Cancer Nanotechnology
·
2022
·Vol. 13
·期 1
·1-16
·
IF 7.917
Chen Xiaoxiao,Wang Lulu,Liu Sijia,Luo Xuezhen,Wang Kai,He Qizhi
Developing multifunctional composites has received widespread attention for cancer treatment. Herein, a metal–phenolic network (MPN)-based composite loading with chemotherapy agents (TAFP) exhibits high anti-tumor therapeutic efficacy via photothermal therapy (PTT), chemo-dynamic therapy (CDT), and chemotherapy. The nanocomposite was formed by mixing the chemotherapeutic drugs (cisplatin, DDP) into the tannic acid (TA) and Fe 3+ network (TAFe) to integrate the synergistic effect of PTT, CDT, and chemotherapy. Due to the acidic tumor microenvironment, the active substances could be released with the degradation of the metal–phenolic network, and the released DDP would induce the chemotherapy. More importantly, the released TA under the acidic environment could increase iron bioavailability by converting Fe 3+ to Fe 2+ , which converts hydrogen peroxide (H 2 O 2 ) to highly toxic hydroxyl radical via the Fenton reaction. Meanwhile, the heat generated from TAFP after near-infrared (NIR) laser irradiation could enhance the therapeutic effect of CDT and chemotherapy. Furthermore, the composite exhibited unique anticancer efficacy in vivo with low toxicity. Collectively, this work may facilitate the development of metal–phenolic network-based photothermal agents for clinic anti-tumor applications.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2023
·Vol. 34
·期 6
·1-9
·
IF 2.8
Chen Wei,Sun Hui,Jin Yingrong,Yang Hualin,He Yi,Zhu Xinghua
Cs 3 Bi 2 I 6 Br 3 perovskite is one of the bismuth iodide family compounds. Because it contains no toxic lead, and has high stability in air and humidity, endowing a potential application prospects in photoelectric and radiation detectors. Herein, the Cs 3 Bi 2 I 6 Br 3 single crystal (Φ13 × 65 mm 3 ) with a (001) preferred direction was grown by using the melt method with solvent-synthesized polycrystalline particles, and the thin single wafer with a thickness up to 0.95 mm was obtained. The as-grown single crystal possesses high infrared transmittance of up to 70% in the range from 400 to 4000 cm −1 and an optical band gap of about 2.03 eV estimated from the visible absorption curve. A highly intrinsic resistivity 2.3 × 10 10 Ω·cm and a dielectric constant about 10 were obtained from the electrical performance parameter measurements. The X-ray sensitivity of the X-ray detector is 55.62 µC/Gy air /cm 2 (incident dose rate 0.24 mGy/s), as well as the signal-to-noise ratio, is up to 301. These results indicate Cs 3 Bi 2 I 6 Br 3 single crystals are a potential material for X-ray detection.
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Biomass Conversion and Biorefinery
·
2023
·
IF 4
Zhang Chengcheng,Liu Shuangmei,Chen Sitong,Yuan Xinchuan,Chen Xiangxue,Jin Mingjie
This work investigated the influence of pretreatment methods (using sulfuric acid, sodium hydroxide, or calcium hydroxide) on the characteristics of biochar prepared from residues generated by lignocellulosic ethanol production. As a result, the biochar prepared from the residue of an acid pretreatment-based process showed better thermal stability than the other two biochars. The weight loss rates of three kinds of biochar at 900 °C were 17.85%, 30.95%, and 36.76%. The specific surface areas of the three biochars were 3.03 m 2 /g, 1.24 m 2 /g, and 8.04 m 2 /g, respectively, with the largest specific surface area found on the biochar of calcium hydroxide pretreatment-based process. FTIR analysis showed that the types of surface functional groups of the biochars were basically the same. The maximum theoretical adsorption capacities of the three biochars for methylene blue were 37.3 mg/g, 48.7 mg/g, and 58.2 mg/g, respectively. The adsorption capacity of biochar from alkali pretreatment for methylene blue was significantly better than that from acid pretreatment. The overall results showed that the properties of biochars prepared from fermentation residues under different pretreatment methods were quite different.
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Science China-Materials
·
2023
·Vol. 66
·期 5
·1949-1958
·
IF 8.1
Jiang Jiawei,Zhang Peisheng,Tian Yong,Lin Zhong,Zhang Chonghua,Cui Jiaxi,Chen Jian,Chen Xudong
High-performance information encryption materials are crucial for developing advanced technologies that prevent information leakage and combat fraud. These materials must be robust, intelligent, and easily programmable. To meet these criteria, we developed an information encryption toolbox based on a series of novel self-healing photoswitchable dual (P1 and P2) and multistate (P3) fluorescent polymers using two photochromic fluorescent diarylethenes, i.e., 4-hydroxybutyl acrylate link 1,2-bis(2-methyl-1-benzothiophene-1,1-dioxide-3-yl)perfuoro-cyclopentene (SDTE), 4-(acryloyloxy)butyl 4-oxo-4-butanoate link 2,3-bis (2-methylbenzo[ b ]thiophen-3-yl)-5,6-dihydro-4 H -thieno[2,3- b ]thiopyran-4-one (BTBA) and hydrogen-bonding units, i.e., 2-ureido-4[1 H ]-pyrimidinone (UPy). Upon irradiation with different wavelength lights, P1/P2 can be alternated between green/red and quenched states, while P3 can be switched among red, green, and quenched states. Using these polymers to fabricate pixel units can produce reconfigurable patterns and codes displaying good mechanical properties and excellent optical characteristics, including rapid photoresponsiveness, robust photoreversibility, superior fluorescent thermal stability, and strong resistance to acid and base corrosion. Furthermore, we also demonstrated the immediate application opportunities of our toolbox in three-dimensional-code arrays and quick response codes.
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IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
·
2022
·Vol. 59
·期 1
·1-9
·
IF 2.723
Chen Sunyu,Xiao Zhanhao,Jiang Wenjin
Osteogenic differentiation is a crucial process of new bone formation. This study aimed to explore the roles and mechanism of SRY-Box Transcription Factor 2 (SOX2) on proliferation and osteogenic differentiation of MC3T3-E1 cells. Bone morphogenetic protein 2 (BMP2) was used to induce the osteogenic differentiation of MC3T3-E1 cells. The expression of SOX2 was determined by quantitative real-time PCR (RT-PCR) at different time points after induction. The SOX2 overexpression plasmids were constructed and transfected into MC3T3-E1 cells. Osteogenic differentiation was evaluated by Alizarin Red S staining and alkaline phosphatase (ALP) assay. The expressions of osteogenic differentiation markers including runt-related transcription factor 2 (Runx2), osteopontin (OPN), and osteocalcin (OCN) were detected by western blot assay. Luciferase reporter and CHIP assays were used to confirm that SOX2 regulated the transcriptional activation of leucine-rich repeat-containing G protein–coupled receptor 4 (LGR4). We found that SOX2 was down-regulated upon BMP2-induced osteogenic differentiation in MC3T3-E1 cells. Overexpression of SOX2 effectively inhibited osteogenic differentiation with decreased ALP activity, calcification, and osteogenic differentiation markers’ expression including Runx2, OPN, and OCN. LGR4 was identified as a target of SOX2, and the inhibitory effect of SOX2 on osteogenic differentiation was reversed by knockdown of LGR4. The present study confirmed that SOX2 suppressed osteogenic differentiation of MC3T3-E1 cells through targeting LGR4, which possesses a therapeutic strategy for bone formation and generation.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2023
·Vol. 415
·期 18
·4343-4352
·
IF 4.3
Liu Min,Wang Simin,Ge Wuxia,Bi Wentao,Chen David Da Yong
To systematically study the influence of host–guest interactions on the analytical performance of direct analysis in real time mass spectrometry (DART-MS), the interactions between cyclodextrins (CDs) and different Sudan dyes were investigated. The results showed that the host–guest interaction between CDs and Sudan dyes did not affect qualitative analysis of the target compounds, but led to a lower signal intensity for Sudan dyes, thus affecting quantitative analysis of the target compounds. The stronger the host–guest interaction, the weaker the signal intensity of target compound on DART-MS. The results also show that both in solution and in solid-phase microextraction (SPME), the addition of organic solvents can weaken the host–guest interaction between CDs and Sudan dyes, thus improving the signal intensity in DART-MS. In SPME, adding organic solvents has a certain practical value and can improve the efficiency of Sudan dye analysis. This study suggests that appropriate sample pretreatment is needed to weaken noncovalent interactions prior to DART-MS analysis to obtain more accurate quantitative results. The data provide some insight into the effects of other noncovalent interactions on the efficiency of DART-MS as an analytical tool, as well as the potential to study intermolecular interactions with DART-MS. Graphical Abstract
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2023
·Vol. 34
·期 2
·1-12
·
IF 2.8
Su Qi,Qu Jing-Jing,Liu Fei,Feng Ai-lin,Yuan Chang-Lai,Liu Xiao,Meng Liu-Fang,Ding Guo-An,Su Ming-wei,Chen Guo-Hua
A series of new systems of the SrCe 1- x Ti x O 3 and SrCe 1− x Zr x O 3 (SCT x and SCZ x , x = 0.0–0.1) ceramics have been prepared by the traditional solid-phase methods. The XRD patterns results show that an ABO 3 -type perovskite structure of the SrCeO 3 ceramic can be obtained as x = 0.0. With the increase in Ti 4+ - and Zr 4+ -ions-doping content of x = 0.02–0.1, the SCT x and SCZ x ceramics basically belong to the perovskite phase with the orthorhombic structure of the space group Pmcn (62), and the results of EDS analysis on the proportion of each element can also verify the correctness of the XRD analytical results. In addition, all the microstructures are dense for the SCT x and SCZ x ( x = 0.0–0.1) samples. The fitting results of complex plane impedance verified that the temperature stability of SCT x solid solution ceramics is more suitable for adjusting to the practical application range. Especially, the SCT x ( x = 0.03) ceramics sintered at 1270 °C for 4 h can obtain the relatively excellent dielectric properties of ε r = 50.16, Q × f = 8,940 GHz (at 5.91 GHz), and τ f = + 0.08 ppm/°C.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2023
·Vol. 21
·期 1
·1-11
·
IF 10.2
Wu Zhihua,Zhao De,Han Xin,Liu Jichang,Sun Ying,Li Yaogang,Duan Yourong
Background Superhydrophobic substrate modifications are an effective way to improve SERS sensitivity by concentrating analyte molecules into a small surface area. However, it is difficult to manipulate low-volume liquid droplets on superhydrophobic substrates. Results To overcome this limitation, we deposited a hydrophilic Ti 3 C 2 T x film on a superhydrophobic ZnO nanorod array to create a SERS substrate with improved analyte affinity. Combined with its interfacial charge transfer properties, this enabled a rhodamine 6G detection limit of 10 −11 M to be achieved. In addition, the new SERS substrate showed potential for detection of biological macromolecules, such as microRNA. Conclusion Combined with its facile preparation, the SERS activity of ZnO/Ti 3 C 2 T x suggests it may provide an ultrasensitive environmental pollutant-monitoring and effective substrate for biological analyte detection. Graphical Abstract
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JOURNAL OF POLYMER RESEARCH
·
2022
·Vol. 30
·期 1
·1-12
·
IF 3.061
Chen Qi,Wang Song,Li Sanxi,Zhang Ailing
To develop transparent flame-retardant epoxy resin (EP) having good mechanical properties, a 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) derived flame retardant (PAHDOPO) was prepared by a neutralization reaction between 10-hydroxy-9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO-OH) and piperazine. When 7% PAHDOPO was added to EP, the obtained flame-retardant EP (EP7) can pass the UL-94 V-0 rating test and exhibit a high limiting oxygen index (LOI) value of 35.8%. Microscale combustion calorimetry investigation results proved that, compared with EP, the peak heat release rate (PHRR) and heat release capacity (HRC) of EP7 decreased by 34.6% and 33.6%, respectively. The observation of the char residue morphology indicated that the addition of PAHDOPO can lead to the formation of the continuous and dense char residue layer, which can improve EP flame retardancy. Meanwhile, compared with EP, EP7 exhibited similar transparency with less than 8% reduction in the average transmittance. Moreover, the mechanical properties of EP7 hardly decreased in comparison with EP. All these results indicated that PAHDOPO can be applied as a high-performance flame retardant of EP with good mechanical properties, transparency, and flame retardancy simultaneously.
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FOOD SCIENCE AND BIOTECHNOLOGY
·
2023
·Vol. 32
·期 7
·903-909
·
IF 2.9
He Yangzheng,Chen Li,Liu Wenqun,Deng Ze-yuan,Li Jing
In this study, gas chromatography–mass spectrometry (GC–MS) coupled with Partial least squares Discriminant Analysis (PLS-DA) was used to analyze the volatiles in Chinese breast milk from different cities (Wuhan, Qingdao and Hohhot) and different lactation stages (colostrum and mature milk). The results showed that breast milk contained 122 volatile substances in 9 major groups, with the largest number of olefins (36) and the highest content of acids. The different volatile compounds of breast milk in three cities were heptanal, 2-pentylfuran, (E)-2,4-decadienal, (E)-2-heptenal, (E)-2-nonenal and 1-octen-3-one, colostrum and mature milk were (E)-2-heptenal, (E)-2-decenal, lauric acid, n -decanoic acid, (E)-2-nonenal and octanoic acid. This study might provide scientific data for the development and optimization of formulas that were more suitable for the health of Chinese infants.
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CELLULOSE
·
2023
·Vol. 30
·期 5
·3061-3072
·
IF 5.7
Li Wei,Du Wenqing,Li Wenbin,Chen Dongzhi,Liu Yang,Ouyang Yiwei
In this work, the hygrothermal aging behavior, finite element analysis and mechanical properties of the ramie fiber (RF) reinforced polyethylene terephthalate glycol (PETG) composites modified with silane coupling agent and carbon nanotubes (CNTs) were investigated. The results show that after 90-days hygrothermal aging, the RF/PETG composites with untreated, KH550-treated, 0.5% CNT-treated and 1.0% CNT-treated modifications have the low water uptakes of 4.55%, 4.36%, 4.30% and 4.15%, respectively. The surface modifications of ramie fibers have no obvious influence on the water uptakes of the RF/PETG composites, which is related to the hydrophilicity difference of surface and cross sections of the RF/PETG composites. The moisture absorption behaviors of the RF/PETG composites conform to Fick’s water diffusion law. The results of the finite element analysis of the RF/PETG composites show a good consistency with the experimental results of the water absorption. As compared with untreated composites, the bending strengths of RF/PETG composites modified with silane coupling agent, 0.5 wt% CNTs and 1.0 wt% CNTs increased with 8.5%, 16.9%, and 20.5%, respectively. The bending strength and modulus of the RF/PETG composites first rapidly decrease and then slowly decrease with the increase of aging time. The RF/PETG composites show different bending fracture behaviors before and after 90-days hygrothermal aging. The developed RF/PETG composites have low water absorption and good mechanical properties, which can broaden the research and application of ramie fiber reinforced composites.
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MRS Advances
·
2023
·Vol. 8
·期 4
·103-107
·
IF 0.8
Martinez E. Gándara,Villarreal N. Elizondo,Coronado K. A. Chavez,Cuellar E. M. López,Hernández A. Guzman,Delgado D. Martínez,Delgado F. Paraguay
The aim of this work is the synthesis of SiO 2 nanoparticles starting from Tequila as green chemistry, which implies something novel. Tequila was used as a capping, a reducer, a surfactant and stabilizer from a solution of silicon tetraacetate, deionized water, acetone, and sodium hydroxide. The structure, optical absorption, and morphological analysis of these nanoparticles were studied using X-ray diffraction (XRD) and UV–Visible spectrophotometer, and TEM. The XRD analysis indicated an amorphous phase of SiO 2 nanoparticles; the size of the synthesized nanoparticle is about 20 ± 30 nm and optical absorption analysis indicated a peak in the 260 nm range. More than 175 constituents were found in Tequila and the most common constituents were 2-methyl-1-butanol and 3-methyl-1-butanol. These higher alcohols are a good disperser and they could not only increase the number of nucleation sites but also reduce the rate of grain growth. A green and cost-effective method for the synthesis of SiO 2 NPs using Tequila which focused on the utilization of a novel and original way, was demonstrated.
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危险品化学品经营许可证（带存储）