MOLECULAR BIOLOGY REPORTS
·
2022
·Vol. 49
·期 4
·2805-2819
·
IF 2.742
Lv Yanni,Hong Daojun,Fu Longsheng,Qian Yisong
Background and purpose Nonmuscle myosin heavy chain IIA, played an essential role in the promotion of tight junction injury in vascular endothelial cells under oxygen glucose deprivation condition. Rat microvascular endothelial cells had been confirmed to have the susceptibility to ox-LDL stimulation under OGD condition. We proposed the hypothesis that lipid metabolic reprogramming might be the root cause for damage to RBMCs tight junction. Methods Untargeted shotgun and targeted lipid metabolomics mass spectrometry approaches combined with principal component analysis was applied to better define the lipids contributing to the variance observed between control and different OGD time. The protein expression of tight junction of RBMCs: occludin, claudin-5, and ZO-1 were detected with immunofluorescence staining and western blot. The proof of the interaction between NMMHC IIA and SREBP1 was investigated via GST-pull down, while their specific binding fragments were also confirmed. The regulation mechanism of NMMHC IIA on SREBP1 was investigated to explore downstream regulatory signaling pathways. Results Untargeted and targeted shotgun lipidomics data revealed that OGD might be the conditional factor in reshaping lipid components. Mechanistic studies showed that with the increase of OGD time, PCA analysis of lipidomics obtained from RBMCs indicated their specificity in reshaping lipid components, while ≥80% major lipid components phospholipids and sphingolipids transferred from phospholipids, sphingolipids, and neutral lipids, of which neutral lipids taken the largest proportion with OGD time course. Perturbing reprogramming of lipid composition was less susceptible to OGD condition via knockdown of NMMHC IIA of vascular endothelial cells. Knockdown of NMMHC IIA could promote tight junction defense to OGD condition. NMMHC IIA could directly bind with SREBP1, then could affect sterol regulatory element binding protein-1 to adjust lipid metabolize reprogramming of RBMCs. Conclusions Mechanistic studies showed that perturbing reprogramming of lipid composition could enhance tight junction damage, which was mediated by the opposing effects of NMMHC IIA.
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PubMed
高影响因子
CATALYSIS LETTERS
·
2022
·Vol. 152
·期 11
·3437-3446
·
IF 2.936
Yue Yihang,Li Yong,Wang Tingting,Wang Shifeng,Han Lin,Du Chun
A Pd/CeO 2 -M with high methanol oxidation performance was prepared from metal–organic framework (MOF). The reaction results indicate that the Pd/CeO 2 -M could achieve 100% methanol oxidation at 200 °C over the traditional Pd/CeO 2 -C at 350 °C. The high-resolution transmission electron microscopy (HRTEM), X-ray diffraction (XRD), and Raman show that the Pd was uniformly distributed over the CeO 2 that was rich in oxygen vacancies. The methanol temperature program surface reaction (MeOH-TPSR) demonstrates that the Pd/CeO 2 -M could effectively decompose methanol at a lower temperature with the assistance of oxygen vacancies compared with Pd/CeO 2 -C. Methanol oxidation was conducted with in-situ Raman, CO diffuse reflectance infrared Fourier transformed spectroscopy (CO-DRIFTS) and in-situ DRIFTS to elucidate the reaction mechanism and establish the structure–activity relationship. The oxygen vacancies have participated in the assistance of methanol oxidation, which was revealed via in-situ Raman. The CO-DRIFTS indicates that the chemisorbed CO was more in linear form, which demonstrates that the Pd particles were over CeO 2 -M with a smaller size. The in-situ DRIFTS experiments show the methanol could be further effectively oxidized to bidentate formate over Pd/CeO 2 -M with the assistance of oxygen vacancies. The Pd/CeO 2 -M catalysis and its enhancement mechanism studies provided a potential strategy in the VOC removal catalysis development. Graphical Abstract
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2022
·Vol. 33
·期 8
·5886-5898
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IF 2.779
Tong Xingyu,Li Wei,Li Jiaying,Lu Shaowei,Wang Baichen,Ma Keming,Yang Chun,Li Qiuwen
Multi-component composite can effectively improve the electromagnetic interference shielding effectiveness (EMI SE) due to the synergistic effects. Herein, graphene aerogel (GA) provides a three-dimensional network framework and in situ generation of titanium dioxide (TiO 2 ) on its network layer by the sol–gel method. After microwave irradiation reduction, the titanium dioxide/microwave-reduced GA (TiO 2 /MRGA) was immersed in epoxy resin solution and cured to obtain its composite. The existence of the Ti–O–C bond proves the favorable combination of TiO 2 and MRGA. Under electromagnetic radiation, MRGA and TiO 2 generate a synergistic effect to improve the EMI SE of the composite. When the mass ratio of TiO 2 to MRGA is 1.5:1 (2.1 wt%+1.4 wt%), the composite exhibits a maximum EMI SE of 32.5 dB in the X band. Moreover, when the mass ratio of TiO 2 to MRGA is in the range of 1 to 1.8, the average EMI SE of the composites increases by 37% compared with that of the MRGA/Epoxy composite. The research indicates that this kind of EMI shielding composite has enormous application potential.
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高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2022
·Vol. 29
·期 24
·36337-36350
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IF 5.19
Wang Bing,Cao Qingtong,Li Guomin,Zhang Jian
Given that the biological treatment of antibiotic wastewater can easily induce resistant bacteria, the photocatalytic degradation of antibiotics is considered as a better method for treating antibiotic wastewater. Therefore, the ability to remove Tylosin (TYL) and Tetracycline (TC) in aqueous solution using rare earth element Tb-doped g-C 3 N 4 under simulated natural solar radiation was investigated. A series of rare earth Tb 3+ doped mesoporous g-C 3 N 4 were successfully prepared by nitric acid treatment and Tb(NO 3 ) 3 ·5H 2 O samples showed significantly higher degradation efficiency for TYL and TC than pure g-C 3 N 4 . Leaching toxicity experiments were carried out on the catalyst using chard seeds and demonstrated negligible toxicity of the leachate from the catalyst. The structure, elemental state, optical properties, morphology, and photogenerated carrier separation of the prepared xTCN catalysts were characterized by XRD, XPS, UV–Vis DRS, TEM, and PL. The results show that Tb doping enhanced the photocatalytic activity of the g-C 3 N 4 catalyst by narrowing the band gap while improving the light-trapping ability; The separation and transport rate of photogenerated carriers were significantly increased after Tb doping. Finally, a simple, efficient, and non-polluting Tb-doped carbon nitride photocatalyst is successfully developed in this paper.
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高影响因子
Tungsten
·
2022
·Vol. 5
·期 1
·179-188
·
IF 0
Shi Xin-Wei,Zhang Sen,Zhou Qiang,Li Jing,Zhu Bai-Lin,Xu Liu-Jie,Gao Qi-Long
Surface modification is a fascinating way to improve the compounding effect between inorganic fillers and polymers. In this study, zirconium tungsten phosphate (ZWP) with negative thermal expansion was surface modified by silane coupling agent 3-(Trimethoxysilyl)propyl methacrylate. The effects of surface modification and the modification mechanism were analyzed in detail by X-ray diffractometer, scanning electron microscopy, Fourier transform infrared spectroscopy and thermal mechanical analysis. The surface modification could effectively reduce the thermal expansion properties of the composite. When the added amount of 3-methacryloxypropyl trimethoxysilaneSilane (trade name: KH570) is 0.50 wt%, the thermal expansion coefficient of ZWP/Aromatic polyimide composite decreased by 9.76%. The surface modification also can effectively improve the dielectric performance of aromatic polyimides. The present work provides one new way to improve the thermal expansion behavior of composites.
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JOURNAL OF MATERIALS SCIENCE
·
2022
·Vol. 57
·期 20
·9187-9201
·
IF 4.682
Pan Hongwei,Wang Zhaokun,Wei Zhaoyang,Zhang Jiaping,Xu Minghan,Zong Chengzhong,Cao Lan,Wang Qingfu
In this study, a TPU/CNTs–ILs flexible sensor with a sandwich structure is prepared by a combination of coating and 3D printing method. First, to promote the dispersion of carbon nanotubes (CNTs), 1-butyl-3-methylimidazole tetrafluoroborate ionic liquids (ILs) are used as modifier. Two layers of thermoplastic polyurethane elastomer (TPU) filaments are printed on the bottom plate via 3D printing and coated with a layer of CNTs–ILs as a conductive layer. Finally, two layers of TPU are printed to encapsulate the conductive layer. It is revealed that the printed TPU/CNTs–ILs flexible sensor exhibited a sensitive resistance response at small and large strains (GF value of 20 and 440 at strains of 5% and 50%, respectively) while retaining high mechanical strength (tensile strength of more than 30 MPa and 600% elongation at break). In addition, the fabricated flexible sensor still displayed good resistance response after being cyclically stretched in the range of 0–50% strain for more than 400 s. Comparing the signal response of different vocal cord vibration frequencies and loudness, it is shown that the flexible device with high sensitivity in sensing can monitor human motion behavior, indicating the TPU/CNTs–ILs flexible sensor with a sandwich structure has excellent application prospects as wearable electronic components. Graphical abstract
Scheme 1. The graphic abstract of the whole experimental process
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高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2022
·Vol. 20
·期 1
·1-22
·
IF 9.429
Li Rong-Tian,Zhu Yi-Dan,Li Wen-Ya,Hou Ying-Ke,Zou Yi-Ming,Zhao Ying-Hua,Zou Quan,Zhang Wen-Hua,Chen Jin-Xiang
A multifunctional nanoplatform with core–shell structure was constructed in one-pot for the synergistic photothermal, photodynamic, and chemotherapy against breast cancer. In the presence of gambogic acid (GA) as the heat-shock protein 90 (HSP90) inhibitor and the gold nanostars (AuNS) as the photothermal reagent, the assembly of Zr4+ with tetrakis (4-carboxyphenyl) porphyrin (TCPP) gave rise to the nanocomposite AuNS@ZrTCPP-GA (AZG), which in turn, further coated with PEGylated liposome (LP) to enhance the stability and biocompatibility, and consequently the antitumor effect of the particle. Upon cellular uptake, the nanoscale metal − organic framework (NMOF) of ZrTCPP in the resulted AuNS@ZrTCPP-GA@LP (AZGL) could be slowly degraded in the weak acidic tumor microenvironment to release AuNS, Zr4+, TCPP, and GA to exert the synergistic treatment of tumors via the combination of AuNS-mediated mild photothermal therapy (PTT) and TCPP-mediated photodynamic therapy (PDT). The introduction of GA serves to reduce the thermal resistance of the cell to re-sensitize PTT and the constructed nanoplatform demonstrated remarkable anti-tumor activity in vitro and in vivo. Our work highlights a facile strategy to prepare a pH-dissociable nanoplatform for the effective synergistic treatment of breast cancer.Graphical Abstract
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2022
·Vol. 33
·期 13
·10131-10141
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IF 2.779
Lu Hao,Dong Yaqiang,Liu Xincai,Liu Zhonghao,Ma Yan,Wu Yue,He Aina,Li Jiawei,Wang Xinmin
The phosphating treatment method has been extensively applied in the field of insulating soft magnetic powders because of its simplicity and ease of operation; however, the specific nanoscale morphology of phosphate coating layers and the interface/connection/interaction with the outer resin are still unclear. In this study, soft magnetic powder cores (SMPCs) with a nanoporous-structured phosphate coating were fabricated, in which the coating has a beneficial adsorption effect on the outer resin and can enhance the bonding force between the organic/inorganic coating. Optimized soft magnetic properties were obtained for the SMPCs with a phosphoric acid content of 0.6 wt%, including a high effective permeability of 61, low core loss of 134.6 mW/cm 3 (measured at 100 mT, 50 kHz), and high DC bias performance of 56% under a superimposed field of 100 Oe due to the favorable interactions between the insulating coating layers. These properties can be used to manufacture micro-magnetic components.
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高影响因子
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2022
·Vol. 38
·期 6
·1467-1474
·
IF 2.726
Chen Liquan,Li Dawei,Ren Jinghan,Li Yameng,Gao Dong,Xing Chengfen
Conjugated porous polymers exhibit considerable advantage as attractive candidate for carbon dioxide(CO 2 ) capture. However, the regeneration of the CO 2 still faces the problem of high energy cost. Here we synthesize a near-infrared region(NIR) light responsive conjugated porous polymer(PDPP-Gu) [DPP=3,6-di(thiophen-2-yl)pyrrolo[3,4-c]pyrrole-1,4(2 H ,5 H )-dione] by constructing porous amorphous networks with a side chain engineering strategy to regulate CO 2 adsorption and release through photothermal conversion. The PDPP-Gu is featured by a torsional conjugated backbone as well as a functional side chain of guanidino group. The donor-acceptor configuration of PDPP-Gu afforded strong absorption in the NIR and an excellent photothermal conversion capability of up to 48.8%, as well as a high surface energy. Moreover, guanidine modified side chain further enhanced the CO 2 -polymers interactions, resulting in a high CO 2 selective adsorption capacity(0.8 mmol/g) at 273 K, 1 bar(1 bar=10 5 Pa). The adsorbed CO 2 can be released under NIR light irradiation. This strategy of molecule design combined the dual features of photothermal conversion and gas adsorption, which is beneficial for the development of materials to dynamically control the adsorption and release of CO 2 through NIR light.
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高影响因子
POLYMER BULLETIN
·
2022
·Vol. 80
·期 3
·2697-2711
·
IF 2.843
Yin Peinan,Wei Chengxiong,Jin Xin,Yu Xiaogang,Wu Chengwei,Zhang Wei
Trans-catheter arterial embolization, as a minimally invasive therapy strategy, has become a choice for treating liver cancer. Development of embolic agents integrated with therapy and imagining functions is desired. Herein, magnetic polyvinyl alcohol (PVA) microspheres as embolic agents are prepared by emulsification method. The diameter of the magnetic PVA microspheres ranges from 10 to 110 μm, and the required size can be obtained by sieving. The temperature of magnetic PVA microspheres suspension could stabilize at 49 °C under the applied magnetic field, which indicates the microspheres have self-regulating temperature hyperthermia characteristic due to the application of magnetic nanoparticles with low Curie point. In addition, magnetic PVA microspheres possess obvious contrast effects on CT and T2-weighted imaging due to the existence of magnetic nanoparticles. Cytotoxicity assay indicates the survival rate of cells cultured with leach liquor of 30 mg/mL PVA/MNPs microspheres is 97.4%, which shows the magnetic microspheres have good cell biocompatibility. The developed magnetic microspheres have the potential to realize embolization, self-regulating temperature hyperthermia, and CT/MR imaging simultaneously in interventional therapy.
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高影响因子
JOURNAL OF POLYMER RESEARCH
·
2022
·Vol. 29
·期 3
·1-13
·
IF 3.061
Li Lingtong,Chen Shaopeng,Guo Xincheng,Qin Jun,Chen Xiaolang,Lu Zongcheng,Wu Hong
In a purpose to develop good dispersity and compatibility of layered double hydroxide (LDH) in polypropylene (PP) matrix, a novel DOPOi-LDH@GO hybrid nanomaterial was fabricated via three-step reactions including the synthesis of DOPO-itaconic acid (DOPOi), an electrostatic adsorption of LDH coating on the surfaces of graphene oxide (GO) (LDH@GO), and the preparation of DOPOi-LDH@GO by an anion exchange. The thermal stability and crystallization behaviors of PP/DOPOi-LDH@GO nanocomposites are greatly different from neat PP. The thermal stability of PP/DOPOi-LDH@GO nanocomposites are lower than that of neat PP. The addition of nanoparticles provides a non-homogeneous nucleus for PP crystals, producing a heterogeneous nucleation mechanism that increases the spherulite density and decreases the spherulite size. The DOPOi-LDH@GO hinders the crystallization of PP and crushes spherulite integrity. The combination of LDH with GO for agglomeration-tolerant and LDH-modified at the interlamination and surface provides a potential way to improve the efficient dispersion and enhanced interfacial adhesion in the PP matrix. Thus, PP/DOPOi-LDH@GO nanocomposites exhibit a wide range of application potentials.
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高影响因子
CATALYSIS LETTERS
·
2022
·Vol. 152
·期 12
·3725-3732
·
IF 2.936
Guo Pan,Zhan Yuzhong,Yang Yanliang,Lu Tianliang
The preparation of high-performance supported Pd catalysts for the hydrogenation of aromatic nitro is of great importance. In this paper, covalent-triazine framework (CTF), an organic porous crystalline material connected by covalent bonds, was employed as the support for the preparation of Pd heterogeneous catalyst. The framework of CTF was maintained due to the utilization of cyclohexene as a moderate reductant for PdCl 2 . The catalysts were characterized by transmission electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. The influence of reaction conditions (temperature, pressure, reaction time, concentration substrate and catalyst dosage) were investigated. At very mild reaction conditions (30 °C, 0.1 MPa H 2 , 2 mg Pd/CTF), the nitrobenzene was nearly stoichiometric hydrogenated to aniline. The Pd/CTF was effective for the conversion of a series of aromatic nitro compounds to the corresponding aromatic amines with good yield. The results showed that Pd/CTF has good catalytic activity and stability in the heterogeneous catalytic hydrogenation. Graphical Abstract
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高影响因子
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