MICROCHIMICA ACTA
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2026
·Vol. 193
·期 4
·262
·
IF 5.4
Sun Guoran,He Jinxing,Yang Rongrong,Han Zhonghui,Zhao Xiaolei
A facile “layer by layer” strategy was used to fabricate core-shell-structured magnetic molecularly imprinted fluorescence encoded microspheres, by integrating a Fe 3 O 4 magnetic core, a ZIF-8 inner-layer, an in-situ grown imprinting shell, and the final encoded quantum dots. This architectural design not only offered the capability of rapid magnetic separation, specific recognition, and sensitive fluorescence response, but also effectively avoided direct contact between the magnetic core and quantum dots, resulting in excellent fluorescence performance. Considering the strong magnetic responsiveness, the obtained microspheres were further employed into magnetic solid phase extraction to selectively capture tetracycline for fluorescence analysis. Under the optimum conditions, the sensor achieved ultra-rapid detection time with 1 min, and exhibited a closely linear relationship (R 2 = 0.9941) in the range 3–200 µg L − 1 with a method detection limit of 3 µg L − 1 . The spiked recoveries ranged from 83.2% to 112.8% in milk, egg, honey, and pork samples, with RSD value < 7.63%. This work offers an ultra-rapid fluorescence analytical strategy with high accuracy, reliability, and anti-interference capability, and could be considered as an ideal alternative for the rapid detection of various trace contaminants.
Section
Graphical
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产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2026
·
IF 18.1
Jiang Qingbin,Xu Huifang,Ye Xinyu,Liu Lingwen,Hui Kwan San,Wu Chao,Gao Kang,Sun Kaitong,Li Haifeng,Zheng Yunshan,Yuan Cheng-zong,Li Zhongliang,Wei Mingdeng,Zha Chenyang,Zeng Jie,Liu Mingkai,Sun Yuanmiao,Cheng Hui-Ming,Hui Kwun Nam
Elucidating the mechanisms governing sulfur redox reactions is important for the development of high-energy-density Li||S batteries. Despite progress, the kinetics of the solid-solid conversion from Li 2 S 2 to Li 2 S remain poorly understood. This work demonstrates that spin-state transitions within reaction intermediates are the key factor of the sluggish kinetics. Guided by density functional theory and machine-learning-assisted catalyst screening, we find a negative correlation between the spin moment of the catalyst and the Gibbs free energy barrier for the Li 2 S 2 to Li 2 S conversion. Among a series of dual-metal doped catalysts, a Co,Ni-doped MoS 2 catalyst, with its high spin moment, modulates the spin states of the reactants, reducing the high free-energy barrier associated with spin-state transitions. Therefore, Li||S batteries incorporating this catalyst show accelerated sulfur conversion, particularly during solid-solid transitions, suppressed polysulfide shuttling, and have stable electrochemical performance. A pouch cell achieves a capacity of 13.2 Ah and a specific energy of 435 Wh kg -1 . These findings show mechanistic understanding into the role of spin moments in sulfur conversion, enabling to design efficient and durable catalysts for Li||S batteries.
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PubMed
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Advanced Fiber Materials
·
2026
·
IF 22.6
Du Xiangheng,Chen Long,Yu Rouhui,Fan Zhongyao,Chen Yaqi,Zhou Tao,Bai Xiaowen,Zhu Meifang,Pan Shaowu
Bioelectronics interface with living systems to capture physiological signals and advance our understanding of health. However, the aqueous and dynamically deforming nature of biological tissues poses significant challenges to the structural stability and long-term reliability of bioelectronic devices, particularly at internal interfaces between dissimilar materials. Here, we report robust and stretchable bioelectronics (RSB) that achieve exceptional aqueous and mechanical stability by introducing a mechanically interlocking interface inspired by traditional wooden mortise–tenon structures. In the RSB, conductive poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) is integrated with fibrous network-decorated elastomeric matrices via spin coating and laser-induced phase separation. As a result, the bioelectronics maintain conductivity under tensile strains exceeding 100% and stable impedance after continuous immersion in phosphate-buffered saline (PBS) for over 30 days. Moreover, the RSB enables high-fidelity electrocardiogram (ECG) monitoring and electrical stimulation-mediated restoration of normal sinus rhythm in rat models. Beyond biological systems, the bioelectronics can be integrated onto robotic fingertips, establishing a paradigm for robot-assisted acquisition of physiological signals through direct human–robot contact. The flexible interlocking interface provides a versatile platform for robust, stretchable, and long-lasting bioelectronic systems across biological and robotic interfaces. Graphical abstract
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Food and Bioprocess Technology
·
2026
·Vol. 19
·期 10
·516
·
IF 5.6
Wang Shaojun,Cao Huaqiang,Ao Sha,Li Yan,Liu Shilin
Lycopene is a naturally occurring lipophilic carotenoid. However, its practical application is severely limited by its poor water solubility and high chemical instability. This study was aimed to develop a high-loading lycopene microcapsule formulation through firstly improving lycopene solubilization by using a hydrophobic natural deep eutectic solvent (NADES) and then enhancing its stability through spray drying microencapsulation. Under thermal–ultrasonic treatment, the optimized NADES was achieved a maximum process-assisted lycopene loading capacity of 30 mg/g. Furthermore, under heating at 80 °C for 8 h, lycopene retention in the microcapsules was 56.53%, compared with 8.27% in the corresponding free solution. Microencapsulation significantly improved the stability of highly loaded lycopene. During 4 weeks of storage at 25 °C, the microcapsules retained 76.31% of the lycopene, while it was almost completely degraded in the free solution (0.48%). Importantly, antioxidant activity was well retained after encapsulation, with DPPH inhibition values of 66.92% (free) and 62.54% (encapsulated). These findings suggested that NADES-based enrichment enabled high lycopene loading, and it would provide effective protection against degradation during processing and storage. Graphical
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BMC Oral Health
·
2026
·
IF 3.8
Tian Jingyu,Chen Lijuan,Yang Yuanyuan,Ding Yu,Meng Jian,Meng Qingfei,Lyons Karl,Mei May Lei
Background To evaluate the effect of the combined use of resin infiltration and the subsequent bioactive glass (BAG) remineralization, with or without 5.25% sodium hypochlorite (NaOCl) pretreatment, on the surface properties of artificial enamel white spot lesions (WSLs) under toothbrushing cycles. Methods One hundred and twelve enamel blocks (4 mm × 4 mm × 2 mm) were cut from the buccal surfaces of the intact human premolars and demineralized to establish artificial enamel WSLs. All enamel blocks were then randomly allocated into four groups: RI/FF, resin infiltration + fluoride-free toothpaste suspension; RI/BAG, resin infiltration + 6% BAG solution; N/RI/FF, 5.25% NaOCl pretreatment + resin infiltration + fluoride-free toothpaste suspension; N/RI/BAG, 5.25% NaOCl pretreatment + resin infiltration + 6% BAG solution. After resin infiltration, one half of the buccal surface was covered as the self-control side, with the other half serving as the experimental side. All specimens were then immersed in the corresponding suspensions and subjected to 55,000 toothbrushing cycles. Surface morphology, elemental analysis, crystal characteristics, surface roughness and surface microhardness of the experimental and control sides were assessed by scanning electron microscopy (SEM) and energy-dispersive spectrometry (EDS) observation, X-ray diffraction (XRD), integrated white-light confocal microscope and microhardness tester, respectively. Results The calcium to phosphate ratios (mean [± standard deviation]) were 2.12 [± 0.18], 2.28 [± 0.12], 2.20 [± 0.14] and 2.32 [± 0.10] for groups RI/FF, RI/BAG, N/RI/FF and N/RI/BAG respectively ( p = 0.038). XRD revealed apatite formation in all groups. The mean surface roughness (Ra and Sq) of the groups were as follows: Ra values (nm): 1104 [± 114], 433 [± 52], 1050 [± 177] and 381 [± 33] respectively ( p < 0.001); Sq values (µm): 7.7 [± 1.0], 4.3 [± 0.3], 7.5 [± 0.4] and 3.9 [± 0.4] respectively ( p < 0.001). The mean surface microhardness (kg/mm 2 ) of the groups were 245 [± 24], 336 [± 29], 336 [± 29] and 355 [± 22] for groups RI/FF, RI/BAG, N/RI/FF and N/RI/BAG respectively ( p < 0.001). Conclusions The combined use of resin infiltration and BAG remineralization seems to be a potential treatment method for enhancing the surface properties of enamel WSLs.
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NATURE MATERIALS
·
2026
·
IF 38
Chen Lixing,Zhang Enkang,Hao Yiqing,Zhu Yinghao,Cui Bingkun,Abernathy Douglas L.,Williams Travis J.,Ikeda Yoichi,Zhang Hao,Liu Feiyang,Wang Wenbin,Wang Qisi,Zhao Jun
High-temperature superconductivity in pressurized and thin-film nickelates has generated intense interest, yet magnetism in their ambient-pressure parent phases remains poorly understood, despite its potentially crucial role in pairing. Progress has been limited by the lack of large single crystals suitable for neutron spectroscopy. Here we overcome this limitation and map the spin order and excitations of single-crystalline La 3 Ni 2 O 7 . We find single-stripe magnetic order with a finite spin gap, anisotropic in-plane excitations and pronounced bilayer modulation revealing antiferromagnetic interlayer coupling. The dispersion is captured by a bilayer Heisenberg-type model with strong interlayer exchange and competing in-plane couplings. Absolute normalization reveals that, although the spin-wave bandwidth is only about 25% of that in cuprates, the local dynamic susceptibility at comparable energies is enhanced, yielding a comparable total fluctuating moment. These results highlight intense mid-energy spin excitations rooted in substantial electronic correlations, establishing a magnetic framework distinct from cuprates and relevant to superconductivity in nickelates.
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CHINESE JOURNAL OF POLYMER SCIENCE
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2026
·
IF 4.6
Chen Jian-Jun,Zhang Jian-Ye,Ye Si-Yi,Wang Chen-Yu,Zhao Yan-Yun,Qiao Xi-Ya,Xu Xin-Yu,Shuai Feng-Ping,Zhang Hai-Fei,Bao Yong-Xin,Liu Zeng-He,Zhu Yu-Tian
Photo-curing three-dimensional (3D) printing enables complex geometries, personalized customization, rapid curing, and excellent spatial resolution; however, conventional photocured resins often suffer from limited mechanical performance, functionality, and sustainability. Herein, we present a novel photothermal dual-curing strategy based on dynamic imidazole-urea-epoxy chemistry to produce 3D printed materials with exceptional strength and toughness. This chemistry is triggered during post-printing thermal treatment, which not only creates new covalent crosslinks, but also synergistically integrates the toughness of polyurethane with the strength of epoxy, resulting in a reinforced network. This transformation also drives a dramatic 26-fold increase in the elastic modulus (from 13 MPa to 338 MPa), enabling a single material to be programmed from a soft and flexible state into a rigid and structural solid. Such a stark property shift unlocks unique functionalities, including shape programmability, enhanced portability, and adaptive performance for multiscenario applications. Furthermore, we extend this strategy to commodity polyurethane foam (PUF) waste and successfully upcycle it into high-performance 3D printing resins. Our work establishes a versatile approach for manufacturing strong, tough, multifunctional, and sustainable 3D printed materials.
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高影响因子
Nature Communications
·
2026
·
IF 18.1
Li Qian,Li Rui,He Meng,Qin Mengmei,Cheng Chuanqi,Zhang Bin
Electrochemical dehalogenative deuteration in D 2 O offers a sustainable and site-specific strategy for synthesizing deuterated molecules. However, this process is limited by restricted deuterium transfer in the interfacial hydrogen bond gap zone at the alkaline interface, resulting in a sluggish reaction rate. Here, an iodide-derived copper catalyst is designed to convert 2-monochloroacetic acid (MCAA) to acetic acid (AA), achieving a yield rate of 1.43 mmol h −1 and lowering the potential by 200 mV compared with that of copper. Mechanistic studies reveal that, as hydrogen bond acceptors, iodide ions enhance the connectivity of interfacial water through I − ···H − O − H···O interactions, thereby facilitating deuterium shuttling and resulting in an Eley−Rideal deuteration mechanism. Moreover, the facilitated electron transfer and enhanced adsorption of MCAA induced by chemically adsorbed iodide ions contribute to the activation of MCAA. 19.8 g of AA- d 4 is obtained at 2.5 A within 40 h, highlighting the great promise of the iodide-modified strategy in catalyst and microenvironment design.
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BIOTECHNOLOGY LETTERS
·
2026
·Vol. 48
·期 5
·125
·
IF 2.5
Wang Shuang,Chen Qiongqiong,Lyu Liting,Zhao Zongbao Kent
Lycopene is a high-value carotenoid with broad applications in the food, pharmaceutical, and cosmetic industries. The oleaginous yeast Rhodotorula toruloides naturally synthesizes mixed carotenoids but fails to accumulate lycopene, primarily due to the bifunctional activity of lycopene cyclase/phytoene synthase Car2, which efficiently converts lycopene into downstream cyclic carotenoids. Here, we engineered R. toruloides for efficient lycopene production using a combinatorial strategy that includes pathway blocking, heterologous enzyme screening, precursor enhancement, and fermentation optimization. CRISPR/Cas9-mediated CAR2 knockout abolished endogenous phytoene synthesizing and lycopene cyclizing activities. Heterologous complementation with exogenous phytoene synthase (CrtB) restored phytoene biosynthesis, and the resultant loss of cyclase activity blocked lycopene cyclization, facilitating robust intracellular lycopene accumulation. Screening three heterologous phytoene synthases identified EgCrtB from Euglena gracilis as the superior enzyme. Co-overexpression of endogenous rate-limiting enzymes involved in the mevalonate pathway further boosted precursor supply. Combined with nitrogen-limited cultivation, which synergistically enhanced lycopene accumulation, the final engineered strain achieved a lycopene content of 0.74 mg/g DCW and a titer of 7.24 mg/L. This work verifies that metabolic pathway modification combined with fermentation regulation can effectively drive lycopene synthesis and accumulation in R. toruloides , offering an early-stage proof-of-concept for further advancing lycopene bioproduction in oleaginous yeast.
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AAPS Journal
·
2026
·Vol. 28
·期 5
·133
·
IF 3.4
Luo Haozhong,Pan Wenxiu,Liu Wenxue,Zhang Yuchen,Zou Meijuan,Piao Hongyu
To address the challenges associated with keloid pharmacotherapy, we developed a melittin (MEL)-modified paclitaxel (PTX) liposomal delivery system as a reconstitutable lyophilized formulation intended for subcutaneous injection. MEL, an amphipathic membrane-active peptide, was incorporated as a functional component to enhance liposome-cell interactions and facilitate intracellular delivery of PTX. This design aimed to improve the in vitro anti-keloid activity of PTX liposomes while providing a lyophilized injectable formulation suitable for reconstitution before use. After MEL modification, the zeta potential shifted upward with increasing MEL content, supporting MEL surface modification of PTX liposomes through electrostatic interactions. Moreover, freeze-dried MEL-modified PTX liposomes showed comparable particle size, zeta potential, and release behavior to the original liposomes. Although the encapsulation efficiency (EE%) of PTX and the modification efficiency (ME%) of MEL were slightly reduced after lyophilization, the formulation maintained good storage stability at 4 ± 2°C for 6 months. Confocal microscopy and flow cytometry analyses using coumarin 6 (C6) instead of PTX showed enhanced cellular uptake in human keloid fibroblasts (HKF). The CCK-8 assay indicated that although MEL-Liposome (600:1) alone did not obviously inhibit HKF proliferation under the tested conditions, MEL-PTX-Liposome (600:1) showed significantly stronger antiproliferative activity than PTX-Liposome. Specifically, MEL-PTX-Liposome (600:1) reduced HKF cell migration to 16.8% (control, 92.6%; PTX-Liposome, 36.9%), representing a significant improvement over PTX-Liposome. These findings support MEL-modified PTX liposomes as a promising reconstitutable lyophilized injectable formulation for subcutaneous anti-keloid therapy and provide a formulation basis for further translational development. Graphical
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2026
·Vol. 61
·期 42
·33149-33167
·
IF 4.4
Guo Hongyan,Shi Dandan,Wang Yiying,Zhao Caiying,Zhong Kaipeng,Cao Jiajia,Xu Naicai,Bian Shaoju
With the increasing popularity of electric vehicles, the demand for lithium batteries is growing. Extracting lithium from salt-lake brine is an important method for lithium separation. This study successfully synthesized high-valence Zr 4+ -doped spinel manganese oxides using a hydrothermal-calcination approach to enhance adsorption capacity and address capacity degradation issues during the cycling of manganese-based lithium-ion sieves (Mn-based LIS). The results indicate that Zr 4+ -doping reduces the particle size and increases specific surface area from 24.22 to 32.70 m 2 g −1 . The adsorption isotherm was well fitted by the Langmuir model for 2% ZrCl 4 -doped H 1.6 Mn 1.6-x Zr x O 4 (2-HMZO) indicating a monolayer chemisorption mechanism, and the theoretical maximum adsorption capacities ( q m ) of 2-HMZO at 298, 308, and 318 K were 55.13, 58.24, and 65.92 mg g −1 , respectively. The adsorption capacity of the 2-HMZO achieved 88% of its theoretical adsorption capacity. After ten cycles of adsorption and desorption, the material maintained the Mn dissolution loss of 3.77%. Meanwhile, theoretical calculations confirmed that Zr 4+ doping enhances structural stability and facilitates easier Li + transport. Combined characterization results further confirmed that the primary Li + adsorption mechanism of 2-HMZO involves ion exchange. This research provides experimental evidence for advancing the practical application of Mn-based LIS and achieving efficient lithium extraction from salt-lake brines. Graphical abstract A spinel-type Zr-doped H 1.6 Mn 1.6 O 4 adsorbent was synthesized via hydrothermal, solid-state and ion-exchange methods, using high-valence Zr 4+ as the dopant ion. The introduction of Zr 4+ significantly enhanced the Li + adsorption capacity of HMO, and it also exhibited excellent ion selectivity in real brine samples. The primary adsorption mechanisms are ion exchange and surface electrostatic interactions. Furthermore, the adsorbent well retains its intact spinel structure even after ten consecutive adsorption-desorption cycles.
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高影响因子
Nature Microbiology
·
2026
·Vol. 11
·期 10
·2883-2900
·
IF 18.7
Zhang Yulin,Dong Zhongwei,Chen Xiaoting,Peng Ke,Huang Qingye,Rao Wutian,Song Shu,Zhang Liming,Gao Shujun,Zhu Caixia,Wang Yuyan,Robertson Erle,Yuan Zhenghong,Wei Fang,Cai Qiliang
Chaperone-mediated autophagy (CMA) is a critical regulator of cancer progression and antiviral responses, often modulated by post-translational modifications. SUMOylation, a reversible post-translational modification, is implicated in viral infection and tumorigenesis, yet its role in CMA regulation remains unclear. Here we demonstrate that oncogenic viruses hijack CMA by inducing nuclear localization and SUMOylation of lysosomal-associated membrane protein 2A (LAMP2A), a central lysosomal receptor. Specifically, tripartite motif containing 32 (TRIM32) mediates SUMO2/3 conjugation to LAMP2A at lysine residues K104, K132 and K289. Using Kaposi’s sarcoma-associated herpesvirus as a model, we found that TRIM32-induced LAMP2A SUMOylation activates CMA, thereby promoting viral persistence, tumour growth and angiogenesis in vivo. Importantly, TRIM32 expression positively correlates with LAMP2A in tumour tissues from patients with Kaposi’s sarcoma-associated herpesvirus-, Epstein–Barr virus- and human papillomavirus-associated cancers, and peptide inhibitors targeting SUMOylated LAMP2A demonstrate potent antitumour and antiviral efficacy in vitro and in mice. Together, our findings position LAMP2A as a promising druggable target for treating virus-associated cancers.
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危险品化学品经营许可证（带存储）