JOURNAL OF NANOBIOTECHNOLOGY
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2026
·
IF 15
Lan Haibo,Wu Zede,Xia Jinghua,Li Qiuyu,Gao Mengdan,Cai Zhuoxiu,Tan Weijing,Liu Minyi,Xu Ziting,Gao Yang,Zhang Li,Zhao Bingxia,Li Yingjia,Liang Yu
Introduction The efficacy of immunotherapy in triple-negative breast cancer (TNBC) is primarily challenged by its inherent low immunogenicity, which is further undermined by the immunosuppressive activity of tumor-associated polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs). The hypoxic microenvironment renders PMN-MDSCs susceptible to ferroptosis and exacerbates immunosuppression. Objectives This study aimed to design a multifunctional nanoplatform comprising Cu/Mn bimetallic metal-organic frameworks decorated with gold (Au) nanozymes (CMAP MOFs) that simultaneously enhances tumor immunogenicity and alleviates immunosuppression. Methods The characteristics of the nanosystem were evaluated using transmission electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, and ultraviolet-visible spectrophotometry. In vitro experiments employed Western blotting, immunofluorescence, and flow cytometry to investigate the mechanisms of enhanced immunogenicity and alleviated immunosuppression in 4T1 cells. In vivo experiments evaluated the therapeutic efficacy of the nanosystem in BALB/c mice bearing implanted 4T1 tumors. Results Within tumor cells, the CMAP MOFs undergo GSH-responsive disintegration. The released Cu/Mn ions catalyze Fenton-like reaction to induce tumor cell ferroptosis and mitochondrial DNA damage, activating cGAS-STING pathway, and facilitating CD8 + T cells recruitment. Simultaneously, released Au nanozymes catalyze H 2 O 2 conversion to O 2 , alleviating hypoxia and preventing PMN-MDSCs ferroptosis and associated immunosuppression. While the immunogenicity-enhancing CMP MOFs group increased CD8⁺ T cell infiltration from 21% to 28.3% with 74.1% tumor growth inhibition, the combined immunogenicity enhancement and immunosuppression relief CMAP MOFs group further boosted CD8⁺ T cell infiltration to 32.4% with superior tumor growth inhibition of 81.3%, with IFN-γ and GZMB expression elevated by 2.2-fold and 2.0-fold (CMP MOFs) and 3.4-fold and 3.0-fold (CMAP MOFs) compared to control. This strategy offers a promising approach for enhancing immunotherapy in TNBC patients. Graphical The alternative text for this image may have been generated using AI.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2026
·Vol. 37
·期 13
·962
·
IF 3.2
Xu Xiaoying,Liu Ming,Zhou Hang,Guo Yangfan,Pei Xuanxu,Li Pengcheng,Yu Shihui
Considering its excellent film-forming properties and biodegradability, chitosan was expected to become one of the new raw materials for green electronic components. However, pure chitosan film was difficult to achieve satisfactory application in the field of ultra-flexible electronic devices due to its insufficient flexibility and poor high-temperature resistance. In this study, citric acid and glycerol were used to modify chitosan to enhance its overall performance. Based on this, a conductive film composed of silver nanowires (AgNWs) embedded into citric acid cross-linked chitosan was fabricated via a transfer method. During the preparation process, the optoelectronic properties of the composite film were improved by the method of heat treatment. The results showed that the composite film exhibited low surface roughness ( RMS = 5.48 ± 1.16), excellent transmittance (the sheet resistance is 15 Ω/sq and the transmittance at 550 nm is 73.7%), good thermal stability (no observable alteration in sheet resistivity and appearance features after being maintained at 180 0 C for 30 min), and outstanding flexibility. When tested as a heater, the film displayed favorable heating performance. The composite film prepared in this study showed the promising development value in the field of flexible electronic devices.
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Experimental Hematology & Oncology
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2026
·Vol. 15
·期 1
·36
·
IF 17.5
Xiong Shumin,Zhou Ren,Wei Chuijin,Wang Xiaomin,Tang Yunhan,Dong Liaoliao,Yu Ping,Pei Duanqing,Chen Zhu,Chen Sai-Juan,Cheng Lin
Background The clinical supply of hematopoietic cells is severely constrained by the limitations of donor donation and inefficient in vitro generation. While generating these cells within interspecies chimeras presents a groundbreaking alternative, the fundamental biological properties and therapeutic potential of the resulting xenogeneic hematopoietic cells remain poorly characterized. Methods We generated xenogeneic hematopoietic cells in rodent models via blastocyst complementation and bone marrow transplantation. A comprehensive comparative analysis of these cells was conducted using single-cell RNA sequencing and proteomics. Their functional efficacy was rigorously evaluated through reverse transplantation into a series of donor-species disease models, including hemorrhagic anemia, thalassemia, thrombocytopenia, and leukemia. Results Bone marrow transplantation yielded significantly higher chimeric efficiency than blastocyst complementation. Xenogeneic hematopoietic cells, including red blood cells, platelets, and white blood cells, exhibited a transcriptional and proteomic profile that was dominantly donor-specific. Crucially, these cells did not elicit significant immune rejection upon reverse transfusion. Functionally, xenogeneic red blood cells rescued models of hemorrhagic anemia and thalassemia, platelets alleviated thrombocytopenia, and xenogeneic T cells engineered with a chimeric antigen receptor effectively suppressed leukemia progression. Furthermore, the implantation of xenogeneic hematopoietic cells partially reconstituted splenic morphology and function in immunodeficient recipients. Conclusion Our study provides the first comprehensive functional validation of xenogeneic hematopoietic cells generated in interspecies bioreactors. We definitively show that these cells possess donor-like molecular identities, evade immune rejection, and serve as effective “seed cells” to rescue a wide spectrum of hematologic diseases. This work establishes a transformative paradigm for utilizing interspecies chimeras to overcome critical shortages in transfusion and cellular therapies.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
·
IF 15
Nannan Wang,Ke Wang,Yuepeng Cao,Guoqing Su,Jinghang Qian,Jingru Shen,Jiayuan Jiang,Zian Chen,Xing Huang,Chengshuai Si,Jun Bao,Lei Ding,Liu Yang
The clinical efficacy of immune checkpoint inhibitors (ICIs) in colorectal cancer (CRC) is restricted by a dense, rigid extracellular matrix (ECM) that acts as a physical barrier to immune infiltration. To address this resistance, a biomimetic nanoplatform (MDPAs) was developed, comprising Defactinib-loaded mesoporous silica nanoparticles encapsulated in PD-L1 antibody-conjugated platelet membranes. Leveraging platelet-mimetic adhesion for tumor accumulation, MDPAs were shown to inhibit the Integrin-FAK-YAP mechanotransduction axis, leading to YAP cytoplasmic sequestration and attenuated cytoskeletal tension. This alleviation of the mechanical niche is associated with enhanced cytotoxic T cell infiltration, which synergizes with co-delivered PD-L1 antibodies to activate antitumor immunity. Single-cell RNA sequencing reveals that MDPAs remodel immune-epithelial-stromal crosstalk, driving tumor cells from a mesenchymal-like phenotype toward an immunologically susceptible, antigen-presenting state. In orthotopic, liver metastasis, and post-surgical recurrence models, MDPA treatment elicited tumor regression and extended survival with a favorable biosafety profile. These findings suggest that modulating tumor mechanics may represent an effective strategy to sensitize refractory CRC to immunotherapy.
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Food Analytical Methods
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2026
·Vol. 19
·期 7
·209
·
IF 3
Xie Mingmeng,Sun Xiaodong,Wen Zijun,Jiang Xinhui,Mao Qiu,Li Siqiao,Wang Wei,Zhang Zhengwei
The widespread use of acetamiprid (ACE) poses increasing threats to food safety and human health due to its environmental persistence and potential toxicity. Herein, a fluorescent europium-based metal–organic framework (Eu-MOF) was synthesized via a facile room-temperature direct mixing strategy, which serves as a rapid and selective fluorescent probe for ACE detection. The dual-ligand Eu-MOF exhibited intrinsic multi-emission properties, with a dominant red fluorescence at 616 nm that is selectively quenched upon ACE exposure. Under optimized conditions, the sensor showed two linear response ranges (0.01–6 and 6–20 µg/mL) with a detection limit as low as 3.03 ng/mL. Mechanistic investigations reveal that the quenching is primarily governed by the inner filter effect (IFE), supported by spectral overlap and unaltered fluorescence lifetime. The probe demonstrates high specificity against common interfering substances and enables accurate quantification of ACE in complex matrices such as apples and oranges, with satisfactory recovery rates (94.35–100.6%) and low relative standard deviations (≤ 1.96%). This work provides a promising platform for rapid, low-cost, and highly sensitive monitoring of pesticide residues in food safety surveillance.
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Scientific Reports
·
2026
·
IF 4.9
Xiang Qingqing,Yu Rong,Huang Li,Liu Qingqing,Qin Nuo,Wang Li,Wu Yan,Fu Hang
Due to a lack of complete mechanistic understanding, there are no specific therapeutics for necrotizing enterocolitis (NEC), a deadly gastrointestinal disease affecting premature newborns. While sodium butyrate offers intestinal protection, its efficacy is strictly dose-dependent, and the underlying mechanisms regulating intestinal epithelial cell (IEC) survival remain elusive. Here, using neonatal murine NEC models and human IECs, we demonstrate that moderate-dose butyrate (50 mg/kg) significantly attenuates mucosal injury and improves survival, whereas high-dose butyrate (250 mg/kg) exacerbates mortality by inducing complex cell death pathways including necroptosis and ferroptosis. Mechanistically, moderate butyrate suppresses glycolysis and intracellular lactate production, which restores expression of the translational regulator PABPC1; PABPC1 then binds to YB-1 mRNA to enhance YB-1 protein synthesis without altering transcription. Elevated YB-1 subsequently binds BCL-2 mRNA, increasing BCL-2 protein levels to inhibit intrinsic mitochondrial apoptosis. Functional validation shows that YB-1 knockdown abolishes butyrate-mediated protection and exacerbates TNF-α-induced apoptosis, while YB-1 overexpression rescues cell viability, and exogenous lactate supplementation reverses these effects by suppressing the PABPC1-YB-1 axis. These findings elucidate a novel Lactate-PABPC1-YB-1-BCL-2 signaling axis through which butyrate safeguards the intestinal epithelium, highlighting precise dosing and the modulation of epithelial translational control as promising therapeutic strategies for NEC.
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Light-Science & Applications
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2026
·Vol. 15
·期 1
·216
·
IF 24
Li Zesen,Li Zhuoran,Cheng Zhongyuan,Borri Claudia,Giannetti Ambra,Lan Ni,Long Junqiu,Chen Wenwei,Cai Xiangran,Yang Jingge,Guan Bai-Ou,Chiavaioli Francesco,Ran Yang
The combination of optical fiber and phototheranostic agents has emerged as a promising strategy to address the challenges of limited light penetration depth and systemic toxicity of nanomaterials. However, the multiplexing potential of fiber-optic probes remains underrated, resulting in enlarged incisions, repeated invasive procedures, and a lack of real-time therapeutic feedback. Herein, we propose a scheme for single‑fiber multifunctional integration leveraging wavelength division multiplexing technology. As a proof-of-concept, by co-immobilizing pH indicator, temperature indicator, and photothermal agent with non-overlapped excitation bands onto tapered optical fiber surface, a fiber-optic theranostic probe enabling closed-loop tumor photothermal therapy was developed. Pre-treatment, the probe can achieve tumor edge identification through revealing the tumor pH gradient. Intra-treatment, the photothermal agent can convert optical energy into heat for photothermal therapy, while simultaneous temperature monitoring enables precise thermal dose control. Post-treatment, rapid efficacy assessment can be achieved via real-time monitoring of the reversal of acidic tumor microenvironment. Animal experiments validate the excellent therapeutic efficacy and biocompatibility of the probe. This research opens new avenues for multifunctional fiber-optic theranostic platforms, where modular wavelength assignment enables customizable minimally invasive interventions and feedback monitoring, holding significant promise for both clinical practice and mechanistic exploration.
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JOURNAL OF ELECTRONIC MATERIALS
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2026
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IF 2.8
Yue Lei,Wan Yu,Wang Yanting,Feng Changhao
Effective detection of n -butanol is essential for human health and environmental protection. Bismuth ferrite is a gas-sensitive material candidate with excellent potential, and rare earth element doping is an effective modification strategy to enhance the gas-sensitive performances of gas sensors. In this work, a series of Y-doped BiFeO 3 nanofibers (BFO, 1% Y-BFO, 3% Y-BFO, and 5% Y-BFO) were prepared by electrospinning. Among them, the gas sensors based on 3% Y-BFO nanofibers exhibited significantly enhanced gas-sensing performances for n -butanol. At an optimum operating temperature of 150°C, the synthesized 3% Y-BFO sensor has a response of 60.2 and a response/recovery time of 9/47 s for 100 ppm n -butanol. In addition, it has a lower limit of detection as low as 0.5 ppm and excellent repeatability. Therefore, gas sensors based on Y-doped BiFeO 3 nanofibers represent a promising solution for the efficient detection of n -butanol.
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Scientific Reports
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2026
·
IF 4.9
Wang Xiang,Luo Kai,Bai He,Zhang Xudong,Qu Jialin,Wang Xiaoqing,Sun Xu,Zhao Yuting,Wang Bin,Zhang Guixin
Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive liver malignancy with rising global incidence and poor prognosis. Despite recent advances in treatment strategies, effective therapeutic options for ICC remain limited. Solamargine (SM), a natural steroidal alkaloid, has demonstrated anticancer activity, yet its mechanisms in ICC are not fully understood. This study shows that SM inhibits ICC progression by inducing both apoptosis and ferroptosis in vitro and in vivo. SM significantly suppressed proliferation, migration, and invasion of ICC cells (HUCCT-1 and HCCC-9810), with minimal cytotoxicity toward normal biliary epithelial cells (HIBEC). Mechanistically, SM induced mitochondrial dysfunction, ROS accumulation, and lipid peroxidation, leading to apoptosis and ferroptosis. Transcriptome sequencing and gene set enrichment analysis (GSEA) revealed that SM treatment activated apoptosis- and ferroptosis-related pathways, including MAPK signaling. Western blot analysis and pharmacological inhibition assays confirmed that p38 MAPK activation was essential for SM-induced cell death, with ROS acting as an upstream activator. In vivo, SM significantly inhibited tumor growth in both orthotopic and subcutaneous ICC mouse models and showed better tolerability than gemcitabine. Tumor tissue analysis further confirmed increased markers of apoptosis and ferroptosis, along with p38 MAPK activation. These findings suggest that SM exerts dual antitumor effects in ICC, which are associated with the induction of apoptosis and ferroptosis and may involve the ROS/p38 MAPK signaling axis, highlighting its potential as a therapeutic candidate for ICC.
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Nature Biomedical Engineering
·
2026
·
IF 26.3
Lai Keren,He Peiyi,He Yuejian,Xu Mingheng,Zhao Xiaoxi,Wang Xinyue,Miao Guifeng,Feng Yanqiu,Wang Xiaorui
Nanomedicines are susceptible to immunogenic clearance before reaching their disease targets, thereby limiting their pharmacodynamic efficacy. To overcome this challenge, PEGylation has been developed and widely used. However, in therapies that necessitate multiple repeated administrations, the immunogenicity of PEGylated nanoparticles often becomes non-negligible, resulting in an accelerated blood clearance (ABC) effect and declining therapeutic efficacy. Here we propose a simple and clinically applicable strategy of pre-intervention with FDA-approved intravenous immunoglobulin (IVIG) before injection of nanoparticles. Pretreatment with IVIG was found to regulate the organism’s immunologic macroenvironment and transiently block the mononuclear phagocyte system, thereby circumventing the anti-PEG antibody-mediated clearance of nanomedicines. The universal applicability of the IVIG pretreatment strategy is demonstrated by its consistent reversal of the ABC effect across five structurally diverse nanomaterials, with sizes of 10–120 nm. IVIG significantly enhances therapeutic efficiency in breast tumours, particularly in large tumours (~350 mm 3 ), with up to a 3.9-fold improvement. Overall, pre-intervention with IVIG opens a new paradigm for addressing the immunogenic clearance issue and enhancing the performance of nanomedicines.
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WATER AIR AND SOIL POLLUTION
·
2026
·Vol. 237
·期 14
·791
·
IF 3.5
Yu Lian,Lu Jiarui,Yu Meng,Duan Yajing,Zhang Baofeng,Zhang Xuan,Wang Xiaoyue,Liang Cunzhen
Cu(I) doped Fe 3 O 4 nanoparticles was loaded onto graphene oxide, Cu-Fe 3 O 4 /GO with binary active sites and accelerated Fe(III)/Fe(II) cycle showed higher tetracycline hydrochloride oxidation efficiency than Fe 3 O 4 and Cu-Fe 3 O 4 , the influences of initial H 2 O 2 concentration, reaction pH, catalyst dosage, reaction temperature and radical scavengers on catalytic performance of Cu-Fe 3 O 4 /GO were investigated. The heterogeneous Fenton reaction over Cu-Fe 3 O 4 /GO surface contained Fe(III)/Fe(II) and Cu(II)/Cu(I) active sites, Fe species were the dominant active centers. Cu-Fe 3 O 4 nanoparticles and GO combined via C–O–Fe bond and formed a stable Cu-Fe 3 O 4 /GO conductive structure, which promoted electrons transfer between Cu-Fe 3 O 4 and H 2 O 2 , thus accelerating Fe(III)/Fe(II) and Cu(II)/Cu(I) cycles. GO significantly improved specific surface area, Cu-Fe 3 O 4 nanoparticles dispersibility, and adsorption performance of catalyst. Furthermore, the strong interaction between GO and Cu-Fe 3 O 4 prevented ions from leach, GO captured the soluble Fe(III) which was efficiently reduced to Fe(II) surf by surrounding H 2 O 2 and Cu(I) surf . The degradation efficiency maintained 80.7% after six cycles, the excellent stability can be ascribed to the strong interaction between Cu-Fe 3 O 4 and GO. Reactive oxygen species scavenging results indicated that surface-bound • OH surf played a dominating role, followed by aqueous • OH aq and superoxide radicals (O 2 •− ).
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Advanced Fiber Materials
·
2026
·
IF 22.6
Liu Haoran,Sun Jiahui,Dong Jiancheng,Zhu Haijun,Peng Yidong,Gu Yanqing,Huang Yunpeng,Liu Tianxi
Excessive exudate accumulation and chronic inflammation are major barriers to diabetic wound repair, leading to infection risk and impaired tissue regeneration. Conventional dressings lack elasticity and intimate skin conformability, often adhering to fragile tissue and causing secondary trauma. Herein, we developed an ultra-conformable Janus dressing composed of a gentamicin sulfate (GS)-loaded styrene–ethylene–butylene–styrene (SEBS) immune-modulating layer and a PEO–PPO–PEO triblock copolymer (F127)/curcumin (Cur)-loaded thermoplastic polyurethane (TPU) pH-visualizing layer. The asymmetric design integrates differences in surface wettability and fiber porosity between the two layers and enables unidirectional and anti-gravity transport of wound exudate from the SEBS/GS side to the TPU/F127/Cur side, effectively preventing fluid reflux and reducing infection risk. The soft and elastic polymeric matrix ensures intimate wound conformity and mechanical protection, while facilitating angiogenesis and collagen deposition. Furthermore, the pH-responsive dressing not only absorbs inflammatory exudates, but also provides visual, dynamic monitoring of the healing process through pH-dependent color changes. In vitro assays and histological analyses demonstrated that GS-mediated immunomodulation via inflammation suppression and microenvironment improvement markedly accelerated wound closure in diabetic models within 12 days. This multifunctional dressing offers a promising pathway toward next-generation, intelligent, and patient-friendly therapies for chronic diabetic wounds. Graphical
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