ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2025
·
IF 3.8
Yang Xiaoying,Liu Qian,Luo Longhui,Tian Wei,Kang Chao,Yang Wanliang,Li Tianxiang,Chen Dongmei,Yan Xiufang
A novel biosensing strategy based on the synergy of aptamer molecular recognition and surface-enhanced Raman spectroscopy (SERS) has been developed to address the growing problem of groundwater and soil contamination by the organophosphorus pesticide diazinon (DZN). By combining a high-affinity aptamer with a plasmonic resonance-enhanced substrate, a SERS biosensing interface with single-molecule detection capability was successfully constructed, and the electrochemical surface-enhanced Raman spectroscopy (EC-SERS) method using AgNPs-modified screen-printed electrodes (SPEs) was also used for sensitive detection of DZN. The results showed that the constructed SERS aptamer sensor was able to specifically identify diazinon in the system where multiple interfering pesticides coexisted, and the detection limit of the sensor for diazinon was up to 5.33 × 10 −10 M. The intensity of the characteristic peaks (602 cm −1 ) showed a good linear response with the concentration of DZN, which demonstrated very high detection sensitivity and specific identification function. The proposed EC-SERS method significantly improves the SERS signals of pesticides by potentiometrically modulating the plasmonic resonance coupling effect at the interface of AgNPs-modified electrodes, inducing an orientationally regularised arrangement of DZN molecules. The SERS aptasensor was used to detect diazinon in wastewater and subsurface soil with good recoveries (83.20%–117.78%), which were in good agreement with the results obtained by high-performance liquid chromatography. The results demonstrated that the SERS aptasensor has good sensitivity, stability, simplicity of operation, and specific identification, which provides a solution with ultra-sensitive response, rapid analysis, and strong anti-interference for the detection of trace pesticide.
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npj Materials Degradation
·
2025
·Vol. 9
·期 1
·1-10
·
IF 7.6
Shi Xin,Zhang Yimeng,Zhang Ruiyong,Li Chengpeng,Wang Can,Wang Xiao,Sand Wolfgang,Duan Jizhou
Biocides are widely employed to mitigate microbiologically influenced corrosion (MIC) in oil and gas fields. However, improper biocide dosing may result in changes to the MIC. This study investigated the corrosion behavior of the biofilm-forming Pseudomonas stutzeri on X70 pipeline steel under sublethal concentrations of tetrakis(hydroxymethyl) phosphonium sulfate (THPS) using cell counting, weight loss measurements, surface characterization, and transcriptomic analysis. The results revealed that THPS accelerated the corrosion of X70 steel in the presence of P. stutzeri , compared to THPS-free conditions. While THPS inhibited the growth of planktonic cells, it promoted biofilm formation on the X70 steel surface. Transcriptomic data suggested that this corrosion acceleration could be attributed to metabolic alterations in P. stutzeri , potentially enhancing electron transfer between bacterial cells and the steel surface. These findings provide guidance for the rational application of biocides in industrial settings.
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RESEARCH ON CHEMICAL INTERMEDIATES
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2025
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IF 3.5
Li Yuhang,Zhang Yu,Dang Qian,Shi Yu,Zhang Chi
In this study, cellulose nanofiber (CNF)/polyvinyl alcohol (PVA)/Fe 3 O 4 hybrid gel beads were synthesized via a reversed-phase suspension method, followed by in situ co-precipitation of Fe 3 O 4 nanoparticles. The structural and morphological properties of the beads were characterized using Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). FTIR analysis confirmed the successful incorporation of Fe 3 O 4 and interactions between CNF, PVA, and the nanoparticles. XRD patterns revealed the crystalline nature of Fe 3 O 4 , while SEM and TEM demonstrated a uniform dispersion of Fe 3 O 4 nanoparticles within the 3D porous network of the gel matrix. The catalytic performance of the hybrid beads was evaluated in the degradation of methylene blue (MB) using sodium borohydride (NaBH 4 ) as a reducing agent. The CNF/PVA/Fe 3 O 4 beads exhibited exceptional catalytic efficiency, achieving complete MB degradation within 6 min at room temperature. The synergistic effect between the well-dispersed Fe 3 O 4 nanoparticles and the porous gel structure enhanced reaction kinetics, demonstrating the material’s potential as an effective and reusable catalyst for dye degradation.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
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2025
·Vol. 36
·期 1
·1-18
·
IF 4.5
Jiang Xiaoge,Chen Xinyi,Li Qiming,Li Xinyi,Zhang Kaiwen,Jiang Jiazhen,Men Xinrui,Chiou Wei-Cho,Chen Song
Owing to its extremely high prevalence and the distressing consequence of tooth loss, periodontitis has attracted substantial research attention. In light of these conditions, graphene-based biomaterials have emerged as a potentially promising approach for periodontal regeneration. This study focuses on the synthesis of polydopamine-coated reduced graphene oxide (RGO@PDA), designed to harness the anti-inflammatory properties of dopamine and the osteogenic potential of graphene oxide for synergistic periodontitis treatment. RGO@PDA was synthesized through a 12-h magnetic stirring process of graphene oxide and dopamine at room temperature. This water-dispersible and biocompatible compound demonstrated remarkable efficacy in enhancing osteogenic differentiation in rat bone mesenchymal stem cells (rBMSCs), evidenced by increased alkaline phosphatase activity, mineralization, and the upregulation of osteogenic genes and proteins. Furthermore, RGO@PDA showed significant capabilities in scavenging reactive oxygen species (ROS) and reducing proinflammatory factor expression. In vivo experiments revealed that RGO@PDA not only alleviated periodontal inflammation but also promoted alveolar bone repair in periodontitis-afflicted rats. These findings underscore RGO@PDA’s dual anti-inflammatory and osteogenic effects, highlighting its potential as a transformative treatment for periodontitis. Graphical
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IONICS
·
2025
·
IF 2.6
Zhao Chenhao,Fan Jianming,Hu Zhibiao,Tu Fengzhang
Nickel selenides’ structural and composition diversity offers promising avenues for advanced battery anodes, yet their practical implementation faces persistent challenges of structural instability and sluggish kinetics. Addressing these limitations, We developed a spatially confined architecture using a template-directed hydrothermal method. This approach readily produced uniform Ni 3 Se 4 nanoparticles (size ~ 110 nm) encapsulated within conductive carbon nanoplates. Time-dependent XRD analysis confirms continuous selenization-driven phase evolution, while XPS/TGA verify the composite (26.8 wt% carbon) comprises Ni 2+ , Se 2 2− , and Se 2− species. This dual-role design—where carbon simultaneously serves as electron highway and volume-change buffer—enables breakthrough lithium storage performance: 586.2 mAh g −1 after 100 cycles (0.2 A g −1 ) with exceptional 375.5 mAh g −1 retention at ultrahigh 5 A g −1 . Electrochemical analysis demonstrates carbon spacers reduce charge-transfer resistance by > 40% versus bare counterparts. The strategically engineered interface provides critical insights for stabilizing conversion-type anodes. This is significant because, although the sodium storage performance remains challenging (167.9 mAh g −1 after 100 cycles), our study reveals fundamental differences when nickel selenide/carbon composites are employed as its anode materials.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-11
·
IF 15.7
Huang Qi,Duan Jingjing,Antonietti Markus,Chen Sheng
Replacing energy- and cost-intensive Solvay process with innovative manufacture protocol, such as operando -electrified synthesis, would provide a simpler, scale-flexible pathway to produce NaHCO 3 . However, the commercialization of such technique is hampered by the bottleneck problem of small productivity, which is two orders of magnitude below traditional Solvay process. This might be attributed to the gap in conditions between embedded processes inside the system, especially low concentrations of local alkaine, which are generated relatively slowly from one-electron hydrogen chemistry, leading to a small CO 2 –to–HCO 3 − conversion ratio. Guided by octet rule, here we embed eight-electron nitrogen chemistry into Solvay process, maximizing local alkalines generation for CO 2 conversion. By further breaking the stumbling scaling relationship with a liquid metal-derived catalyst, the system achieves productivity up to 3.63 mol L −1 h −1 .
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JOURNAL OF NANOPARTICLE RESEARCH
·
2025
·Vol. 27
·期 10
·1-16
·
IF 2.6
Zhu Junqiao,Tang Wei,Sun Zhiting,Zhu Xinhai,Quan Qiang,Yin Jiaxin,Huang Qiugui,Jia Guoxia,Zhao Yang,Tang Yuqin,Zhang Yan,Xie Linhao,Zhao Jianfu
Multiple cycles of transarterial embolization chemotherapy for hepatocellular carcinoma (HCC) can easily cause the overexpression of P-glycoprotein (P-gp), leading to multidrug resistance (MDR) of HCC. Herein, we linked PLA (polylactic acid) with doxorubicin (DOX) through acid-sensitive hydrazone bonds to prepare PLA-ADH/DOX. Then, PLA-ADH/DOX and disulfiram (DSF) were physically encapsulated into PLGA-PEG (polylactic-co-glycolic acid-polyethylene glycol) as the backbone to fabricate a drug delivery system (DOX/DSF NPs) by nanoprecipitation and emulsion solvent evaporation method. The data of physicochemical characterization showed that DOX/DSF NPs enabled excellent stability at room temperature and pH sensitivity in an acidic environment. More importantly, DOX/DSF NPs could avoid P-gp-mediated efflux through endocytosis pathways and inhibit the function of P-gp by DSF, which increases cellular uptake of DOX in HepG2/DOX cells (hepatocellular DOX-resistant cancer cell line) and promotes DOX to enter the nucleus of HepG2/DOX cells for exerting the therapeutic effect in vitro. In addition, DOX/DSF NPs could increase intracellular reactive oxygen species (ROS) levels and reduce intracellular adenosine triphosphate (ATP) levels, thereby further inhibiting the function of P-gp, increasing intracellular concentration of drugs, and ultimately overcoming MDR in HCC. Hence, the combination of DOX and DSF delivered by DOX/DSF NPs with pH-sensitive and sequentially controlled drug release may provide a new way for MDR of HCC.
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WATER AIR AND SOIL POLLUTION
·
2025
·Vol. 236
·期 15
·1-24
·
IF 3
Zang Shuyan,Wang Shuai,Li Xue,Chen Xinru,Wang Qian,Wang Juan
The removal of both organic and inorganic arsenic is crucial for safeguarding the environment and human health, which constitutes a key aspect of sustainable development. In this study, a novel method integrating Fenton oxidation with ZIF-8 adsorption was developed for the simultaneous treatment of roxarsone (ROX) and arsenite (As(III)) from wastewater. ZIF-8 was hydrothermally synthesized and characterized using X-ray Photoelectron Spectroscopy (XPS), Fourier Transform Infrared Spectroscopy (FT-IR), X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Elemental Mapping (EM), Brunauer–Emmett–Teller (BET) surface area analysis, and zeta potential analysis. Comprehensive characterization demonstrated that the synthesized ZIF-8 exhibited a well-defined rhombic dodecahedral morphology with smooth crystal surfaces and an exceptionally high specific surface area of 1836.23 m 2 /g. Under the optimized conditions for Fenton oxidation (4.90 mmol/L H 2 O 2 , 0.1380 g/L FeSO 4 ·7H 2 O, pH 3, 30 min) and ZIF-8 adsorption (0.1 g/L ZIF-8, pH 6, 180 min, 25℃), the integrated system exhibited remarkable removal efficiencies of 92.32% for ROX (20 mg/L) and 95.16% for As(III) (1 mg/L). Specifically, compared to the individual processes, the removal efficiency of ROX was increased by 20.59% (versus Fenton-only) and 52.63% (versus ZIF-8-only), while that of As(III) was enhanced by 29.17% and 35.51%, respectively. Additionally, the integrated system exhibited maximum adsorption capacities of 107.76 mg/g for ROX and 17.70 mg/g for As(III), further confirming the presence of synergistic effects between Fenton oxidation and ZIF-8 adsorption. The adsorption processes for ROX and As(III) followed pseudo-second-order kinetics and were best described by the Langmuir adsorption model, suggesting chemisorption and monolayer adsorption on a homogeneous surface. The removal mechanism in the synergistic method involved three primary pathways: oxidation reactions (•OH), electrostatic interactions (-OH/-NH 2 ), and precipitation (FeAsO 4 ). This study demonstrates that the proposed synergistic method (Fenton@ZIF-8) is a promising technology for the simultaneous removal of both organic and inorganic arsenic species from contaminated water, with strong potential for practical application in wastewater remediation.
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JOURNAL OF MATERIALS SCIENCE
·
2025
·
IF 3.9
Li Xuefei,Jiang Pan,Wu Zumin,Yu Wei,Guo Zhiwei
The severe wear of friction pairs in water-lubricated bearings, resulting from lubricating film instability under boundary lubrication, has hindered their development and application. Enhancing surface wettability to improve interfacial adsorption capacity for water molecules and promote stable water film formation under harsh operating conditions represents an effective approach for ameliorating lubrication performance in water-lubricated bearings. Hydrophilic-modified Si 3 N 4 /polyurethane (PU) composite materials were fabricated utilizing Si 3 N 4 ceramic/PU composite material fabrication technology combined with PMPC and β-cyclodextrin surface grafting techniques. Surface characteristics, mechanical properties, and tribological performance were systematically evaluated, specifically elucidating the influence mechanisms of hydrophilic groups on wettability and lubrication behavior. Results demonstrate that distinct hydrophilic groups differentially affect composite material performance, with β-cyclodextrin exhibiting more pronounced effects. Compared to the control group, the contact angles of PMPC and β-cyclodextrin-modified composite materials were decreased by 5.69% and 10.53%, respectively. Surface-bound hydrophilic groups lowered water-lubricated friction coefficients and effectively suppressed friction-induced vibration. Superior enhancement of tribological properties was provided by β-cyclodextrin modification relative to PMPC, with optimal performance achieved at solution –OH concentrations of 0.6 mol/L. This work presents a viable strategy for mitigating tribological challenges in water-lubricated bearing materials operating under boundary lubrication state. Graphical abstract
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Nature Protocols
·
2025
·
IF 16
Dong Zhen,Wu Chunlong,Chen Jiayi,Jiang Wenhao,Piatkevich Kiryl D.,Zhu Yi,Guo Tiannan
Filter-aided expansion proteomics (FAXP) is a spatial proteomics approach designed for high-resolution analysis of formalin-fixed, paraffin-embedded (FFPE) tissues. Here we describe the integration of hydrogel-based tissue expansion with mass spectrometry, enabling isotropic expansion and robust protein retention while preserving spatial features. The FAXP workflow consists of several sequential steps, including tissue section dewaxing, in situ protein anchoring, hydrogel embedding, homogenization, staining, isotropic expansion, microdissection and filter-aided in-gel digestion to maximize peptide recovery. The Protocol integrates laser capture microdissection, enabling the precise isolation of single cells and subcellular components for subcellular spatial proteomics analysis. The approach achieves up to a fivefold linear expansion factor of FFPE tissue, including extracellular matrix-rich samples such as colorectal cancer, with less than 6% distortion, enabling the identification of an average of 2,368 proteins from single mouse liver nucleus shape and 3,312 proteins from single mouse liver cell shape using an Astral mass spectrometer. The method is compatible with diverse tissue types, including extracellular matrix-rich specimens, and integrates seamlessly with imaging workflows, such as immunostaining, for spatially resolved proteomic analysis. FAXP enables researchers to obtain comprehensive proteomic profiles with strong reproducibility and high sensitivity. The entire workflow takes ~27 h and requires only commercially available reagents and supplies and is thus accessible for researchers with intermediate expertise in tissue processing, microscopy and proteomics. FAXP can advance spatial proteomics-based studies, in particular of cancer heterogeneity, neurodegenerative diseases and cellular microenvironments within FFPE tissues, including archival clinical samples.
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Journal of Food Measurement and Characterization
·
2025
·
IF 3.3
Hu Lu,Li Yuanbin,Li Shanshan,Wu Chengyu,Wang Zhenyuan,Zhang Jichuan,Huang Chujie,Zhang Jiaheng
Chronic oxidative stress and inflammation accelerate skin aging by inducing structural compromise in intracellular components and extracellular matrix (ECM) degradation. Plant-derived bioactive peptides have attracted great attention for their outstanding biological activities. However, before protein hydrolysis, the traditional extraction strategy of protein was unsustainable for its polluting solvents and reagents. Tricholoma matsutake ( T. matsutake ) is rich in proteins, vitamins, poly-peptides and double-chain polysaccharides. Several natural deep eutectic solvents (NaDESs) were synthesized for the efficient extraction of protein from T. matsutake . The highest yield of protein (52.5 ± 0.66%) was obtained from extraction at 35 of matrine/1,2-Propanediol (MaPd) concentration for 2 h, a solid-liquid ratio of 40 mL/mg. Furthermore, the optimal peptides were prepared by protein hydrolysis with 20% alkaline protease at 55 °C for 90 min. Notably, T. matsutake peptides were good in scavenging radicals and in decreased levels of IL-1α, IL-6. Meanwhile, T. matsutake peptides exhibited anti-skin aging ability by preventing the secretion of MMP-1 and MMP-3, degradation of collagen I and elastin. The study demonstrates that NaDES combined with enzymolysis extraction is a suitable, green technique with high potential of peptides from T. matsutake . Therefore, T. matsutake peptides can be considered for developing crude drug formulations and functional food or cosmetics materials with anti-inflammatory and Anti-aging properties.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-18
·
IF 15.7
Wang Weili,Ye Binglin,Liu Yao,Li Zhi,Huang Qianying,Zhou Jialin,Hu Min,Jiang Jun,Wang Weilin,Mao Zhengwei,Ding Yuan
Metronomic photodynamic therapy is a long-term, low-dose treatment strategy that employs optical devices with continuous photosensitizer administration and requires stable device attachment with a consistent power source. These factors significantly limit patient mobility. Currently, no metronomic photodynamic therapy modality can operate independent of external devices, underscoring the critical need for in vivo light sources that function without external energy inputs. In this study, we integrate self-luminous bacteria with a photosensitizer in alginate microcapsules to create a self-driven metronomic photodynamic therapy that can be securely implanted within a tumour, thereby enabling continuous light emission without requiring an external energy source or ongoing replenishment of photosensitive reactants. By harnessing nutrients from the tumour microenvironment, this system sustains the generation of reactive oxygen species. A single injection effectively eliminates larger tumours (>300 mm 3 ) in an opaque melanoma mouse model and transplanted hepatocarcinoma rabbit model. Self-driven metronomic photodynamic therapy demonstrates advantages over traditional photodynamic therapy, indicating its potential as a versatile therapeutic approach for cancer treatment with deeply situated lesions.
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