CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Qidong Zha,Yuanting Deng,Zuozhu Yin,Yuhua Chen,Chan Xie,Zhen Hong,Yidan Luo,Mingshan Xue
The development of multifunctional coatings that simultaneously address corrosion resistance and hydrodynamic drag reduction is essential for the next generation of amphibious platforms such as electric vertical take-off and landing aircraft (eVTOLs), which frequently operate in harsh marine environments. Lightweight aluminum alloys, though widely used in eVTOL components due to their high strength-to-weight ratio, are inherently prone to localized corrosion and surface drag when exposed to saltwater immersion and dynamic fluid flow. To overcome these dual limitations, we present a biomimetic bifunctional coating inspired by the hierarchical silicification of diatom frustules. The system integrates a pH-responsive cobalt-based metal–organic framework (Co-MOF) loaded with benzotriazole (BTA), encapsulated within a layered silica shell and further modified with a fluorine-free, low-surface-energy HDTMS layer. This composite enables both environmentally triggered corrosion inhibitor release and robust superhydrophobicity (contact angle: 163.3° ± 1.2°, sliding angle: 2.3°). The coating retains a high impedance modulus (>10 9 Ω·cm 2 ) after 30 days of immersion in 3.5 wt% NaCl, with BTA release efficiency reaching 85 % under acidic conditions. Drag-reduction performance remains stable over 40 cycles, achieving a maximum drag reduction of 31.5 %. Meanwhile, after undergoing 10 abrasion cycles, the coating still maintained a contact angle of 147°, demonstrating hydrophobic properties. This work demonstrates a synergistic material platform tailored for eVTOL marine operations, offering a pathway to extend service life, reduce energy consumption, and support the advancement of low-altitude, low-carbon transportation technologies.
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Acta Biomaterialia
·
2025
·
IF 9.6
Jie Wang,Shenyuan Ouyang,Gaolong Lin,Dingwei Li,Bingyu Ding,Yumo Chen,Bingjie Tong,Ting Ouyang,Helin Xu,Wenzhi Wu
Current therapies for ulcerative colitis (UC) face critical challenges, including systemic toxicity and inadequate mucosal regeneration. Herein, we present a pioneering dual-mechanism therapeutic platform integrating pH-independent acid-treated sucralfate (ASF) with autophagy-inducing spermidine (Spd) to synergistically address UC pathogenesis. Unlike conventional pH-dependent barrier therapies, ASF forms a mechanically tunable, injectable hydrogel that adheres robustly to colonic mucosa regardless of local pH. Spermidine was easily mounted into ASF hydrogel matrix via electrostatic interaction, with more than 90 % encapsulation efficiency. Moreover, the mechanical strength of ASF hydrogel was precisely modulated by adjusting spermidine amount in formula, making it suitable for effective gut mucosa coverage. Importantly, in vitro permeability test showed that spermidine-loaded ASF hydrogel (Spd-ASF) demonstrated the selective barrier functionality, blocking > 80 % of Escherichia coli and LPS penetration while allowing nutrient permeability. Moreover, micro-CT images demonstrated that rectally infused Spd-ASF hydrogel was uniformly adhered to the colon wall at least for 8 h. In DSS-induced colitis mice, rectally administrating Spd-ASF hydrogel uniquely restored colon length to near-normal levels ( vs. 30 % shortening in controls), reduced proinflammatory cytokines (TNF-α, IL-6, IL-1β) by 60–75 %, and doubled goblet cell density. Mechanistically, Spd-ASF reprogrammed macrophage behavior by activating autophagy and enhancing efferocytosis, driving M2 polarization to resolve inflammation. Notably, Spd-ASF uniquely reversed dysbiosis, elevating beneficial Lactobacillus while suppressing colitis-associated Muribaculaceae and Clostridia . This study is the first to combine mucoadhesive biomaterial engineering with autophagy-mediated immunomodulation, offering a paradigm shift in UC therapy by simultaneously shielding the mucosa and reprogramming inflammatory pathways. Statement of significance Here, autophagy-inducing spermidine (Spd) and pH-independent acid-treated sucralfate (ASF) were combined to create the novel dual-mechanism hydrogel (Spd-ASF), which works in concert to combat UC pathogenesis. The selective barrier functioning of Spd-ASF hydrogel was established by its capacity to permit nutritional permeability while preventing the transfer of toxins (LPS) and pathogenic bacteria ( E. coli ). Additionally, rectally infused Spd-ASF hydrogel was consistently attached on the colon wall for at least eight hours, as seen by micro-CT images. Spd-ASF therapy doubled the density of goblet cells, decreased proinflammatory cytokines (TNF-α, IL-6, and IL-1β) by 60–75 %, boosted helpful Lactobacillus , and lowered pathogenic Muribaculaceae and Clostridia . It also restored colon length in DSS-induced colitis animals. Spd-ASF's therapeutic action was closely linked to promoting cellular efferocytosis and triggering macrophage autophagy.
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Acta Biomaterialia
·
2025
·
IF 9.6
Kaiwen Bao,Yunfan Li,Yantao Li,Shuai Wu,Sheng Ni,Xiong Zhao,Ya Wang,Yi Liang,Qiao Chen,Xinmei Duan,Da sun,Li Zhu,Wei Wu
The escalating challenges of antifungal drug resistance, toxicity, and limited therapeutic strategies for oral candidiasis (OC) necessitate innovative treatment approaches. This study developed a pH-responsive baicalein-based nanocarrier by coupling baicalein with phenylboronic acid-functionalized polymethyl vinyl ether-maleic anhydride to encapsulate amphotericin B (AMB). The nanocarrier was further camouflaged with macrophage membranes, forming a biomimetic dual-drug nanoplatform (MPPB@A NPs) for synergistic antifungal-antioxidant therapy against OC. MPPB@A NPs leverage macrophage membrane coating to enhance active targeting of β-glucans on C. albicans , while borate ester bonds enable pH-responsive drug release at pH 5.5. MPPB@A NPs were demonstrated to effectively disrupt C. albicans biofilms and scavenge reactive oxygen species (ROS). In murine OC models, MPPB@A NPs significantly reduced oral fungal burden (11.17% of the free AMB group) and alleviated oxidative stress. Subsequently, ROS-mediated inflammation was reduced. Furthermore, MPPB@A NPs exhibited the favorable biocompatibility, including hemolysis rates below 5%, reduced cytotoxicity, and significantly lower nephrotoxicity compared to free AMB. Therefore, this study provides a promising strategy to overcome AMB toxicity and resistance while promoting the synergistic antifungal-antioxidant therapy for OC management. Statement of Significance Current oral candidiasis therapies face challenges of drug resistance and systemic toxicity. This study has the potential to address these limitations using a biomimetic nanoplatform combining macrophage membrane camouflage with a pH-responsive carrier, enabling targeted dual-drug delivery to infection sites. The membrane coating facilitates tissue accumulation, while pH-triggered release delivers amphotericin B within acidic fungal biofilms, disrupting Candida albicans. Baicalein, as a nanocarrier component, exhibits antioxidant and anti-inflammatory effects. This strategy synergistically combats fungal infection and associated oxidative stress damage while significantly enhancing drug biocompatibility and reducing systemic toxicity, offering a clinically translatable solution.
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Food Chemistry-X
·
2025
·
IF 8.2
Huiyi Wang,Jie Wu,Wenjing Yu,Hui You,Jiangqi Xu,Haitao Chen,Baoguo Sun
Antimicrobial active packing has demonstrated great potential in extending food shelf life. However, developing new intelligent and responsive antimicrobial strategies is still desirable. Here, a 2-hydroxy-4-methoxybenzaldehyde (HMB)-decorated chitosan film (HDCF) via surface Schiff-base coupling is designed. HDCF shows excellent storage stability and pH-responsive release, enabling a switch in antimicrobial mode from “defense” to “attack” under acid conditions. Before HMB release, HDCF exhibits broad spectrum antifungal adhesion capabilities against Penicillium citrinum , Penicillium chrysogenum and Aspergillus niger , and antibacterial adhesion capabilities against Staphylococcus aureus . Under acidic conditions, with HMB release, HDCF displays enhanced release-antifungal performance against A. niger , P. citrinum and Candida albicans and release-antibacterial performance against S. aureus . In addition, HDCF is effective in food preservation for cherry tomatoes and tomato juice and has good UV barrier properties. Therefore, this HDCF provides a new path for diversiform antimicrobial designs in the new generation of food packaging.
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MICROCHEMICAL JOURNAL
·
2025
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IF 5.1
Chong Chen,Yufei Liu,Kai Zhang,Qiao Fan,Tingting Luo,Shigui Peng,Lanlan Wei,Yucheng Yin,Min He,Jie Yu
Human sweat pH closely correlates with physiological states, making its monitoring vital for health maintenance and personalized medicine. A flexible electrochemical sweat pH sensor was fabricated using a poly(3,4-ethylenedioxythiophene):indigo carmine/screen-printed carbon electrode (PEDOT:IC/SPCE). The sensing performance of pH sensor is optimized by adjusting the structure of functional coating through voltage design in electropolymerization process. The results show that the pH sensor prepared under 1.0 V constant voltage polymerization has the best performance. The sensor has a wide detection range (pH 2–11), high sensitivity (65 mV/pH) and good accuracy (deviation ≤ ±0.25 pH vs. commercial pH meter). Comprehensive stability tests were conducted, including repeatability, continuous operation, anti-interference ion resistance, storage stability, and mechanical bending tests. This work demonstrates the potential of wearable electrochemical sensors for health management applications.
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CELLULOSE
·
2025
·
IF 4.8
Wan Weimin,Wang Yuying,Li Ziqi,Wang Xi,Luo Jun
In recent years, cellulose nanocrystals (CNCs) have been used to deliver drugs, showing great potential in exploring new methods for cancer chemotherapy. Nevertheless, insolubility, low stability, and bioavailability of the potential bioactive compounds obstruct the development of bioactive formulations. Here, we constructed a pH-responsive nanocarrier that can actively target hepatocellular carcinoma cells (HCC) to deliver insoluble drug curcumin (Cur). Firstly, the polyethyleneimine (PEI) was coated onto the surface of CNCs (CNCs@PEI), and then the 3-carboxyphenylboronic acid (BA) was grafted with the coated PEI (CNCs@PEI-BA). After that, Cur formed a borate structure with BA to load Cur (CNCs@PEI-BA-Cur) showed a high drug loading capacity of 15.74%. CNCs@PEI-BA-Cur actively target HCC, enter into lysosomes, and release Cur in response to the low pH value environment. Importantly, CNCs@PEI-BA-Cur released 10.7-folds of Cur in acidic environments (pH = 5.4) more than in neutral environments (pH = 7.2). Furthermore, the nanocarrier showed efficient active targeting of HCC and increased intracellular Cur concentrations, which allowed for the effective killing of HCC in 2D cell and 3D hepatoma cell microsphere models in vitro. In conclusion, this targeted and pH-responsive nanocarrier was expected to enhance the therapeutic of insoluble drugs for HCC.
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MICROCHEMICAL JOURNAL
·
2025
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IF 5.1
Yuelin Wang,Yangyue Zhang,Jiwei Shen,Yinmao Wei,Chaozhan Wang
Selective separation and enrichment of human urinary catecholamines (CAs) at neutral pH are crucial for biomedical and clinical diagnostics. Herein, a novel carboxyl/boronic acid dual-functionalized three-component covalent organic polymer (COP), designated as TpBD-COOH 0.25 [B(OH) 2 ] 0.75 , was rationally designed via the combination of a multivariate synthetic strategy and post-synthetic modification. The adsorption behaviors of COPs with different functional group ratios were investigated using static adsorption and selectivity experiments. The results demonstrate that TpBD-COOH 0.25 [B(OH) 2 ] 0.75 can selectively extract CAs under neutral pH via synergistic interactions, including boronate affinity and electrostatic interactions at neutral pH. The adsorbent exhibits rapid adsorption kinetics, reaching adsorption equilibrium within 10 min, and demonstrates high adsorption capacity. The latter is determined to be 476.2 μmol dopamine/g of the adsorbent. Furthermore, TpBD-COOH 0.25 [B(OH) 2 ] 0.75 was successfully recycled five times without a notable decline in its adsorption capacity, highlighting its excellent reusability. The feasibility of this approach for practical use was validated by selectively enriching low-concentration cis-diol-containing compounds (cis-diols) from human urine samples under neutral pH conditions. Therefore, this method shows promise for broader applications in the analysis of other cis-diols.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2025
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IF 5.6
Qifen Li,Leixiang Wang,Yuxin Li,Shukai Nan,Ziqing Tan,Qian Yang,Chengbo Li,Xianrui Xie,Huanhuan Yan,Guige Hou,Shun Duan,Yu-Qing Zhao
We report highly efficient, antioxidant, anti-inflammatory, pH-responsive antibacterial coatings developed via direct assembly of a nature compound tannic acid (TA) with the cationic antibiotic quaternized polyethyleneimine (QPEI). The surface of polypropylene was modified with these coatings. Under acidic conditions, the coatings significantly enhanced the antibacterial performance against Staphylococcus aureus and Escherichia coli, and the antibacterial rate reached more than 90 %. The free radical scavenging rate could exceed 91 %. Thus, the excess reactive oxygen species (ROS) could be cleared, and the oxidative stress production could be significantly reduced. In vitro anti-inflammatory experiments revealed that the coatings significantly reduced the expression of TNF-α and IL-6 and promoted the release of IL-10. These results indicated the excellent anti-inflammatory effects of the coatings. In vivo experiments revealed that the coatings could rapidly achieve bactericidal effects and subsequently prevent inflammatory reactions, thereby inhibiting the generation of fibrosis. Through molecular docking simulation experiments, the mechanism of LBL self-assembly between QPEI and TA components has been clarified for the first time. By designing the surface coating of a material and combining it with bioactive components, multiple functions could be achieved to meet the clinical needs of stoma patches and promote the development of medical materials.
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Biomaterials Research
·
2024
·
IF 8.1
Lin Liu,Yucen Yao,Yang Liu,Bingrong Hong,Ziqing Li,Xuejun Chen,Yaofeng Zhang,Hongbo Fu,Degong Yang,Chunrong Yang
Management of myocardial ischemia–reperfusion injury (MIRI) in reperfusion therapy remains a major obstacle in the field of cardiovascular disease, but current available therapies have not yet been achieved in mitigating myocardial injury due to the complex pathological mechanisms of MIRI. Exogenous delivery of hydrogen sulfide (H 2 S) to the injured myocardium can be an effective strategy for treating MIRI due to the multiple physiologic functions of H 2 S, including anti-inflammatory, anti-apoptotic, and mitochondrial protective effects. Here, to realize the precise delivery and release of H 2 S, we proposed the targeted H 2 S-mediated gas therapy with pH-sensitive release property mediated by platelet membranes (PMs). In this study, a biomimetic functional poly(lactic-co-ethanolic acid) nanoparticle (RAPA/JK-1-PLGA@PM) was fabricated by loading rapamycin (RAPA; mTOR inhibitor) and JK-1 (H 2 S donor) and then coated with PM. In vitro observations were conducted including pharmaceutical evaluation, H 2 S release behaviors, hemolysis analysis, serum stability, cellular uptake, cytotoxicity, inhibition of myocardial apoptosis, and anti-inflammation. In vivo examinations were performed including targeting ability, restoration of cardiac function, inhibition of pathological remodeling, and anti-inflammation. RAPA/JK-1-PLGA@PM was successfully prepared with good size distribution and stability. Utilizing the natural infarct-homing ability of PM, RAPA/JK-1-PLGA@PM could be effectively targeted to the damaged myocardium. RAPA/JK-1-PLGA@PM continuously released H 2 S triggered by inflammatory microenvironment, which could inhibit cardiomyocyte apoptosis, realize the transition of pro-inflammation, and alleviate myocardial injury demonstrated in hypoxia/reoxygenation myocardial cell in vitro. Precise delivery and release of H 2 S attenuated inflammatory response and cardiac damage, promoted cardiac repair, and ameliorated cardiac function proven in MIRI mouse model in vivo. This research outlined the novel nanoplatform that combined immunosuppressant agents and H 2 S donor with the pH-sensitive release property, offering a promising therapeutic for MIRI treatment that leveraged the synergistic effects of gas therapy.
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EUROPEAN POLYMER JOURNAL
·
2024
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IF 5.8
Jinyun Cai,Haiyi Zhong,Xinghai Huang,Jianwei Luo,Peiyuan Li
Curcumin (Cur) is of interest due to its widely reported pharmacology, which is limited by its low water solubility and low bioavailability of clinical use. Here, we report the characterization and application of a multiple stimulus-responsive nanogel loaded with Cur. Sensitive P(AM-co-NIPAM) nanogels for pH, temperature, and reduction stimuli were prepared by reflux precipitation polymerization method using AM and NIPAM as raw materials. DLS and SEM analyses showed that the fabricated nanogels had a uniform size distribution with spherical and nucleated-shell structures. By adjusting the feeding amounts of reactive monomers, cross-linkers, and initiators, a series of monodisperse nanogels with different particle sizes could be obtained. The representative nanogels have different Cur-loaded behaviors at different temperatures, times, and initial concentrations of the drug, as well as a sensitive release to changes in pH, temperature, or reducing conditions. Cur-P(AM-co-NIPAM) nanogels showed superior antioxidant activity over the free Cur in vitro . Meanwhile, it inhibited LPS and H 2 O 2 -induced oxidative stress, which could effectively inhibit the cellular production of excessive reactive oxygen species and had a protective effect against LPS-induced cellular damage. This nanogel controlled release system significantly improved the safety limit of Cur without hemolytic behavior and had good cytocompatibility. The successful development of such Cur nanogels will lead to advanced materials that can be functionalized and optimized for the controlled delivery of small molecules or biomolecules for targeted therapeutic and biomedical applications.
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ADVANCED MATERIALS
·
2024
·Vol. 36
·期 33
·2400433
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IF 27.4
Chaohui Wang,Jun Zhang,Kanghua Miao,Mairui Long,Siyuan Lai,Shijun Zhao,Xiongwu Kang
Integrating high-entropy philosophy and nanocrystal-specific orientation into a single catalyst represents a promising strategy in development of high-performance catalysts. Nonetheless, shape-controlled synthesis of high-entropy alloy (HEA) nanocrystals is challenging owing to the distinct redox potentials and growth dynamics of metal elements. Herein, a one-pot co-reduction method is developed to fabricate ruthenium (Ru)-doped PtFeNiCuW octahedral HEA nanocrystals onto carbon nanotubes (Ru–PtFeNiCuW/CNTs). It is demonstrated that Ru dopants and W(CO) 6 promote the concurrent reduction and growth of other metal precursors to obtain higher yield and larger size of HEA nanocrystals, despite low Ru content in Ru–PtFeNiCuW/CNTs. As an electrocatalyst toward hydrogen evolution reaction (HER), Ru–PtFeNiCuW/CNTs exhibits low overpotentials of 9, 16, and 34 mV at a current density of 10 mA cm −2 and Tafel slopes of 19.2, 27.9, and 23.1 mV dec −1 in acidic, alkaline, and neutral electrolytes, respectively. As a cathodic catalyst, Ru–PtFeNiCuW/CNTs operates for up to 1500 and 1200 h in acidic and alkaline electrolyte, respectively, at a current density of 50 mA cm −2 in a two-electrode system for full water splitting. Theoretical calculations reveal accelerated kinetics of H 2 O dissociation on W sites and *H desorption on hollow Cu–Cu–Cu and Cu–Cu–Pt sites.
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Advanced Composites and Hybrid Materials
·
2025
·Vol. 8
·期 3
·1-19
·
IF 21.8
Xue Wenhui,Fan Qianqian,Wei Zhicheng,Zhu Junxiang,Wu Hao,Xu Kefeng
The development of smart indicator labels capable of visually monitoring food freshness through colorimetric changes is becoming increasingly vital for enhancing food safety and reducing waste. Despite this progress, most existing smart labels are tailored to specific food categories, limiting their versatility and broader application. To address this challenge, we have designed a multifunctional dual-channel fluorescent probe, SiO 2 -FITC/Ru(phen) 3 2+ , by co-doping FITC and Ru(phen) 3 2+ into silica nanoparticles. This innovative probe was seamlessly integrated into direct ink writing (DIW) 3D printing, enabling the fabrication of 4D smart labels with adjustable void fractions using bio-inks that leverage shear-thinning properties. These smart labels exhibit a linear and highly sensitive response to ammonia (NH 3 ) concentrations ranging from 50 to 15,000 ppm and carbon dioxide (CO 2 ) levels between 0 and 30% (v/v), with rapid detection times as short as 4 min. The integration of fast, intuitive, and precise detection mechanisms allows for non-destructive and real-time food freshness monitoring across diverse product categories, including vegetables, seafood, and meat products. In practical applications, the labels demonstrated exceptional accuracy in detecting spoilage indicators in shrimp, yellow croaker, pork, chicken breast, mushrooms, broccoli, fresh-cut cantaloupe, and spinach underscoring their adaptability and effectiveness. In conclusion, this work demonstrates the successful integration of nanotechnology with DIW 3D printing to produce versatile smart labels capable of accurately monitoring food freshness across various matrices. The scalability and adaptability of this approach offer significant potential for enhancing food safety and quality control in diverse sectors of the food industry. Graphical
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