CHEMISTRY-A EUROPEAN JOURNAL
·
2012
·Vol. 18
·期 49
·15676-15682
·
IF 5.925
Xiao-Jiao Kang,Yun-Lu Dai,Ping-An Ma,Dong-Mei Yang,Chun-Xia Li,Zhi-Yao Hou,Zi-Yong Cheng,Jun Lin
Graphical Dual response : Monodisperse poly(acrylic acid)-modified Fe 3 O 4 (PAA@Fe 3 O 4 ) hybrid microspheres with dual responses (magnetic field and pH) were successfully fabricated (see figure). The drug release behavior was strongly dependent on pH value due to the unique properties of PAA. Furthermore, doxorubicin (DOX)-loaded PAA@Fe 3 O 4 composites show an enhanced magnetically guided anticancer effect. Monodisperse poly(acrylic acid)-modified Fe 3 O 4 (PAA@Fe 3 O 4 ) hybrid microspheres with dual responses (magnetic field and pH) were successfully fabricated. The PAA polymer was encapsulated into the inner cavity of Fe 3 O 4 hollow spheres by a vacuum-casting route and photo-initiated polymerization. TEM images show that the samples consist of monodisperse porous spheres with a diameter around 200 nm. The Fe 3 O 4 spheres, after modification with the PAA polymer, still possess enough space to hold guest molecules. We selected doxorubicin (DOX) as a model drug to investigate the drug loading and release behavior of as-prepared composites. The release of DOX molecules was strongly dependent on the pH value due to the unique property of PAA. The HeLa cell-uptake process of DOX-loaded PAA@Fe 3 O 4 was observed by confocal laser scanning microscopy (CLSM). After being incubated with HeLa cells under magnet magnetically guided conditions, the cytotoxtic effects of DOX-loaded PAA@Fe 3 O 4 increased. These results indicate that pH-responsive magnetic PAA@Fe 3 O 4 spheres have the potential to be used as anticancer drug carriers.
研究领域:
材料科学
·
生物医学工程
·
药学
✓ 已验证
DOI
高影响因子
SENSORS
·
2017
·Vol. 17
·期 6
·1316
·
IF 2.677
Zike Jiang,Xinsheng Yu,Yingyan Hao
This paper presents a simple, high resolution imaging approach utilizing ratiometric planar optode for simultaneous measurement of dissolved oxygen (DO) and pH. The planar optode comprises a plastic optical film coated with oxygen indicator Platinum(II) octaethylporphyrin (PtOEP) and reference quantum dots (QDs) embedded in polystyrene (PS), pH indicator 5-Hexadecanoylamino-fluorescein (5-Fluorescein) embedded in Hydromed D4 matrix. The indicator and reference dyes are excited by utilizing an LED (Light Emitting Diode) source with a central wavelength of 405 nm, the emission respectively matches the different channels (red, green, and blue) of a 3CCD camera after eliminating the excitation source by utilizing the color filter. The result shows that there is low cross-sensitivity between the two analytes dissolved oxygen and pH, and it shows good performance in the dynamic response ranges of 0–12 mg/L and a dynamic range of pH 6−8. The optode has been tested with regard to the response times, accuracy, photostability and stability. The applied experiment for detecting pH/Oxygen of sea-water under the influence of the rain drops is demonstrated. It is shown that the planar optode measuring system provides a simple method with low cross-talk for pH/Oxygen imaging in aqueous applications.
研究领域:
生物化学
·
环境科学
·
分析化学
✓ 已验证
DOI
高影响因子
MACROMOLECULAR RAPID COMMUNICATIONS
·
2015
·Vol. 36
·期 6
·533-537
·
IF 4.941
Hao Meng,Jing Zheng,Xiufang Wen,Zhiqi Cai,Jiawei Zhang,Tao Chen
A simple strategy is provided to construct a novel pH- and sugar-induced shape memory hydrogel based on dynamic phenylboronic acid (PBA)–diol interactions formed by PBA-modified sodium alginate (Alg-PBA) and poly(vinyl alcohol) (PVA). The dynamic PBA–diol ester bonds serve as temporary cross-links and stabilize the deformed shape of the hydrogel. The disassociation of the PBA–diol ester bonds is explored in acidic conditions and aqueous solutions of glucose and fructose, which endow the hydrogel with shape memory performances.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Biomaterials Science & Engineering
·
2015
·
IF 0
Qiu Li,Yiguang Jin,Miao Li,Jun-Xing Dong
Tumor targeting and controlled drug release at the target are the key problems for cancer pharmacotherapy. A simply structured pH-responsive nanocarrier was prepared to achieve the above aims in this study. A four-armed star copolymer, tetra-(methoxy-poly(ethylene glycol)-poly(2-(N,N-diethylamino)ethyl methacrylate)-poly(ε-caprolactone) pentaerythritol ((mPEG-pDEA-PCL)4-PET, PDCP), was synthesized via the ring-opening polymerization, atom transfer radical polymerization and click chemistry, which formed a monomolecular nanocarrier in water. Its size and zeta potential were strongly pH-dependent from 71 nm and 2.1 mV at pH 8 to 127.5 nm and 25.4 mV at pH 5. The morphological change of pDEA chains was the basic reason. The chains were protonated at lower pH so as to freely extend to the aqueous media, though they were hydrophobic at higher pH to coat on the surface of hydrophobic cores. The star-shaped PDCP had a large hydrophobic core to load hydrophobic drugs (e.g., paclitaxel). High effective drug entrapment in the blood circulation and rapid drug release at the tumor tissues was achieved in PDCP due to its pH-responsive function. The MCF-7 cytotoxicity of the paclitaxel-loaded PDCP nanocarriers at pH 6.5 was similar to free paclitaxel. And the PDCP nanocarriers were well internalized by the MCF-7 cells according to the flow cytometry and laser confocal microscopy. The paclitaxel-loaded PDCP nanocarriers showed the comparable in vivo anticancer effect to the paclitaxel solution (Taxol) although the former’s toxicity was much lower than the latter. The star-shaped pH-responsive monomolecular PDCP nanocarriers are suitable to deliver hydrophobic anticancer drugs for cancer therapy with tumor targeting and controlled drug release.
研究领域:
药学
·
生物医学工程
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
JOURNAL OF MATERIALS SCIENCE
·
2019
·Vol. 54
·期 7
·5695-5711
·
IF 3.442
Qin Jiejie,Huang Yan,Yan Guoqing,Wang Jun,Hu Liefeng,Zhang Panpan,Tang Rupei
In this work, the tumor-targeted ultra-pH-responsive conjugates (PBA/Dex-g-OE) and nontargeted conjugates (Dex-g-OE) were successfully prepared and could easily self-assemble into stable micelles with lower CMC values in neutral aqueous solution. Transmission electron microscopy and dynamic light scattering measurement indicated that the resulting micelles have desirable size distribution and regular spherical shape. The PBA/Dex-g-OE micelles possessed high stability in physiological condition and were pH sensitive to both extracellular and intracellular acidic conditions. Doxorubicin (DOX) was efficiently loaded to give the DOX-loaded micelles (PBA/Dex-g-OE-DOX and Dex-g-OE-DOX) with the desirable drug loading contents. In vitro cellular uptake and growth inhibition assays suggested that PBA/Dex-g-OE-DOX micelles were more efficiently internalized by monolayer tumor cells and three-dimensional multicellular tumor spheroids (MCTS) than nontargeted micelles (Dex-g-OE-DOX), leading to the fast and complete destruction of MCTS in vitro.
研究领域:
药剂学
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
GREEN CHEMISTRY
·
2025
·
IF 9.2
ZhiWei Dong,YaLing Jia,Zeyu Wang,Antony Rajendran,Wen-Ying Li
Electrocatalytic CO2 reduction to formic acid is a promising strategy to obtain value-added chemicals and achieve the carbon cycle. However, its practical application is generally impeded by the limited accessibility of CO2 to the catalyst's surface and the lack of efficient universal catalyst across different pH levels. Herein, we report a new catalyst, i.e., SnS2 decorated with hydrophobic polymer polyvinylidene fluoride (SnS2+PVDF), for the effective electrocatalytic CO2 reduction to formate/formic acid across a wide pH range in a flow cell. This catalytic system accomplishes a remarkable Faradaic efficiency for the formic acid production in alkaline (98%), neutral (86%), and acidic (93%) electrolytes. Also, the single-pass carbon efficiency reaches up to 72.77% in acidic electrolyte. Water contact angle measurements in association with the in-situ attenuated total reflectance surface-enhanced infrared absorption spectroscopy results indicate that the inclusion of PVDF creates a hydrophobic microenvironment which increases the CO2/H2O ratio near the surface of SnS2 particles. As a consequence, SnS2 particles enjoy the enhanced CO2 concentration around their surface to form many three-phase (solid-liquid-gas) boundary. In-situ Raman spectra combined with electrocatalytic studies reveal that SnS2 undergoes reconstitution to form catalytically active Sn/SnS2 during the reaction. These findings ensure and expand the generality of hydrophobic microenvironment regulation strategy in promoting electrocatalytic CO2 reduction to formic acid.
研究领域:
化学
·
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2024
·
IF 6.1
Wenxue Li,Siyuan Chen,Shiwang Xie,Xianmao Lu,Zhou Li,Yujia Lv,Dan Luo
Bacteriorhodopsin is a biological material with excellent photosensitivity properties. It can directly convert optical signals into electrical signals and is widely used in various biosensors. Here, we present a bR-based wearable pH biometer that can be used to monitor wound infection. The mechanism of the pH-sensitive effect of the bR electrode is explained, which generates a transient photovoltage under light irradiation and a negative photovoltage when the lamp is turned off. Since the photoelectric signal of bR is affected by different pH values, the photovoltage is changed by adjusting the pH value. The ratio (Vn/Vp) of negative photovoltage (Vn) to positive photovoltage (Vp) has a good linear relationship (R2 = 0.9911) in the pH range of 4.0–10.0. In vitro experiments using rats as a model confirmed that this wearable pH biometer can monitor pH changes that occur in wound infection.
研究领域:
生物技术
·
生物工程
·
传感器
·
医疗器械
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
·
2024
·
IF 5.6
Yongkang Zhang,Heyi Xia,Qiaochu Yang,Zhiyuan Xu,Wenbo Wang,Ziyu Yuan,Zesen Li,Shifang Cao,Bai-Ou Guan,Ling Qiu,Yang Ran
Hydrovoltaic is an emerging technology that aims to harvest energy from water flow and evaporation, in which the plasmonic hydrogen ions are generated by the interaction between water and hydrovoltaic device. However, the volume of the water sample for the interaction is usually ultra-small due to the compact size of hydrovoltaic device, making the quantification and characterization of the hydrogen ions in such water sample an elusive goal. To address this issue, a miniature fiber-optic pH probe is proposed using a unilaterally tapered-microfiber Bragg grating. The microfiber Bragg grating has an intrinsic Bragg reflection signal with a narrow linewidth. The fiber probe is functionalized by coating the sodium alginate, which can respond to the variation of pH mediated by the alteration of the hydrophilicity. The rigidity and robustness of microfiber Bragg grating facilitates the encapsulation of the sensor into a sampling capillary, allowing for the detection of trace aqueous sample less than 2 μL. The pH sensitivity of the tapered-μFBG-based sensor is 62.8 p.m./pH (R 2 = 0.995) with a limit resolution of 0.096 pH. The sensor performed a practical application in the monitoring and characterization of the hydrovoltaic microdevice, which can generate microcurrent as soaked in the water. This work demonstrates a promising technology in the fields of materials, energy, biology and medicine, in which the detection of the microsamples is inevitable.
研究领域:
材料科学
·
能源技术
·
生物学
·
医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2024
·Vol. 16
·期 21
·10448-10457
·
IF 5.8
Feng Yang,Shiwen Gong,Die Hu,Lihua Chen,Wenyuan Wang,Bo Cheng,Jing Yang,Binbin Li,Xinyu Wang
With continuous advances in medical technology, non-invasive embolization has emerged as a minimally invasive treatment, offering new possibilities in cancer therapy. Fluorescent labeling can achieve visualization of therapeutic agents in vivo, providing technical support for precise treatment. This paper introduces a novel in situ non-invasive embolization composite material, Au NPs@(mPEG-PLGTs), created through the electrostatic combination of L-cysteine-modified gold nanoparticles (Au NPs) and methoxy polyethylene glycol amine-poly[(L-glutamic acid)-(L-tyrosine)] (mPEG-PLGTs). Experiments were undertaken to confirm the biocompatibility, degradability, stability and performance of this tumor therapy. The research results demonstrated a reduction in tumor size as early as the fifth day after the initial injection, with a significant 90% shrinkage in tumor volume observed after a 20-day treatment cycle, successfully inhibiting tumor growth and exhibiting excellent anti-tumor effects. Utilizing near-infrared in vivo imaging, Au NPs@(mPEG-PLGTs) displayed effective fluorescence tracking within the bodies of nude BALB-c mice. This study provides a novel direction for the further development and innovation of in situ non-invasive embolization in the field, highlighting its potential for rapid, significant therapeutic effects with minimal invasiveness and enhanced safety.
研究领域:
生物医学工程
·
癌症治疗
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 94
·91940-91948
·
IF 3.289
Haozhe He,Yanrong Ren,Zhanfeng Wang,Zhigang Xie
An effective strategy was developed to fabricate pH-responsive poly(ether amine) hollow nanoparticles for the controllable loading and release of anticancer drugs. The amphiphilic poly(ether amine) containing coumarin groups (gPEAC) was first synthesized, which was further modified with myristic acid to form comb-like poly(ether amine) (acPEAC). The nanoscale micelles formed by acPEAC in aqueous solution were cross-linked through the photo-dimerization of coumarin groups. Then hollow micelles were obtained by removing their hydrophobic cores of myristic ester. The anticancer drug doxorubicin (DOX) was directly loaded into the micelles without any organic solvent. The DOX-loaded micelles displayed desirable pH-sensitive release behaviours. Moreover, the hollow micelles exhibit great potential for loading drugs and controllable release, and drug-loaded micelles indicate comparable anticancer efficacy as free DOX. This work highlights the potential for the rational design of functional polymers as smart drug carriers.
研究领域:
生物材料学
·
药剂学
·
肿瘤学
✓ 已验证
DOI
高影响因子
Soft Matter
·
2012
·Vol. 8
·期 23
·6364-6370
·
IF 4.39
Fenggui Chen,Chunliang Li,Xiaoyan Wang,Guangming Liu,Guangzhao Zhang
In the present study, by use of the atom transfer radical polymerization (ATRP) method, we have prepared well-defined 6-arm star-shaped poly[2-(dimethylamino)ethyl methacrylate] (PDEM) and poly(acrylic acid) (PAA) containing a fluorescent triphenylene core and have studied the pH and ion-species sensitive fluorescence properties of such two star polyelectrolytes. The results obtained by analytical ultracentrifugation indicate that the star PDEM molecules will aggregate together as the pH increases over the pKa but the star PAA molecules will keep a monomeric state over the whole pH range. For both PDEM and PAA, the fluorescence intensity decreases with increasing pH, indicating that the fluorescence intensities of PDEM and PAA are dominated by aggregation induced fluorescence quenching and the chain conformation controlled nonradiative relaxation, respectively. This suggestion is further confirmed by the fact that the star PDEM molecules can form excimers at high pHs and no excimer emission peak can be observed for the star PAA molecules. In the studies of ion-specific fluorescence properties at different pH, for both of the two polyelectrolytes, the ion specificity is determined by the counterion condensation for the charged chains, whereas nonelectrostatic ion adsorption governs the specific ion effect for the uncharged chains.
研究领域:
高分子化学
·
物理化学
✓ 已验证
DOI
高影响因子
Polymers
·
2025
·Vol. 17
·期 9
·1204
·
IF 4.9
Yi Guo,Cheng Yao
In this study, polymerized silicone surfactants were modified with polyether and tertiary amine groups with the aim of improving the surface performance. Various PSiEO/(PO)-OH(CH3) surfactants were synthesized and their structures and performance were characterized through1H NMR, FTIR spectroscopy, static surface tension, dynamic surface tension, zeta potential, and dynamic light scattering measurements. Subsequently, the modified silicones were incorporated as surfactants in aqueous solutions with different pH values. The surfactants with different hydrophobic/hydrophilic groups and end-capping groups exhibited different surface performances over a wide pH range. Thermodynamic parameters indicated that the micellization and adsorption of these surfactants were endothermic and spontaneous processes driven by entropy. The processes were hindered by increasing the solution pH and modification with hydrophobic groups. The aggregation behavior was significantly different under acidic, neutral, and basic aqueous conditions.
研究领域:
材料科学
·
表面化学
·
物理化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）