International Journal of Nanomedicine
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2024
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IF 6.6
Wenpeng Yu,Jingli Ding,Jianfeng Chen,Ying Jiang,Jinping Zhao,Jichun Liu,Jianliang Zhou,Jinping Liu
Introduction Excessive generation of reactive oxygen species (ROS) following myocardial ischemia-reperfusion (I/R) can result in additional death of myocardial cells. The rapid clearance of ROS after reperfusion injury and intervention during subsequent cardiac repair stages are crucial for the ultimate recovery of cardiac function.Methods Magnesium-doped mesoporous bioactive glasses were prepared and loaded with the antioxidant drug gallic acid into MgNPs by sol-gel method. The antioxidant effects of MgNPs/GA were tested for their pro-angiogenic and anti-inflammatory effects based on the release characteristics of GA and Mg2+ from MgNPs/GA. Later, we confirmed in our in vivo tests through immunofluorescence staining of tissue sections at various time points that MgNPs/GA exhibited initial antioxidant effects and had both pro-angiogenic and anti-inflammatory effects during the cardiac repair phase. Finally, we evaluated the cardiac function in mice treated with MgNPs/GA.Results We provide evidence that GA released by MgNPs/GA can effectively eliminate ROS in the early stage, decreasing myocardial cell apoptosis. During the subsequent cardiac repair phase, the gradual release of Mg2+ from MgNPs/GA stimulated angiogenesis and promoted M2 macrophage polarization, thereby reducing the release of inflammatory factors.Conclusion MgNPs/GA acting on multiple cell types is an integrated solution for comprehensive attenuation of myocardial ischaemia-reperfusion injury and cardiac function protection.
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高影响因子
FOOD CHEMISTRY
·
2025
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IF 9.8
Hongyuan Zhao,Jiale Han,Mengyuan Zhao,Zhenzhen Hui,Zirong Li,Sridhar Komarneni
This work presents a convenient and easy-to-operate method for synthesizing the functionally integrated nanocomposite of nitrogen-doped multi walled carbon nanotube networks (N-CNTs) and cobalt 2-methylimidazole (ZIF-67) nanoparticles. The N-CNTs@ZIF-67 nanocomposite was utilized to design a novel electrochemical sensing platform for detecting gallic acid (GA). The N-CNTs@ZIF-67 modified glass carbon electrode (GCE) demonstrated high sensitivity for GA electrochemical detection (LOD: 10.17 nM, detection concentration: 0.5–20 μM). N-CNTs provided efficient electron transport channels for the GA electrochemical detection reaction, which improved the transfer rate of electrons/ions at the interface of sensing electrode/electrolyte. ZIF-67 nanoparticles with highly porous structure could adsorb GA molecules and promote the oxidation reaction. Besides that, N-CNTs provided more active sites on carbon nanotube networks by nitrogen-doping, which significantly enhanced the catalytic activity. The prepared N-CNTs@ZIF-67/GCE sensor exhibited favorable GA sensing detection performance, realizing an accurate analysis of GA in beverage samples (Recovery: 96.77–107.93 %, RSD: 1.07–4.38 %).
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Food Chemistry-X
·
2026
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IF 9.2
Yan Zhu,Haizhu Wu,Weijia Yang,Bertrand Charrier,Hisham Essawy,Antonio Pizzi,Xiaojian Zhou,Xinyi Chen
The excessive use of petroleum-based packaging necessitates the need for sustainable, biodegradable alternatives. This study developed a high-performance active packaging film by incorporating chemically modified cellulose nanocrystals (CNCs) into a soy protein isolate (SPI) matrix. CNCs were functionalized via silanization with 3-aminopropyltriethoxysilane (APTES) followed by covalent gallic acid grafting. Compared to glycerol-plasticized SPI, the composite films showed significantly enhanced mechanical strength (237.3% increase in tensile strength, from 2.17 to 7.32 MPa), improved water vapor barrier (30.16% reduction in permeability), nearly 100% UV blocking at 200–350 nm, antioxidant activity (12.4% DPPH scavenging), and antibacterial properties. In a 7-day banana preservation test, the optimized film effectively delayed weight loss, softening, and browning while remaining biodegradable, showing visible degradation within 20 days in soil. This work demonstrates a feasible interfacial design strategy for developing multifunctional SPI-based nanocomposite films with high potential for fresh-keeping packaging of perishable fruits such as bananas.
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JOURNAL OF POLYMER SCIENCE
·
2025
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IF 3.6
Zefeng Li,Jing Xu,Pingbo Zhang,Mingming Fan,Pingping Jiang,Shijun Chen,Xunxun Sheng
Conventional food packaging plastics are difficult to degrade under natural conditions, causing long-lasting environmental harm. With the aim of addressing this problem, this study develops a novel biodegradable composite food packaging film based on polybutylene adipate-terephthalate (PBAT) and polyurethane (PU). MOF-5 nanoparticles are prepared via the ambient temperature precipitation method and modified with gallic acid (GA). PBAT/PU/GA@MOF-5 composite films are fabricated by the solvent casting method. The findings demonstrate that the introduction of GA@MOF-5 enhances the compatibility between PBAT and PU and reduces phase separation; therefore, it augments the mechanical performance of the resultant composite films. These composite films manifest excellent mechanical, thermal degradation, and antioxidant properties, performing remarkably in apple freshness tests. Furthermore, the incorporation of GA@MOF-5 endows the films with significant antimicrobial activity, showing restraint on the proliferation of both Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ). This study offers an innovative idea for biodegradable food packaging materials design and expands the application prospect of the PBAT/PU composite system in the food packaging field. Graphical Multifunctional degradable food packaging film based on PBAT/PU/GA@MOF-5.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2021
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IF 3.764
Ruifeng Liang,Ruiquan Yu,Rui Wang,Zhixuan Zhou,Gongyan Liu
Owing to the overuse of antibiotics, antibiotics and antibiotic-resistant bacteria (ARB) are frequently detected in aquatic environments, which has aroused widespread concern regarding its impact on the balance of ecosystems and human health. Removing antibiotics and ARB in contaminated water via a trustworthy, sustainable, and low-cost approach is quite difficult. Furthermore, silver nanoparticles (AgNPs) have been proven to be a promising catalyst for generating reactive oxygen species (ROS) via activating peroxymonosulfate (PMS) for the efficient removal of antibiotics. Unfortunately, frequent biofouling on the membrane surface will negatively impact the water purification performances of the filtration processes by decreasing water flux. Herein, gallic acid-modified silver nanoparticles (GA@AgNPs) were selected to facilely and robustly decorate a conventional polyamide microfiltration (PMF) membrane by various interactions between amino and catechol groups without reducing its water permeability. Moreover, the as-prepared GA@AgNPs-PMF membrane exhibited strong antibacterial activity, which could effectively migrate biofouling on the membrane surface. In addition, the GA@AgNPs-PMF membrane could effectively generate ROS via activating PMS, facilitating the removal of antibiotics, and achieving ∼80% removal efficiency within 3 h. Therefore, the GA@AgNPs-PMF membrane developed in this work is a promising low-energy membrane system for the practical removal of antibiotics and ARB.
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FOOD CHEMISTRY
·
2025
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IF 9.8
Jinyu Chen,Siyang Wang,Beibei Jia,Zhirui Ji,Ximing Li,Dengyong Liu,Zijian Wu
The binding of high-dose polyphenols can induce aggregation of myofibrillar protein (MP), which compromises its gelling and emulsifying functionalities. Herein, zein/anionic polysaccharide nanoparticles were fabricated for efficient encapsulation of gallic acid (GA), to inhibit the excessive modification of MP by GA (180 μM/g). The GA encapsulation hindered the aggregation of MP, facilitating more proteins to participate in the construction of a denser and strengthened gel network with more entrapped water, and promoting the diffusion of the proteins to the oil surface, resulting in a lower interfacial tension and a more uniform droplet distribution. The electronegativity, hydrophilicity and viscosity of these polysaccharides also helped to improve the gel quality and emulsion stability. Overall, the presence of sodium alginate showed the best improvement effect, followed by gum arabic and xanthan gum. This work provides a strategy to mitigate phenolic antioxidant-induced damage to functionalities of meat proteins.
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高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Hongyuan Zhao,Mengyuan Zhao,Jiale Han,Zirong Li,Jing Tang,Zhankui Wang,Guifang Wang,Sridhar Komarneni
Gallic acid (GA) has important application value in several fields of foods, medicines, and chemical engineering. However, the excessive intake of GA may cause gastrointestinal discomfort and nerve damage. Herein, an economical room-temperature fabrication strategy was reported for the preparation of zeolitic imidazolate framework-8 (ZIF-8) nanoparticles combined with graphitized and carbonylated carbon nanotubes (GCMCN) networks, which were used to achieve the ultrasensitive electrochemical detection of GA. The GCMCN@ZIF-8 nanocomposite modified electrode realized an accurate and rapid analysis of GA (Linear concentration range: 0.1–20 μM, LOD: 4.77 nM). GCMCN networks with graphitization and carboxylation boosted the electrical conductivity of electrode modification layer and enhanced the electrochemical interface area between sensing electrode and electrolyte. ZIF-8 nanoparticles with more active interaction sites and high porosity possessed high adsorption capacity for GA molecules. The fabricated electrochemical sensing platform exhibited good GA quantitative analysis property in food samples (Recovery: 93.88–106.73 %, RSD: 1.04–3.73).
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FOOD RESEARCH INTERNATIONAL
·
2025
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IF 8
Ruixue Liu,Min Gao,Li Zhang,Shihan Wang,Ying Yang,Jing Bai,Ruohan Wang,Yongsheng Wang,Zhihan Wang
This study investigated the impacts of gallic acid (GA) on the structural and functional properties of Rana chensinensis ovum protein isolate (RCOPI)-gellan gum (GG) Pickering emulsion gels. An innovative Pickering emulsion gel system (RGAGG-eg) was successfully developed. Mechanistic studies revealed that GA may act as a molecular bridge, utilizing its own phenolic hydroxyl and carboxyl groups to enhance the interaction of RCOPI-GG through hydrogen bonding. This resulted in a 21.23 % reduction in the particle size of the RGAGG-cx, indicating that a denser crosslinked network was obtained. The particle size of the RGAGG-em droplets is reduced by 32.39 % as a result of the more closely bound complex particles being more securely adsorbed on the surface of the oil droplets. The helical change of the GG structure caused the emulsion to gel during the heating phase. CLSM and SEM confirmed GA-induced microstructural compaction, while rheological analysis demonstrated improved gel strength (G' > G''). The RGAGG-eg met IDDSI levels 4 pureed properties ideal for dysphagia management. As a proof-of-concept, the system achieved 98.26 % β-carotene encapsulation efficiency with 69.81 % bioaccessibility. Those results suggested the RGAGG-eg demonstrated dual functionality as a nutrient carrier and texture-modified food.
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DIAMOND AND RELATED MATERIALS
·
2025
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IF 5.1
Hongyuan Zhao,Mengyuan Zhao,Xinya Xu,Yuyang Zhang,Zirong Li,Sridhar Komarneni
In this work, an ultrasensitive gallic acid (GA) electrochemical sensor was developed by using β-cyclodextrin-encapsulated and Ketjenblack carbon-embedded helical multi-walled carbon nanotubes (β-CD/HMCT/KC) networks, which were prepared by using ultrasound assisted one-pot strategy. β-CD not only achieved the good adsorption and enrichment of GA through host-guest inclusion interactions but also promoted the uniform dispersion of HMCT and KC. HMCT facilitated the rapid electron transport through continuous tube-wall bending pathways, and the unique helical morphology further increased the surface corrugation, significantly enhancing the density of active sites. KC with branched-chain morphology enabled the formation of branched-chain-like conductive carbon networks. The electrochemical performance of β-CD/HMCT/KC modified sensor was performed by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and differential pulse voltammetry (DPV). The multifunctional integration of β-CD/HMCT/KC enhanced the sensitivity of GA electrochemical analysis (Limit of detection: 8.8 nM, limit of quantification: 29.33 nM, linear concentration range: 0.5–20 μM). The practical evaluation of GA detection in food samples (teas and fruit juices) showed good recoveries of 96.03–104.37 % and low relative standard deviations of 2.30 %–4.57 %.
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INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
·
2026
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IF 5.2
Jinming Dai,Chenghui Zhang,Mei Bai,Tariq Aziz,Nada K. Alharbi,Fatma Alshehri,Ashwag Shami,Fahad Saad Alhodieb,Saleh A. Alsanie,Mansour Alblaji,Haiying Cui
The quorum sensing (QS) system is a critical drug target that regulates the toxins production and biofilms formation in pathogens. This study elucidates the mechanism by which the plant polyphenol gallic acid (GA) acts as a QS inhibitor targeting the LuxS/AI-2 system in Escherichia coli O157: H7, and evaluates its potential for antibiofilm applications. Results show that GA broadly interferes with the transcription of genes in the AI-2 synthesis pathway and inhibits AI-2 production. Molecular docking combined with in vitro enzymatic inhibition assays identified LuxS as a key target of GA. Thermodynamically favored, GA binds to LuxS via hydrogen bonds and van der Waals interactions, forming a stable ground-state complex that alters the enzyme's secondary structure and inhibits its activity. Further mechanistic analysis indicates that GA induces conformational changes in the protein, reduces active site volume, and restricts key catalytic residues, thereby blocking substrate access. Under simulated meat broth conditions, GA significantly enhances the biofilm-inhibitory effect of conventional disinfectants even at subinhibitory concentrations on food-contact surfaces. These findings provide theoretical support for the potential utilization of GA as a QS-targeted antibiofilm adjuvant in the food industry.
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Journal of Materials Chemistry B
·
2026
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IF 6.2
Yan Du,Miao Zhang,Hongyan Jiang,Genmeng Yang,Ruike Xu,Ziqing Lin,Zhuo Wang,Yurong Sun,Hongqiang Gao,Kuangpin Liu,Hailei Wang
Acne is a chronic skin disorder closely associated with the over-proliferation of P. acnes within hair follicles. To avoid the overuse of antibiotics and address the low efficiency of conventional transdermal drug delivery, this study reported a chitosan oligosaccharide/gallic acid-modified ε‑poly‑L‑lysine/polyvinyl alcohol microneedles (CEGP MNs) patch for acne treatment. The patch possessed sufficient needle length (600 μm) and mechanical strength (0.8 N/needle) to penetrate the stratum corneum and dissolve rapidly in the dermis, thereby releasing the active ingredients COS and EPL‑GA. Experiments demonstrated that COS and EPL‑GA effectively kill bacteria through their enhanced antibacterial action, with an antibacterial rate exceeding 80%, thus alleviating acne‑related inflammation. Furthermore, owing to the antioxidant and anti‑inflammatory properties of GA, CEGP MNs significantly reduced the expression levels of TNF‑α, IL‑6, and IL‑1β. Meanwhile, CEGP MNs up‑regulated the expression of IL‑10 and maintained VEGF at a moderate level to create favorable conditions for the acne repair phase, helping to reduce pigmentation and prevent scar formation. Consequently, in a severe acne mice model induced by P. acnes, the biocompatible CEGP MNs exhibited promising therapeutic effects. This study proposes an effective acne treatment strategy based on the transdermal delivery of natural compounds.
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NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 20
·9879-9886
·
IF 3.3
Xiaopeng Wang,Jianping Zeng,Shixin Xie,Liangliang Tao,Xiangying Sun
In this work, easily accessible carbon dots (N, B-CDs) were synthesized via a one-step microwave method. In the powder state, N, B-CDs exhibited bright blue fluorescence and stable green phosphorescence with a lifetime of 539 ms, visible to the naked eye for 9 s. Due to their excellent phosphorescent properties, N, B-CDs have been successfully applied in information encryption. Graphic security and information encryption schemes were designed using N, B-CDs and rhodamine 6G. N, B-CDs contained many hydroxyl and amino groups on the surface, which can be utilized to detect specific ions and compounds. N, B-CDs have been successfully applied to detect Sn2+ and gallic acid (GA). Theoretical calculations and mechanistic studies suggested that the sensing of Sn2+ was attributed to the photoinduced electron transfer between Sn2+ and N, B-CDs, and the limit of detection (LOD) was determined as 3.5 μM with the 3s/k rule. In addition, N, B-CDs and GA form cross-links, as determined by Fourier transform infrared spectral analysis, with an LOD of 0.35 μM with the 3s/k rule.
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