BMEMat
·
2024
·
IF 0
He Ren,Zewen Wu,Jingxuan Li,Nan Zhang,Coo Yee Nah,Jiexin Li,Jingyu Zhang,Jonathan F. Lovell,Liyun Zhang,Yumiao Zhang
Rheumatoid arthritis (RA) is a systemic autoimmune disease that leads to the destruction of articular cartilage and bone. RA is characterized by immune cell infiltration and abnormal proliferation of synoviocytes in the joints. Herein, we developed a biomimetic formulation via co-loading the anti-inflammatory agent Celastrol (Cel) along with the stabilizer Vitamin K (VK) in antirheumatic methotrexate (MTX)-conjugated Pluronic F127 (F127) micelles. Micelles were then coated with B cell derived membrane, yielding MTX loaded Cel Micelle (CeViM)-micelle@B, which were investigated for RA treatment. VK, used at levels well within safety margins, was identified as a carrier compound that could stabilize Cel within micelles, increasing the encapsulation efficiency of Cel. In addition, MTX, a front-line RA therapeutic, was chemically grafted to F127 via a responsive linker sensitive to the chemically reducing environments. As such, CeViM-micelle@B released pristine MTX in response to the intracellular reducing environments, which combined with Cel to suppress pro-inflammatory responses. B cell membrane coating enhanced accumulation of CeViM-micelle@B in joints, leading to a 75% decrease of inflammatory cytokine secretion in vitro, and significantly ameliorated cartilage and bone structures in the collagen-induced arthritis murine model. Taken together, this biomimetic nanoparticle holds potential as a next-generation targeted RA treatment.
研究领域:
免疫学
·
药理学
·
纳米医学
·
自身免疫疾病
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DOI
BIOORGANIC CHEMISTRY
·
2021
·
IF 5.275
Shiyang Zhou,Huiying Zou,Gangliang Huang,Guangying Chen,Xueming Zhou,Shuheng Huang
Four series of double-ring conjugated enones were designed, synthesized and studied for the inhibition of synovial cell activity through the modification of Dysodensiol K core structure, double-ring, double-bond and double-carbonyl groups. For in vitro synovial cell assay of rats, compound 151 and 168 exhibited good inhibitory activities, with IC 50 values of 2.71 ± 0.18 and 2.68 ± 0.16 μM respectively. At the same time, the LDH release and LD 50 test results revealed that the target compounds were low cytotoxicity and acute toxicity. For in vivo CIA model test through the oral administration, compounds 151 and 168 were exhibited similar effect to positive control group methotrexate.
研究领域:
药物化学
·
药理学
·
风湿病学
✓ 已验证
DOI
PubMed
高影响因子
Journal of Integrative Neuroscience
·
2021
·Vol. 20
·期 1
·67-75
·
IF 2.117
Dong-Xing Liu,Di Zhang,Wei-Min Hu,Yan-Fang Chang,Xiao-Hui Wang,Lin Li
Overactivation of the PI3-K/Akt/mTOR signaling pathway and inhibition of autophagy in the brain are involved in Alzheimer’s disease. The present paper’s goal was to explore the potential mechanisms of geniposide to protect against Alzheimer’s disease. We treated the human neuroblastoma SH-SY5Y cell line with Aβ1-42 as an Alzheimer’s disease in vitro model to explore the potential mechanisms of geniposide to protect against Alzheimer’s disease. Further, SH-SY5Y cells damaged by Aβ1-42 were treated with geniposide. Akt/mTOR-related proteins and autophagy-associated proteins were measured to reveal the molecular mechanisms by which geniposide protects against Aβ1-42-induced toxicity. Results showed that Akt and mTOR’s geniposide inhibited phosphorylation induced by Aβ1-42, enhanced expression of the LC3II/LC3I ratio, and Atg7 and Beclin1 expression and inhibited expression of p62 induced by Aβ1-42. Our results lead us to hypothesize that inhibition of the Akt/mTOR signaling pathway and autophagy enhancement are fundamental molecular mechanisms for geniposide to protect against Aβ toxicity.
研究领域:
神经科学
·
药理学
·
细胞生物学
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产品关联
DOI
PubMed
高影响因子
Bioresources and Bioprocessing
·
2020
·Vol. 7
·期 1
·1-13
·
IF 0
Zhao Jianbo,Liang Xingxing,Cao Hui,Tan Tianwei
Photo-controlled release hydrogel provides a new strategy for treating tumours. Under the stimulation of external light sources, the ability to release the entrapped drug on time and space on demand has outstanding advantages in improving drug utilisation, optimising treatment, and reducing toxicity and side effects. In this study, a photo-controlled drug delivery system for disulphide cross-linked polyaspartic acid (PASP-SS) hydrogels encapsulating proteinase K (ProK) adsorbed with platinum nanoparticles (PtNPs) was designed. The injectable cysteamine-modified polyaspartic acid (PASP-SH) sol and PtNPs adsorbed by ProK (ProK-PtNPs) as regulatory factors were prepared. Then, ProK-PtNPs and lentinan were dissolved in the sol, and the oxidant was added to the matrix to form the gel in situ quickly after injection. Finally, the degradation of PASP-SS hydrogel by ProK and the controllability of drug release under near-infrared (NIR) light irradiation were elucidated. In vitro degradation of hydrogels and drug release experiments showed that the degradation rate of PASP-SS hydrogel significantly increased and the drug release rate increased significantly under near-infrared radiation. The results of cytotoxicity test showed that PASP-SS, ProK-PtNPs, and lentinan all had more than 90% cell survival rate on NIH3T3, and the lentinan released from the carrier obviously inhibited the proliferation of MCF7. PASP hydrogel has the potential to respond to on-demand light control.
研究领域:
生物材料学
·
肿瘤治疗
·
药剂学
✓ 已验证
产品关联
DOI
CHEMISTRY OF MATERIALS
·
2024
·
IF 7.2
Huan Pei,Luyong Zhang,Huanhuan Cheng,Shibin Wang,Zhihua Yang,Fangfang Zhang,Shilie Pan
Four hydroxyfluorooxoborates, α-K2[B3O3F4(OH)] (I), β-K2[B3O3F4(OH)] (II), Cs(NH4)3[B3O3F4(OH)]2 (III), and RbCs5[B3O3F4(OH)]3 (IV), with identical fundamental building block (FBB) [B3O3F4(OH)]2–, were obtained successfully and characterized comprehensively. A phase transition between I and II was detected, which led to a space group evolution from centrosymmetric to noncentrosymmetric. The F– and OH– substitution effect was studied based on II and its hydroxyborate derivative K2[B3O3(OH)5], which reveals the corresponding changes in the band gap and the nonlinear optical properties. In addition, the cationic-size effect on the arrangement of the [B3O3F4(OH)]2– FBBs and the birefringent properties were discussed for the title compounds. This study contributes to the advancement of structural chemistry and sheds some light on the structure–property relationship studies of hydroxyfluorooxoborates.
研究领域:
材料化学
·
晶体学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2021
·
IF 6.953
Chunjun Yan,Zheng Zhou
Prion diseases are fatal neurodegenerative diseases caused by the conformational transition of the cellular prion protein (PrP C ) to the abnormal pathological prion protein (PrP Sc ). In this work, the effects of ellagic acid (EA) and pentagalloylglucose (PGG) on prion protein (PrP) fibrillization were investigated. Fluorescence quenching experiments indicated that both EA and PGG could specifically interact with native human PrP with binding affinities of 1.92 × 10 5 and 2.36 × 10 5 L·mol −1 , respectively. Thioflavin-T (ThT) fluorescence assays showed that the binding of EA or PPG could effectively inhibit the nucleation and elongation of PrP fibrilization and reduce the amount of PrP fibrils generated. EA and PGG could also lead to a significant disaggregation of PrP fibrils. Circular dichroism (CD) measurements suggested that EA- or PPG-bound PrP could preserve a higher content of α-helical structures than β-sheet-rich PrP fibrils. The PrP aggregates formed in the presence of EA or PGG showed lower resistance to proteinase K (PK) digestion. Overall, the present work reported the inhibitory effect of EA and PGG on PrP fibrillization. These two natural polyphenols could be potential prodrug molecules for the prevention and treatment of prion diseases.
研究领域:
神经科学
·
生物化学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS LETTERS
·
2025
·
IF 2.7
Ying Chen,Chang Liu,Mengxue Hu,Qingfang Li,Jing Su
In this work, KCuCl₃ and K₂CuCl₄·2H₂O crystals were synthesized via a solution evaporation method. Their crystal structures were verified by XRD, while the (110) interplanar spacing of K₂CuCl₄·2H₂O was further identified by HRTEM and the corresponding SAED. Thermal behavior was examined using TG/DSC. Both compounds exhibit reversible discoloration in response to temperature (20–100 °C) and humidity (0–80 % RH). UV–Vis absorption reveals band gaps of 3.05 eV for KCuCl₃ and 3.09 eV for K₂CuCl₄·2H₂O. PL spectra show blue-green emission, with CIE coordinates indicating a warmer hue for K₂CuCl₄·2H₂O, primarily attributed to the Cu 2+ centers. The strong light absorption and efficient PL response of these halides highlight their potential for humidity sensing and luminescent device applications.
研究领域:
材料科学
·
无机化学
·
光学材料
·
晶体学
·
传感器技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2025
·Vol. 109
·期 1
·e70351
·
IF 3.8
Lulu Jiang,Wenqi Lei,Zhiming Zhao,Kejia Chen,Chuangchang Lei,Donglin Han
Ba 3 MoNbO 8.5 is a recently emerging hexagonal perovskite-derivative oxide with high oxide ion conductivity. Mo and Nb-sites were commonly doped with acceptor dopants to regulate the transport properties. In this work, Ba-site was introduced with cation deficiency and doped with K. The tolerance of Ba-deficiency ( x ) in Ba 3‒ x MoNbO 8.5‒ x is within 0.03–0.06, and the solubility of K ( x ) in Ba 3‒ x K x MoNbO 8.5‒ x /2 is higher than 0.3. Although forming Ba-deficiency of x = 0.03 does not influence the conductivity significantly, doping K to x = 0.15 and 0.3 decreases the bulk conductivity obviously. Furthermore, even though these samples can be hydrated, H 2 O/D 2 O isotope effect was not observed, indicating that there is no or negligibly small proton conduction, and hydration even decreases the bulk conductivity. Interestingly, doping K reduces the difference in conductivity between the measurements in the dry and wet atmospheres. By annealing in a wet atmosphere for 90 h, the Ba 2.7 K 0.3 MoNbO 8.35 composition is unstable at 400°C, but shows good chemical stability at 600°C.
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 7
·3409-3416
·
IF 3.925
Hao Liu,Yaowei Wang,Fengqi Zhang,Congcong Xu,Xiaoyuan Liao,Yan Jiang,Shuxiang Lu
A series of K-based oxide catalysts supported on aluminium oxide (γ-Al2O3) with different surface areas were synthesized using an impregnation method and investigated by the decomposition of sulfones from oxidized diesel fuels. The synthesized catalysts were characterized by N2 adsorption–desorption isotherms, CO2-TPD and HR-SEM methods to explore the relationship between the structure of the catalysts and sulfone conversion. The results showed that the K element was highly dispersed on the surface of γ-Al2O3. The prepared catalyst was further applied in the decomposition reaction of dibenzothiophene sulfone (DBTS) to evaluate the catalytic performance. The sulfone conversion could achieve 63.9% in 10% K2O/3-Al2O3 within 20-minute reaction time at 260 °C. Moreover, our experimental test showed that the sulfone conversion was linearly correlated with the logarithm of the total basic sites of the K2O/γ-Al2O3 catalyst.
研究领域:
化学工程
·
催化科学
✓ 已验证
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2026
·
IF 6.7
Tingting Lv,Jiadong Wu,Linyu Yang,Kunjie Zhu,Kaixing Zhu,Haibing Li,Hongyu Mi
Aqueous zinc-ion batteries (AZIBs) present a highly attractive option with substantial potential for energy storage applications. However, issues such as the structural instability and slow zinc-ion diffusion of the cathode have hindered Zn//vanadium battery development. In this study, K + was chosen as a superior pre-insertion ion to form a novel layered potassium vanadate hydrate (K 1.44 V 8 O 20 ·1.8 H 2 O) cathode. Take advantage of the low electronegativity of K + , the M-O (Metal-Oxygen) bond in vanadium oxide cathode was dramatically enhanced. This leads to a significant enhancement in structural stability and a concurrent suppression of vanadium dissolution in the vanadium oxide cathode. Density functional theory (DFT) calculations were used to elucidate its superior Zn ion diffusion kinetics. The K 1.44 V 8 O 20 ·1.8 H 2 O exhibits outstanding cycling stability (specific capacity of 167.3 mAh g −1 after 9990 cycles at 6 A g −1 ) and excellent rate performance (78.64 % capacity retention after 10,000 cycles at 10 A g −1 ). This study proposes a viable strategy for the design of a stable vanadium oxide cathode.
✓ 已验证
产品关联
DOI
高影响因子
Educational Research and Evaluation
·
2026
·
IF 1.3
Tzu-Hua Wang,Ence Surahman
Studies on assessment for STEM learning practices have reported several forms of meaningful assessment, however, few systematic reviews have evaluated assessment trends in K–12 context. Hence, in this study, assessment practices in K-12 STEM education were systematically reviewed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. A total of 56 empirical research articles published between 2013 and 2025 on the Web of Science were carefully selected. Notable trends were observed in the research context, educational grade levels, course subjects, assessment methods and objectives, research methods, sample size, findings, and future research directions reported in the included studies. Reported assessment methods included surveys, questionnaires, examinations, and peer-based, authentic, and game-based assessments. Overall, the findings offer insights for K-12 STEM educators regarding the development of appropriate assessment methods tailored to the unique requirements of each STEM field.
✓ 已验证
DOI
高影响因子
Nature Chemistry
·
2026
·
IF 24.5
Liu Youquan,Jiang Xingxing,Molokeev Maxim S.,Plyaskin Mikhail,Su Zhenhuang,Lin Qianru,Sheng Jie,Wen Wen,Gao Xingyu,Dove M. T.,Lin Zheshuai
Isotropic zero thermal expansion (ZTE) materials are essential for applications requiring extreme dimensional stability, yet their operation is typically limited to narrow temperature windows below 400 K. Here we report the incorporation of flexible interstitial groups via fractionally occupied atoms into a closed-framework sodalite structure (Cd 4 Al 6 O 12 SO 4 , CASO). This material exhibits isotropic ZTE, with a thermal expansion coefficient of 0.21(23) × 10 −6 K −1 from 11 K to 893 K. The high-temperature ZTE behaviour originates from the preserved transverse vibrations that drive negative thermal expansion—arising from the enhanced vibrations of positionally disordered ligand atoms—which effectively counterbalance the intrinsic positive thermal expansion. Moreover, CASO maintains structural integrity up to 1,100 K, features a solar-blind ultraviolet transparency window down to 275 nm and exhibits thermally induced optical fluctuations at least twice as low as those of conventional optical materials. This work provides both a high-performance crystal for extreme thermal environments and a strategy for designing wide-temperature-range ZTE materials. The alternative text for this image may have been generated using AI.
✓ 已验证
DOI
PubMed
高影响因子
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