CHINESE JOURNAL OF POLYMER SCIENCE
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2026
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IF 4.6
Li Yun-Tao,Sun Shun-Peng,Jia Ya-Meng,Li Shu-Sheng,Zong Chuan-Yong,Jiang Xu-Bao,Zhu Xiao-Li
Traditional acrylate reactive diluents, which are derived from fossil resources, are known to exhibit significant irritation and allergenic potential, leading to their prohibition in high-end electronics, particularly in wearable devices. To address these limitations, four bio-based acrylate reactive diluents (BRDs) were synthesized via the reaction of alcohols derived from renewable sources, piperitol, vanillin, eugenol, and isosorbide, with methacrylic anhydride. The viscosity of the synthesized BRDs and the T g of their corresponding polymers were systematically evaluated and compared with those of the petroleum-based diluent isobornyl acrylate (IBOA). The BRDs were then blended with acrylate-terminated polyurethane (APU) to formulate a series of UV-curable polyurethane adhesives (APU-BRDs). The results suggest that BRDs effectively reduce the viscosity of APU. By selecting and combining BRDs, the bonding strength of APU-BRDs to polar substrates such as PC and glass can reach 20 MPa. Even for non-polar substrates like PE, the strength is close to 5 MPa. The values obtained in this study exceed those of adhesives prepared using the conventional petroleum-based diluent IBOA. Furthermore, the study explored the potential application of APU-BRDs in smart wearable devices, confirming their suitability for next-generation wearable technology.
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高影响因子
Science China-Materials
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2026
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IF 7.7
Yin Peng,Yang Zhu,Pu Hongting
The localized overheating in high-rate lithium-ion battery (LIB) or lithium metal battery (LMB) accelerates dendrite formation, which disrupts the uniformity of current density and thermal distribution. This study constructs a Janus-structured and polybenzimidazole (PBI) welded separator (JNS@PBI) with polypropylene nanofibers (PPNFs) (via multilayer co-extrusion) on one face and nanoscale carbon black-modified PPNFs (CPPNFs) on the other. The CPPNFs layer with electronic conductivity homogenizes the interfacial current distribution and heat dissipation, while the PPNFs layer provides electronic insulation. PBI with welding function and intrinsic ionic conductivity not only improves mechanical properties but also enhances the lithium-ion transport. The synergistic transport of ions and electrons is available at the interface between JNS@PBI and the solid electrolyte interphase. Density functional theory (DFT) calculations further elucidate how JNS@PBI enhances interfacial ion transport and regulates lithium deposition. JNS@PBI exhibits high porosity (71.3%), superior electrolyte uptake (451%), and high ionic conductivity (1.80 mS cm −1 ). Electrochemical tests further confirm the exceptional interfacial stability, stable polarization voltage during 2000 h of plating/stripping cycles, remarkable rate capability and cycling endurance, high-capacity retention rates of 85.2% after 700 cycles at 1 C and 90.3% after 1500 cycles at 3 C high rate are observed in assembled LiFePO 4 /graphite full cells. This provides a promising way for next-generation separators for high-safety LIB or LMB.
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Advanced Composites and Hybrid Materials
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2026
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IF 15.5
Yang Minghui,Hua Zhirui,Shi Xiaolin,Song Yantao,Tan Haiyan,Zheng Dingyuan,Zhang Yanhua
In nature, the plant cuticle serves as a sophisticated organic barrier, where a rigid polysaccharide framework is integrated with self-assembled epicuticular waxes to resist environmental stressors. Inspired by this evolutionary paradigm, we propose a “skeleton-skin” dual-reinforced strategy to fabricate a robust, superhydrophobic, and antibacterial wood composite (SPAFD). A rigid internal “Skeleton” was constructed by selectively removing lignin and conducting in-situ ring-opening polymerization of polylactic acid within the cellulose scaffold, achieving a 746% increase in compressive strength. Simultaneously, a durable external “skin” was engineered through the synergistic interfacial assembly of arachidic acid and 1H, 1H, 2H, 2H-perfluorodecyltriethoxysilane, mimicking the hierarchical protection of plant waxes. Supported by density functional theory calculations, this integration overcome interfacial kinetic barriers to reach a deep thermodynamic basin, while establishing a localized low-energy electrostatic shield that masks substrate polarity. Consequently, the SPAFD composite achieves stable superhydrophobicity (water contact angle > 154°) and maintains its non-wetting integrity under severe mechanical abrasion, chemical corrosion, and long-term hydrothermal aging (80 °C, 80% RH for 56 days). Additionally, a dual “passive-active” antibacterial mechanism was achieved, combining physical anti-adhesion with chemical sterilization via slow-release lactic acid. This work provides a theoretically guided approach for transforming wood into high-performance structural materials for rigorous outdoor applications. Graphical
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Nature Communications
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2026
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IF 18.1
Haoyu Yin,Chenghan Xie,Yunbo Dai,Ziming Cao,Shun Ao,Wenjia Wu,Zongyao Zhou,Jun Ma,Bruce E Logan,Zhongbiao Wu,Le Shi
The electro-oxidation of formaldehyde at low potential with anodic hydrogen evolution offers an energy-saving way for hydrogen production. Coupling this reaction in an acidic catholyte with an alkaline anolyte within an acid-alkali hybrid electrochemical system enables self-powered hydrogen production with electricity generation. However, the performance of such systems is constrained by the membrane: conventional forward-bias bipolar membranes suffer from high ohmic resistance due to the delamination, while monopolar ion exchange membranes lead to undesirable acid-alkali neutralization. To address these limitations, we design a composite ion exchange membrane, composed of a through-pore anion exchange membrane and a cation exchange membrane. Employing this membrane, the resulting system achieves a Faradaic efficiency for hydrogen of 198 ± 3 % and outputs a peak power density of 142 mW cm −2 . A numerical model demonstrates that the through-pore anion exchange membrane effectively regulates charge carrier transport, yielding low resistance and improved acid-alkali utilization efficiency. Here, we provide a promising pathway for sustainable hydrogen production by enabling the efficient conversion of acid-alkali chemical energy into electricity. Membrane limitations constrain the performance of acid-alkali hybrid electrochemical system. Here, the authors design a composite ion exchange membrane applying in such system, yielding low resistance and improved acid-alkali utilization efficiency with efficient electricity and hydrogen production.
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PubMed
高影响因子
Cell Death Discovery
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2026
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IF 10.4
Yuan Naonao,Ma Zhibo,Xue Zihan,Li Qingwen,Zhou Xi,Liu Jing,Lin Yanping,Gu Shiqi,Yi Sichuan,Lu Yao,Lan Peixiang
Distinct macrophage activation states play key roles in the formation and progression of heart allograft fibrosis. However, the exact molecular mechanisms that regulate the balance between inflammatory and pro-fibrotic macrophage responses during fibrosis remain poorly understood. Identifying and targeting the key molecule that regulates the differentiation of inflammatory and pro-fibrotic macrophages might be a pivotal strategy for mitigating fibrosis and prolonging allograft survival. Here, using single-cell sequencing analysis of human heart allografts fibrosis patient samples, we identified a population of macrophages that undergo epigenetic reprogramming through DNA methylation regulated by DNA methyltransferase DNMT1. DNMT1 small-molecule inhibitor 5-AzaC significantly attenuated graft fibrosis and prolonged allograft survival by inhibiting both inflammation and excessive tissue repair. Mechanistically, DNMT1-targeted macrophages suppress the DNA methylation level of the CpG island in the first intron of PTPRD, promoting PTPRD expression, which in turn inhibits the activity of STAT3 and STAT6 pathways, thereby suppressing the differentiation of inflammation and pro-fibrotic macrophages. Based on this, we developed a macrophage-targeted nanocarrier, MV/PEG-LPs, to load 5-AzaC, thereby enhancing its therapeutic precision for allograft fibrosis. Our results reveal a novel target, DNA methylation in macrophages, for the treatment of fibrosis-related diseases.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
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2026
·Vol. 61
·期 35
·26130-26141
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IF 4.4
Zhang Liheng,Miao Huaibin,Li Fangfei
Microporous SAPO-34 molecular sieves are prone to rapid deactivation due to coke deposition in the methanol-to-olefins (MTO) reaction, primarily because of diffusion limitations. To address this issue, we propose a metal–organic framework (MOF)-assisted one-step hydrothermal synthesis strategy. For the first time, UiO-66 is introduced into the SAPO-34 synthesis system, successfully constructing SAPO-34 crystals with a stepped, special morphology. The results indicate that the addition of UiO-66 causes the samples to gradually aggregate and stack, forming an abundant hierarchical pore structure. Meanwhile, Zr species are incorporated into the molecular sieve framework, which effectively modulates the acidic properties by significantly reducing the strength of the strong acid sites. When applied to the MTO reaction, the UiO-66-modified SAPO-34 exhibits a significantly prolonged catalytic lifetime and enhanced selectivity towards light olefins (ethylene and propylene) compared to the unmodified SAPO-34. This enhanced performance is attributed to the abundant hierarchical pores providing rapid diffusion channels, and the reduced acid strength retarding coke deposition. This study provides a new design strategy for the one-step construction of hierarchical pore structures coupled with the introduction of metal species to regulate acidity.
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高影响因子
Science China-Life Sciences
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2026
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IF 9.6
Liu Zichao,Yang Huai,Zhang Zenan,Kuang Chenke,Deng Liyong,Li Yueyong,Jin Linyuan,Nie Hongjun,Wang Guihua,Du Meng,Chen Zhiyi
The limited therapeutic efficacy of radiotherapy (RT) in breast cancer is closely linked to hypoxia, which is caused by structurally abnormal vascular networks in the tumor microenvironment (TME). Tumor vascular normalization has emerged as a promising strategy to enhance radiosensitization by alleviating hypoxia. However, current vascular normalization methods face critical limitations, including off-target effects and inadequate spatiotemporal precision. Therefore, developing precise and efficient vascular normalization strategies is crucial for improving RT efficacy. In this study, we developed a tumor vascular normalization strategy based on ultrasound-targeted cavitation for radiosensitization. We synthesized VEGFR2-targeted microbubbles (MB@VEGFR2) to selectively accumulate on tumor vascular endothelial cells. Ultrasound-targeted cavitation enhanced local tumor blood perfusion, increased vascular diameter and maturity, and effectively alleviated hypoxia. By monitoring the time window of vascular normalization and administering RT within this period, tumor growth was significantly suppressed, with a 2.5-fold reduction in tumor volume compared to RT alone. Mechanistically, ultrasound-targeted cavitation promoted ATP release from endothelial cells, activating the PI3K/AKT/eNOS pathway to elevate nitric oxide (NO) production by 4-fold, thereby inhibiting abnormal vascular formation. This study demonstrates that ultrasound-targeted cavitation precisely achieves tumor vascular normalization, effectively improving RT efficacy.
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高影响因子
Journal of Neuroinflammation
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2026
·Vol. 23
·期 1
·71
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IF 11.5
Geng Fan,Zhao Na,Zhou Lv,Liu Xue-ting,Chen Xiu,Wang Zhi-Tian,Zhang Zhi-Jun,Ren Qing-Guo
Background Alzheimer’s disease (AD) is characterized by extracellular Aβ deposition and tau hyperphosphorylation, leading to synaptic dysfunction and cognitive decline. Mounting evidence indicates that circadian rhythm disorders are associated with increased AD risks. Growing evidence implicates the microbiota-gut-brain axis and its metabolites as critical modulators of both circadian physiology and AD pathology. However, the molecular mechanism through which circadian disturbance modulates gut-brain communication to influence AD pathogenesis remains poorly understood. Methods Core circadian clock gene expression was assessed across four AD human brain datasets, and found Cry2 to be the only gene consistently downregulated. To investigate its functional role in vivo, we established a mouse model with hippocampal-specific Cry2 knockdown. Cognitive performance, gut microbiota composition, and metabolic alterations were evaluated using the Morris water maze, 16 S rRNA sequencing, and untargeted metabolomics, respectively. Intestinal barrier integrity, blood-brain barrier function, and neuroinflammatory signaling were examined through immunohistochemistry, immunofluorescence, and Western blotting. The contribution of microbiota disturbance was tested using fecal microbiota transplantation (FMT). The involvement of sphingolipid signaling was further assessed through FMT, pharmacological modulation with the S1PR agonist FTY720, NLRP3 knockout mice, and microglial assays. Results We found that the expression of Cry2 consistently decreased in the AD group in four AD-related datasets. Then, knockdown of Cry2 in the hippocampus ( shCry2 ) caused dysbiosis of gut microbiota, intestinal barrier impairment, cognitive dysfunction and tau pathology in mice. Intriguingly, along with the disturbance in intestinal sphingolipid metabolism pathways, activation of the S1P/NLRP3/IL-1β pathway was found in the brain of shCry2 mice. Transplantation of “ shCry2 microbiota” mimicked the pathological and behavioral changes induced by hippocampal Cry2 deficiency. Administration of S1PR agonist FTY720 significantly improved cognitive impairment and decreased the expression of NLRP3 in shCry2 mice, and knockdown of Cry2 in NLRP3 −/− mice alleviated tau pathology and cognitive impairment. FTY720 and S1PR1 antagonist W146 dose-dependently modulated the expression of NLRP3 in BV2 cells. Overexpressing Cry2 in the hippocampus significantly alleviated the tau pathology and cognitive decline in APP/PS1 mice. Conclusion Hippocampal Cry2 deficiency leads to cognitive impairment through the gut-brain axis mediated S1P/NLRP3/IL-1β pathway and might provide a potential therapeutic target for AD.
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高影响因子
Cell Death & Disease
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2026
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IF 12.2
Yin Min-Yue,Li Xue,Zhang Jun-Qi,Lin Bo-Shen,Zhang Chang-Hao,Liu Yu-Hang,Zhang Shu-Tian,Xie Si-An
Extracellular matrix (ECM) stiffening and metabolic reprogramming are hallmarks of colorectal cancer (CRC) progression; however, the mechanistic link between biomechanical cues and cholesterol metabolism remains poorly defined. Here, we delineate a mechano-metabolic pathway in which matrix stiffness activates the mechanosensitive Ca²⁺ channel Piezo1 to drive structural reorganization of the Golgi apparatus, promoting its close apposition with the endoplasmic reticulum (ER). This organelle remodeling facilitates the proteolytic activation and nuclear translocation of SREBP2, thereby transcriptionally upregulating HMGCR, the rate-limiting enzyme for cholesterol synthesis, and elevating intracellular cholesterol. HMGCR upregulation is functionally essential for stiffness-induced epithelial-mesenchymal transition (EMT) and CRC progression. Mechanistically, HMGCR-mediated cholesterol accumulation promotes phosphorylation of β-catenin at Ser552, which disrupts β-catenin/E-cadherin complexes at adherens junctions, leading to β-catenin nuclear accumulation and EMT execution. Therapeutically, combined pharmacological inhibition of matrix crosslinking and cholesterol synthesis synergistically suppresses tumor growth and invasion while restoring epithelial architecture in vivo. Collectively, these findings reveal that Piezo1-dependent Golgi-ER reorganization triggers SREBP2-driven cholesterol synthesis, ultimately fueling β-catenin-mediated junctional disassembly and metastasis, and highlight the therapeutic promise of co-targeting tumor mechanics and metabolism.
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高影响因子
Nature Communications
·
2026
·Vol. 17
·期 1
·1474
·
IF 18.1
Hu Lv,He Yaolong,Wang Dong,Li Wanxia,Yao Jingming,Zhang Xiaolong,Zhu Jinfeng,Chen Huaican,Yin Wen,Wang Yanru,Yan Kejun,Wang Jinzhu,Li Hui,Chen Fang,Liu Yating,Lai Junqi,Chen Qi,Ma Jie,Jiao Shuhong,Wang Guorui,Shi Siqi,Chen Liwei,Huang Jianyu,Ma Cheng
Although Li-ion conductivity has been the primary focus during decades of solid-electrolyte research, the mechanical compliance is equally important. For most state-of-the-art solid electrolytes, the mechanical compliance is characterized by the hardness above 1 GPa and Young’s modulus above 15 GPa. Here, we report a particularly compliant solid electrolyte, 1.4Li 2 O-0.75ZrCl 4 -0.25AlCl 3 , whose hardness and Young’s modulus reach 0.22 and 1.41 GPa, respectively. Meanwhile, it shows an ionic conductivity of 2.55 mS cm −1 at 25 °C and an estimated cost of $43.70 L −1 , considerably lower than that of the Li 2 ZrCl 6 solid electrolyte known for cost-effectiveness ($140.01 L −1 ). The improved mechanical compliance and fast Li-ion transport in 1.4Li 2 O-0.75ZrCl 4 -0.25AlCl 3 enable decent cell performance. With high positive electrode active material loading above 20 mg cm −2 , these two types of cells achieve areal capacities of 3.62 mAh cm −2 (85.78% capacity retention) and 3.92 mAh cm −2 (90.11% capacity retention), respectively, after 100 cycles under 0.1 C at 25 °C. The simultaneous achievement of highly competitive mechanical compliance, Li-ion conductivity, and cost-effectiveness in 1.4Li 2 O-0.75ZrCl 4 -0.25AlCl 3 have the potential to pave the way for the realization of commercial, practical all-solid-state Li batteries.
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高影响因子
Journal of Bionic Engineering
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2026
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IF 4.4
Chang Jiaqing,Gao Song,Dong Chaowei,Li Zhaobang,Liu Yang,Cui Jinsheng
In narrow, unstructured environments such as environmental monitoring and minimally invasive medical procedures, micro soft robots exhibit unique advantages due to their flexible movement capabilities and small size. Existing micro soft robots often employ single physical field control, making it difficult to achieve multi-dimensional complex movement behaviors. This study, based on the bio-mimicry of the swimming principle of the cownose ray, designed and prepared a cownose ray-inspired micro soft robot with dual light and magnetic responsiveness. Firstly, a photosensitive hydrogel was prepared using a certain proportion of hollow glass microspheres (HGMP), polydopamine (PDA), poly(N-isopropylacrylamide) (PNIPAM), and agarose. Under 808 nm near-infrared light irradiation, the hydrogel achieves a maximum upward floating speed of 23.31 mm/s in water. Then, a magneto-elastic composite film was prepared using a certain proportion of neodymium-iron-boron (NdFeB) and polydimethylsiloxane (PDMS), which will undergo controllable bending deformation under the action of a magnetic field. Finally, by integrating the photosensitive hydrogel and the magneto-elastic film, a cownose ray-inspired micro soft robot with both light and magnetic responsiveness was prepared. By controlling the on-off state of near-infrared light, the robot can achieve multi-modal behaviors such as floating, moving, diving, and hovering. Simultaneously, it can perform straight swimming under magnetic field drive. This study enriches the driving modes of micro soft robots and provides a reference method for the multi-physical-field driving of robots in complex environments.
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高影响因子
Discover Oncology
·
2026
·Vol. 17
·期 1
·1080
·
IF 2.8
Xu Yuan,Li Liping,Li Zhouhua,Yang Yanqiang,Xing Hongquan,Ma Xuehua,Zhang Xinyi
Objective Drug resistance remains a major clinical challenge in advanced lung adenocarcinoma. Identifying commonly dysregulated resistance-associated genes may provide mechanistic insights for novel therapeutic strategies. Methods RNA-seq data from eight TCGA LUAD patients with documented TKI treatment were analyzed using the limma empirical Bayes framework for exploratory differential expression analysis. WDR17 association with clinicopathological features was evaluated in the TCGA cohort. Single-cell transcriptomics from publicly available datasets (GSE139386 and GSE260499) was used to characterize WDR17 distribution in TKI-resistant cell lines. In vitro experiments assessed the functional relevance of WDR17 in drug sensitivity. Results Exploratory differential expression analysis identified WDR17 as significantly downregulated in the non-responding group (log2 FC = − 1.11, adjusted P = 0.026). In the broader TCGA-LUAD cohort, high WDR17 expression was associated with longer overall survival (HR = 0.78, 95% CI: 0.67–0.91, P < 0.001). Single-cell analysis revealed that WDR17 was predominantly expressed in a cell state characterized by protein homeostasis and metabolic stress. Computational estimation using the EPIC algorithm suggested a positive correlation between WDR17 expression and CD8 + T-cell infiltration (P < 0.05). In vitro experiments confirmed that WDR17 overexpression enhanced crizotinib sensitivity in resistant cells, whereas knockdown reduced sensitivity in parental cells. Conclusion This exploratory study identified WDR17 as a candidate biomarker associated with TKI resistance in lung adenocarcinoma, potentially involved in maintaining protein homeostasis and metabolic balance. These preliminary findings warrant validation in larger, independent cohorts.
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高影响因子
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