SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2022
·
IF 4.831
Xin Zhang,Xin Xie,Lingjun Zhang,Kaibin Yao,Yingzhou Huang
Optoplasmonic hybrid structures composed of photonic and plasmonic elements with excellent optical properties are of great significance for the development of surface-enhanced Raman spectroscopy (SERS) substrates. In this work, the optoplasmonic hybrid structure is composed of SiO 2 microsphere and two-dimensional (2D) plasmonic- metal organic frameworks (MOF) film. Among them, the 2D plasmonic-MOF film is prepared from silver nanoparticles encapsulated by zeolitic imidazole acid framework (AgNP@ZIF-8) by self-assembly method. This optoplasmonic hybrid structure with gas adsorption properties could be used as a SERS substrate for 4-Mercaptophenol (4-MP) gas detection. Experimental data show that this substrate is dependent on the thickness of the ZIF shell and the size of the SiO 2 microspheres . In addition, it is confirmed by the electromagnetic field simulation of finite-difference time-domain method (FDTD). The optoplasmonic hybrid microstructures exhibit good uniformity for detection of 4-MP gas molecules. This work not only broadens the understanding of our optoplasmonic hybrid structure, but also has broad application prospects in SERS and gas sensing related fields.
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ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Yusai Zhou,Gui Zhao,Jingming Bian,Xiaoli Tian,Xuejun Cheng,Hong Wang,Hongyu Chen
Forged signature threatens the authenticity of personal identity. Here, an effective SERS anti-counterfeiting system is designed for personal signatures. Mixed ligands improve the complexity of Raman spectra and expand the coding capacity. Fourteen distinct combinations are created from mere five ligands, and great expansion is possible with modest expansion of the ligand library. On the other hand, the (Au-aggregate)@Ag@PSPAA nanostructure significantly increases the surface-enhanced Raman scattering (SERS) intensity and stability so that excellent performance is achieved in SERS detection. By integrating these strategies, SERS inks are produced and applied in signature anti-counterfeiting. The resulting spectra are converted to barcodes that are readily detected through a smart phone APP. With these improvements, this work brings SERS one step closer toward practical applications in signature anti-counterfeiting.
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APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Wei Zhang,Tianxing Zheng,Bin Ai,Panpan Gu,Yuduo Guan,Yu Wang,Zhiyuan Zhao,Gang Zhang
Au-polymer-Au nanogap ( Au-P-Au)-coupled gold nanoparticle (Au NP) platforms are fabricated via a combination of nanoskiving and polymer-assisted assembly. The structure consists of multiple types of nanogaps, specified as nanogaps within Au-P-Au, narrow nanogaps between assembled Au NPs, and nanogaps between Au NPs and the edge of the nanogap. The electric field is strongly enhanced in the nanogaps due to the confinement of incident light, generating multiple “hot spots”. The Au-P-Au-coupled Au NP platform promotes a significant surface-enhanced Raman scattering (SERS) performance, achieving a maximum enhancement factor of 1.36 × 10 8 and a sensitive detection of glucose. The united nanofabrication technology for Au-P-Au-coupled Au NP platforms with a considerable SERS enhancement would facilitate the applications of nonlinear optics, nano-photonics, and surface-enhanced spectroscopy.
研究领域:
纳米光学
·
材料科学
·
光谱学
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Food Bioscience
·
2026
·
IF 6.2
Qiaoqiao Shi,Li Lu,Tao Liu,Qian Chen,Dezhao Kong,Hua Ye
Kanamycin (KAN) residues in food pose a serious risk to human health, necessitating the development of rapid and sensitive detection methods. Herein, a novel surface-enhanced Raman scattering (SERS) aptasensor for ultrasensitive detection of kanamycin, which integrates hollow Au/Ag alloy nanourchins (HAAA-NUs) tags with high-density “hot spots” and exonuclease III (Exo III)-assisted cyclic amplification. In the presence of KAN, its specific binding with the KAN aptamer (KAN-Apt) triggers the release of complementary DNA (cDNA), followed by hybridization with hairpin DNA (HAP) and Exo III-mediated digestion, resulting in cyclic amplification of target DNA. The amplified target DNA serves as a bridging mediator that specifically hybridizes with the DNA1 immobilized on Fe 3 O 4 @Au nanoparticles (NPs) and the DNA2 anchored on PATP-loaded HAAA-NUs, leading to the formation of a Fe 3 O 4 @Au NPs-DNA1/target DNA/DNA2-HAAA-NUsPATP complex, which subsequently produces a strong SERS signal. In addition, the background signal can be effectively reduced through magnetic separation. Under optimal conditions, the SERS aptasensor exhibited a wide detection range for KAN from 1 to 10 5 fg/mL with a good linear correlation (R 2 = 0.9913), and a limit of detection (LOD) as low as 0.12 fg/mL. It also performed satisfactorily in the analysis of real samples (milk and honey), achieving good recoveries ranging from 89.72% to 112.54%. Moreover, the method demonstrated excellent specificity and stability.
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MICROCHIMICA ACTA
·
2021
·Vol. 188
·期 8
·1-11
·
IF 5.833
Feng Jun,Lu Hao,Yang Yu,Huang Wenyi,Cheng Hao,Kong Hongxing,Li
Lijun
By in situ synthesis of gold nanoparticles (AuNPs) within the acid-etched (AE) MIL-101 (Cr) framework, AE-MIL-101 (Cr) nanocomposites embedded with AuNPs (AuNP/AE-MIL-101 (Cr)) were prepared as surface-enhanced Raman scattering (SERS) substrate. AuNPs are uniformly distributed and stabilized inside the metal-organic framework (MOF), thus forming more SERS hotspots. The SERS performance of AuNP/AE-MIL-101 (Cr) was evaluated using 4-mercaptophenylboronic acid (4-MPBA), 4-mercaptobenzoic acid (4-MBA), benzidine, and rhodamine 6G (R6G). The SERS substrate displays satisfying stability with very low background signal. When benzidine is used as the Raman reporter, the limit of detection (LOD) can reach 6.7 × 10 −13 mol·L −1 , and the relative standard deviation (RSD) of the intra- and inter-batch repetitive tests is less than 5.2%. On this basis, we developed a method for the detection of human carboxylesterase 1 (hCE 1) in human serum using AuNP/AE-MIL-101 (Cr) nanocomposite as SERS substrate and enzyme-linked immunosorbent assay (ELISA) colorimetric substrate as SERS marker. This method was used to determine hCE 1 in clinical serum samples without complicated sample pretreatment, and the detection results were consistent with the data determined by ELISA. In the concentration range 0.1–120 ng·mL −1 , the SERS signal intensity of benzidine at 1609 cm −1 gradually decreases with the increase of hCE 1 concentration (R 2 = 0.9948). The average recoveries of hCE 1 in human serum are in the range 84 to 108%, with RSDs lower than 7.7%. Graphical abstract
By using AuNP/acid etching-MIL-101(Cr) metal organic framework (MOF) as SERS substrate and enzyme-linked immunosorbent assay (ELISA) colorimetric substrate as the SERS marker, a rapid and sensitive method for the determination of human carboxylesterase 1 (hCE1) in human serum samples has been developed.
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ANALYTICAL SCIENCES
·
2020
·Vol. 36
·期 9
·1025-1030
·
IF 2.049
Xiaoxuan LI,Lijun LI,Yuhan HE
Based on the reversible covalent binding between borates and glycoproteins, we proposed a scheme that can specifically recognize and detect immunoglobulin G (IgG). The application of magnetic materials to enrich SERS probes can provide an enhanced signal and repeatability. The results showed that the prepared sandwich-like complex displayed high sensitivity and excellent selectivity for IgG. The Raman peak intensity showed a good linear relationship in the concentration range of 1 mg/mL – 1 ng/mL. The linear equation was y = 657.93x + 2963.9, R2 = 0.996. Parallel testing of this sandwich-like complex proved to have excellent repeatability. This method provided a new possibility for clinical non-immunity and the quantitative detection of IgG.
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SENSORS
·
2018
·Vol. 18
·期 10
·3458
·
IF 2.475
Chao Zhuang,Yifan Xu,Ningsheng Xu,Jinxiu Wen,Huanjun Chen,Shaozhi Deng
Plasmonic gold nanorods play important roles in nowadays state-of-the-art plasmonic sensing techniques. Most of the previous studies and applications focused on gold nanorods with relatively small aspect ratios, where the plasmon wavelengths are smaller than 900 nm. Gold nanorods with large aspect ratios are predicted to exhibit high refractive-index sensitivity (Langmir 2008, 24, 5233–5237), which therefore should be promising for the development of high-performance plasmonic chemical- and bio-sensors. In this study, we developed gold nanorods with aspect ratios over 7.9, which exhibit plasmon resonances around 1064 nm. The refractive index (RI) sensitivity of these nanorods have been evaluated by varying their dielectric environment, whereby a sensitivity as high as 473 nm/RIU (refractive index unit) can be obtained. Furthermore, we have demonstrated the large-aspect-ratio nanorods as efficient substrate for surface enhanced Raman spectroscopy (SERS), where an enhancement factor (EF) as high as 9.47 × 108was measured using 4-methylbenzenethiol (4-MBT) as probe molecule. Finally, a type of flexible SERS substrate is developed by conjugating the gold nanorods with the polystyrene (PS) polymer. The results obtained in our study can benefit the development of plasmonic sensing techniques utilized in the near-infrared spectral region.Keywords:large aspect ratios;gold nanorods;refractive index sensitivities;SERS;plasmonic sensing
研究领域:
纳米技术
·
光学
·
化学传感器
·
生物医学工程
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MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Yan Song,Weiyang Gao,Liang Sun,Junda Bai,Yi Zhang,Jingnan Zhu,Hua Xing,Chongyang Liang
The large decline in breast cancer mortality has been driven by rapid development and continuous progress in diagnostic techniques. However, it remains difficult to diagnose malignant lesions in distal branching ducts using mainstream techniques such as immunofluorescence ultrasound, molybdenum target, and ductoscopy. Combined with existing reports, we found that CEA level by ELISA in 13 patient 's nipple aspirate fluids (NAF) may be positively correlated with the malignancy of breast lesions. Here, considering the low content of CEA in NAF and the need for automated techniques for batch clinical testing, a magnetic induced mixing surface-enhanced Raman spectroscopy technique (SERS) was used to quantitatively analysis CEA concentration in NAF. In the appearance of CEA, an antibody-conjujated silver nano-probe (AgNPs-Ab1/4-ABP) can be linked onto the surface of another antibody-conjujated magnetic-probe. This immune sandwich-like structure enables more AgNPs-Ab1/4-ABP to remain in situ in the magnetic field. The magnetic spontaneous collection effect brings second SERS signal amplification at 1140 cm −1 approximately. After testing 10 clinical samples, the signal of Magnetic-Field Amplified SERS was not affected by the complex components in NAF, and a good linear range of 0.5–20 ng mL −1 could be achieved. This method might potentially be useful in the differential diagnoses of benign lesions with breast cancer and clinical follow-up of non-surgical intervention nipple discharge patients.
研究领域:
医学
·
生物化学
·
肿瘤学
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JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
·
2023
·Vol. 38
·期 2
·274-279
·
IF 1.6
Hao Zhenbang,Tian Qihang,Cao Shiyi,Han Xiaoyu,Zhang Jihong,Xie Jun,Zhao Xiujian
Novel hollow Au Ag alloy nano urchins were synthesized via Ag seeds growth method, and self-assembly coated on the wall and end-tip of silica fiber for fiber probe fabrication. The nano urchins homogeneously distributed on fiber surface because of fiber silanization. The sizes and tip sharpness of the nano-urchins could be controlled by Ag seeds. The elements distribution analysis indicated there was high Ag content in tip-top for better surface enhance Raman scattering performance. The detectable concentration could be as low as 10 −8 M using crystal violet molecules as analyte. Moreover, the fiber probes were stable in air, due to Au in the alloy. This fiber probe could be used for low content single molecular analysis.
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Journal of Physical Chemistry C
·
2015
·
IF 4.772
Jingjing Hao,Ting Liu,Yingzhou Huang,Guo Chen,Anping Liu,Shuxia Wang,Weijia Wen
The electromagnetic field redistribution in metal nanostructure–film systems exhibits great capability of confining light on plain film, which has great significance in surface-enhanced Raman scattering (SERS) of a molecule on plain film or 2D material. In this work, the SERS spectra of a monolayer molecule on metal or dielectric film were investigated with the help of a metal nanoparticle–nanowire structure. The results indicated that SERS intensity from an adjacent nanoparticle was much greater than that from an individual nanowire, which was confirmed by the simulated electric field distribution through finite method. The polarization dependence of both experimental and simulated data pointed out the importance of electromagnetic field redistribution in this phenomenon. Furthermore, the shape independence of a nanoparticle found in this work greatly improved the application prospect of this nanoparticle–nanowire assisted SERS on film.
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TALANTA
·
2025
·
IF 6.1
Shuang Jiang,Yue Zhao,Qingyu Meng,Rongheng Ma,Xiaomeng Sun,Xiaoming Lyu,Li Zhang,Guangrun Wu,Xiaotong Wang,Yiyang He,Jiayue Liang,Yuxin Qiao,Zhibin Wang,Yanli Wu,Jing Wu,Chunjuan Yang,Huimin Yu,Yang Li
Medicinal and edible homologs (MEHs) offer significant preventive and therapeutic benefits for various diseases and health functions. However, the widespread application of MEHs faces significant challenges, particularly in quality control, rapid identification, and authentication. In this study, we present a novel approach that combines surface-enhanced Raman spectroscopy (SERS) based on spectral set, referred to as “SERSome”, with deep learning to develop an identification model for analyzing MEHs. The platform uses silver nanoparticles prepared via reduction with NaBH 4 , activation with sodium borohydride, and aggregation with calcium ions. The method avoids the use of additional protective agents during the reaction process, thereby reducing interference from the protective agents and other materials. Additionally, the method also overcomes the fluorescence interference from MEHs. SERSomes provide comprehensive molecular fingerprint recognition, significantly enhancing the system's detection accuracy. The introduction of Ca 2+ as aggregator promotes the aggregation of silver nanoparticle, significantly enhancing the electromagnetic field of the nanoparticle system. The study achieves up to 98% accuracy in identifying specific MEHs. The integration of SERSomes with deep learning offers a promising methodology for the rapid and modern detection of MEHs, advancing the MEHs industry and contributing to the protection of human health.
研究领域:
分析化学
·
生物医学
·
人工智能
·
食品科学
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ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Xiaoyu Tian,Bo Zhang,YanYan Li,Junsheng Yang,Liangbo Sun,Houchang Pei,Qiang Cao,Qianqian Lin
The noble-metal-free surface-enhanced Raman scattering (SERS) substrates have gained significant attention due to their abundant sources, signal uniformity, biocompatibility, and chemical stability. However, the lack of controllable synthesis and fabrication methods for high-SERS-activity noble-metal-free substrates hinders their practical applications. In this study, we demonstrate the use of a femtosecond laser direct writing technique to precisely manipulate and modify microstructures, resulting in enhanced SERS signals from Sb2S3 nonmetal-oxide semiconductor materials. Compared with unpatterned Sb2S3 samples, the Sb2S3 microstructures exhibited up to a 16-fold increase in Raman scattering intensity. Interestingly, our results indicate that the femtosecond laser can induce a transformation in the crystalline state of Sb2S3 and significantly enhance the Raman spectrum signal within the Sb2S3 microstructures. This enhancement is also highly dependent on the period and depth of the microstructures, possibly due to the cavity effects, resulting in a stronger local field enhancement.
研究领域:
材料科学
·
光谱学
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危险品化学品经营许可证（带存储）