PHYTOTHERAPY RESEARCH
·
2025
·
IF 6.3
Xiao-Man Ji,Xin-Xin Dong,Jia-Peng Li,Guang-Jie Tai,Shu Qiu,Wei Wei,Ceaser Wankumbu Silumbwe,Davaadagva Damdinjav,Joseph Nicolao Otieno,Xiao-Xue Li,Ming Xu
Vascular aging is a major contributor to age-related cardiovascular diseases (CVDs) and type 2 diabetes mellitus (T2DM) induced early arterial aging and excessive senescent cells (SCs) burden in vessels. Inhibiting cellular senescence or eliminating SCs could effectively improve aging-related CVDs. Fisetin, a flavonoid extracted from cotinus coggygria scop, has shown potential in alleviating aging by clearing SCs. This study investigated the unexplored mechanisms and efficacy of fisetin in alleviating T2DM-related aortic aging. The T2DM mouse model was induced using a high-fat diet and low-dose streptozotocin injection. Chronic fisetin treatment's protective effects against aortic aging were assessed via senescence-associated beta-galactosidase (SA-β-Gal) staining, histopathology, and vasomotor function. RNA-sequencing and western blotting identified relevant signaling pathways and protein expression. Fisetin's effects on SCs and senescence-associated secretory phenotype (SASP) factors were evaluated through cell viability, apoptosis, and co-culture assays. Docking simulations suggested fisetin as a potential Phosphoinositide 3-kinase (Pi3k) inhibitor. In vivo, chronic fisetin treatment reduced aortic SCs burden, alleviating T2DM-related and natural aortic aging. In vitro, fisetin selectively induced apoptosis of senescent endothelial cells via regulating the Pi3k-Protein Kinase B (Akt)-B-cell lymphoma (Bcl)-2/Bcl-xl pathway and suppressed SASP and its detrimental effects. Furthermore, fisetin combined with metformin therapy showed superior anti-aging effects on T2DM-related aortic aging compared to metformin monotherapy. In conclusion, chronic fisetin treatment alleviates T2DM-related aortic aging via clearing the SCs burden and abrogating the SASP factors. Fisetin combined with metformin therapy might be a potential therapeutic strategy for T2DM-related CVDs.
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ENVIRONMENTAL POLLUTION
·
2025
·
IF 7.3
Qian Wang,Tao Zhang,Xuemei Liu,Shuo Liu,Xinyue Wang,Xiaoming Wang
Although 6:2 fluorotelomer alcohol (6:2 FTOH) is a common compound in landfill leachate, its anaerobic biotransformation and partitioning remain poorly understood. This study investigated the anaerobic biotransformation and partitioning of 6:2 FTOH in landfill leachate microcosms. At the end of the experiment, 19.4 mol% of the initial 6:2 FTOH partitioned into the gas phase. Therefore, anaerobic leachate could represent a significant pathway for semi-volatile 6:2 FTOH to the landfill gas or enter the atmosphere. The anaerobic biotransformation of 6:2 FTOH in leachate conformed to the first-order bi-exponential degradation model and the half-life was 12 days. The 6:2 fluorotelomer carboxylic acid (6:2 FTCA) was the main biotransformation product, accounting for 8 mol%. Moreover, microbial community composition showed the genus of Pseudomonas, DMER64, and Fastidiosipila may play a role in the biotransformation of 6:2 FTOH. This study elucidates the potential significance of biotransformation processes on both the partitioning and environmental fate of 6:2 FTOH within landfill leachate.
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ENERGY
·
2025
·
IF 9.4
Qi Zhou,Liu Wu,Jingyue Wang,Jie Liang
Lignin, with its complex structure and high stability, poses a significant challenge in the directed depolymerization to obtain aromatic-rich bio-oil. To prevent the formation of hard-shelled char resulting from the melting and agglomeration of lignin during pyrolysis, this study proposed a dual strategy combining Ca(OH) 2 pretreatment and Beta zeolite, which demonstrated a synergistic effect through β-O-4 bond cleavage, effectively suppressing lignin condensation while achieving high aromatic selectivity. In this study, the influence of various operational parameters was examined. Key variables including pretreatment procedures, concentration levels, catalyst selection, catalyst-to-raw material ratio, carrier gas velocity, and pyrolysis thermal conditions were analyzed to determine their effects on the critical processes. Pretreatment with 5 wt% Ca(OH) 2 significantly reduced lignin agglomeration during pyrolysis. Using Beta zeolite (1:1 mass ratio) in CFP at 500 °C with 75 mL/min carrier gas flow increased bio-oil yield from 5.0 wt% to 7.5 wt% and enhanced aromatic selectivity from 1.9 area% to 84.9 area%. Using 2-phenoxy-1-phenylethanol (α-OH-PPE) as a model compound, we found Ca(OH) 2 pretreatment and Beta zeolite together enhanced β-O-4 bond cleavage in lignin. This synergistic approach facilitated efficient bond cleavage and showed remarkable effectiveness in aromatic production.
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ANALYTICA CHIMICA ACTA
·
2019
·
IF 5.256
Feng Zhang,Mengke Wang,Lili Zhang,Xingguang Su
Herein, we developed a novel and sensitive ratiometric fluorescence strategy for pH sensing and urea detection based on MoS 2 quantum dots (MQDs) and 2, 3-diaminophenazine (DAP). The DAP was pH-sensitive and can be used as pH indicator while MQDs was pH-insensitive and acted as a reference fluorescent signal. The fluorescence intensity of DAP at 568 nm exhibited increases gradually while the fluorescence intensity of MQDs at 420 nm kept unchanged as the pH changed from 3.0 to 9.0. So the ratio of the two fluorescence intensities at 568 nm and 420 nm can be used to monitor the change of pH. The pH-sensing system showed a linear and reversible respond to pH in the range of 3.8–6.0 with an interval of 0.2 pH unit. Furthermore, the enzymatic reaction of urea in the presence of urease can lead to the pH increase of the solution, which can be used to detect urea by using the above-mentioned pH-sensing system. There exhibited a good linear relationship between the ratiometric fluorescence intensity of I 568 /I 420 and urea concentrations ranging from 5 to 700 μM. And a low detection limit of 1.8 μM was obtained. The proposed strategy exhibited excellent selectivity and sensitivity. Additionally, the developed ratiometric fluorescence strategy was successfully applied to detect urea in water samples.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Jingru Huang,Haiyan Zhao,Na Li,Min Cui,Cong Zhang
Sunset yellow(SY) is a synthetic azo food dye, which is extensively utilized in the food processing industry. Nevertheless, its potential detrimental impacts on human health necessitate meticulous consideration. Consequently, the development of a user-friendly and rapidly responsive assay for the monitoring and analysis of SY in food products is of utmost importance. This study introduces an innovative electrochemical sensor based on polyoxometalates decorated with polypyrrole and multi-walled carbon nanotubes [Co 4 (PW 9 O 34 ) 2 @PPy-MWCNTs] for SY detection. The Co 4 (PW 9 O 34 ) 2 composite was prepared by using the nitrogen-containing ligand (1,4-bis (1-imidazolyl) butane) and the conductive polypyrrole was coated on Co 4 (PW 9 O 34 ) 2 , which avoided the solution of polyoxometalates in the electrolyte and improved the electrochemical stability. Multi-walled carbon nanotubes was employed to further enhance electron transfer rate. Research has shown that Co 4 (PW 9 O 34 ) 2 @PPy-MWCNTs exhibits superior electron transfer rates and remarkable electrocatalytic activity, which significantly amplify the oxidation signal of SY. Under optimal experimental conditions, the established detection range for SY is 10–1150 μM, with a detection limit of 0.425 μM. Additionally, the Co 4 (PW 9 O 34 ) 2 @PPy-MWCNTs modified electrode has good anti-interference and stability. The Co 4 (PW 9 O 34 ) 2 @PPy-MWCNTs modified electrode was successfully applied to detect SY in Fanta with yielding recovery rates between 97.79 % and 101.48 %, demonstrating substantial application potential as an effective means for SY detection.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Jinglong Fan,Xiangyu Meng,Qinghu Guo,Zhonghua Yao,Hanxing Liu,Hua Hao
The development of piezoelectric ceramics combining high piezoelectric response with excellent temperature stability has become increasingly crucial for advanced applications. In this work, the relaxor ferroelectric Pb(In 1/2 Nb 1/2 )O 3 was incorporated into BiScO 3 -PbTiO 3 system and successfully synthesized as 0.05Pb(In 1/2 Nb 1/2 )O 3 -(0.95- x )BiScO 3 - x PbTiO 3 (PIN-BS- x PT) ceramics by the conventional solid-state reaction. Systematic characterization of phase structure, microstructure and electrical properties reveals the formation of a morphotropic phase boundary at x = 0.59, which exhibits optimal electromechanical properties with piezoelectric coefficient d 33 = 522 pC/ N, Curie temperature T C = 402 °C and planar electromechanical coupling coefficient k p = 0.56. Remarkably, the PIN-BS-0.59PT ceramic demonstrates remarkable performance stability, achieving both high strain response (0.12 % at 20 kV/cm) and minimal temperature-dependent variation (13.5 % between 30 and 200 °C). Furthermore, the PIN-BS-0.59PT ceramic retains ～90 % of its initial d 33 value after annealing at 300 °C, demonstrating exceptional thermal depolarization resistance. These findings position PIN-BS- x PT ceramics as promising candidates for high-temperature piezoelectric applications.
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ACS Applied Nano Materials
·
2025
·
IF 5.5
Bojun Zhang,Mingliang Zhang,Sinong Wang,Jinchan Zhao,Zhenyu Dai,Yizhuo Li,Shiliang Mei,Wanlu Zhang,Ruiqian Guo
Paper-based cultural relics possess great historical and cultural value but are vulnerable to irreversible degradation from high-energy ultraviolet (UV) light exposure and acidification, threatening their long-term preservation. Current paper protection predominantly relies on exogenous materials with single functions, which not only provide limited protective effects but also pose a risk of secondary damage. In this study, we developed a Dual-Functional paper by directly integrating a carbon quantum dot–magnesium hydroxide (CQDs@Mg(OH)2) nanocomposite into the papermaking process, thereby endowing the paper with intrinsic resistance to both acidification and UV-induced photodegradation, which reduces the reliance on subsequent protective treatments and fundamentally enhances the paper’s longevity. The results demonstrate that the functional paper integrated with CQDs@Mg(OH)2 nanocomposites shows good structural compatibility and strong resistance to degradation. Under the conditions of both UV exposure and dry-heat aging, the functional paper demonstrates excellent resistance to photooxidative and acid-induced degradation, indicating its strong potential for extending the longevity of paper-based materials. Additionally, the fluorescent properties of CQDs reveal promising potential as optical anticounterfeiting markers. This work opens an avenue for the design of long-lasting functional paper enabled by carbon-based materials, with promising applications in the preservation of paper-based cultural heritage.
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ACS Catalysis
·
2024
·
IF 11.3
Jiafu Li,Yanran Feng,Xingyun Li,Tianjun Zhang,Xia Liu,Ning Wang,Qiming Sun
Ultrafine metal alloy nanoparticles are emerging as highly effective catalysts for the generation of hydrogen from ammonia borane (AB) hydrolysis. The fabrication of multimetallic alloys with high activity, stability, and metal utilization remains the biggest challenge. Herein, sub-2 nm ternary Rh–Ru–Ni alloys were encapsulated within the interlayers of layer-stripped montmorillonite (MMT) via a simple impregnation method. Experiment and theory results revealed that the synergistic effect of the trimetallic alloy significantly lowers the energy barrier for the AB hydrolysis reaction, by boosting the adsorption and O–H dissociation of H2O molecules. The optimized Rh0.8Ru0.2Ni0.25@MMT-S catalyst achieves high turnover frequency values of 2961 and 784 min–1 at 298 and 273 K, respectively, as well as high recycling stability and thermal resistance. Moreover, the encapsulation method has versatility and can be also applied to synthesize ultrafine Pt- and Ir-based nanoparticles. This study not only highlights the role of the synergistic effect in trimetallic alloys for improving hydrogen evolution but also offers a route to design highly efficient and stable metal nanocatalysts for other applications.
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INORGANIC CHEMISTRY
·
2025
·
IF 4.7
Weishun Jian,Xinyu Hu,Jinqiang Gao,Jingyao Zeng,Yu Mei,Haoji Wang,Ningyun Hong,Jiangnan Huang,Kai Wang,Wentao Deng,Guoqiang Zou,Hongshuai Hou,Hongyi Chen,Xiaobo Ji
Na4Fe3(PO4)2(P2O7) (NFPP) is a promising cathode material for sodium-ion batteries with cost-effectiveness and structural stability. However, its electrochemical behaviors are seriously hindered by its [P2O7] distortion at high voltage. To address this challenge, we introduce a distortion criterion and optimize the local crystal field environment by incorporating Cr3+ into Fe3 sites adjacent to [P2O7]. This substitution elongates Fe1–O bonds, enhances Fe1 activity, and suppresses [P2O7] distortion, facilitating fast Na+ diffusion and structural reversibility, as validated by X-ray absorption fine structure (XAFS) and density functional theory (DFT) calculations. Based on c-axis changes during high-voltage operation, a quantitative method for assessing [P2O7] distortion is proposed and confirmed by operando X-ray diffraction (XRD). The optimized NFPP-0.15Cr exhibits exceptional rate performance (91.74 mAh g–1 at 50C), long-term cycling stability (88.81% capacity retention after 10,000 cycles at 50C), and wide temperature tolerance (−40 to 60 °C). This study provides a strategic approach for designing high-performance iron-based mixed phosphate cathodes, advancing their practical application in sodium-ion batteries.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2025
·Vol. 26
·期 6
·2727
·
IF 4.9
Kang Li,Xiaomei Ge,Wei Liu,Lei Huang,Xinye Lv,Yuhui Tang,Zhehao He,Yingxue Yang,Miaofen Chen,Jianguo Zeng,Pi Cheng
B-cell lymphoma-2 (Bcl-2) family proteins are fundamental regulators of intrinsic cell apoptosis, and overexpression of apoptotic proteins (Bcl-2 and Mcl-1) is a characteristic of many haematological malignancies. Thus, it is necessary to discover novel inhibitors to treat leukemia. In the current study, we synthesized a series of quercetagetin derivatives (compounds2a–2t,3a–3jand4a–4g) and evaluated their anticancer activities on four leukemia cells (U937, K562, K562R and KG-1). Among those synthesized derivatives, compounds2aexhibited the best antiproliferative activity (IC50= 0.276, 0.159, 0.312 and 0.271 µM to U937, K562, K562R and KG-1, respectively). In addition,2ainduced apoptosis in K562 and markedly arrested the cell cycle G2/M phase of K562. The Western blot assay showed that2ais a potential inhibitor that can effectively suppress the expression of Bcl-2 and Mcl-1. The molecular docking study predicted that2ahad firm interactions with the active pockets of Bcl-2 and Mcl-1. Finally, in silico pharmacokinetic evaluation of2aindicated its potential as an anti-leukemia drug lead in the future.
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BioNanoScience
·
2025
·Vol. 15
·期 2
·1-12
·
IF 3.2
Liang Tisong,Jing Pu
The poor stability of chlorophyll has inhibited its application in food industry. Our previous study showed that the stability of chlorophyll can be enhanced by incorporating with sodium caseinate (NaCas). This present work further explored the characteristics of NaCas–chlorophyll dispersion in simulated gastrointestinal digestion and its inhibitory effects on human epithelial colorectal adenocarcinoma cells (Caco-2 cells). Results indicated that the gastrointestinal digestion resulted in alterations to the physical appearance of the NaCas–chlorophyll dispersion. Fourier-transform infrared spectroscopy illustrated that the second structure of NaCas underwent alterations during gastrointestinal digestion. Morphological observation revealed that the digested NaCas–chlorophyll dispersion exhibited granular morphology with smaller particle size. The Caco-2 cells exposed to digested NaCas–chlorophyll dispersion exhibited decreased viability and destroyed mitochondrial structure, which may be related to the enhanced absorptivity of the NaCas–chlorophyll dispersion following gastrointestinal digestion. These findings provided theoretical basis for understanding the characteristics changes and biological activity of NaCas–chlorophyll dispersion during gastrointestinal digestion.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2025
·Vol. 36
·期 15
·1-12
·
IF 2.8
Li Meiling,Cao Yongze,Cheng Lihong,Fan Yuhan,Wang Yichao,Li Xiangping,Zhang Xizhen,Chen Baojiu
A series of Er 3+ /Yb 3+ co-doped NaY(WO 4 ) 2 (NYWO) phosphors are prepared by molten salt synthesis (MSS) with Na 2 SO 4 as solvent. The holding temperature, holding time, and solvent-to-solute mass ratio parameters are regulated. The structure, morphology, and luminescence properties of the samples were tested by XRD, SEM, and fluorescence spectrometers, respectively. The lamellar sample is prepared at 900℃ for 5 h when solvent-to-solute is 3, which has the highest pure green upconversion luminescence (UCL) intensity under 980 nm laser excitation. It is demonstrated that the UCL intensity of the samples prepared by MSS is higher than that of solid sintered samples. The maximum absolute sensitivity (S A ) and relative sensitivity (S R ) are 0.012184 K⁻ 1 at 507 K and 0.01102 K⁻ 1 at 303 K, respectively. These materials can be used for pure green luminescence displays and temperature sensing.
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