CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Lu Li,Zeting Huang,Jiahui Liang,Yuanxiang Jin,Weihua Peng
pH-responsive STB Microgels enable targeted oral delivery of B. coccoides. • Co-encapsulating L-theanine and Blautia synergistically mitigates obesity and steatosis. • STB Microgels remodel gut microbiota and significantly boost SCFAs production. • STB Microgels promotes WAT browning, potentially via the Gut-SCFAs-Adipose axis. With the sharp increase in the global prevalence of obesity and its complications, traditional treatments face significant challenges. Recently, the strategy of co-delivering probiotics and active substances for weight loss has garnered widespread attention. We designed and fabricated calcium alginate-based SA@The/Bla Microgels (STB Microgels) for the co-encapsulation of the next-generation probiotic Blautia coccoides ( B. coccoides ) and the natural compound L-theanine to ameliorate obesity and metabolic syndrome. The optimized microgels had a particle size of 253 μm and a B. coccoides encapsulation efficiency of 83.41% ± 3.37%. They formed a pH-responsive physical matrix that resisted gastric acid degradation through protonation-induced densification and enabled targeted intestinal release via ion-exchange mechanisms. In vivo imaging confirmed that encapsulation significantly prolonged the gastrointestinal retention and persistence of B. coccoides . In a high-fat diet (HFD)-induced obese mouse model, STB Microgels effectively alleviated weight gain, dyslipidemia, and hepatic steatosis. Mechanistically, the treatment remodeled the gut microbiota by enriching beneficial bacteria such as B. coccoides and increasing the production of short-chain fatty acids (SCFAs). These increased SCFAs were consistent with the upregulation of thermogenic genes (e.g., Ucp1 , Prdm16 ) in adipose tissues, indicative of white adipose tissue browning and brown adipose tissue activation. Consequently, this co-encapsulation strategy is associated with the amelioration of metabolic disorders, potentially via the “Gut-SCFAs-Adipose Axis” offering an engineered bio-delivery strategy for oral probiotics. Download: Download high-res image (378KB) Download: Download full-size image
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高影响因子
Foods
·
2026
·Vol. 15
·期 7
·1134
·
IF 6
Wei Zhao,Peng Yang,Mingyun Chen,Dongyu Gu,Dajun He
Raspberry (Rubus idaeusL.) fruits have been widely used due to their abundance of diverse polyphenolic compounds, whereas research on the chemical composition and bioactivity of their stems and leaves remains limited. In this study, the ethyl acetate extract of raspberry stems and leaves was evaluated for inhibitory activity against α-glucosidase and α-amylase. Guided by affinity ultrafiltration–mass spectrometry, 16 potential active components were further isolated and characterized. Among these, 13 compounds exhibited binding affinity for α-amylase, while 5 compounds showed binding affinity for α-glucosidase. Quercetin-3-O-β-D-glucoside-7-O-β-D-gentiobioside was isolated from raspberry stems and leaves for the first time. Procyanidin C3and quercetin exhibited significant inhibitory effects on the two enzymes. Molecular docking studies hinted at the interactions between these compounds and the key active sites of the two enzymes. These findings suggest that phenolic compounds in raspberry stems and leaves may possess potential as α-glucosidase and α-amylase inhibitors, providing a scientific basis for further research on their application as functional components for blood glucose control.
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AQUACULTURE
·
2025
·
IF 3.9
Luyao Xu,Jiamin Li,Ao Luo,Jiujie Zhou,Samwel M. Limbu,Jialing Xu,Peiyan Lu,Tingting Li,Xiaoxuan Qi,Mo Peng
To comprehensively investigate effects of dietary l -carnitine (LC) on growth performance, lipid metabolism, oxidative stress, mitochondrial function and endoplasmic reticulum (ER) stress in farmed fish fed high-carbohydrate-diets (HCD), 960 rice field eels (17.09 ± 0.14 g) were chosen and randomly assigned to 16 cages. These fish were fed a control diet (15 % α-starch, CON), a high-carbohydrate-diets (35 % α-starch, HCD), a HCD supplementing with 1.2 ‰ LC (HC/LLC), and a HCD supplementing with 2.4 ‰ LC (HC/HLC). Results of 8-week feeding trial showed that HCD increased liver lipid content, induced liver dysfunction, oxidative stress and ER stress, but not affected growth performance. Dietary LC supplementation significantly increased weight gain rate and specific growth rate and decreased liver lipid content. In the meantime, LC reduced the activity of serum ALT, improved liver's antioxidant capacity, thereby mitigating liver damage. Dietary LC positively regulated expression of genes related to oxidative stress, such as keap1 , nrf2 , cat and sod . Furthermore, LC supplementation upregulated expression of genes related to the mitochondrial function, such as crls1 and lclat1 (cardiolipin metabolism) , pgc1α, pparα and cpt1 (mitochondrial β-oxidation) . Intriguingly, administering LC-fortified diets to fish resulted in downregulation of ER stress-related gene expression, such as grp78, ire1 and atf6 . It is first reported in this study that the incorporation of LC into the diet of HCD-fed fish facilitates lipid metabolism through concurrent enhancement of mitochondrial function, reduction of oxidative stress, and alleviation of ER stress.
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INDUSTRIAL CROPS AND PRODUCTS
·
2023
·
IF 5.9
Jia-Ni Zhang,Meng-Han Ma,Xing-Ling Ma,Feng-Lian Ma,Qing-Yu Du,Jia-Nan Liu,Xing-Cai Wang,Qi-Peng Zhao,Yong-Jie Yu,Yuanbin She
The effect of drying methods on the variations of volatile, semi-volatile, and involatile compounds in Elaeagnus angustifolia L. (E.A.) flower was comprehensively investigated by using gas chromatography-mass spectrometry (GC-MS) and ultrahigh performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS) based untargeted metabolomics combined with our recently developed automatic data analysis software AntDAS for the first time. About 21 volatile compounds, 44 semi-volatile compounds, and 17 involatile compounds were identified and showed significant differences among drying methods. Chemometric methods like principal components analysis (PCA), and partial least squares-discriminant analysis (PLS-DA) were used in combination with heatmap analysis to reveal the relationship between compound compositions and drying methods. Finally, it was concluded that room-temperature drying is more conducive to preserving volatile compounds in E.A. flower, and hot air drying is better for preserving semi-volatile and involatile compounds. This work can provide guidelines for industrial processes of E.A. flower.
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CHEMOSPHERE
·
2022
·
IF 8.943
Yayan Tong,Yalin Wu,Huahua Bai,Shuangying Li,Liushan Jiang,Qingxiang Zhou,Chunmao Chen
Due to the strong metal-sulfur interaction between mercapto groups and metal ions , which can be used to functionalize polyamidoamine dendrimer decorated Fe 3 O 4 nanoparticles for high enrichment of trace heavy metal ions from waters. Based on this concept, polyamidoamine dendrimer modified Fe 3 O 4 nanomaterials were functionalized with l -Cysteine and a new magnetic solid phase extraction for rapid adsorption and separation of Hg 2+ , Pb 2+ , Co 2+ and Cd 2+ from waters was established. The factors affecting extraction efficiency have been optimized. Upon the optimal parameters, the established method provided good linear ranges of 0.1–200 μg L −1 for Hg 2+ and 0.05–200 μg L −1 for Pb 2+ , Co 2+ and Cd 2+ , and high sensitivity with limits of detection (LOD) of 0.018 μg L −1 , 0.014 μg L −1 , 0.013 μg L −1 and 0.025 μg L −1 for Cd 2+ , Pb 2+ , Co 2+ and Hg 2+ , respectively. Real water samples were utilized to validate the proposed method, and achieved results revealed that the proposed method was sensitive, effective, stable and suitable for monitoring Pb 2+ , Cd 2+ , Co 2+ and Hg 2+ in environmental waters. This work provided a novel strategy for the simultaneous analysis of target cations in waters, and a new direction for developing decoration method of nanomaterials according to specific purpose.
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REACTIVE & FUNCTIONAL POLYMERS
·
2021
·
IF 3.975
Hao Li,Weijun Zhen,Chengyuan Dong,Ling Zhao
Nano boron nitride-trimethylolpropane tris (3-mercaptopropionate) grafted poly (L-lactic acid) (BN-TTMP-PLLA) was prepared with nonmetallic organic catalyst by thiol-ene click chemistry. By orthogonal experiment and range analysis, the optimum reaction conditions of BN-TTMP-PLLA were as follows: reaction time of 2.5 h, photoinitiator addition amount of 0.04 g, TTMP addition amount of 0.9 g, and mass ratio of PLLA-AA to BN-570 of 1:1. The product was characterized by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy, which showed that PLLA was successfully grafted onto BN surface. Furthermore, PLA/BN-TTMP-PLLA nanocomposites were prepared by melt blending with BN-TTMP-PLLA as modifier to enhance the performance of PLA . Compared with pure PLA, the impact strength and elongation at break of PLA/BN-TTMP-PLLA (0.5 wt%) nanocomposites were increased by 1.58 times and 7.34 times, respectively. Molecular dynamics simulation calculation showed that E Interaction between PLA and BN before and after functionalization decreased from −177.44 kcal/mol to −516.42 kcal/mol, which proved that intermolecular interactions between them were strengthened. In addition, PLA/BN-TTMP-PLLA (0.5 wt%) nanocomposites during melting and isothermal crystallization were studied by Rheonaut technology for simultaneous rheometry and FTIR, which demonstrated that the crystallization properties of PLA was clearly improved due to the strong hydrogen bonding effect between BN-TTMP-PLLA and PLA.
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Microorganisms
·
2020
·Vol. 8
·期 3
·319
·
IF 4.152
Xuewei Li,Beibei Li,Shurui Cai,Yu Zhang,Mingjie Xu,Chunmei Zhang,Bo Yuan,Ke Xing,Sheng Qin
Black spot disease, which is caused by the pathogenic fungalCeratocystis fimbriata, seriously affects the production of sweet potato and its quality during postharvest storage. In this study, the preliminary identification of the rhizosphere actinomycete strain SPS-33, and its antifungal activity of volatilesin vitroandin vivowas investigated. Based on morphological identification and phylogenetic analysis of the 16S rRNA gene sequence, strain SPS-33 was identified asStreptomyces lavendulae.Volatile organic compounds (VOCs) emitted by SPS-33 inhibited mycelial growth and sporulation ofC. fimbriatain vitroand also induced a series of observable hyphae morphological changes. In anin vivopathogenicity assay, exposure to SPS-33 significantly decreased the lesion diameter and water loss rate in sweet potato tuberous roots (TRs) inoculated withC. fimbriata. It increased the antioxidant enzymes’ activities of peroxidase, catalase, and superoxide dismutase as well as decreased malondialdehyde and increased total soluble sugar. In the VOC profile of SPS-33 detected by a headspace solid-phase micro extraction (HS-SPME) and gas chromatography-mass spectrometry (GC-MS), heptadecane, tetradecane, and 3-methyl-1-butanol were the most abundant compounds. 2-Methyl-1-butanol, 3-methyl-1-butanol, pyridine, and phenylethyl alcohol showed strong antifungal effects againstC. fimbriata. These findings suggest that VOCs fromS. lavendulaeSPS-33 have the potential for pathogenC. fimbriatacontrol in sweet potato postharvest storage by fumigant action.Keywords:Ipomoea batatas(L.) Lam.;Streptomyces lavendulae;volatile organic compound;fumigant;antimicrobial
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ENVIRONMENTAL POLLUTION
·
2020
·
IF 6.793
Dongmei Qiao,Hongfei Lu,Xiaoxian Zhang
Adding exogenous low-molecular weight organic acids is an effective technique to improve phytoremediation of Cd-contaminated soil and has been well documented, but how acid application rate affects remediation efficiency and its underlying limiting factors remains elusive. We investigated this using pot experiments with rapeseed ( Brassica napus L.) as the model plant. Plastic pots packed with a sandy loam contaminated by Cd at 4.838 mg/kg were amended with acetic acid, oxalic acid , citric acid , malic acid and tartaric acid, respectively, at an application rate gradient varying from 0.0 to 12.0 mmol/kg. Plants in each pot were harvested after growing for five months, and we then measured the exchangeable, carbonate, Fe–Mn oxide, organic and residual Cd in the rhizosphere, as well as Cd in both roots and shoots. The results showed that all organic acids improved plant uptake of Cd and, compared with the control without acid addition, they could improve Cd uptake by more than 100%. The enhanced Cd extraction was due to the increase in exchangeable Cd in the rhizosphere. Plant Cd was weakly correlated to the amount of Cd lost from a unit volume of the rhizosphere due to root extraction ( R 2 = 0.06), but a good negative correlation was found between them after normalizing the lost Cd by root biomass ( R 2 = 0.36). Mass balance analysis revealed that the average Cd content in soil (rhizosphere and bulk soils combined) was much higher than the Cd content in the rhizosphere, and the improved Cd mobility after acid addition was thus due to the increased chelation. As diffusion of ligands in water is one order in magnitude smaller than diffusion of Cd ions, our results suggested that Cd migration from the bulk soil into the rhizosphere was a major factor limiting Cd phytoextraction by rapeseed after adding the exogenous organic acids.
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高影响因子
MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 11
·1-9
·
IF 5.479
Wu Huifang,Tong Changlun
A ratiometric fluorometric assay for silver(I) is described. The method makes use of a dually emitting quantum dot hybrid, which is composed of (a) blue-fluorescent silicon- and nitrogen-doped carbon quantum dots (CQDs), and (b) of red-emitting CdTe quantum dots (QDs) capped with N-acetyl-L-cysteine. The red-emitting CdTe QDs undergo strong and specific quenching by Ag(I), whereas the blue-emitting N,Si-CQDs are not quenched. The two kinds of QDs are mixed and used as a ratiometric fluorescent probe. A linear relationship is found between the log of intensities [(I 608 /I 441 ) 0 /(I 608 /I 441 )] and the concentration of Ag(I) in the range from 5.0–1000 nM, and the limit of detection (at S/ N = 3) is 1.7 nM. Possible interferents (including 17 general metal ions, 12 anions and fulvic acid) do not interfere with the determination. The assay was successfully used for the determination of Ag(I) in surface water and wastewater samples. The fluorescence quenching mechanism of the ratiometric assay system was also discussed in detailed.
Schematic representation of a ratiometric probe composed of silicon- and nitrogen-doped carbon quantum dots (N,Si-CQDs) and CdTe quantum dots capped by N-acetyl-L-cysteine (CdTe QDs). This dual-emission QDs hybrid was fabricated for ultrasensitive and highly selective detection of silver(I) in water samples.
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Food Bioscience
·
2023
·
IF 5.2
Zuanyuan Huang,Mengwei Hu,Xiuyi Peng,Rui Wang,Xiaoxiao Song,Junyi Yin
Small black soybean ( Vigna Mungo L.) is a kind of medicinal and edible plant with many potential health benefits for the human body. In this study, we investigated the potential anti-gastric ulcer effect of Vigna Mungo L. polysaccharides (VMP) using an acetic acid-induced gastric ulcer model in SD rats . The impact of VMP on the levels of antioxidant factors and growth factors in gastric tissue homogenate , serum metabolites, short-chain fatty acids (SCFAs) and gut microbiota in SD rats were analyzed. The results revealed that VMP exhibited a beneficial role in facilitating the healing process of gastric ulcers, specifically by reducing the area of gastric ulcers, increasing the levels of epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF), and improving oxidative stress status. Additionally, VMP modulated 20 potential serum biomarkers associated with gastric ulcers, thereby exerting a significant impact on multiple crucial metabolic pathways. Notably, VMP notably increased the levels of SCFAs, including acetic acid, propionic acid , i-butyric acid, n-butyric acid, i-valeric acid, n-valeric acid, in the colonic contents of rats with gastric ulcers. Furthermore, VMP effectively ameliorated gut microbiota dysbiosis in gastric ulcer rats by reducing the relative abundance of Firmicutes , Lachnospiraceae_NK4A136_group , Quinella and Lactobacillus , while increasing the relative abundance of Bacteroidota , Bacteroides , Oscillospiraceae_UCG-005 , Muribaculaceae , Parasutterella and Ruminococcus . Correlation analysis showed that the relative abundance of Parasutterella and Lachnospiraceae_NK4A136_group were closely related to the changes of SCFAs and serum metabolites. These findings provide potential groundwork for the development of health products aimed at preventing and treating gastric ulcers.
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FOOD RESEARCH INTERNATIONAL
·
2023
·
IF 8.1
Xiao Jia,Pei Yu,Qi An,Jingnan Ren,Gang Fan,Zelan Wei,Xixiang Li,Siyi Pan
The effect of microwave treatment on the content of glucosinolates (GSL) in radish seeds and volatile odor compounds in the microwaved radish seed oils (MRSO) is still unclear. In this study, a total of 13 GSL were identified and quantified in five radish seed varieties by UPLC-IMS-QTOF-MS, among which glucoraphenin, glucoraphasatin, glucoerucin accounting for up to 90 %. Total GSL decreased by 47.39–67.88% after microwave processing. Moreover, 58 odor compounds were identified in MRSO, including 6 sulfides, 12 nitriles, 2 isothiocyanates, 10 alcohols, 12 aldehydes, 5 ketones, 6 acids, and 5 others. The major odor compounds were (methyldisulfanyl)methane, dimethyltrisulfane, (methylsulfinyl)methane, 3-(methylsulfanyl)-1-propanol, methyl thiocyanate, hexanenitrile, 5-(methylsulfanyl)pentanenitrile, and 4-isothiocyanato-1-butene with odor activity value (OAV) higher than 1. The principal components analysis (PCA) results can distinguish MRSO from five different radish seed varieties, three of which (H20-18, H20-19 and H20-28) were in one group and other two (H20-23 and H20-26) were in another group. In addition, aliphatic GSL showed positive correlations with sulfides, isothiocyanates, and nitriles, while negative correlations with alcohols. This work provides a new insight into the odor contribution of GSL degradation products.
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Polymers
·
2018
·Vol. 10
·期 12
·1329
·
IF 2.935
Lingyu Liu,Xudong Zhu,Yanbo Zeng,Hailong Wang,Yixia Lu,Jian Zhang,Zhengzhi Yin,Zhidong Chen,Yiwen Yang,Lei Li
In this paper, we report a new composite of reduced graphene oxide/Fe3O4-ionic liquid based molecularly imprinted polymer (RGO/Fe3O4-IL-MIP) fabricated for diphenylamine (DPA) detection. RGO/Fe3O4-IL-MIP was prepared with RGO/Fe3O4as supporter, ionic liquid 1-vinyl-3-butylimidazolium hexafluorophosphate ([VC4mim][PF6]) as functional monomer, ionic liquid 1,4-butanediyl-3,3’-bis-l-vinylimidazolium dihexafluorophosphate ([V2C4(mim)2][(PF6)2]) as cross-linker, and diphenylamine (DPA) as template molecule. Fourier transform infrared spectroscopy, thermal gravimetric analysis, scanning electron microscopy, and vibrating sample magnetometer were employed to characterize the RGO/Fe3O4-IL-MIP composite. RGO/Fe3O4-IL-MIP was then drop-cast onto a glassy carbon electrode to construct an electrochemical sensor for DPA. The differential pulse voltammetry (DPV) peak current response for 20 μM DPA of RGO/Fe3O4-IL-MIP modified glassy carbon electrode (GCE) was 3.24 and 1.68 times that of RGO/Fe3O4-IL-NIP and RGO/Fe3O4-EGDMA-MIP modified GCEs, respectively, indicating the advantage of RGO/Fe3O4-IL-MIP based on ionic liquid (IL) as a cross-linker. The RGO/Fe3O4-IL-MIP sensor demonstrated good recognition for DPA. Under the optimized conditions, the RGO/Fe3O4-IL-MIP sensor exhibited a DPA detection limit of 0.05 μM (S/N = 3) with a linear range of 0.1–30 μM. Moreover, the new RGO/Fe3O4-IL-MIP based sensor detected DPA in real samples with satisfactory results.Keywords:reduced graphene oxide;Fe3O4;molecularly imprinted polymer;ionic liquid cross-linker;electrochemical sensor;diphenylamine
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高影响因子
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