Small
·
2024
·Vol. 20
·期 47
·2404830
·
IF 13
Xueying Luan,Lingfei Guo,Hongdong Li,Weiping Xiao,Guangrui Xu,Dehong Chen,Caixia Li,Yunmei Du,Zexing Wu,Lei Wang
The developed strategies for synthesizing metal phosphides are usually cumbersome and pollute the environment. In this work, an ultrafast (30 s) quasi-solid-state microwave approach is developed to construct cobalt–molybdenum phosphide decorated with Ru (Ru/Co x P-MoP) featured porous morphology with interconnected channels. The specific nanostructure favors mass transport, such as electrolyte bubbles transfer and exposing rich active sites. Moreover, the coupling effects between metallic elements, especially the decorated Ru, also act as a pivotal role on enhancing the electrocatalytic performance. Benefiting from the effects of composition and specific nanostructure, the prepared Ru/Co x P-MoP exhibits efficient HER performance with a current density of 10 mA cm −2 achieved in 1 m KOH, 0.5 m H 2 SO 4 , seawater containing 1 m KOH and 1 m PBS, with overpotentials of 52, 59, 55, 90 mV, and coupling with good stability. This work opens a novel and fast avenue to design metal-phosphide-based nanomaterials in energy-conversion and storage fields.
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Small
·
2024
·
IF 13
Xinqing Duan,Lei Li,Zehui Peng,Mingqiang Wang,Yanxin Liu,Dar-Jen Hsieh,Kuan-Chang Chang
The burgeoning implantable biodevices have unlocked new frontiers in healthcare, promising personalized monitoring strategies tailored to specific needs. Herein, hyaluronic acid (HA) is harnessed to create fully biocompatible, acidity-sensitivity and cleft-adjustable neuromorphic devices. These HA-biodevices exhibit remarkable sensitivity to pH variations, effectively mimicking biological acid-sensing ion channels (ASICs) through protonation reactions between electronegative atoms and hydrogen ions, even at ultralow driving voltage (5 mV). They can monitor joint cartilage acidity by tracking changes in proton concentration and successfully diagnose the onset of arthritis. Furthermore, by adjusting the synaptic device's cleft distance, which determines responsiveness, power efficiency and plasticity, HA-based neuromorphic devices can be tailored to meet the unique demands of various implantation sites, providing both high-sensitivity and low-heat dissipation, thus broadening their application scopes. Moreover, the HA-biodevices maintain stable performance across various bending degrees, up to a curvature radius of 7.5 mm, with flexibility and deformation resilience enabling installation on joints of varying curvatures. The combination of all-biocompatibility, high sensitivity, low heat dissipation, ultralow low power (2 pW), and extraordinary deformation tolerance paves the way for the development of versatile, multipurpose medical monitoring devices with immense potential in the field of healthcare.
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ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Xueyi Liu,Pei Zhang,Huijia Song,Xiaoshuang Tang,Yi Hao,Yibing Guan,Tie Chong,Sameer Hussain,Ruixia Gao
Prostate cancer is the most common malignancy diagnosed in men. Androgens are directly related to its pathogenesis. Inhibition of the androgen receptor (AR) is considered to be the most promising therapeutic approach for the treatment of prostate cancer. In this study, a new type of pH-responsive dual androgen-blocking nanodrug (FASC MIPs) based on a molecularly imprinted polymer has been designed and synthesized. The nanodrug could selectively sequester testosterone from the prostate tumor through specific molecular imprinting sites and simultaneously deliver the AR inhibitory drug bicalutamide, which ultimately leads to enhanced synergistic therapy of prostate cancer. FASC MIPs demonstrate excellent pH responsiveness in a simulated tumor microenvironment due to the presence of chitosan and significantly inhibit the growth of prostate cancer cells (LNCaP cells) by blocking the G1 phase of cytokinesis. Additionally, the nanodrug also displayed excellent antitumor properties in a xenograft mouse model of prostate cancer without any sign of detrimental effects on healthy tissues and organs. Both in vitro and in vivo studies verified the augmented and synergistic therapeutic effects of FASC MIPs, and the proposed dual-androgen-blocking strategy could explore novel avenues in prostate cancer treatment.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yuanhao Qiu,Tangyu Yang,Huizi Zhang,Hongmei Dai,Huashan Gao,Wenpo Feng,Dan Xu,Jinyou Duan
pH could play vital role in the wound healing process due to the bacterial metabolites, which is one essential aspect of desirable wound dressings lies in being pH-responsive. This work has prepared a degradable hyaluronic acid hydrogel dressing with wound pH response-ability. The aldehyde-modified hyaluronic acid (AHA) was obtained, followed by complex mixture formation of eugenol and oregano antibacterial essential oil in the AHA-CMCS hydrogel through the Schiff base reaction with carboxymethyl chitosan (CMCS). This hydrogel composite presents pH-responsiveness, its disintegration mass in acidic environment (pH = 5.5) is 4 times that of neutral (pH = 7.2), in which the eugenol release rate increases from 37.6 % to 82.1 %. In vitro antibacterial and in vivo wound healing investigations verified that hydrogels loaded with essential oils have additional 5 times biofilm removal efficiency, and significantly accelerate wound healing. Given its excellent anti-biofilm and target-release properties, the broad application of this hydrogel in bacteria-associated wound management is anticipated.
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FOOD RESEARCH INTERNATIONAL
·
2025
·
IF 8
Tao Zhang,Ruowei Huang,Xiaoqi Xu,Yaoguang Chang,Changhu Xue
This study was aimed at enhancing the stability of the medium internal phase emulsion by modulating the electrostatic interaction between fucoidan (FUC) and sodium caseinate (NaCS). Firstly, the macro and microstructure of FUC-NaCS electrostatic complexes with the mass ratio of ranged from 0.01: 2 to 4: 2 were examined at pH 3.0. As the concentration of FUC increased, the complexes transformed a soluble state to phase separation and then returned to the homogeneous state, with the turbidity and particle size initially increasing and then decreasing. The zeta potential of the complexes gradually declined, and the zero-point was corresponding to the phase separation region where the ratio of FUC-NaCS was around 0.75: 2. The microstructure by TEM and SEM demonstrated that the NaCS particles were bonded to the FUC cross-linking chain network via electrostatic interaction to form self-assembling complexes. Subsequently, the simulated digestion results suggested that the FUC-NaCS complexes could delay the hydrolysis of NaCS and displayed greater stability in gastric environments. Based on the above results, the FUC-NaCS complexes were utilized to emulsify and stabilize medium chain triglycerides (MCT). The droplets of the FUC-NaCS emulsion at 4: 2 was more dispersed with a smaller diameter, and also exhibited superior stability during stomach digestion and concurrently high digestibility during intestinal digestion, making FUC-NaCS complexes a potential choice for pH-triggered release of emulsions, especially in gastrointestinal environment.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Jun Yang,Guancheng Jiang,Maen M. Husein,Wei Zhang,Shengming Huang,Fuyan Kang,Tengfei Dong,Yinbo He,Lili Yang
Assembling protective metal-organic framework (MOF) coatings for structurally fragile natural enzymes broadens their potential industrial applications. In this study, we developed an enhanced two-step biomimetic mineralization strategy, whereby cellulase acts as a biological template to pre-concentrate Zn 2+ on its surface, subsequently initiating the rapid in situ formation of zeolitic imidazolate framework-8 (ZIF-8). This approach yields a cellulase@ZIF-8 composite that effectively combines enzyme activity retention with the structural robustness of the MOF. Cellulase actively mediated ZIF-8 nucleation and framework construction through precise interfacial coordination with imidazole ligands and Zn 2+ , thus achieving in situ encapsulation. Compared with free cellulase, cellulase@ZIF-8 maintained over 90 % residual activity under acidic conditions and over 60 % activity at 80 °C. Remarkably, under alkaline conditions (pH = 9) or after 30 days of storage, cellulase@ZIF-8 residual activity exceeded twice that of the free enzyme. Even after 10 recycles, cellulase@ZIF-8 retained 60.5 % residual activity, exhibiting outstanding environmental tolerance and reusability. Our results suggest that the spatial confinement provided by ZIF-8, along with its ability to induce conformational rearrangement in the enzyme, underlies the enhanced stability and environmental tolerance observed. We further showed a pH-responsive release of cellulase facilitated by the ZIF-8 framework, enabling burst release of >90 % cellulase in a short time under acidic environment. This work offers valuable insights into enzyme-MOFs design and their applications in biocatalysis, controlled release, and adaptive biomaterials.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2025
·
IF 8.3
Yuehuan Zhang,Yangqin Feng,Qiang Yuan
Modulating the electronic structure of nanoclusters with high-valence metals is essential for boosting the activity of pH-universal hydrogen evolution reaction (HER) catalysts. Here, we enhance the high-valence Mo-induced strong metal-support interaction (SMSI) between anchored amorphous sub-2 nm PtRu nanoclusters and phosphomolybdic acid (H 3 PMo 12 O 40 , PMo 12 ) through a one-pot route. The optimized Pt 0 · 63 Ru 0 · 37 /PMo 12 catalyst requires overpotentials of only 27 mV (alkaline), 38 mV (neutral), and 14 mV (acidic) to drive 10 mA cm −2 . Its mass activities (9.89, 8.77, and 9.67 A mg −1 Pt + Ru ) are 3.99, 4.59, and 3.01 times higher than those of Pt/C, respectively. Structural analysis and in situ Raman experiments confirm that the electronic structure modulation between PMo 12 and PtRu clusters accelerates water adsorption/desorption, thereby enhancing HER kinetics. Finally, the assembled Pt 0 · 63 Ru 0 · 37 /PMo 12 || IrO 2 anion exchange membrane electrolyzer operates stably for over 300 h at 500 mA cm −2 . This study broadens the support selection for pH-universal water-splitting catalysts.
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Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Junren Zhu,Wei Ding,Zhenzhen Jiang,Ting Peng,Xintao Tan
Remediating persistent organic contaminants in near-neutral aquatic environments remains a challenge for conventional homogeneous Fe(II,III)-mediated sulfate radical-based advanced oxidation processes (SR-AOPs), which typically require acidic pH or generate hazardous byproducts. This study introduces an electro-activated sulfite process (Fe-EC/S(IV)) employing sacrificial iron electrodes to overcome these limitations. Continuous anodic Fe 2+ release sustains active FeHSO 3 + complexes, enabling efficient S(IV) activation at pH 4−6. Mechanistic analysis identifies SO 4 •− as the dominant oxidant, formed via inner-sphere electron transfer within FeHSO 3 + complexes, followed by aerobic chain reactions (SO 3 •− → SO 5 •− → SO 4 •− ). The system achieves rapid oxcarbazepine degradation (pseudo-first-order constant, k obs = 1.15 min −1 ), representing a 57.5-fold kinetic enhancement over standalone Fe-EC at pH 6. Notably, the process intrinsically suppresses the carcinogenic BrO 3 − formation (<1 μg L −1 ) through the S(IV)-mediated reductive quenching of bromine intermediates, substantially outperforming Fe-EC/peroxomonosulfate systems (11.3 μg L −1 BrO 3 − ). Demonstrating >70% removal in natural waters without pH adjustment or added electrolytes, and broad-spectrum efficacy (77.9–91.7%) across contaminant classes, this electrochemically sustained process offers a novel AOP paradigm integrating the radical-based oxidation with inherent byproduct control for complex water remediation scenarios.
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C-Journal of Carbon Research
·
2025
·Vol. 11
·期 3
·53
·
IF 2.9
Huan Liu,Yuxin Ding,Longping Zhou,Shirui Xu,Bo Liao
Carbon dots (CDs), a class of carbon-based fluorescent nanomaterials, have garnered significant attention due to their tunable optical properties and functional versatility. In this study, we developed a hybrid material by grafting pH- and temperature-responsive copolymers onto CDs via reversible addition-fragmentation chain-transfer (RAFT) polymerization. Triamino-tetraphenylethylene (ATPE) and N-isopropylacrylamide (NIPAM) were copolymerized at varying ratios and covalently linked to CDs, forming a dual-responsive system. Structural characterization using FTIR,1H NMR, and TEM confirmed the successful grafting of the copolymers onto CDs. The hybrid material exhibited pH-dependent fluorescence changes in acidic aqueous solutions, with emission shifting from 450 nm (attributed to CDs) to 500 nm (aggregation-induced emission, AIE, from ATPE) above a critical pH threshold. Solid films of the hybrid material demonstrated reversible fluorescence quenching under HCl vapor and recovery/enhancement under NH3vapor, showing excellent fatigue resistance over multiple cycles. Temperature responsiveness was attributed to the thermosensitive poly(NIPAM) segments, with fluorescence intensity increasing above 35 °C due to polymer chain collapse and ATPE aggregation. This work provides a strategy for designing multifunctional hybrid materials with potential applications in recyclable optical pH/temperature sensors.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Xiaoqing Liu,Pengxiang Hao,Wenliang Wang,Guanying Guo,Congcong Wu,Rifang Ge
Dental caries is one of the most common chronic diseases in the world. Prevention of secondary caries caused by bacterial infection, endowing dental restorative resin materials with effective resistance to harmful bacteria and microbial invasion, is an important direction in dental material development. In this study, we prepared a polyamino acid derivatives nanocarrier (PLG-g-mPEG) that can encapsulate both amoxicillin and polylysine (PL), which could achieve synergistic and rapid sterilization under acidic conditions. Then we utilized 1% (wt) pH-responsive nanoparticles (PPA NPs) for antimicrobial modification of dental resins. The results showed that the mechanical strength of the modified resin was not significantly different from that of the unmodified resin; the surface hydrophilicity of the modified resin was increased; the rapid and efficient killing of oral bacteria under acidic conditions could be realized. Incorporating PPA NPs into dental resin provides long-term antimicrobial activity for antimicrobial and anti-caries restorations. Furthermore, it can also be used to combine with other dental adhesives, cements, and sealants to achieve potent antimicrobial functionality.
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Food Bioscience
·
2025
·
IF 5.9
Liang Peng,Chao Ma,Xiujuan Huang,Zhang Minrui,Xueni Huang,Lining Qi,Pimin Gong
Dormancy can enhance the spray-drying resistance of lactic acid bacteria(LAB), but it can also prolong their revival time during fermentation. There was a close relationship between dormancy and intracellular protein aggregation, and pH was an important factor that affects protein aggregation. This study innovatively elucidates the molecular mechanism by which extracellular pH coordinates the dormancy-metabolism balance in Lactobacillus bulgaricus ( L. bulgaricus )through regulation of intracellular protein aggregation dynamics. This study revealed that subtle environmental pH variations can induce significant reversible transitions in protein aggregation states, exhibiting remarkable pH sensitivity (with a 40-fold difference in solubility between pH 6.0-6.5) and directly influencing industrial performance characteristics. Significantly, quantitative relationships between pH-regulated protein aggregation levels and both cellular stress resistance and metabolic activity were established, thus providing theoretical foundations and practical guidance for developing high-viability probiotic preparations. Furthermore, this study integrated environmental factor regulation, protein conformational changes, and microbial industrial performance into a unified framework, opening new avenues for the industrial application of probiotics.
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NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Liaoliao Xie,Zhaomeng Sun,Xiaoqing Zhang,Baoxin Li,Mei Liu
Identifying and detecting bacteria are crucial for ensuring food safety and environmental monitoring. We have developed a detection system based on pH-responsive fluorescent carbon dots (pH-CDs). This system leverages the fact that Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) exhibit significantly higher sugar metabolism capabilities compared to other foodborne pathogens, enabling the identification and detection of S. aureus and E. coli. As the pH of the solution increased from 3 to 7.5, the fluorescence intensity of the pH-CDs gradually decreased. In the presence of glucose and lactose, S. aureus and E. coli participated in metabolic processes, which converted these sugars into acidic products, thereby inducing a reduction in the solution pH. The decrease in pH, in turn, triggered an enhancement in the fluorescence intensity of pH-CDs. Therefore, the pH-CD sensor enabled quantitative detection of S. aureus and E. coli with a robust linear response (R2 > 0.99), detection limits of 3–6 CFU mL−1, and reliable recoveries of 97–102% in real water samples, confirming its suitability for application. Furthermore, pH-CDs can also be utilized to identify S. aureus and E. coli, which differ in their capacity to metabolize lactose. The proposed fluorescent sensing system provides a novel approach for the rapid identification and quantification of S. aureus and E. coli, holding significant potential for practical applications.
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