LANGMUIR
·
2020
·
IF 3.557
Shaoqiao Li,Zhuliu Xiao,Kairui Guo,Huihui Gan,Jirong Wang,Yong Zhang,Liping Yu,Zhigang Xue
Porous membranes fabricated from poly(vinylidene fluoride) (PVDF) and a star polymer with linear poly(ethylene glycol) (PEG) arms and cycloPEG cores were fabricated via the phase-separation method. The porous gel polymer electrolytes (PGPEs) were obtained by immersing the porous membranes in the electrolyte solution. When the additive amount of star polymer was up to 20 wt %, the prepared membrane had the largest porosity and the pores were uniformly distributed in the membrane. The star polymer can not only decrease the crystallization of PVDF and enhance the absorption of liquid electrolyte but also offer ion conduction channels (cycloPEG cores). Therefore, the PGPE with 20 wt % star polymers exhibited competitive ionic conductivities of 1.27 mS cm–1 at 30 °C and 2.89 mS cm–1 at 80 °C. To stabilize the liquid electrolyte in the holes of porous membranes, a gelator was introduced in the liquid electrolyte to form gelled porous gel polymer electrolytes (GPGPEs), and the leakage of liquid electrolytes was thus remarkably reduced. The ionic conductivity of GPGPEs with 20 wt % star polymer and 1.5 wt % gelator was importantly improved at high temperatures (6.02 mS cm–1 at 80 °C). We systematically investigated the electrochemical performances of PGPEs without star polymer, PGPEs with star polymer, and GPGPEs with star polymer. The incorporation of star polymers with linear PEG arms and cycloPEG cores into the PGPEs and GPGPEs significantly improved the electrochemical performances of the lithium metal/LiFePO4 cell assembled with the PGPEs or GPGPEs.
研究领域:
材料科学
·
电化学
·
储能技术
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DOI
PubMed
高影响因子
RSC Advances
·
2018
·Vol. 8
·期 12
·6373-6380
·
IF 2.936
Bingbing Wang,Hongming Lou,Hongli Xu,Junpeng Zhao,Qiujun Wang,Qiao Shi,Yonghong Deng
In this work, a novel star-comb copolymer based on poly(d,L-lactide) (PDLLA) macromonomer and poly(ethylene glycol)methyl ether methacrylate (PEGMA) was prepared, and the electrochemical properties were studied, with the aim of using it as a solid polymer electrolyte in lithium ion batteries. The six-arm vinyl functionalized PDLLA macromonomer was synthesized by a ring-opening polymerization (ROP) of D,L-lactide and subsequently an acylation of the hydroxy end-groups. A series of free-standing solid polymer electrolyte membranes from different ratios of PDLLA, PEGMA and LiTFSI were prepared through solvent-free free radical polymerization under UV radiation. The chemical structure of the obtained polymers was confirmed by 1H NMR and FTIR. The as-prepared six-arm star-comb solid polymer electrolytes (PDLLA-SPEs) exhibit good thermal stability with Td5%s of ∼270 °C and low Tgs of −48 to −34 °C. The electrochemical characterization shows that the PDLLA-SPEs possess a wide electrochemical window up to 5.1 V with an optimal ionic conductivity of 9.7 × 10−5 S cm−1 at 60 °C at an EO/Li+ ratio of 16 : 1. Furthermore, the all-solid-state LiFePO4/Li cells display extraordinary cycling and rate performances at 60 °C by curing the PDLLA-SPEs directly on the cathode. These superior properties of the six-arm star-comb PDLLA-SPE make it a promising candidate solid electrolyte for lithium batteries.
研究领域:
材料科学
·
电化学
·
能源存储
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DOI
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2018
·Vol. 219
·期 12
·1800061
·
IF 2.492
Mingqi Wang,Yunfei Wang,Sijie Zhao,Xiaolong Zhang,Hua Wei
Incorporation of the reducible disulfide links into delivery systems has been repeatedly highlighted to realize, elegantly, the tradeoff between extracellular stability and intracellular high therapeutic efficacy. Of all the reported introducing strategies, esterification, seemingly the most extensively-adopted one, suffers from relatively low yield, especially for the esterification coupling between two macromolecules, due to the low condensation efficiency. To improve the coupling efficiency, Cu(I)-catalyzed azide−alkyne cycloaddition (CuAAc) click coupling with high efficiency and high selectivity is used to incorporate disulfide links to the star-shaped amphiphilic block copolymers in this study. Interestingly, besides such synthetic advantages, the click coupling-introduced disulfide joints further endow the resulting star-shaped copolymer-based nanocarriers with higher therapeutic efficacy than the analogues containing esterification-generated disulfide links, in terms of better buffering capacity, greater selective drug release in reducing over nonreducing environments, and higher in vitro cytotoxicity. The disclosed effect of introducing strategy of disulfide link on the delivery efficacy of the drug carriers provides new insights into the structure–property relationship of reduction-sensitive delivery systems, as well as offering new opportunities for the future design and development of intelligent nanocarriers toward enhanced therapeutic efficacy.
研究领域:
药剂学
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高分子化学
·
生物医学工程
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DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2024
·
IF 10.5
Tao Bo,Chenfei Wang,Dingjin Yao,Qiuyu Jiang,Yitong Zhao,Feifei Wang,Wei He,Weiyi Xu,Hao Zhou,Ming Li,Si Zhang,Ruyi Xue
Gene delivery to macrophages holds great promise for cancer immunotherapy. However, traditional gene delivery methods exhibit low transfection efficiency in macrophages. The star -shaped topological structure of polymers is known to encapsulate genes inside their cores, thereby facilitating sustained release of the genetic material. Herein, combining the structural advantages of star polymers and the transfection advantages of poly (β-amino ester)s (PAEs), we developed a novel linear oligomer grafting-onto strategy to synthesize a library of multi-terminal star structured PAEs (SPAEs), and evaluated their gene delivery efficiency in various tissue cells. The transfection with human hepatocellular carcinoma cells (HepG2, HCC-LM3 cells and MHCC-97H cells), rat normal liver cells (BRL-3 A cells), human ovarian cancer cells (A2780 cells), African green monkey kidney cells (Vero cells), human cervical cancer cells (HeLa cells), human chondrosarcoma cells (SW1353 cells), and difficult-to-transfect human epidermal keratinocytes (HaCaT cells) and normal human fibroblast cells (NHF cells) showed that SPAEs exhibited superior transfection profile. The GFP transfection efficiency of top-performing SPAEs in HeLa cells (96.1%) was 2.1-fold, and 3.2-fold higher compared to jetPEI and Lipo3000, respectively, indicating that the star-shaped topological structure can significantly enhance the transfection efficiency of PAEs. More importantly, the top-performing SPAEs could efficiently deliver Nod2 DNA to difficult-to-transfect RAW264.7 macrophages, with a high transfection efficiency of 33.9%, which could promote macrophage M1 polarization and enhanced CD8+ T cell response in co-incubation experiments. This work advances gene therapy by targeting difficult-to-transfect macrophages and remodeling the tumor immune microenvironment.
研究领域:
生物技术
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药学
·
免疫学
·
癌症研究
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Xia Zhou,Shuilai Qiu,Linxin He,Xin Wang,Yulu Zhu,Fukai Chu,Bibo Wang,Lei Song,Yuan Hu
As a typical aerospace advanced resin-based material, the high brittleness and poor fire safety performance of bismaleimide resin (BMI) has been the key factor restricting its further development. Therefore, two star-shaped allyl functionalized phosphazene small molecules (HMACP, HECP) were designed and synthesized utilizing the nucleophilic substitution reaction between hexachlorocyclotriphosphazene (HCCP) and allyl alcohol/eugenol for enhancing the flame retardant and toughness of BMI . It’s observed with the inclusion of HMACP and HECP, the heat and smoke release behavior of BMI/HMACP and BMI/HECP are effectively suppressed. The fire risk of BMI samples are evaluated by fire growth index (FGI) and fire performance index (FPI) calculated by cone calorimeter results. And with the addition of 5 wt% HMACP and HECP, the FGI of BMI/HMACP-5 and BMI/HECP-5 possess the lowest values of 1.51 and 1.04 kW/(m 2 s), respectively. Besides, the FPI of BMI/HMACP-5 and BMI/HECP-5 are highest and the values are 0.36 and 0.37 (m 2 s)/kW, respectively, which indicates that the fire safety performance of BMI/HMACP-5 and BMI/HECP-5 are significant improved. Meanwhile the impact strength of BMI/HMACP-5 and BMI/HECP-5 are increased by 117% and 195%, respectively, which means the toughness of BMI resin with the modification of HMACP and HECP is improved. The flame retardant mechanisms of BMI/HMACP and BMI/HECP are investigated systematically. Comparative analysis of the similarities and differences between BMI/HMACP and BMI/HECP are also conducted. Therefore, it can be drawn that the designed HMACP or HECP can effectively improve the toughness and fire safety performance of BMI.
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产品关联
DOI
高影响因子
CELLULOSE
·
2020
·Vol. 27
·期 14
·8369-8383
·
IF 4.21
Zhang Qiu-yan,Liu Xiao-hui,Ren Yuan-lin,Zhang Yan-guang,Cheng Bo-wen
Abstract A novel phosphoramidate salt fire retardant (FR) with high phosphorus–nitrogen (P–N) content, tris(2-aminoethyl)amine phosphoramidate salt (TAEAPA), was synthesized by a simple design philosophy. A three-arm star-like structure FR with a high level of P or N content was obtained. Phosphorus and nitrogen contents of TAEAPA increased up to 8.6 at% and 14.5 at%, respectively. Subsequently, TAEAPA was employed to finish lyocell fibers through the classical dip-dry-cure technique. Consequently, the thermal stability and fire retardancy of finished lyocell fibers were improved significantly, as evidenced by thermogravimetric and vertical flammability test. Finished lyocell fibers exhibited higher char residues (39.2 wt%) and lower degradation rate (0.6%/°C) under nitrogen atmosphere. Besides, lyocell fabrics finished by 300 g/L of TAEAPA finishing solution only had a char length of 53 mm when exposed to flame more than 60 s, and immediately extinguished after the removal of flame. Thermogravimetry-infrared and pyrolysis gas chromatography/mass spectrometry coupled techniques confirmed that the high contents of P and N included in TAEAPA played a good synergistic effect on both condensed and gaseous phase during the thermal pyrolysis process of lyocell fibers. Graphic abstract
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产品关联
DOI
高影响因子
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
·
2017
·
IF 1.591
Xianwu Jing,Zhiyu Huang,Hongsheng Lu,Baogang Wang
A four-armed anionic star-shaped block polymer, containing an anionic polymer poly(2-Acrylamido-2-methylpropanesulfonic acid) (PAMPS) as the core group and poly(2-(Dimethylamino)ethyl methacrylate) (PDM) as the terminal group, was synthesized by using the Atom Transfer Radical Polymerization (ATRP) method. The (PAMPS50-PDM50)4 aqueous solution exhibited both polyelectrolyte and hydrophobic associative characteristics, that is, a low concentration of NaCl results in decreasing viscosity but a high concentration of NaCl results in increasing viscosity. The four-armed anionic block polymer shows a CO2-reversible property at high concentrations of brine. Viscosity, pH, and ζ potential demonstrate the switchability jointly; the values could be switched from relatively low to high cyclically. These transitions could actually be attributed to the protonation of tertiary amine groups in PDM blocks, and the mechanism was proved by 1H NMR.
研究领域:
化学工程
·
材料科学
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产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2018
·
IF 6.578
Jinfang Zhang,Cheng Ma,Hua Hou,Xiaofeng Li,Libao Chen,Douglas G. Ivey,Weifeng Wei
Limited ionic conduction and poor solid/solid interfacial stability are crucial characteristics that impede the practical application of solid polymeric electrolytes. Herein, a star-shaped solid composite electrolyte (SCE) containing multifunctional components, including anion-trapping boron moieties (B-PEGMA), poly(ethylene glycol)methyl ether methacrylate (PEGMEM) and octavinyl octasilsesquioxane (OV-POSS) nanofiller, was developed via a simple free radical polymerization method. The unique star-shaped structure induced by OV-POSS is beneficial to increasing the movement of polymer chains and forming continuously interconnected ion-conducting channels and the boron moieties can promote lithium salt dissociation and increase the effective transmission of Li + in the electrolyte. This SCE exhibits an extremely high ionic conductivity of 3.44 × 10 −4 S cm −1 and a high Li ion transference number of 0.58 at 25 °C, as well as excellent interfacial compatibility with the Li electrode leading to excellent rate performance and good cyclic stability in all-solid-state Li batteries.
研究领域:
材料科学
·
电化学
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产品关联
DOI
高影响因子
DRUG DELIVERY
·
2021
·
IF 6.419
Fangyuan Guo,Nan Yu,Yunlong Jiao,Weiyong Hong,Kang Zhou,Xugang Ji,Huixing Yuan,Haiying Wang,Aiqin Li,Guoping Wang,Gensheng Yang
Chemotherapeutic treatments are indispensable in the treatment of breast cancer. However, the emergence of multidrug-resistance, strong cell toxicity, and poor targeting selection has inhibited their clinical application. In this study, two synergistic drugs, doxorubicin (DOX) and curcumin (CUR), were co-administered to overcome multidrug resistance (MDR). Based on the characteristics of the tumor microenvironment, we developed folic acid-modified nanoparticles ((DOX + CUR)-FA-NPs) based on a star-shaped polyester (FA-TRI-CL) to enhance the tumor targeting selectivity and drug loading (DL) capacity. The (DOX + CUR)-FA-NPs displayed a characteristic spheroid morphology with an ideal diameter (186.52 nm), polydispersity index (0.024), zeta potential (–18.87 mV), and good entrapment efficiency (97.64%/78.13%, DOX/CUR) and DL (20.27%/11.29%, DOX/CUR) values. In vitro pharmacokinetic and pharmacodynamic experiments demonstrated that the (DOX + CUR)-FA-NPs were gradually released, and they displayed the highest cell apoptosis and cellular uptake in MCF-7/ADR cells. Additionally, in vivo results illustrated that (DOX + CUR)-FA-NPs not only displayed significant tumor targeting and anticancer efficacy, but also induced less pathological damage to the normal tissue. In summary, co-administered DOX and CUR appeared to reverse MDR, and this targeted combinational nanoscale delivery system could thus be a promising carrier for tumor therapies in the future.
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产品关联
DOI
PubMed
高影响因子
ELECTROCHIMICA ACTA
·
2014
·
IF 4.086
Kai Wang,Wenge Yang,Yonghong Hu,Yumei Kai,Ying Shi
A novel star-shaped monomer 1,3,5-Tri[2-(3,4-ethylenedioxythien-2-yl)vin-1-yl]benzene (TEDOT-V-B) was synthesized by Wittig coupling reaction. The copolymers with BEDOT-V at different feed ratios were prepared onto the ITO-coated glass by cyclic voltammetry (CV) method and the electrochromic properties were reported. The influences of different feed ratios on the spectroelectrochemical and kinetic properties were investigated. Spectroelectrochemical studies indicated that the maximum absorption wavelengths of the copolymer films bathochromically shifted with feed ratios. In addition, the copolymers had tunable and low band gaps. When the feed ratio of BEDOT-V-B/BEDOT-V was 1:3, the copolymer film showed the fastest oxidation switching time of 0.9s (567 nm) and 0.9s (967 nm) and the fastest reduction switching time of 0.8s (567 nm) and 0.9s (967 nm). Compared with PBEDOT-V, the copolymers showed tunable and multicolored electrochromism through feed ratios and the RGB colors were achieved. Additionally, the surface morphology of the copolymer film was investigated by scanning electron microscope (SEM).
研究领域:
材料科学
·
电化学
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产品关联
DOI
高影响因子
Polymer Chemistry
·
2015
·Vol. 6
·期 12
·2192-2203
·
IF 5.52
Yun Zhang,Maohua Chen,Xiaoming Luo,Hong Zhang,Chaoyu Liu,Huiyan Li,Xiaohong Li
Micelle behaviors have been studied intensively for linear block copolymers, and amphiphilic polymers with a non-linear architecture, including star polymers, dendrimers, and hyperbranched polymers are showing advantages in the loading of anticancer drugs. In the current study, multiarmed amphiphilic copolymers with drug conjugates were developed for the construction of micelles to alleviate premature drug release during circulation and to achieve glutathione (GSH)-mediated intracellular drug delivery. Folic acid (FA) was grafted on some of the arms of 4-armed poly(ethylene glycol) (4-arm-PEG) as the targeting groups of micelles, and ε-caprolactone (ε-CL) was copolymerized with PEG from the rest of the arms, followed by camptothecin (CPT) conjugation through dithiodipropionic acid. The effect of the number of arms used for FA conjugation and the length of PCL blocks on micelle properties, reductive sensitivity, cellular uptake, and antitumor activities were evaluated. The amphiphilic copolymers with star-shaped miktoarms were self-assembled into micelles with an average size of around 100 nm and critical micelle concentrations (CMCs) as low as 0.8 μg mL−1. The distribution of hydrophobic PCL segments in more arms resulted in micelles with lower CMCs, higher structural stability, and greater sensitivity of CPT release in the presence of GSH. But, the conjugation of FA on fewer arms led to lower FA densities and less efficient cellular uptake of the micelles. In view of the performance of cellular uptake, CPT loading, and reduction-sensitive release, micelles from 4-armed copolymers with FA conjugation on two arms and PCL copolymerization on another two arms resulted in the most significant antitumor activities. It is suggested that the composition and arm structure of amphiphilic copolymers with star-shaped miktoarms show significant effects on micelle behavior, and optimal antitumor activities can be achieved through judicious selection of multiple arms for conjugating targeting groups and chemotherapeutic drugs.
研究领域:
药学
·
聚合物化学
·
癌症研究
·
药物递送系统
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产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2015
·Vol. 132
·期 27
·
IF 1.768
Lijing Teng,Wangyan Nie,Yifeng Zhou,Linyong Song,Pengpeng Chen
The purpose of this study was to investigate the suitability of a six-arm star-shaped poly( l -lactide)s (s-PLLA) as controlled drug carriers for hydrophobic drug molecules. First, s-PLLA was synthesized by ring-opening polymerization of l -lactide using sorbitol as initiator and stannous octoate as catalyst. The structure and molecular weight ( M w ) of s-PLLA was characterized with 1 H NMR, 13 C NMR, and GPC. Second, rifampicin (RIF) used as a model drug was encapsulated within the microspheres of s-PLLA via oil-in-water emulsion/solvent evaporation technique. The morphology, drug encapsulation efficiency (EE), and in vitro release behavior of the prepared microspheres were studied in details. Results indicated that the average diameters of s-PLLA microspheres can be controlled between 8 and 20 µm by varying the copolymer's concentration or M w . The EE of RIF was mainly determined by the concentration of s-PLLA. The in vitro study showed that the burst release behavior can be depressed by increasing the M w of the s-PLLA. Present work suggests that the synthesized s-PLLA could be used as a new material for drug delivery. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 42213.
研究领域:
材料科学
·
药学
·
生物医学工程
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）