COLLOIDS AND SURFACES B-BIOINTERFACES
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2015
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IF 4.152
Yiyin Chen,Le Van Minh,Jianwen Liu,Borislav Angelov,Markus Drechsler,Vasil M. Garamus,Regine Willumeit-Römer,Aihua Zou
Bioavailability of baicalin (BAI), an example of traditional Chinese medicine, has been modified by loading into liposome. Several liposome systems of different composition i.e., lipid/cholesterol (L), long-circulating stealth liposome (L-PEG) and folate receptor (FR)—targeted liposome (L-FA) have been used as the drug carrier for BAI. The obtained liposomes were around 80 nm in diameter with proper zeta potentials about −25 mV and sufficient physical stability in 3 months. The entrapment efficiency and loading efficiency of BAI in the liposomes were 41.0–46.4% and 8.8–10.0%, respectively. The morphology details of BAI lipsosome systems i.e., formation of small unilamellar vesicles, have been determined by cryogenic transmission electron microscopy (cryo-TEM) and small angle X-ray scattering (SAXS). In vitro cytotoxicity of BAI liposomes against HeLa cells was evaluated by MTT assay. BAI loaded FR-targeted liposomes showed higher cytotoxicity and cellular uptake compared with non-targeted liposomes. The results suggested that L-FA-BAI could enhance anti-tumor efficiency and should be an effective FR-targeted carrier system for BAI delivery.
研究领域:
药剂学
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肿瘤学
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药物递送系统
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纳米技术
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REACTIVE & FUNCTIONAL POLYMERS
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2013
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IF 2.505
Li Zhang,Yakai Feng,Hong Tian,Changcan Shi,Miao Zhao,Jintang Guo
Novel biodegradable amphiphilic ABA triblock copolymers , i.e. poly(3(S)-methyl-morpholine-2,5-dione- co - p -dioxanone)-block-poly(ethylene glycol)-block-poly(3(S)-methyl-morpholine-2,5-dione- co - p -dioxanone) [P(MMD- co -PDO)- b -PEG- b -P(MMD- co -PDO)], were successfully prepared by ring-opening polymerization of 3(S)-methyl-morpholine-2,5-dione (MMD) and p -dioxanone (PDO) in the presence of poly(ethylene glycol) 6000 as an initiator. These triblock copolymers were characterized by 1 H NMR, 13 C NMR, Fourier transform infrared, gel permeation chromatography and differential scanning calorimetry measurements. P(MMD- co -PDO)- b -PEG- b -P(MMD- co -PDO) could self-assemble into stable nanosized microspheres with critical micellar concentrations of 0.41–0.66 μg/mL. The microspheres showed high hydrolytic degradation. In addition, doxorubicin (DOX) was chosen as a model drug and successfully encapsulated into the microspheres by hydrogen-bond interaction and hydrophobic effect . The transmission electron microscopy and dynamic light scattering measurements revealed that these microspheres were ellipsoidal nanoparticles with diameters ranged from 50 to 100 nm. These copolymer microspheres exhibited high loading capacity (LC), encapsulation efficiency (EE) of DOX and sustained drug release behavior in phosphate buffered solution (PBS). Moreover, the release rate of DOX from those microspheres in pH 4.0 PBS was faster than that in pH 7.4 due to pH sensitivity of the polymer–drug systems and the degradation of the matrix polymers . These amphiphilic depsipeptide multiblock copolymers would be potential promising carriers for anti-tumour drug delivery.
研究领域:
药剂学
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生物材料
·
肿瘤学
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JOURNAL OF POLYMERS AND THE ENVIRONMENT
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2023
·Vol. 31
·期 8
·3551-3564
·
IF 5.3
Zhang Chen,Qi Yuhong,Zhang Zhanping
Marine biofouling has become the main factor of marine economic loss. In this article, we studied the relationship between the PS-PEG hydrogels properties and the anti-bio adhesive behavior, such as amphiphilic, swelling degree, elastic modulus and roughness. Testing the adhesion behavior of marine bacteria and benthic diatom on PS-PEG hydrogel with different polystyrene microspheres content. Meanwhile, the influence of polystyrene microsphere content on the antifouling performance of hydrogel was emphatically analyzed and proposed the anti-bio adhesive behavior mechanism of PS-PEG hydrogels. The results showed that the antifouling performance of PS-PEG hydrogels was significantly enhanced by adding polystyrene microspheres. In the marine bacterial adhesion behavior, when polystyrene microspheres were added at 14.2 wt.%, the bacterial adhesion rate was respectively 3.85% and 0.01% for rinsing and washing samples, and the bacterial removal rate was 99.74%. In addition, in the benthic diatom adhesion behavior, the chlorophyll concentration a-values after rinsing and washing samples were only 0.019 mg/L and 0.002 mg/L with the same content of polystyrene microspheres, and the removal rate was 89.6%. At the same time, polystyrene microspheres enable PS-PEG hydrogels to exhibit amphiphilic, which could form a hydration layer by surface reorganization in seawater, the hardness and toughness of PS-PEG hydrogel substrate can be increased by adding appropriate polystyrene microspheres, and it also reduced the surface roughness of hydrogels after swelling in seawater. Accordingly, PS-PEG hydrogels can achieve efficient anti-bio adhesive behavior mainly through the synergistic effect of a highly hydrated layer, unstable surface and low roughness.
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Materials
·
2023
·Vol. 16
·期 6
·2277
·
IF 3.4
Si Xu,Shanshan Liang,Bing Wang,Jiali Wang,Meng Wang,Lingna Zheng,Hao Fang,Tingfeng Zhang,Yi Bi,Weiyue Feng
Pre-coating with a protein corona on the surface of nanomaterials (NMs) is an important strategy for reducing non-specific serum protein absorption while maintaining targeting specificity. Here, we present lipoic acid-terminated polyethylene glycol and transferrin bi-functionalized MoS2nanosheets ([email protected]2-PEG NSs) as a feasible approach to enhance cellular uptake.[email protected]2-PEG NSs can maintain good dispersion stability in cell culture medium and effectively protect MoS2NSs from oxidation in ambient aqueous conditions. Competitive adsorption experiments indicate that transferrin was more prone to bind MoS2NSs than bovine serum albumin (BSA). It is noteworthy that single HepG2 cell uptake of[email protected]2-PEG presented a heterogeneous distribution pattern, and the cellular uptake amount spanned a broader range (from 0.4 fg to 2.4 fg). Comparatively, the intracellular Mo masses in HepG2 cells treated with[email protected]2-PEG and MoS2-PEG showed narrower distribution, indicating homogeneous uptake in the single HepG2 cells. Over 5% of HepG2 cells presented uptake of the[email protected]2-PEG over 1.2 fg of Mo, about three-fold that of[email protected]2-PEG (0.4 fg of Mo). Overall, this work suggests that Tf coating enhances the cellular uptake of MoS2NSs and is a promising strategy for improving the intracellular uptake efficiency of cancer cells.Keywords:bi-functionalization;[email protected]2-PEG nanosheets;HepG2 cellular uptake
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CHEMOSPHERE
·
2023
·
IF 8.8
Chaoyang Zhang,Conghao Gao,Shumin Yang,Xin He,Yue Chen,Xiao Qin,Yulin Tang
Chloramphenicol (CAP) is used extensively in industry and daily life, but its abuse has seriously affected the environment and public health. In this paper, a new composite PbO 2 electrode was obtained through the modification Sm and polyethylene glycol (PEG), and an electrocatalytic oxidation technology of CAP degradation was investigated. The results showed that the catalytic degradation ability and industrial service life of the PEG-Sm-PbO 2 composite electrode were significantly enhanced. Co-doping inhibited the growth of grains, resulting in the formation of refined pyramidal grains on the surface of the electrode, which increased the number of active spots. The industrial service life of the modified electrode was improved by 87.0%. In addition, the degradation effect under different conditions and mechanism of CAP were also explored. The optimal conditions for CAP degradation were explored, at which time the CAP degradation rate reached 99.1%. The degradation process was in accordance with the primary reaction kinetics, and the apparent rate constant of CAP at the PEG-Sm-PbO 2 electrode was raised by 57.1% in comparison with the unmodified electrode, indicating that the modification facilitated the degradation of CAP in the electrode. Finally, two possible CAP degradation pathways were deduced. The results will provide technical support and a theoretical basis for the degradation of persistent organic pollutants.
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Materials Today Bio
·
2023
·
IF 8.2
Lin Huang,Wantao Wang,Yiwen Xian,Lei Liu,Jinghao Fan,Hongmei Liu,Zhaomin Zheng,Decheng Wu
Intervertebral disc (IVD) degeneration occurred with the increasing age or accidents has puzzled peoples in daily life. To seal IVD defect by injectable hydrogels is a promising method for slowing down IVD degeneration. Herein, we reported a rapidly in situ forming injectable chitosan/PEG hydrogel (CSMA-PEGDA-L) through integrating photo-crosslink of methacrylate chitosan (CSMA) with Schiff base reaction between CSMA and aldehyde polyethylene glycol (PEGDA). The CSMA-PEGDA-L possessed a stronger compressive strength than the photo-crosslinked CSMA-L hydrogel and Schiff-base-crosslinked CSMA-PEGDA hydrogel. This chitosan/PEG hydrogel showed low cytotoxicity from incubation experiments of nucleus pulpous cells. When implanted on the punctured IVD of rat's tail, the CSMA-PEGDA-L hydrogel could well retard the progression of IVD degeneration through physical plugging, powerfully proven by radiological and histological evaluations. This work demonstrated the strategy of in situ injectable glue may be a potential solution for prevention of IVD degeneration.
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International Journal of Polymeric Materials and Polymeric Biomaterials
·
2022
·
IF 3.221
Yuting Zhang,Chenlu Dai,Jiugang Yuan,Ping Wang
Maintaining a moist wound environment facilitates the wound healing process. However, traditional dressings such as medical gauze are difficult to meet this condition and easy to cause wound infection when the gauze is replaced. In this paper, a novel multifunctional medical dressing based on keratin porous materials was prepared by the freeze-drying method. Keratin was first modified by poly (ethylene glycol) dimethacrylate (PEGDMA) to increase its hydrophilicity. Then, the carboxymethyl chitosan (CMCS) was mixed with keratin solution to further improve the pore-forming properties, and finally, the solution was dried through the freezing method to obtain the porous dressing. The performance of the dressing was detailed and studied using DPPH free radical scavenging ability, water retention, blood coagulation, and bacteriostasis tests. The results showed that PEGDMA grafting greatly improved moisture retention from 22 to 43. CMCS blending not only improved the uniform and compact of the pore structure, but also effectively improved blood coagulation and antibacterial properties. After blending with CMCS, the performance of the keratin porous material was greatly improved. Carboxymethyl chitosan is positively charged, which makes the negatively charged platelets easy to aggregate, so the coagulation performance is greatly improved, and the BCI decreased to 15%. At the same time, the antibacterial performance against Staphylococcus aureus was greatly improved, and the optimal condition was PEG-g-KR:CMCS = 6:4. The PEG-g-KR/CMCS dressing prepared in this method had the characteristics of promoting wound healing, good moisture absorption and water retention, excellent blood coagulation performance and strong bacteriostasis. It is of great significance to the research and application of composite dressings.
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Asian Journal of Pharmaceutical Sciences
·
2022
·
IF 9.273
Yaqiao Li,Lingxiao Li,Qianhui Jin,Tian Liu,Jin Sun,Yongjun Wang,Zhijun Yang,Zhonggui He,Bingjun Sun
PEGylation has been widely used to improve the pharmacokinetic properties of prodrug self-assembled nanoparticles (prodrug-SANPs). However, the impacts of the amount of PEG on the self-assemble stability, cellular uptake, pharmacokinetics, and antitumor efficacy of prodrug-SANPs are still unknown. Herein, selenoether bond bridged docetaxel dimeric prodrug was synthesized as the model prodrug. Five prodrug-SANPs were designed by using different mass ratios of prodrugs to PEG (W prodrug /W DSPE-mPEG2000 = 10:0, 9:1, 8:2, 7:3 and 6:4), and defined as Pure drug NPs, 9:1NPs, 8:2NPs, 7:3 NPs and 6:4 NPs, respectively. Interestingly, 8:2 NPs formed the most compact nanostructure, thus improving the self-assemble stability and pharmacokinetics behavior. In addition, the difference of these prodrug-SANPs in cellular uptake was investigated, and the influence of PEG on cytotoxicity and antitumor efficacy was also clarified in details. The 8:2 NPs exhibited much better antitumor efficacy than other prodrug-SANPs and even commercial product. Our findings demonstrated the pivotal role of the amount of PEG on prodrug-SANPs.
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Small
·
2022
·Vol. 18
·期 14
·2106533
·
IF 15.153
Xin Zhang,Yumei Ran,Qianqian Fu,Jianping Ge
Traditional thermochromic photonic crystal (PC) usually has a slow and reversible thermal response, which limits its application in thermal printing. Here, the authors develop a thermochromic “SiO 2 -PC/PEG” double layer structure with a responding time of milliseconds for fast thermal printing. Controlled by the print-head, the polyethylene glycol (PEG) melts, infiltrates, and solidifies within the interparticle voids, which instantly and irreversibly changes the refractive index and produces the PC pattern. Multicolor printing can be realized by tuning the size and type of colloidal particles. Resolution as high as 300 DPI is achieved to print the high-resolution patterns and then the grayscale patterns based on the control of pixel densities. Different from fiber thermal paper, the “SiO 2 -PC/PEG” film has no toxic bisphenol A and possesses superior light stability for keeping the images longer. It is fully compatible with the commercial printer, which provides a mature solution for fast and convenient preparation of PC patterns.
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Journal of Materials Chemistry B
·
2020
·Vol. 8
·期 14
·2805-2813
·
IF 5.344
Shiyu Wan,Boya Zhang,Sai Li,Bin He,Yuji Pu
Photoimmunotherapy, which combines local photothermal therapy (PTT) with immunological stimulation, is a promising modality for cancer treatment. Herein, we have reported a photothermal-immunotherapy of melanoma using pegylated black phosphorus nanosheets (BP-PEG NSs) and imiquimod (R837) as the photothermal conversion agent and the immunoadjuvant, respectively. The photothermal stability of BP NSs was remarkably enhanced after the modification of poly(ethylene glycol) (PEG) by electrostatic interactions. The in situ generation of tumor-associated antigens by PTT elicited a strong immune response in the presence of R837, achieving a photoimmunotherapy of B16 melanoma. This photoimmunotherapy stimulated a stronger immune response both in vitro and in vivo than monotherapy, inducing a much greater release of cytokines such as IL-6, IL-12, and TNF-α. In vivo antitumor studies in B16 tumor-bearing mice demonstrated that photoimmunotherapy showed the best tumor inhibition effects. Our study suggested that BP-PEG NS-based PTT primed with an immunoadjuvant can be used for synergistic photoimmunotherapy of melanomas.
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Biomaterials Science
·
2020
·Vol. 8
·期 12
·3334-3347
·
IF 6.183
Haoqi Tan,Junjie Sun,Dawei Jin,Jialin Song,Miao Lei,Artem Antoshin,Xin Chen,Meng Yin,Xue Qu,Changsheng Liu
Poor mechanical performances severely limit the application of hydrogels in vivo; for example, it is difficult to perform a very common suturing operation on hydrogels during surgery. There is a growing demand to improve the mechanical properties of hydrogels for broadening their clinical applications. Natural polyphenols can match the potential toughening sites in our previously reported PEG-lysozyme (LZM) hydrogel because polyphenols have unique structural units including a hydroxyl group and an aromatic ring that can interact with PEG via hydrogen bonding and form hydrophobic interactions with LZM. By utilizing polyphenols as noncovalent crosslinkers, the resultant PEG-LZM-polyphenol hydrogel presents super toughness and high elasticity in comparison to pristine PEG-LZM with no obvious changes in the initial shape, and it can even withstand the high pressure from sutures. At the same time, the mechanical properties could be widely adjusted by varying the polyphenol concentration. Interestingly, the PEG-LZM-polyphenol hydrogel has a higher water content than other polyphenol-toughened hydrogels, which may better meet the clinical needs for hydrogel materials. Besides, the introduction of polyphenols endows the hydrogel with improved antibacterial and anti-inflammatory abilities. Finally, the PEG-LZM-polyphenol (tannic acid) hydrogel was demonstrated to successfully patch a rabbit myocardial defect by suturing for 4 weeks and improve the wound healing and heart function recovery compared to autologous muscle patches.
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Nanomedicine
·
2024
·
IF 4.7
Yumei Wang,Yue Zhou,Dongliang Zhai,Hao Deng,Xiaoliang Chen
Aim: Nano-hydroxyapatite (nHA) is a good nanocarrier to load 223Ra, but the low specific activity (sp.act.) of 223Ra@nHA limits its application in medicine. Methods: We proposed a method for preparing nHA using PEG as a template, which significantly increases the sp.act of 223Ra@nHA and a new method to loaded 99mTc for in vivo tracking. Results: The nHA synthesized using PEG as a template was associated with higher sp.act for 223Ra in comparison to nHA with identical particle size and without PEG. The nHA load 99mTc-MDP was associated with higher labeling rate and stability in comparison to 99mTc. Conclusion: All these findings suggest that using PEG as a template and 99mTc-MDP could be the most effective of synthetic 223Ra/99mTc@nHA.
研究领域:
纳米技术
·
放射药学
·
癌症治疗
·
材料科学
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危险品化学品经营许可证（带存储）