SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2019
·
IF 2.931
Lirong Jiang,Qiao Hu,Tianhong Chen,Douyong Min,Hou-Qun Yuan,Guang-Ming Bao
Mutagenic formaldehyde (FA) is usually abused to preserve seafood, thus it is very necessary to detect harmful formaldehyde in seafood with a simple and effective method. In this work, we facilely prepared a new fluorescent probe RBNA , which showed a remarkable fluorescence lighting-up response towards FA with high sensitivity and selectivity, fast response (within 5 min) and a low detection limit (0.21 μM). The fluorescence intensity is linearly related to the concentration of FA ranging from 0 to 120 μM (R 2 = 0.9952), which enables it to quantitatively determine the concentration of FA. This probe was successfully used to detect FA in seafood samples with good recoveries (80–119%). Furthermore, the probe has been utilized to image FA in living cells and zebrafish with good performance. Therefore, this probe has a good capability for rapid and sensitive determination of FA in seafood.
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ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Zelun Zhi,Yajuan Su,Yuewei Xi,Liang Tian,Miao Xu,Qianqian Wang,Sara Padidan,Peng Li,Wei Huang
In recent years, microbial colonization on the surface of biomedical implants/devices has become a severe threat to human health. Herein, surface-immobilized guanidine derivative block copolymers create an antimicrobial and antifouling dual-functional coating. We report the preparation of an antimicrobial and antifouling block copolymer by the conjugation of polyhexanide (PHMB) with either allyl glycidyl ether or allyloxy polyethylene glycol (APEG; MW 1200 and 2400). The allyl glycidyl ether modified PHMB (A-PHMB) and allyloxy polyethylene glycol1200/2400 modified PHMB (APEG1200/2400-PHMB) copolymers were grafted onto a silicone rubber surface as a bottlebrush-like coating, respectively, using a plasma-UV-assisted surface-initiated polymerization. Both A-PHMB and APEG1200/2400-PHMB coatings exhibited excellent broad-spectrum antimicrobial properties against Gram-negative/positive bacteria and fungi. The APEG2400-PHMB coating displayed an improved antibiofilm as well as antifouling properties and a long reusable cycle, compared with two other coatings, due to its abundant PEG blocks among those copolymers. Also, the APEG2400-PHMB-coated silicone coupons were biocompatible toward mammalian cells, as revealed by in vitro hemocompatibile and cytotoxic assays. An in vivo study showed a significant decline of Escherichia coli colonies with a 5-log reduction, indicating the APEG2400-PHMB coating surface worked effectively in the rodent subcutaneous infection model. This PHMB-based block copolymer coating is believed to be an effective strategy to prevent biomaterial-associated infections.
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International Journal of Environmental Research and Public Health
·
2017
·Vol. 14
·期 9
·970
·
IF 2.101
Gehui Wang,Jianjiang Lu,Zhenni Xing,Shanman Li,Zilong Liu,Yanbin Tong
Despite risks associated with perfluoroalkyl acids (PFAAs) in many regions, little is known about their prevalence in Xinjiang. We determined the presence of 13 PFAAs in 293 beef muscle and liver samples collected in 22 cities covering northern, southern, and eastern Xinjiang using liquid chromatography, coupled with tandem mass spectrometry. Overall, the average values for PFAAs were relatively low compared with previous studies. Liver presented higher mean levels of total PFAAs at 1.632 ng/g, which was over 60-fold higher than in muscle (0.026 ng/g). Among the PFAAs analyzed, medium-chain compounds were dominant, accounting for more than 70% of the total. Perfluorooctane sulfonate (PFOS) was highly prevalent in the liver with the highest mean concentration (0.617 ng/g) and detection frequency (80%). When comparing the three regions of Xinjiang, we found differences in PFAA profiles, with the northern region showing the highest levels. Furthermore, the average daily intake and hazard ratios of PFOS and perfluorooctanoic acid varied by region, urban/rural environment, gender, ethnicity, and age. The highest risk value of 13 PFAAs was estimated to be 0.837 × 10−3, which is far below 1, indicating that there is no health risk posed by eating beef muscle and liver in Xinjiang.Keywords:perfluoroalkyl acids;muscle;liver;average daily intake;health risk;Xinjiang
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Royal Society Open Science
·
2019
·Vol. 6
·期 10
·
IF 2.515
Lisheng Shi,Jiayan Ge,Fuqiang Zhang,Shuangxi Nie,Chengrong Qin,Shuangquan Yao
Adsorbable organic halogen (AOX) is generally formed by the reaction of residual lignin in pulps with chlorine dioxide during bleaching. Lignin has a complex structure. Different functional groups and bonds are present in lignin structures. Phenolic hydroxyl is one of the important functional groups in lignin, and it significantly influences the chemical properties and reactivity. To study the effect of phenolic hydroxyl on AOX formation, vanillyl alcohol (VA) was selected as the phenolic lignin model compound, and veratryl alcohol (VE) was selected as the non-phenolic lignin model compound in this study. The kinetics of AOX formation by the reaction of VA or VE with chlorine dioxide was studied. The effects of pH, chlorine dioxide, lignin model compound concentration and reaction temperature on AOX formation are discussed. The activation energies of the reaction of VA and VE with chlorine dioxide are 16 242.47 J mol−1 and 281.34 J mol−1, respectively. Thus, we found that the non-phenolic lignin can react with chlorine dioxide to form AOX more easily than phenolic lignin.
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ACS Applied Polymer Materials
·
2022
·
IF 4.855
Chunming Tang,Yuancheng Qin,Cailing Ni,Jianping Zou
Hg/Hg(II) is deemed to be the most toxic heavy metal to humans. Therefore, designing suitable adsorbents to simultaneously achieve high capacity, rapid mercury adsorption, and fluorescence detection is still an important challenge in overcoming Hg2+ pollution. Here, we report a flexible alkylamine covalent organic framework (TpTSC), which has been used as an efficient adsorbent and achieves the dual-functional application of TpTSC for Hg2+, with a fluorescence detection limit of 2 ppm and simultaneously a removal capacity of 1035 mg g–1. It can remove 10 ppm mercury solution to below 2 ppb (drinking water standard) within 10 min, and the removal rate is as high as 99.98%. To a certain extent, it exceeds the recently reported thioether or thiol functionalized adsorbents. The kinetic study shows that TpTSC displays a very high Kd value, with Kd = 1.2 × 109 mL g–1, which has a strong affinity for mercury. In addition, TpTSC displays a good recycling capacity, with a removal rate of over 90% after five cycles. In conclusion, sulfur modification is a useful strategy for developing dual-functional COFs to simultaneously remove and detect toxic heavy metal ions.
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PLoS One
·
2019
·Vol. 14
·期 7
·e0220005
·
IF 2.776
Shuyao Zhang,Zheling Zhang,Xiaoling Zhang,Jian Zhang
In present work, a highly sensitive biosensor with high selectivity for glucose monitoring is developed based on novel nano-composites of nitrogen doped graphene quantum dots (N-GQDs) and a novel bimetallic Cu/Ni core-shell nanoparticles (CSNPs) (Cu@Ni CSNPs/N-GQDs NCs). With the tuned electronic properties, N-GQDs helped bimetallic core-shell structure nanomaterials from aggregation, and separate the charges generated at the interface. This novel nano-composites also have the good electrical conductivity of N-GQDs, catalyst property of Cu/Ni bimetallic nano composite, Cu@Ni core-shell structure and the synergistic effect of the interaction between bimetallic nano composite and N-GQDs. While modified the electrode with this novel nano-composites, the sensor’ linear range is 0.09 ~ 1 mM, and the limit of detection (LOD) is 1.5 μM (S/N = 3) with a high sensitivity of 660 μA mM -1 cm -2 , and rapid response time (3 s). Its’ LOD is more than 74 times lower than the traditional Cu@Ni CSNPs modified working electrode. It also has higher sensitivity and wider linear range. This indicates the great potential of applying this kind of nano composites in electrode modification.
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RSC Advances
·
2014
·Vol. 4
·期 57
·29968-29974
·
IF 3.708
Yongjuan Wang,Yuming Zhou,Tao Zhang,Man He,Xiaohai Bu
This work describes a facile approach for the delaminating of Ni–In-layered double hydroxides (LDHs) by the intercalation of acetate anions in the LDHs gallery using co-precipitation method. The acetate-intercalated Ni–In LDHs exhibited swelling behavior in water and delaminated into semitransparent suspensions on the action of water. The transmission electron microscopy (TEM) and atomic force microscopic (AFM) observations revealed the formation of unilamellar LDHs nanosheets. This simple method did not need reflux at high temperatures, overcoming the deficiency of using organic solvents, resulting in a steady colloidal suspension of 2D nanosheets. The unique properties of 2D ultrathin nanosheets with full access to the positively charged activity sites make them attractive in terms of the improvement of DNA adsorption. The effect of dosage on the adsorption of DNA and the adsorption isotherm were investigated in detail. The equilibrium data were found to be well described by both the Langmuir and Freundlich models. Based on the mechanism of adsorption, the adsorption sites of exfoliated nanosheets can be easily occupied by highly negatively charged small anions through electrostatic interactions. The adsorbed DNA can be released via the addition of a hydrogen phosphate solution.
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AAPS PHARMSCITECH
·
2021
·Vol. 22
·期 7
·1-7
·
IF 3.246
Wang Beilei,Shan Xiaoxiao,Lv Shujie,Zha Liqiong,Zhang Caiyun,Dong Qiannian,Chen Weidong
3-O-β-D-galactosylated resveratrol (Gal-Res) was synthesized from resveratrol (Res) and 3-O-β-D-galactose (Gal) in our previous study. In order to improve the pH sensitivity and bioavailability of Gal-Res, Gal-Res nanoparticles (Gal-Res NPs) were prepared using polydopamine (PDA) as a drug carrier. The drug loading (DL %) and entrapment efficiency (EE %) of Gal-Res NPs were 46.80% and 88.06%. The average particle size, polydispersity index (PDI), and Zeta potential of Gal-Res NPs were 179.38 ± 2.83 nm, 0.129 ± 0.013, and − 28.05 ± 0.36 mV, respectively. The transmission electron microscope (TEM) showed that Gal-Res NPs had uniform spherical morphology. Compared with the fast release of raw Gal-Res, the in vitro release of Gal-Res NPs was slow and pH-sensitive. The results of the blood vessel irritation and hemolysis test demonstrated that Gal-Res NPs had good hemocompatibility. The pharmacokinetics study in rats showed that area under the curve of plasma drug concentration time (AUC 0→600 ) and half-life (t 1/2 ) of Gal-Res NPs were enhanced 1.82-fold and 2.19-fold higher than those of raw Gal-Res. The in vivo biodistribution results showed that Gal-Res NPs were more distributed in liver tissue than Gal-Res. Gal-Res NPs with high bioavailability and liver accumulation were hopeful drug delivery systems (DDS) to treat liver diseases. Graphical abstract
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BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
·
2022
·Vol. 108
·期 4
·672-677
·
IF 2.807
Li Chao,Xu Shen,Guan Dong-xing,Chen Xian-xian,He Huan
Bioaccessibility of hydrophobic organic contaminants (HOCs) from unintentional ingestion of soil is increasingly assessed with in vitro gastrointestinal models incorporating a sorption sink. In this study, the bioaccessibility of DDTs in contaminated soils (n = 11) was determined using “unfed” unified bioaccessibility method (UBM) and fed organic estimation human simulation test (FOREhST) with/without Tenax as an absorbent. By adding Tenax, the bioaccessibility of DDTs determined using UBM was significantly increased from 4.9–30.6% to 31.6–86.0%. In contrast, the bioaccessibility of DDTs determined using FOREhST without/with Tenax were similar with values of 20.0–60.9% vs 31.5–47.6%, implying that the influence of food components on the absorption efficiency of the sink should not be overlooked. Much high fraction of DDTs (bioaccessibility: 11.7–24.8%) remained in FOREhST supernatant after Tenax collection, suggesting that prediction of bioavailability through bioaccessibility obtained by absorbent needs to be treated with caution when bioaccessibility is determined using a “fed state” in vitro method.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2015
·Vol. 16
·期 6
·13507-13527
·
IF 2.862
Arshad Mehmood Abbasi,Xinbo Guo,Xiong Fu,Lin Zhou,Youngsheng Chen,Yong Zhu,Huaifeng Yan,Rui Hai Liu
Mango (Mangifera indicaL.), also called “the king of fruits”, is one of the most popular fruits in tropical regions. Pulp and peel samples of mango cultivars were analyzed to estimate total phenolic, total flavonoid and total anthocyanin contents. Phenolic acids, hydrophilic peroxyl radical scavenging capacity (hydro-PSC) and oxygen radical scavenging capacity (ORAC)in vitrowere also determined. Total phenolics and flavonoid contents were found maximum in the peel of Xiao Tainang and Da Tainang cultivars, respectively, whereas Xiao Tainang also exhibited significant antioxidant capacity. Noteworthy, concentrations of gallic acid, protocatechuic acid, ferulic acid, chlorogenic acid and caffeic acids at 79.15, 64.33, 33.75, 27.19 and 13.62 mg/100 g fresh weight (FW) were quantified for Da Tainang, Xiao Tainang and of Jidan cultivars, respectively. Comparatively, a higher level of phenolics and significant antioxidant capacity in mango peel indicated that it might be useful as a functional food and value-added ingredient to promote human health.Keywords:mango;phenolics;flavonoids;anthocyanins;phenolic acids;ORAC;hydro-PSC
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NEW JOURNAL OF CHEMISTRY
·
2019
·Vol. 43
·期 8
·3309-3316
·
IF 3.069
Wei Jin,Yanqiu Fu,Weiquan Cai
In this paper, a CuS/graphene oxide (GO)/multiwalled carbon nanotube (MWCNT) nanocomposite was prepared for the first time for ultrasensitive electrochemical non-enzymatic H2O2 detection in the alkaline environment. The morphology and microstructure of the CuS/GO/MWCNT nanocomposite were systematically characterized, in which the novel hybrid architectures of the nanoparticles, nanotubes and nanosheets are determined. As a result, the as-fabricated electrochemical sensor exhibits an excellent H2O2 amperometric response with a wide linear range from 0.45 mM to 60 mM, a low detection limit of 0.6 μM and an ultra-high sensitivity of 386 μA mM−1 cm−2. Besides, the long-term stability and outstanding reproducibility were also evaluated, suggesting the promising potential for the determination of H2O2 in practical applications.
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Frontiers in Pharmacology
·
2022
·
IF 5.988
Jiang-Tao Ke,Heng Zhang,Yan-Hong Bu,Pei-Rong Gan,Fang-Yuan Chen,Xin-Tong Dong,Yan Wang,Hong Wu
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by a joint hypoxia microenvironment. Our previous untargeted metabolomics study found that sphingolipid (SPL) metabolism was abnormal in the joint synovial fluid samples from adjuvant arthritis (AA) rats. Geniposide (GE), an iridoid glycoside component of the dried fruit of Gardenia jasminoides Ellis, is commonly used for RA treatment in many Asian countries. At present, the mechanism of GE in the treatment of RA, especially in the joint hypoxia microenvironment, is not entirely clear from the perspective of SPL metabolism. The purpose of this research was to explore the potential mechanism of abnormal SPL metabolism in RA joint hypoxia microenvironment and the intervention effect of GE, through the untargeted metabolic analysis based on the ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS). Arthritis index, foot swelling and histopathology were used to assess whether the AA rat model was successfully established. The SPLs extracts collected from AA rats' synovial tissue, serum and rheumatoid arthritis synovial fibroblasts (RASFs, MH7A cells, hypoxia/normoxia culture) were analyzed by metabolomics and lipdomics approach based on UPLC-Q-TOF/MS, to identify potential biomarkers associated with disorders of GE regulated RA sphingolipid metabolism. As a result, 11 sphingolipid metabolites related to RA were screened and identified. Except for galactosylceramide (d18:1/20:0), GE could recover the change levels of the above 10 sphingolipid biomarkers in varying degrees. Western blotting results showed that the changes in ceramide (Cer) level regulated by GE were related to the down-regulation of acid-sphingomyelinase (A-SMase) expression in synovial tissue of AA rats. To sum up, this research examined the mechanism of GE in the treatment of RA from the perspective of SPL metabolism and provided a new strategy for the screening of biomarkers for clinical diagnosis of RA.
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