JOURNAL OF MOLECULAR STRUCTURE
·
2021
·
IF 3.196
Jiancheng Zhao,Rui Liu,Zhenzhou Zhang,Qianqian Xing,Honghong Chang,Xianglin Hou,Yingxiong Wang
The tautomer structure of monosaccharides plays an important role in its conversion and utilization, which is mainly manifested in the selectivity of the product and the reaction mechanism. The tautomer distributions of N -acetyl- D -glucosamine (GlcNAc), a natural nitrogen-containing monosaccharide were investigated by quantitative 1 H NMR ( 1 H qNMR) and 13 C NMR ( 13 C qNMR) at 298 K under the condition commonly utilized for biorefinery. Catalysts used for biorefinery, i.e. BaCl 2 , KCl, ZnCl 2 , MgCl 2 , B(OH) 3 , SnCl 4 ·5H 2 O and amino acid ionic liquid were introduced into D 2 O or DMSO‑ d 6 to explore the tautomer distributions of GlcNAc. The introduction of ZnCl 2 and SnCl 4 ·5H 2 O promoted the conversion of α-pyranose to β-pyranose. The introduction of amino acid ionic liquid has little effect on the percentage of tautomers in D 2 O. However, when the amino acid ionic liquid, such as [Thr]Cl, was introduced into DMSO‑ d 6 , the proportion of β-pyranose increased to 29.06%, compared with no catalyst introduced. Besides, we also studied the tautomer distributions of GlcNAc in commonly utilized reaction solvents for biorefinery, such as N,N -dimethylformamide, N , N -dimethylacetamide, N -methyl-2-pyrrolidinone, ethylene and glycerol. In these solvents, the proportion of β-pyranose in N,N -dimethylformamide and glycerol was reduced to 25.84% and 38.38%, respectively. This study provides the basic experimental data of tautomer distributions of GlcNAc, and guided the conversion and utilization of GlcNAc in the future.
研究领域:
生物化学
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分析化学
✓ 已验证
DOI
高影响因子
GOLD BULLETIN
·
2020
·Vol. 53
·期 2
·55-62
·
IF 1.706
Li Degui,Luo Yujia,Lan Jiaxin,Luo Zhihong,Li Fujie,Luo Kun
Ligand exchange was triggered at toluene/water emulsion interface between homogeneous gold nanoparticles (Au NPs) with triphenylphosphine (PPh 3 ) and D-penicillamine (D-PA), resulted in amphiphilic Janus Au NPs with both phosphine and thiolate ligands. TEM and XRD analyses indicate that the product is composed of Au nanocrystals in an average diameter of about 3.7 nm. XPS, FTIR, Raman, and 1 H NMR analyses demonstrate that the Au NPs are protected with hydrophilic D-PA molecules and lipophilic PPh 3 ligands in a molecular ratio of ca. 1.8. The NOESY analysis and contact angle measurement further suggest that the D-PA and PPh 3 molecules are spontaneously separated to form compartmentalized hydrophilic and lipophilic regions on the individual Au NPs, which exhibit good catalytic performance and recyclability on the reduction of 4-nitrophenol. The results demonstrate that amphiphilic Janus Au NPs can be synthesized by partly exchange of PPh 3 with D-PA at toluene/water emulsion interface and are potentially applicable for other phosphine/thiolate pairs to modify Au NPs.
研究领域:
材料科学
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纳米技术
·
化学
✓ 已验证
产品关联
DOI
高影响因子
BIOMEDICINE & PHARMACOTHERAPY
·
2018
·
IF 3.457
Yuhui Wang,Jinyang Shen,Xiaolin Yang,Ye Jin,Zhonglin Yang,Rufeng Wang,Fuming Zhang,Robert J. Linhardt
Background Glucocorticoid hormones are implicated in the pathogenesis of Alzheimer’s disease (AD) and other diseases including diabetes, hyperlipidemia , and osteoporosis . Akebia saponin D (ASD) possesses numerous pharmacological activities , including as an anti-AD, anti-hyperlipidemia, anti-diabetes, and anti-osteoporosis agent. The anti-AD effect of ASD is possibly through its regulation of glucocorticoid levels. Purpose The present study was undertaken to investigate the neuroprotective effects of ASD on Aβ 25-35 -induced cognitive deficits and to elucidate its underlying mechanism of action. Methods The AD rat model was established by an intracerebroventricular injection of Aβ 25-35 into the lateral ventricles. Spatial learning and anxiety state were assessed by Morris water maze task and elevated plus-maze assay, respectively. The degree of hypertrophy of adrenal gland was analyzed using the viscera coefficient. Corticosterone and ACTH concentrations in the plasm were measured using biochemical assay kits. The activity of 11β-hydroxysteroid dehydrogenase type-1 (11β-HSD1) in liver and groin fat pad was assessed by measuring cortisol production. Results Compared with the control group, AD rats displayed significant spatial learning and reference memory impairments, serious anxiety disorders, obvious hypertrophy of adrenal gland, elevated corticosterone and ACTH levels in the plasma, and increased 11β-HSD1 activity in liver and groin fat pad. ASD could significantly ameliorate the memory deficits and anxiety symptoms, markedly reduce the viscera coefficient of adrenal gland, observably decrease corticosterone and ACTH concentrations, and showed no effect on the activity of 11β-HSD1. Conclusions These results indicate that ASD might exert a significant neuroprotective effect on cognitive impairment, driven in part by reducing systemic corticosterone level by down-regulation of the hypothalamic-pituitary-adrenal (HPA) axis.
研究领域:
神经科学
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药理学
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内分泌学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
·
2023
·
IF 5.2
Pei Li,Zhishuang Yang,Ting Lei,Yujie Dai,Yang Zhou,Dekang Zhu,Hongyan Luo
Objectives: To elucidate the role of a novel carbapenem-hydrolysing class D β-lactamase (RAD-1) from Riemerella anatipestifer. Methods: We applied WGS and bioinformatic analysis to screen putative β-lactamase genes in R. anatipestifer SCVM0004. A putative class D β-lactamase gene was cloned into pET24a and transferred into Escherichia coli BL21 (DE3) for antibiotic susceptibility determination and protein purification. Meanwhile, the purified native protein was used to determine the enzymatic activities. Results: A class D β-lactamase, RAD-1, was identified in the genome of R. anatipestifer SCVM0004. It was distinct from all characterized class D β-lactamases (≤42% amino acid sequence identity). Searching in GenBank showed that blaRAD-1 was widely disseminated among R. anatipestifer. Genomic environment analysis indicated that the chromosomal structures of blaRAD-1-located regions were relatively conserved. Expression of RAD-1 in E. coli results in elevated MICs for various β-lactam antibiotics, including penicillins, extended-spectrum cephalosporins, a monobactam and carbapenems. Moreover, kinetic analysis of purified RAD-1 revealed: (i) high-level activity against penicillins; (ii) highest affinity for carbapenems; (iii) moderate hydrolysis of extended-spectrum cephalosporins and a monobactam; and (iv) no activity for oxacillin and cefoxitin. Conclusions: This study identified a novel chromosomally located class D carbapenemase RAD-1 (Bush-Jacoby functional group 2def) in R. anatipestifer SCVM0004. Moreover, bioinformatic analysis confirmed that the RAD-1 was widely prevalent and conserved in R. anatipestifer.
研究领域:
微生物学
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基因组学
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抗菌素耐药性
·
生物信息学
✓ 已验证
DOI
PubMed
高影响因子
GREEN CHEMISTRY
·
2023
·Vol. 26
·期 2
·979-991
·
IF 9.8
Shipeng Chen,Jinping Wang,Li Feng,Zebin Song,Xiaoji Wang,Yubin Ke,Lin Hua,Yange Fan,Zheng Li,Yimin Hou,Baoyu Xue,Luke Liu
To prevent the entry of toxic sulphur-containing contaminants into the atmosphere, extractive desulphurization of fuels with an ionic liquid (IL) as an extractor is a benign and efficient strategy, as compared with traditional hydrodesulphurization. However, ILs have some drawbacks like toxicity, non-biodegradability, low recyclability, and partial solubility in the fuel (leading to contamination), which limit their practical applications. Supramolecular ionogels, obtained from the gelation of ILs, not only retain the desulphurization function of ILs, but also prevent the leakage and achieve the renewable utilization of ILs. Hence, they are effective in overcoming the abovementioned limitations. Herein, a series of efficient D-gluconic acetal-based gelators (NG6, 12, 18 and NGO18) that can harden four different ILs at low concentrations was developed. They were thermally reversible and stable at room temperature with self-healing properties. The gelation and self-healing mechanisms of these gels were also systematically investigated. Furthermore, their desulphurization capacities in fuel-mimicking solutions of thiophene (T), benzothiophene (BT) and dibenzothiophene (DBT) in hexane were investigated. The effects of the concentration of sulphur compounds, fuel volume and temperature on the efficiency of sulphur removal were studied. Interestingly, the NG18-IL2 ionogel was the best-performing, which showed outstanding mechanical properties and fast and complete self-healing characteristics, along with 40.99, 49.76 and 51.68% removal efficiencies for T, BT and DBT, respectively, and 100% for T, BT and DBT in a multi-stage approach. Additionally, the ionogel could be reused six times and regenerated, all of which make it a low-cost and environment-friendly desulphurization material for practical applications.
研究领域:
材料科学
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环境科学
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化学工程
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry A
·
2023
·Vol. 11
·期 26
·14311-14319
·
IF 11.9
Lantao Liu,Ziyu Sun,Yaping Lu,Jiapeng Zhang,Yiming Li,Gaixia Zhang,Xiaohong Chen,Sasha Omanovic,Shuhui Sun,Huaihe Song
Due to the environmental friendliness and high safety of aqueous Zn-ion hybrid capacitors (ZIHCs), the exploration of high-performance porous carbon electrodes for ZIHCs has recently attracted significant attention. However, most of the reports focus on the preparation method and modification of porous carbon, and rarely explore the mechanisms of material synthesis/fabrication in the carbonization process. In this study, we developed a simple self-template method for preparing N-doped porous carbon from D-calcium pantothenate (DCP). More importantly, the morphology evolution, heteroatom doping, and defect generation of the DCP during carbonization are clarified. Based on a clear understanding of the carbonization mechanism, assisted by DFT theoretical simulations, we find the optimal carbonization temperature of the DCP-derived porous carbon for ZIHCs. The assembled ZIHCs exhibit excellent rate performance (140 mA h g−1 at 0.2 A g−1 and 86.2 mA h g−1 at 6.4 A g−1), and high energy density and power density (111.1 W h kg−1 and 4835.2 W kg−1, respectively). This work provides a constructive avenue for designing high-performance ZIHC electrode materials.
研究领域:
材料科学
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电化学
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能源存储
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纳米材料
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碳材料
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电化学储能
✓ 已验证
DOI
高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-11
·
IF 14.7
Liu Hong-Zhi,Shu Xiao-Xuan,Huang Mingjie,Wu Bing-Bing,Chen Jie-Jie,Wang Xi-Sheng,Li Hui-Lin,Yu Han-Qing
Polymerization-driven removal of pollutants in advanced oxidation processes (AOPs) offers a sustainable way for the simultaneous achievement of contamination abatement and resource recovery, supporting a low-carbon water purification approach. However, regulating such a process remains a great challenge due to the insufficient microscopic understanding of electronic structure-dependent reaction mechanisms. Herein, this work probes the origin of catalytic pollutant polymerization using a series of transition metal (Cu, Ni, Co, and Fe) single-atom catalysts and identifies the d -band center of active site as the key driver for polymerization transfer of pollutants. The high-valent metal-oxo species, produced via peroxymonosulfate activation, are found to trigger the pollutant removal via polymerization transfer. Phenoxyl radicals, identified by the innovative spin-trapping and quenching approaches, act as the key intermediate in the polymerization reactions. More importantly, the oxidation capacity of high-valent metal-oxo species can be facilely tuned by regulating their binding strength for peroxymonosulfate through d -band center modulation. A 100% polymerization transfer ratio is achieved by lowering the d -band center. This work presents a paradigm to dynamically modulate the electronic structure of high-valent metal-oxo species and optimize pollutant removal from wastewater via polymerization.
研究领域:
环境科学
·
催化化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Foods
·
2025
·Vol. 14
·期 9
·1648
·
IF 5.1
Feng Yang,Xin Qi,Yan Chen,Kai Tang,Mengyang Fang,Yanwei Song,Jiufen Liu,Lianming Zhang
In this study, β-cyclodextrin (β-CD) functionalized graphene quantum dots (GQDs) was employed to augment the array of chiral recognition sites, thereby enhancing the affinity of GQDs/β-CD composite for imprinting molecules and realizing heightened chiral selectivity. The incorporation of GQDs/β-CD into the synthesis of molecularly imprinted polymers (MIPs), synergizing with the host-guest inclusion properties of β-CD and the abundant carboxyl groups of GQDs, enhanced the chiral recognition capacity of MIPs materials. Consequently, a novel MIPs/(GQDs/β-CD) sensor with chiral recognition capabilities tailored for D-carnitine was successfully fabricated. The binding mechanism between GQDs/β-CD and D-carnitine was elucidated via Ultraviolet-visible spectroscopy and Fourier transform infrared spectroscopy. The variation in the response signal (ΔI) of the probe molecule exhibited a linear correlation with the logarithm of D-carnitine concentration (lgC) in the range of 1.0 × 10−12mol/L to 1.0 × 10−9mol/L, and the detection limit (3δ/S) was calculated as 2.35 × 10−13mol/L. These results underscore a 7.15-fold enhancement in the selectivity of MIPs/(GQDs/β-CD) sensor for D-carnitine recognition. Moreover, the sensor presented commendable efficacy in real-world scenarios, yielding recovery rates ranging from 98.5% to 103.0% during the determination of D-carnitine content in real samples.
研究领域:
分析化学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Science China-Life Sciences
·
2024
·
IF 8
Zhang Yinghui,Liu Yadan,Jiang Bing,Chen Lifan,Hu Jie,Niu Buying,Chang Jie,Fan Zisheng,Zhou Jingyi,Wang Yajie,Teng Dan,Ma Ning,Wang Xiaofeng,Yang Ruirui,Zheng Mingyue,Zhang Sulin
The development of STING inhibitors for the treatment of STING-related inflammatory diseases continues to encounter significant challenges. The activation of STING is a multi-step process that includes binding with cGAMP, self-oligomerization, and translocation from the endoplasmic reticulum to the Golgi apparatus, ultimately inducing the expression of IRF3 and NF-κB-mediated interferons and inflammatory cytokines. It has been demonstrated that disruption of any of these steps can effectively inhibit STING activation. Traditional structure-based drug screening methodologies generally focus on specific binding sites. In this study, a TransformerCPI model based on protein primary sequences and independent of binding sites is employed to identify compounds capable of binding to the STING protein. The natural product Licochalcone D (LicoD) is identified as a potent and selective STING inhibitor. LicoD does not bind to the classical ligand-binding pocket; instead, it covalently modifies the Cys148 residue of STING. This modification inhibits STING oligomerization, consequently suppressing the recruitment of TBK1 and the nuclear translocation of IRF3 and NF-κB. LicoD treatment ameliorates the inflammatory phenotype in Trex1 −1− mice and inhibits the progression of DSS-induced colitis and AOM/DSS-induced colitis-associated colon cancer (CAC). In summary, this study reveals the potential of LicoD in treating STING-driven inflammatory diseases. It also demonstrates the utility of the TransformerCPI model in discovering allosteric compounds beyond the conventional binding pockets.
研究领域:
免疫学
·
药理学
·
分子生物学
·
炎症
·
药物发现
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Mengtian Cui,He Wang,Xia Fan,Jianhao Zhang,Changrui Xing,Wenjing Yan
The widespread use of organophosphorus pesticides (OPPs) in foods, poses a serious threat to human and environmental health, it is crucial to develop methods that can efficiently degrade residual OPPs . Herein, a chiral TiO 2 photocatalyst was developed by modification TiO 2 with D-cys/Au NPs (DAT) for the simultaneous degradation of four OPPs (chlorpyrifos, chlorpyrifos-methyl, malathion, and parathion) by natural light. The influence of D-Au NPs concentration on the degradation process was optimized, along with the initial pesticide concentration. Under optimal conditions, the photocatalytic degradation efficiencies of DAT for four OPPs were 96.7 %, 56.9 %, 42.6 %, and 49.2 %, respectively, after 12 h of natural light exposure. 12 degradation products of OPPs were identified, among which three products were identified for the first time. The degradation pathway revealed that the degradation of OPPs by DAT involves the oxidation of the P═S bond and the cleavage of the P-O bond and C-O bond. This study establishes a theoretical foundation for applying chiral TiO 2 nanomaterials for the photocatalytic degradation of OPPs in foods.
研究领域:
环境科学
·
食品科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
POLYMER DEGRADATION AND STABILITY
·
2024
·
IF 6.3
Jinke Yu,Ling Sun,Lan Ding,Yufei Cao,Xiaohui Liu,Yuanlin Ren,Yuesheng Li
When confronted with a fire, the flammability of rigid polyurethane foam (RPUF) makes it extremely easy to burn violently. In this work, a green biomass derived flame retardant coating was synthesized with phytic acid as acid source, D-sorbitol as carbon source and glycine as gas source. A simple UV curing technique was used to improve the flame retardancy of RPUF . Coated RPUF exhibited a limiting oxygen index value of up to 39.7 % and successfully met UL-94 testing criteria with V-0 rating. In comparison to control RPUF, coated RPUF showed an extended ignition time of 3 s, a remarkable reduction of approximately 60 % in the peak heat release rate, and possessed commendable smoke suppression property. The flame retardant mechanism was analyzed, unveiling the emergence of compact char residue on the surface of coated RPUF after burning, accompanied by the liberation of non-combustible gases. Therefore, these results demonstrated that cost-effective UV-curable flame retardant coating forms protective char layer on the surface of RPUF, providing efficient flame retardancy while preserving its excellent properties.
研究领域:
材料科学
·
化学工程
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
Small
·
2024
·Vol. 20
·期 10
·2302943
·
IF 13
Yanfen Wan,Yingfei Hu,Hongyu Tu,Wenbo Zhuang,Xuemin Geng,Tian Zhang,Jinghao Zhang,Ming Wen,Peng Yang
Herein, an integrated solar-thermal-power protocol is presented at a micro-nanoscopic level to maximize the energy utilization efficiency involving utilization period and utilization patterns, and the nexus of freshwater production and nanogeneration is realized. This sophisticated vaporization device is constructed with the merits of thermally confined evaporation space in favor of recycling latent heat of condensation and optimizing light absorption based on the local sunlight angle of incidence. Inspired by a bird's nest, Sb 2 WO 6 /D-Fructose composites are prepared as photothermal absorbers to achieve a superior water evaporation rate of 2.78 kg m −2 h −1 in the Multi-stage evaporator. In addition, a synergistic tandem photo thermal-electric device with a combination of solar-driven water evaporation and further waterflow-driven hydrovoltaic generation, which can output a stable voltage of up to 360.8 mV with effective utilization of steam energy and a limited water source, is exploited. Such integrated configurations pave a pathway for clean water production and renewable power generation simultaneously toward energy issues.
研究领域:
能源材料科学
·
环境科学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）