen (CEA) as a model analyte, demonstrating its great potential for early cancer diagnosis. Moreover, the developed colorimetric assay method can be easily adapted to detection of other biomolecules (nucleic acids, saccharides, small molecules and so on) by simply changing the recognition pairs.
研究领域:
分析化学
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纳米技术
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生物医学工程
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癌症诊断
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PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2020
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IF 5.774
Chun Tong,Liquan Jing,Minqiang He,Meng Xie,Wei Wei,Yuanguo Xu,Hui Xu,Huaming Li
Designing a green and efficient catalyst to effectively degrade antibiotics is still one of the hot topics of research. Firstly, 1D nanorod Fe 2 O 3 /NaNbO 3 composite was successfully prepared by the two steps strategy through hydrothermal combined calcination method. In addition, the photocatalytic activity of the samples was evaluated by the degradation of tetracycline (TC) under visible light irradiation. The test results show that the 5% Fe 2 O 3 /NaNbO 3 nanorod material exhibits superior degradation rate of TC (89.4% removal efficiency in 90 min), and shows 5.62 times than that of NaNbO 3 nanorods. Under UV–visible light irradiation, 5% Fe 2 O 3 /NaNbO 3 nanorod composite with H 2 O 2 solution can degrade 97.4% of TC in 60 min, which is 12.1 times greater to that of the pure NaNbO 3 nanorods. The outstanding degradation performance may be attributed to the introduction of Fe 2 O 3 nanoparticles, which can activate H 2 O 2 more efficiently and produce more free radicals to degrade pollutants. At the same time, the 5% Fe 2 O 3 /NaNbO 3 nanorod composite can also act as an activate persulfate (PS) and generate SO 4 − to efficiently degrade TC. In addition, the catalyst also showed good performance in degrading TC in the presence of different anions and cations. Plant growth experiment ( mung bean seeds ) results showed that the degradation products have obvious lower toxicity. This study provides new domain about the designing of a photo-Fenton catalyst having dual ion synergy (Fe 3+ /Fe 2+ and Nb 5+ /Nb 4+ ) and full spectrum response.
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CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Lingling Hu,Yuhong Liao,Dehua Xia,Fei Peng,Li Tan,Shaoyun Hu,Changshuo Zheng,Xiaolong Lu,Chun He,Dong Shu
A visible-light-driven photocatalytic fuel cell system integrating electro-Fenton process (EF-PFC), comprised of oxygen vacancies-rich rGO/BiO 1−x I photoanode and biomass-derived N-doped carbon (BNC) cathode, was developed to eliminate organic pollutant and generate electricity synchronously. The structure and properties of rGO/BiO 1−x I were characterized by means of XRD, SEM, TEM, solid-state EPR, FTIR, Raman, XPS, UV-vis DRS and PL spectra. The photoelectrochemical activity of rGO/BiO 1−x I was characterized by Mott-Schottky plots, photocurrent responses and EIS. The experimental results indicated that the introduced oxygen vacancies and graphene modification not only promoted the light-harvesting ability but also greatly improved the generation and transfer rate of charge carriers. Most importanly, BNC, acted as cathode, could efficiently reduce oxygen to H 2 O 2 , thus leading to more ·OH production in the presence of Fe 2+ . Simultaneously, the photogenerated electron could efficiently accelerate Fe 2+ /Fe 3+ redox cycling for continuous Fenton reaction and increasing electricity generation in synergistic EF-PFC system. Using formic acid as sacrificial fuel, approximately 68% removal efficiency was reached in rGO/BiO 1−x I-BNC EF-PFC system under visible light irradiation for 240 min while the photocurrent density ( J sc ) and the maximum power density ( P max ) were measured to be 133.18 μA cm −2 and 17.50 μW cm −2 . Furthermore, the radicals trapping experiments, hydrogen peroxide quantitative studies and ESR tests clearly revealed the mechanism of enhanced performance in rGO/BiO 1−x I-BNC EF-PFC system. Therefore, this engineered rGO/BiO 1−x I-BNC EF-PFC system with the cooperation of Fe 2+ /Fe 3+ redox is a promising means to eliminate organic pollutants and generate electricity synchronously.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2025
·
IF 6.2
Yuejie Qiu,Longbin Li,Leping Zhang,Jianxin Jiang,Liwei Zhu
This study develops a catalytic system using pyruvic acid (PYA) and Fe2+ to efficiently coproduce xylo-oligosaccharides (XOS) and (manno-oligosaccharides) MOS from food material (Gleditsia sinensis Lam. fruit.) and its waste peel, respectively. The system achieved maximum yields of 67.12% XOS and 57.32% MOS without toxic byproducts such as furfural and 5-hydroxymethylfurfural (5-HMF) below 130 °C. The process employs a two-stage mechanism, where PYA cleaves galactose side chains and xylan backbones, while Fe2+ stabilizes β-1,4-glycosidic bonds, resulting in polymerization degree ratios of X2–3/X4–5 at 0.975 and M2–3/M4–5 at 0.96. The composite oligosaccharides, PFMX, showed significant prebiotic effects, enhancing Bifidobacterium adolescentis growth to 3.4 × 108 CFU/mL─144% higher than commercial fructooligosaccharides (FOS). The concentration of short-chain fatty acids (SCFAs) was 15.09 g/L, with specific products propionic acid (1.44 g/L) and butyric acid (0.15 g/L). PFMX effectively regulates substrate utilization and SCFA metabolism, offering a promising strategy for developing functional foods that target gut inflammation.
研究领域:
催化化学
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碳水化合物化学
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食品科学与技术
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益生元与肠道微生物
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绿色化学
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生物炼制
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PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Yanjun Guo,Chuan Cao,Lixia Zheng,Yuxiang Zhong,Pingzhou Duan,Xiang Hu
A MOF-derived carbon/metal oxide composite (Fe/Ce@NPC-600) by doping Ce into NH 2 -MOF-101(Fe) precursor and simple one-step carbonization was fabricated. Fe/Ce@NPC-600 as a floating cathode was innovatively applied to the solar photoelectro-Fenton (SPEF) process to increase the yield of H 2 O 2 and activate it for degradation tetracycline (TC). The characterizations showed that the presence of Ce greatly increased the content of Fe 2+ and photoresponse ability in the material. Thanks to the synergistic effect of Fe and Ce, Fe/Ce@NPC-600 cathode could efficiently degrade TC by 98.2 % within 30 min, and the removal rate of total organic carbon (TOC) was 68.2 %, and the photoelectric synergistic enhancement factor ( f PEF ) was 1.4. Besides, based on machine learning, a XGB model was established to predict electrode performance. The degradation mechanism and pathway of TC were also proposed. Our results inspired the application of floating cathodes, MOF-derived materials and artificial intelligence for advanced oxidation processes for efficient removal of emerging contaminants.
研究领域:
环境科学
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材料科学
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化学工程
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人工智能
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高影响因子
Antioxidants
·
2024
·Vol. 13
·期 6
·665
·
IF 6
Wenjing Xing,Chunmin Ma,Yang Yu,Fenglian Chen,Chunhua Yang,Na Zhang
The salt taste-enhancing and antioxidant effect of the Maillard reaction on peanut protein hydrolysates (PPH) was explored. The multi-spectroscopic and sensory analysis results showed that the Maillard reaction products (MRPs) of hexose (glucose and galactose) had slower reaction rates than those of pentose (xylose and arabinose), but stronger umami and increasing saltiness effects. The Maillard reaction can improve the flavor of PPH, and the galactose-Maillard reaction product (Ga-MRP) has the best umami and salinity-enhancing effects. The measured molecular weight of Ga-MRP were all below 3000 Da, among which the molecular weights between 500–3000 Da accounted for 46.7%. The products produced during the Maillard reaction process resulted in a decrease in brightness and an increase in red value of Ga-MRP. The amino acid analysis results revealed that compared with PPH, the content of salty and umami amino acids in Ga-MRPs decreased, but their proportion in total free amino acids increased, and the content of bitter amino acids decreased. In addition, the Maillard reaction enhances the reducing ability, DPPH radical scavenging ability, and Fe2+chelating ability of PPH. Therefore, the Maillard reaction product of peanut protein can be expected to be used as a substitute for salt seasoning, with excellent antioxidant properties.
研究领域:
食品科学
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营养学
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化学
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感官分析
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PubMed
高影响因子
ACS Omega
·
2024
·
IF 3.7
Xinyue Chen,Yongkang Cui,Shujuan Wang
In the realm of postcombustion carbon capture, diethylenetriamine (DETA), recognized for its substantial CO2 absorption capacity, presents a formidable challenge due to its corrosive impact on equipment. This study delves into the corrosion behavior of 20# carbon steel immersed in DETA solutions under varying conditions, employing weight loss and electrochemical methods. The investigation incorporates scanning electron microscopy/energy-dispersive spectroscopy and X-ray diffraction analyses for characterization. Corrosion experiments were also conducted in monoethanolamine (MEA) solutions for a comparative analysis. Results from the corrosion tests in DETA solutions mirror the temperature-dependent corrosion rate (CR) observed in MEA. However, a distinctive trend emerges as the CO2 loading of DETA increases from 0.2 mol CO2/mol amine to 1.2 mol CO2/mol amine, leading to a continuous decrease in the CR of carbon steel─contrary to MEA solutions. This anomaly is attributed to DETA’s robust complexing ability with metal ions and its elevated solubility of Fe2+ in solution. Additionally, an examination of the corrosion mechanism in the presence of oxygen was conducted through characterizing the specimen surface and solution precipitates postexperiment. The absence of a protective FeCO3 layer can be attributed to insufficient concentrations of free Fe2+ and CO32– in the solution, failing to achieve the minimum saturation required for protective film formation. The insights gained from studying the corrosion behavior of carbon steel in DETA solutions lay the groundwork for subsequent developments in corrosion inhibitors.
研究领域:
化学工程
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材料科学
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环境工程
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DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2025
·
IF 14.3
Hualing He,Qing Jiang,Yuhang Wan,Md Hasib Mia,Xueru Qu,Mi Zhou,Xingyu He,Xiaoqian Li,Min Hong,Zhicai Yu,Siqi Huo
Biopolymer-based temperature-sensing fibers are increasingly employed to realize the eco-friendly concept of wearable electronics. However, keeping their long-term development remains challenging due to limited mechanical robustness and poor environmental tolerance. Herein, a bionic autonomous self-healing thermoelectric (TE) aerogel fiber with visual damage warning function (STDF) inspired by biological skin was prepared via a coaxial wet spinning strategy, which yielded a core-shell heterogeneous structure with a protective sheath with an intrinsic self-healing ability and a temperature-sensing core layer. The core layer of STDF, composed of flexible thermoplastic polyurethane embedded with rigid Ti 3 C 2 T x MXene, effectively minimizes disruptions in continuous conductive pathways during repeated extreme bending. Featuring a synergistic network of reversible hydrogen bonds and dynamic Schiff-base linkages constructed among oxidized alginate, sericin, and tannic acid, the fractured STDF aerogel fiber exhibits exceptional water-responsive self-healing efficiency (97.51% stress recovery). Moreover, the visual damage location in STDF fiber is enabled through a coloration reaction at the damaged interface between the Fe 2+ ions and 1,10-phenanthroline incorporated into the core and sheath layers, respectively. Furthermore, the resultant STDF demonstrates a wide-range temperature-sensing performance at 100–500°C and an ultrasensitive alarm response time (within 2 s) when encountering fires. This work sheds new light on the design of bionic temperature sensing fibers with environment-adaptive self-healing and damage warning abilities for improved reliability and durability in real-world wearable application scenarios.
研究领域:
材料科学
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纳米技术
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可穿戴电子器件
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热电材料
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自修复材料
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柔性传感器
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生物聚合物
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智能纺织品
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柔性机器人
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先进制造技术
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Jingru Cui,Zhonghui Xue,Zhengxian Zhang,Huanhuan Zhu,Mingsan Miao,Yagang Song,Xiaofang Li,Huahui Zeng,Xiangxiang Wu
Chemodynamic therapy (CDT) is currently constrained by insufficient endogenous H 2 O 2 , enhanced antioxidant defense, weakly acidic conditions in pancreatic cancer. However, the CDT's immunotherapeutic potential hinges on radical-mediated immunogenic cell death (ICD) induction, motivating development of potent self-cascading radical nanogenerators. Herein, this work engineers carrier-free nanoparticles (IAA NPs) through metal-organic self-assembly of Fe 3+ , artesunate (AS) and PD-L1 antibody (αPD-L1), exhibiting high drug loading (AS: 80.62%, Fe 3+ : 4.57%, and αPD-L1: 14.81%), excellent stability and GSH/pH-dependent drug release. IAA NPs achieve GSH-triggered Fe 3+ reduction to Fe 2+ , catalyzing AS decomposition into carbon-centered radicals, with this radicalogenesis being H 2 O 2 /pH-independent while concurrently depleting intratumoral GSH antioxidant. These free radicals effectively induce ICD via apoptosis pathway, eliciting CRT exposure, HMGB1/ATP release, and efficient DC maturation. In Pan02 tumor-bearing mice, IAA NPs efficiently triggers ICD, promoting DC maturation, intratumoral CD4 + /CD8 + T-cell infiltration, and markedly inhibiting tumor growth. Concurrently, αPD-L1 blocks PD-1/PD-L1 pathway and restores T cell recognition, thereby enhancing the antitumor immune response. In addition, the favorable pharmacokinetic profiles, coupled with inherent biocompatibility and biosafety, collectively enhance IAA NPs’ translational potential. Basically, IAA NPs represent a novel strategy to improve combination chemodynamic-immunotherapy through radical-induced ICD and PD-L1 blockade.
研究领域:
纳米医学
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癌症免疫治疗
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化学动力学治疗
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药物递送系统
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生物无机化学
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肿瘤微环境
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免疫学
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高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-23
·
IF 15.7
Wang Yandong,Li Haodong,Lin Junyang,Li Yutang,Zhang Keqin,Li Hui,Fu Qiang,Jiang Yanyan
Conventional immunotherapy exhibits low response rates due to the immunosuppressive tumor microenvironment (TME). To overcome this limitation, this study introduces ZFPG nanoparticles (ZFPG NPs) with ZnFe 2 O 4 @Pt cores and glucose oxidase (GOx) shells. The ZFPG NPs possess five-enzyme activities, good sonosensitivity, and remarkable magnetic targeting properties, which facilitate sono-metallo-immunotherapy for prostate cancer treatment in male mice. Specifically, the magnetic targeting ability effectively improves their accumulation in tumors while still showing enrichment in the liver and kidneys. The multienzyme cascade catalysis and sonosensitivity of these NPs effectively deplete glutathione and glucose, and enhance the generation and utilization of H 2 O 2 , thereby inducing multiple ROS bursts. Furthermore, these comprehensive effects up-regulate the HMOX1 to promote the Fe 2+ and lipid peroxides accumulation, thereby inducing immunogenic ferroptosis. This strategy facilitates anti-tumor immunity by ameliorating the immunosuppressive TME and inhibiting lung metastatic progression. This joint warfare strategy offers a powerful solution to address conventional immunotherapy limitations.
研究领域:
纳米技术
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癌症免疫治疗
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生物医学工程
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分子生物学
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肿瘤学
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PubMed
高影响因子
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