JOURNAL OF HAZARDOUS MATERIALS
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2020
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IF 9.038
Zhi-Ling Li,Rui Cheng,Fan Chen,Xiao-Qiu Lin,Xiao-Jing Yao,Bin Liang,Cong Huang,Kai Sun,Ai-Jie Wang
Antibiotics commonly exist in municipal, livestock and industrial wastewaters . However, the response of key microbiota performance in wastewater treatment plants to antibiotic exposure lacks systematic research. In this study, the short-term acute stress of four commonly used antibiotics (sulfamethoxazole, chlortetracycline, ciprofloxacin, and amoxicillin) on microbial denitrification performance was systematically investigated. All tested antibiotics exhibited the inhibitory effects in varying degrees by repeated addition for six cycles. The nitrate removal efficiencies ( NrE ) decreased to 7.98–26.80%, accompanied by the significant decrease of the expressed nar G gene, by exposure to sulfamethoxazole, chlortetracycline or amoxicillin. Nitrite reduction was inhibited more severely than nitrate reduction , which was further verified by the low- or non-expressed nir S and nos Z genes. Furthermore, a higher antibiotic concentration made stronger inhibitory effect. Except for chlortetracycline, 2.09–6.80 times decrease of k value was commonly observed as concentration increased from 10 to 50 or 100 mg L −1 . Even in a short period (24 h), antibiotics largely decreased the abundance of the dominant denitrifying bacterial genera ( Thauera , Comamonas , etc.), while, some unclassified populations ( Labrenzia , Longilinea, etc.) were enriched. This study provides theoretical researches on the microbial denitrification behaviors influenced by exposure to different antibiotics.
研究领域:
环境微生物学
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废水处理
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生态毒理学
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DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
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2019
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IF 9.518
Xuwen Gao,Kena Fu,Li Fu,Huaisheng Wang,Bin Zhang,Guizheng Zou
Novel optical labels for biosensing in near-infrared (NIR) region (especially between 800 and 900 nm) are arousing much attention for higher penetrating capability, less scattering and lowered autofluorescent background. Herein, a water-soluble electrochemiluminophore with effective electrochemiluminescence (ECL) around 815 nm is developed via doping dual-stabilizers-capped CdTe nanocrystals (NCs) with Co 2+ species in a growth-doping way. The Co 2+ -doped CdTe NCs not only can preserve the highly-passivated surface states of dual-stabilizers-capped CdTe NCs, but also exhibit efficient red-shifted photoluminescence (PL) and ECL into the promising optical NIR window of 800–900 nm. A spectrum-based ultrasensitive NIR ECL immunosensor is consequently fabricated with the Co 2+ -doped CdTe NCs as tags for the first time, which can selectively and sensitively determine human carcinoembryonic antigen with a wide linearity range from 1 fg/mL to 10 pg/mL and a low limit of detection at 0.2 fg/mL (S/N = 3). This work opens a way to screen novel NIR electrochemiluminophore as well as to modulate the ECL performance of NCs via surface doping and engineering.
研究领域:
材料科学
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纳米技术
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分析化学
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生物传感器
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DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
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2015
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IF 6.723
Jing Li,Wenjing Wang,Liang Zhao,Li Rong,Shijie Lan,Hongchen Sun,Hao Zhang,Bai Yang
Despite the success of galvanic replacement in preparing hollow nanostructures with diversified morphologies via the replacement reaction between sacrificial metal nanoparticles (NPs) seeds and less active metal ions, limited advances are made for producing branched alloy nanostructures. In this paper, we report an extended galvanic replacement for preparing branched Au–Ag NPs with Au-rich core and Ag branches using hydroquinone (HQ) as the reductant. In the presence of HQ, the preformed Ag seeds are replaceable by Au and, in turn, supply the growth of Ag branches. By altering the feed ratio of Ag seeds, HAuCl4, and HQ, the size and morphology of the NPs are tunable. Accordingly, the surface plasmon resonance absorption is tuned to near-infrared (NIR) region, making the branched NPs as potential materials in photothermal therapy. The branched NPs are further coated with polydopamine (PDA) shell via dopamine polymerization at room temperature. In comparison with bare NPs, PDA-coated branched Au–Ag (Au–Ag@PDA) NPs exhibit improved stability, biocompatibility, and photothermal performance. In vitro experiments indicate that the branched Au–Ag@PDA NPs are competitive agents for photothermal ablation of cancer cells.
研究领域:
材料科学
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纳米技术
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癌症研究
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治疗学
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产品关联
DOI
PubMed
高影响因子
Acta Biomaterialia
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2023
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IF 9.7
Tao Liao,Zhongyin Chen,Ying Kuang,Zhe Ren,Wenqian Yu,Wen Rao,Linwei Li,Yun Liu,Ziqiang Xu,Bingbing Jiang,Cao Li
As a controllable, simple method with few side effects, near-infrared (NIR) light-based photothermal therapy (PTT) has been proven an effective cancer therapeutic approach. However, PTT-induced inflammation is a potential negative factor. And the overexpressed heat shock proteins (HSPs) by cancer cells can protect them from hyperthermia during PTT. In this work, small-size Ti 3 C 2 T x MXene nanosheets with high photothermal conversion efficiency in the region of NIR, high cargo loading capability and good free radical scavenging capability were chosen for cancer PTT and anti-inflammation. And (-)-epigallocatechin gallate (EGCG) was applied to form EGCG/Fe metal-polyphenol nanodots on the nanosheets. EGCG being released in acid cancer cells could reduce the expression of HSPs and could be used for anti-inflammation. As a result, the complex nanosheets named MXene@EGCG could achieve enhanced cancer PTT and be anti-inflammatory. Both in vitro and in vivo studies proved the good photothermal ability of MXene@EGCG and demonstrated that it could inhibit the expression of HSPs in tumor cells and relieve PTT-induced inflammation. Therefore, the nanosheets show good results in tumor ablation with a low level of inflammation, which provides another possibility for cancer therapy. Statement of significance Photothermal therapy (PTT)-induced inflammation plays an essential role in some important stages of tumor development and is unfavorable for cancer treatment. And hyperthermia leads to the overexpression of heat shock proteins (HSPs) in cancer cells, which limits the therapeutic effect of PTT. Therefore, we coated small-size Ti 3 C 2 T x MXene nanosheets with (-)-epigallocatechin gallate (EGCG)/Fe metal-polyphenol nanodots and named them as MXene@EGCG. This system shows a good photothermal conversion efficiency at 808 nm. And it can release EGCG in cancer cells to inhibit the expression of HSPs, thus achieving an enhanced cancer PTT. Both MXene and EGCG can also diminish the PTT-trigged inflammation. Both in vitro and in vivo studies prove the good anti-cancer PTT effect and anti-inflammation capability of MXene@EGCG.
研究领域:
生物医学工程
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纳米技术
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癌症治疗
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药学
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2023
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IF 11.9
Lin Li,Fenglian Qi,Jiong Guo,Jing Fan,Wenxiang Zheng,MURTAZA GHULAM,Weizhi Wang,Zihui Meng,Lili Qiu
Plasmonic nanostructures have attracted extensive attentions for killing cancer cells in photothermal therapy due to their significant absorption activities and photothermal conversion capabilities. However, the development of anisotropic plasmonic nanostructures with tunable near-infrared (NIR) absorptions remains a great challenge. In this study, Fe2O3@Au hexagonal nanodisks (NDs) are prepared by a space-confined growth approach. By choosing the uniform and size-tunable Fe2O3 nanodisks as initial templates, the localized surface plasmon resonance (LSPR) peaks of Au NDs are accurately tuned in the NIR therapeutic window. In addition, by improving the effective photothermal absorption, a high photothermal conversion effect that can exceed 70 °C with 808 nm laser irradiation for 7 min is achieved by 120 nm Fe2O3@Au NDs. We further demonstrate that these Fe2O3@Au NDs simultaneously have both low cytotoxicity and high photothermal therapy (PTT) performance of 89 % cancer cell inactivation rate, which can be employed as photothermal therapeutic agents for effective photothermal therapy for cancer cells. This study will provide new insights into a wide range of applications for designing anisotropic plasmonic structures with LSPR enhancement activities.
研究领域:
纳米技术
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生物医学工程
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癌症治疗
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材料科学
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产品关联
DOI
高影响因子
Polymers
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2020
·Vol. 12
·期 5
·1181
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IF 3.426
Lan Yao,Haihui Li,Kai Tu,Lifen Zhang,Zhenping Cheng,Xiulin Zhu
Polymeric nanomaterials made from amphiphilic block copolymers are increasingly used in the treatment of tumor tissues. In this work, we firstly synthesized the amphiphilic block copolymer PBnMA-b-P(BAPMA-co-PEGMA) via reversible addition-fragmentation chain transfer (RAFT) polymerization using benzyl methacrylate (BnMA), poly (ethylene glycol) methyl ether methacrylate (PEGMA), and 3-((tert-butoxycarbonyl)amino)propyl methacrylate (BAPMA) as the monomers. Subsequently, PBnMA-b-P(APMA-co-PEGMA)@NIR 800 with photothermal conversion property was obtained by deprotection of thetert-butoxycarbonyl (BOC) groups of PBAPMA chains with trifluoroacetic acid (TFA) and post-modification with carboxyl functionalized ketocyanine dye (NIR 800), and it could self-assemble into micelles in CH3OH/water mixed solvent. The NIR photothermal conversion property of the post-modified micelles were investigated. Under irradiation with NIR light (λmax= 810 nm, 0.028 W/cm2) for 1 h, the temperature of the modified micelles aqueous solution increased to 53 °C from 20 °C, which showed the excellent NIR photothermal conversion property.Keywords:amphiphilic block copolymer;self-assembly;NIR photothermal conversion;reversible addition-fragmentation chain transfer (RAFT) polymerization
研究领域:
材料科学
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肿瘤学
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纳米医学
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产品关联
DOI
PubMed
高影响因子
Advanced Science
·
2025
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IF 14.1
Luyue Jiang,Chenguang Ma,Yiping Zhao,Jiazhi Li,Gen Li,Shuang Jin,Haoyang Su,Ye Tian,Yingkang Yang,Yunfu Luo,Lei Huang,Peijie Chen,Yiming Gao,Yi Wei,Yike Xiang,Lunming Qin,Kaihuan Zhang,Yifei Ye,Pengyi Tang,Liuyang Sun
Optoelectronic neuromodulation has transformed neuroscience research and holds great promise for treating neurological disorders. However, conventional optoelectronic methods rely on ultraviolet/visible light, which poorly penetrates tissue and typically necessitates surgically implanted optical fibers for deep-brain stimulation. Here, a heterostructure is presented that integrates near-infrared (NIR)-excitable upconversion nanoparticles (UCNPs) and broadband-absorbing CsPbBr 3 perovskite quantum dots (QDs). This nanostructure converts deeply penetrating 980 nm NIR light into localized electrical stimuli, enabling immediate and precise modulation of neuronal activity without implants. In vitro, NIR illumination of this heterostructure reliably increases the firing rate of wild-type dopaminergic (DA) neurons in acute brain slices. Importantly, in vivo, transcranial NIR stimulation of the heterostructure in the secondary motor cortex (M2) and ventral tegmental area (VTA) modulates neuronal activity, triggers turning behavior, and promotes dopamine release. Moreover, it exhibits negligible neuroinflammation and structural stability in brain tissue over at least four weeks. By integrating a stable heterostructure for efficient NIR-driven photocurrent generation, the method offers a non-genetic, minimally invasive platform for precise neuromodulation in wild-type animals.
研究领域:
神经科学
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生物医学工程
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纳米技术
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光电学
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神经工程
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DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
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2020
·Vol. 55
·期 24
·10435-10452
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IF 3.553
Zhang Kailian,Zhou Man,Yu Changlin,Yang Kai,Li Xiaoxiao,Yang Shi,Guan Jie,Dai Wenxin,Huang Weiya
Wide spectral responsive photocatalysts are of great importance for making full use of solar energy and broad application in highly efficient photocatalytic wastewater treatment, production of H 2 O 2 , etc. Thereinto, it is significative to open an appropriate way to extend the absorption to the NIR region, in which it accounts for ~ 49% in the solar spectrum. In this work, we synthesized successfully the new-style NaYF 4 :Yb 3+ , Er 3+ /Ag 2 CrO 4 photocatalyst via the hydrothermal and followed precipitation method, and it exhibited the more excellent photocatalytic performances than Ag 2 CrO 4 for the photocatalytic H 2 O 2 production and disposals of pollutants, such as methyl orange (MO), methylene blue (MB), rhodamine B (RhB) and tetracycline (TCs). The morphological, structural and optical behavior were investigated by XRD, SEM, N 2 adsorption/desorption, TEM, XPS, UV–Vis DRS, UC luminescence and photoelectrochemical experiments. It revealed that NaYF 4 :Yb 3+ , Er 3+ /Ag 2 CrO 4 photocatalyst presented stronger absorptive capacity in the visible–NIR region by the benign fluorescence resonance energy transfer (NaYF 4 :Yb 3+ , Er 3+ can convert near-infrared light to visible light via upconversion process), and showed more efficient charge transfer and separation than that of pure Ag 2 CrO 4 . The primary reactive species of ·O 2 − and h + by the trapping experiments played a considerable important role in the photocatalytic process. A promising potent system was suggested for the highly efficient utilization of sunlight in the enhancement of photocatalytic activities.
研究领域:
材料科学
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环境科学
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光化学
·
太阳能利用
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DOI
高影响因子
Theranostics
·
2022
·
IF 11.6
Yong Qian,Jiahui Zhang,Jinglu Zou,Xingyu Wang,Xiangfu Meng,Hongji Liu,Yefeng Lin,Qianwang Chen,Lei Sun,Wenchu Lin,Hui Wang
Rationale: All kinds of non-metal and metal-based nanozymes have been extensively explored as Fenton agents for Chemodynamic therapy (CDT). However, the low catalytic efficiency of non-metallic nanozymes and the susceptibility to oxidation and long-term toxicity of metallo-nanozymes limit their potential in CDT. Methods: In this study, we report a magneto-solvothermal method to tune the crystallinity and shape of polyethylene glycol (PEG)-ylated urchin-like nickel nanoclusters (named as 9T-PUNNC) at a high magnetic field with an intensity of 9 T for enhanced combined photothermal-chemodynamic therapy. Results: The needle-like protrusions on the surface of 9T-PUNNC can effectively increase the reception of NIR light in second NIR window (NIR-II) and transform it into local hyperthermia, achieving effective photothermal treatment. The light and heat generated by NIR-II further promotes the release of Ni 2+ and improves the ability of Ni 2+ -mediated chemodynamic therapy (CDT). In addition, the surface coating of PEG on the surface of 9T-PUNNC improves its stability and biocompatibility of nanocrystals. In vitro and in vivo results indicate that the 9T-PUNNC could efficiently kill tumor cells (nearly 12 times more than control group) and inhibit tumor growth (nearly 9 times smaller than control group) under NIR-II irradiation through the synergistic effect of combined treatments. Conclusions: we developed a novel synthetic strategy to tune crystallinity and shape of PUNNC for enhanced NIR-II responsive photothermal conversion efficiency and accelerated acid-induced dissolution for improved ·OH generation. Such 9T-PUNNC enable a combined chemodynamic-photothermal treatment to provide superior therapeutic efficacy due to their highly synergistic effect.
研究领域:
生物医学工程
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纳米医学
·
肿瘤治疗
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DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2026
·
IF 11
Lei Chen,Jianwen Song,Zhenya Shen,Ji Qi
Occlusive thrombi within blood vessels are a primary cause of life-threatening cardiovascular diseases, which continue to pose significant global health challenges. Here, we report a polymer nanoplatform that integrates near-infrared II (NIR-II) light-triggered photothermal thrombolysis with intrinsic antithrombotic functionality. A novel semiconducting polymer, featuring intense NIR-II absorption and exceptionally high photothermal conversion, is rationally engineered to enable rapid and localized light-to-heat thrombolysis. A thermosensitive hydrogen sulfide (H 2 S) donor is also incorporated, generating multifunctional “nanosweepers” that combine synergistic photothermal and gas-mediated thrombolytic activity. The formulation is further functionalized with bis-serotonin groups, which confer myeloperoxidase- and hydrogen peroxide-responsive thrombus-targeting capability, ensuring selective accumulation and site-specific therapy. This agent possesses robust NIR-II absorption, high photothermal conversion efficiency (77.2%), and pronounced thrombus-specific enrichment. Importantly, the combination of localized photothermal heating and on-demand H 2 S release enable rapid, near-complete thrombolysis in both carotid and lower-limb arterial thrombosis models, achieving almost full restoration of blood flow. This work establishes a versatile and highly efficient strategy that integrates precise NIR-II photothermal conversion with H 2 S-mediated redox regulation, providing a promising platform for site-specific multimodal synergistic treatment of life-threatening thrombotic disorders. The findings offer new insights into the design of multifunctional, precision therapeutics for vascular disease management.
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF LUMINESCENCE
·
2022
·
IF 4.171
Lin Xiang,Xianju Zhou,Yongjie Wang,Li Li,Sha Jiang,Guotao Xiang,Chuan Jing,Jingfang Li,Lu Yao
Near infrared (NIR) light emitting phosphors have attracted more and more attention with the development of science and technology . Herein, we report a series of environmentally-friendly low-cost Fe 3+ -activated ZnGa 2 O 4 phosphors which exhibit intense broadband NIR light emitting. According to density functional theory (DFT) calculations, ZnGa 2 O 4 host possesses an indirect wide bandgap. The emission of the Fe 3+ -doped phosphors demonstrates a wide band spanning from 650 to 850 nm, with the maximum at 720 nm and a full width at half maxima (FWHM) of 70 nm, showing a large overlap with the absorption of phytochromes (PR and PFR). The luminescence intensity remains at 71% when the temperature is raised to 423 K. The phosphors are fabricated into light emitting diodes (LEDs) which produces strong NIR emission with CIE color coordinates of (0.65, 0.31). All these results suggest that ZnGa 2 O 4 :Fe 3+ is a promising NIR luminescent material , which is expected to be a candidate for indoor plant culture LEDs.
研究领域:
材料科学
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光电子学
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农业生物技术
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固体物理
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无机化学
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DOI
高影响因子
Journal of Materials Chemistry C
·
2024
·Vol. 12
·期 30
·11386-11393
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IF 5.7
Xinyao Dong,Na Zhou,Minfeng Tian,Yanan Ji,Jingxuan Wang,Jianing Fan,Heyang Li,Wen Xu,Ping Duan,Xiumei Yin
Rare-earth doped oxysulfides have gained considerable attention as a luminescence host material owing to its good chemical stability and high efficiency. In this study, Er3+-sensitized La2O2S nanoparticles are prepared by the high-temperature co-precipitation method. La2O2S:2%Er3+ is selected to construct La2O2S:Er3+@La2O2S core/shell structures through epitaxial growth, and the luminescence properties are studied. The surface defects of La2O2S:Er3+ are repaired by the inert protective shell, and the luminescence intensity of the core/shell nanocrystals is increased by 9.6 times. Finally, MAPbI3 is spin-coated over the La2O2S:Er3+@La2O2S film to construct narrow band near-infrared photodetectors. Under 1550 nm excitation, the response rate is 23 mA W−1, detection rate is 2.57 × 108 Jones, and response time is 220 ms.
研究领域:
材料科学
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纳米技术
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光电子学
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光子学
·
稀土掺杂
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）