WATER RESEARCH
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2024
·
IF 11.4
Jiawen Zhang,Qingchun Ge
A large amount of organophosphorus-containing wastewater is produced in spent lithium-ion battery disposal. Forward osmosis (FO) offers unique advantages in purifying this kind of wastewater if suitable draw solutes – the core of FO technology, are available. Herein we synthesize several pH-sensitive zinc complexes, namely ZnATMP-iNa ( i = 0, 1, 2, 3, 4), from ZnSO 4 and amino tris(methylene phosphonic acid) (ATMP) obtained from scale inhibitor wastes for organophosphorus-containing wastewater remediation. Among these ZnATMP-iNa, ZnATMP-3Na best meets the standards of an ideal draw solute. This makes ZnATMP-3Na outperform other reported draw solutes. 0.6 M ZnATMP-3Na produces a water flux of 12.7 LMH, 136 % higher than that of NaCl and a solute loss of 0.015 g/L, lower than that of NH 4 HCO 3 (0.83 g/L). In organophosphorus-containing wastewater treatment, ZnATMP-3Na has higher water recovery efficiency (8.3 LMH) and sustainability than NaCl and NH 4 HCO 3 , and is sufficient to handle large quantities of wastewater. Remarkably, the pH-responsive property allows ZnATMP-3Na to be readily recovered through pH-control and reused in FO. The ionic property, expanded cage-like structure and easy-recycling make ZnATMP-3Na achieve sustainable FO separation and superior to other draw solutes. This study provides inspiration for draw solute design from wastes and extends FO application to organophosphorus-containing wastewater remediation.
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LANGMUIR
·
2024
·
IF 3.7
Kang Wang,Jia-Qing Li,Jun Lu,Dan Wang,Shun He,Jie-Xin Wang,Jian-Feng Chen
An intelligent delivery nanoformulation could enhance the utilization efficacy, uptake, and translocation of pesticides in plants. Herein, a redox/pH-triggered and fluorescent smart delivery nanoformulation was designed and constructed by using hollow mesoporous organosilica nanoparticles (HMONs) and ZnO quantum dots as the nanocarrier and capping agent, respectively. Boscalid was further loaded to generate Boscalid@HMONs@ZnO with a loading rate of 9.8% for controlling Botrytis cinerea (B. cinerea). The quantity of boscalid released by Boscalid@HMONs@ZnO in a glutathione environment or at pH 3.0 was 1.3-fold and 1.9-fold higher than that in a neutral condition. Boscalid@HMONs@ZnO has 1.7-fold the toxicity index of boscalid technical against B. cinerea in antifungal experiments. Pot experiments revealed that the efficacy of Boscalid@HMONs@ZnO was significantly enhanced more than 1.27-fold compared to commercially available water-dispersible granules of boscalid. Due to the fluorescence properties of Boscalid@HMONs@ZnO, pesticide transport’s real-time monitoring of pesticide translocation in tomato plants could be observed by confocal laser scanning microscopy. Fluorescence images revealed that HMONs@ZnO had been effectively transported via treated leaves or roots in tomato plants. This research showed the successful application of HMONs@ZnO as a nanocarrier for controlling disease and offered an effective avenue to explore the real-time tracking of pesticide translocation in plants.
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ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Guiqiang Qi,Kang Chen,Wenhua Guan,Junyu Xie,Xiangyan Chen,Guanhua Zhang,Ran Yan,Geng Yang
Photothermal therapy (PTT) and photodynamic therapy (PDT) provide targeted approaches to cancer treatment, but each therapy has inherent limitations such as insufficient tissue penetration, uneven heat distribution, extreme hypoxia, and overexpressed HSP90 in tumor cells. To address these issues, herein, by encapsulating the IR780 dye and glucose oxidase (GOx) enzyme within ZIF-8 nanoparticles, we created a versatile system capable of combining photodynamic and enhanced photothermal therapy. The integration of the IR780 dye facilitated the generation of reactive oxygen species and hyperthermia upon light activation, enabling dual-mode cancer cell ablation. Moreover, GOx catalyzes the decomposition of glucose into gluconic acid and hydrogen peroxide, leading to the inhibition of ATP production and downregulation of heat shock protein 90 (HSP90) expression, sensitizing cancer cells to heat-induced cytotoxicity. This synergistic combination resulted in significantly improved therapeutic outcomes. Both in vitro and in vivo results validated that the nanoplatform demonstrated superior specificity and favorable therapeutic responses. Our innovative approach represents a promising strategy for overcoming current limitations in cancer treatments and offers the potential for clinical translation in the future.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2024
·
IF 3.3
Jia-Cheng Liu,Bin Nie,Yu-Qiao Wang,Jia-Nan Yan,Hai-Tao Wu
BACKGROUND Previous studies have investigated complexation and coacervation of scallop Patinopecten yessoensis male gonad hydrolysates (SMGHs) and polysaccharides influenced by pH and blending ratio. It has been found that SMGHs/polysaccharide composite shows better gel properties under strongly acidic conditions. Thus, the complexation and coacervation of SMGHs and gellan gum (GG) were investigated via turbidimetric titration at different pH values (1–12) and biopolymer blending ratios (9.5:0.5–6:4). RESULTS Both pH c and pH φ1 exhibited ratio-independent behavior with constant values at approximately pH 5.8 and pH 3.8, respectively, dividing SMGHs/GG blends into three phases named mixed polymers, soluble complexes and insoluble coacervates, respectively. Overall, SMGHs and GG exhibited synergistic gelation under neutral and acidic conditions, with the initial storage modulus ( G' ) increasing by approximately 42.5-, 573.7- and 3421-fold and 97.7-, 550.3- and 0.5-fold, respectively, at pH 7, 5 and 3, compared with SMGHs and GG. As pH decreased from 7 to 3, the initial G' and viscosity η values of SMGHs/GG gels increased by 20.1- and 2.3-fold, respectively, exhibiting the greatest increase in gel strength. Moreover, the free water in the SMGHs/GG system significantly shifted toward lower relaxation times attributed to the immobilization of the outer hydration layers. SMGHs/GG gels in the insoluble phase exhibited denser networks and rougher surfaces, supporting the enhanced rheological properties and water retention capacity of the gel. CONCLUSION This work provides a basic foundation for the development of pH-driven SMGHs/GG gelation by examining complexation and coacervation processes. © 2024 Society of Chemical Industry.
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JOURNAL OF CONTROLLED RELEASE
·
2025
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IF 11.5
Dali Chen,Yunai Du,Xitong Wang,Huihong Li,Xinjiao Wu,Xiaoqin Kuang,Chunjiayu Li,Jianing Zhao,Yerong Xiong,Minjie Sun,Jiasheng Tu,Siyan Liu,Chunmeng Sun
Active-targeting nanomedicines have been widely employed in cancer treatment for increasing therapeutic index. However, the limited permeability caused by the binding site barrier (BSB) and size hindrances compromises their clinical antitumor efficacy in patients. Herein, learning from the liquid-liquid phase separation (LLPS) of bio-macromolecules, we report phase-separating glycopeptides (HEP) from polyhistidine (PHis) grafted hyaluronic acid (HA), which can sense the tumor extracellular pH and concomitantly overcome size and BSB dilemmas for enhanced tumor penetration. HEP aggregates into nanodroplets in solution at neutral pH. Upon reaching the acidic extracellular environment of tumors, the pH-responsive PHis triggers a phase separation, converting the coacervate nanodroplets into monomeric glycopeptides. This enables HEP conjugated with the platinum prodrug (HEPPt) to deeply penetrate into tumors by overcoming the BSB effect arising from the interaction between nanodroplets and cluster of differentiation 44 (CD44), as well as resolving the size challenges. Moreover, HEPPt in monomeric states exhibits promoted cellular uptake after pH-triggered phase separation, attributed to the transmembrane effect of exposed PHis. Subsequently, the rapid release of Pt(II), triggered by tumor intracellular reducing environment, exerts excellent antitumor activity. The phase-separating glycopeptides represent a promising platform for improving tumor penetration and intracellular delivery of therapeutic agents.
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DESALINATION
·
2024
·
IF 8.3
Wenshuang Zhang,Yongsheng Li,Yikun Zhu,Yiwei Gao,Hongchao Wang,Chongbin Wang,Yuanyuan Feng
Nanofiltration (NF) membranes can inevitably suffer from external damage in the practical application process, causing the loss of their original function and performances. In this work, the β-CD-D X -S were synthesized for the first time through one-step polymerization of SBMA, DMAEMA and double bond functionalized β-CD. Subsequently, the membrane was successfully fabricated via interfacial polymerization using the constructed β-CD-D X -S as aqueous phase monomer alone. The prepared β-CD-D X -S/PES membrane exhibits novel self-healing performance attributing to the host-guest interaction between DMAEMA and β-CD. The membranes also possess excellent pH-responsive property attributing to the protonation and deprotonation behavior under different pH environments of dimethylamine unit in DMAEMA. The grafted DMAEMA and SBMA enhanced the hydrophilic property of membrane, reducing electrostatic adsorption of pollutants on the surface of membrane. The hydrophobic binding site inside the cavity of β-CD can accommodate dimethylamino group in the DMAEMA which could be regulate the spatial structure of β-CD-based materials, strengthening salt/dye selectivity of membrane. The results indicated that the prepared β-CD-D X -S/PES membranes possess good potential for NF applications.
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LANGMUIR
·
2025
·
IF 3.9
Yuanbo Li,Taiming Zhang,Yanru Ding,Yuhao Chen,Yukui Rui
The iron-based metal–organic frameworks (Fe-MOFs) NH2-MIL-101(Fe) (MIL) has gained widespread attention as a drug carrier material in agriculture. In this study, a multifunctional nanocomposite, MIL@A@D@C, was successfully synthesized by loading the fungicide azoxystrobin (AZOX) and immunoinducer d-cellobiose (D) onto MIL, followed by surface modification with carboxymethyl cellulose (CMC). The loading capacity of MIL was optimized by varying solvent conditions and the mass ratio of MIL to AZOX, revealing that ethanol as the reaction solvent and a MIL: AZOX mass ratio of 1:4 resulted in the highest loading efficiency (6.73%). MIL@A@D@C exhibited pH- and cellulase-responsive controlled release behavior. In vitro antifungal assays demonstrated that MIL@A@D@C at a low concentration of 1 ppm effectively inhibited Colletotrichum graminicola (the causal agent of maize anthracnose). Foliar application experiments further confirmed that the composite formulation achieved significant inhibition at a low dosage of 10 ppm, outperforming commercial azoxystrobin products. Plant and animal safety assessments indicated that MIL@A@D@C possessed enhanced biosafety. These findings highlight the potential of MIL@A@D@C as an environmentally friendly and highly effective nanodelivery system for crop disease management.
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ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Qin Chen,Lei Wang,Siyu Li,Weifeng Zhao,Ka Li
Despite significant improvements in acute and chronic wound care, determining optimal timing for individualized dressing changes remains a critical clinical challenge, with a lack of objective and precise evaluation criteria. To meet this need, a multilayer colorimetric dressing is designed that integrates unidirectional exudate drainage, pH, and moisture monitoring. An ice-templated polyurethane sponge featuring aligned microchannel structures is developed to achieve exudate drainage. The pH colorimetric module is fabricated by embedding phenol red indicator into hydrogel via solution diffusion, while the moisture colorimetric module incorporates carbon-encapsulated Fe 3 O 4 (Fe 3 O 4 @C) nanoparticles doped photonic crystal hydrogel. This dressing overcomes the key limitations of traditional electrochemical sensors, which require wired connections and power source, by employing visible light-based colorimetric analysis with RGB quantification. The dressing achieves a unidirectional exudate drainage rate of 2.35 µL s −1 , with a pH monitoring range of 5.0–8.0 and a humidity detection range of 11–100%. Proof-of-concept studies conducted both in vitro and in infected rat models validate the capability of the dressing for real-time monitoring of wound microenvironment pH and humidity levels. This innovative technology offers a clinically viable approach to determine optimal dressing change frequency, thereby enhancing healing outcomes while minimizing infection risks.
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FOOD HYDROCOLLOIDS
·
2019
·
IF 5.839
Yinxia Chen,Meihu Ma
This study investigated the impact of ultrasound pretreatment and phenolic binding on the structure characteristic and foaming properties of egg white (EW). EW treated without ultrasound (NEW) and with ultrasound (UEW) (power for 28% and time for 25 min: on-time 3 s and off-time 2 s) were incubated separately at 25 °C for 2 h with gallic acid (GA) and epigallocatechin gallate (EGCG) at pH 7.0. Phenolic treatment caused a significant loss of sulfhydryl content, with a more remarkable effect observed in UEW, especially at 120 μmol/g concentration. Both phenolics significantly decreased the surface hydrophobicity and slightly increased the disordered secondary structure of protein. Additionally, the microenvironment polarity of protein molecules was increased by phenolic treatment corroborated by UV absorption blue shift, especially for 240 μmol/g GA-UEW. After ultrasound pretreatment, low EGCG concentration (20 μmol/g) significantly increased the foaming ability. The 240 μmol/g EGCG treatment notably increased the reduced foaming stability by ultrasound from 81.00 to 95.10% ( p < 0.05), which was due to high absolute ξ-potential value. This study has shed light on the mechanisms underlying the influence of unfolding structure by ultrasound treatment on phenolic binding.
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BIOMACROMOLECULES
·
2018
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IF 5.738
Junhua Li,Xuequan Zhang,Mingying Zhao,Lihuang Wu,Kui Luo,Yuji Pu,Bin He
Nanoparticle- and microsphere-based drug delivery systems (DDSs) have attracted wide attention in cancer therapy; those DDSs that are responsive to tumor environment can selectively identify tumor and normal tissues and therefore have shown enhanced anticancer efficacy and alleviated systemic toxicity. Here, tumor-pH-sensitive polymeric microspheres, which are prepared by multiblock poly(l-lactide) with pH-sensitive acetal bonds in the backbone, are employed to efficiently load water-soluble anticancer drug doxorubicin hydrochloride (DOX·HCl, drug loading content: ∼10%). The pH-sensitive DOX-loaded hollow microspheres were in the size range 2–10 μm and exhibited acid-accelerated degradation of polymer matrix and drug release, and thereby efficient in vitro cancer cell inhibition. The microspheres were further intratumorally injected into breast-tumor-bearing mice, and the in vivo anticancer experiment showed that pH-sensitive DOX-loaded microsphere showed better antitumor efficiency and prolonged life-span than its counterpart that does not have pH-responsive property. Moreover, negligible organ toxicity, especially cardiotoxicity that generally exists in DOX-involved chemotherapy where DOX is administrated by intravenous injection, was observed for DOX-loaded microspheres. Hence, tumor-pH-sensitive polymeric microspheres have appeared to be a simple and efficient platform for delivering hydrophilic anticancer drug with excellent anticancer efficacy and low systemic toxicity.
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ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Shanshan Qi,Ruifeng Luo,Xiaoqin Han,Wenbiao Nie,Naijing Ye,Chaomei Fu,Fei Gao
Rhein (RH), a natural anthraquinone compound, is considered an effective treatment candidate for ulcerative colitis (UC), whose multiple biological activities contribute to UC, including anti-inflammation, antioxidation, intestinal barrier repair, and microflora regulation. However, the application of RH is severely limited by its low water solubility, low bioavailability, and poor colonic targeting. Although some nanoparticles have been developed for the oral delivery of RH, most of them mainly highlighted only one effect of some drug delivery strategies but the above multiple biological activities. Therefore, a multiple polysaccharide-based nanodelivery system, comprising chitosan (CS) and fucoidan (FU), with pH/reactive oxygen species (ROS) sensitivity and mucosal adhesion, was developed and first used to load RH as a comprehensive treatment for UC. Briefly, RH-F/C-NPs were prepared using the polyelectrolyte self-assembly method; the average size of RH-F/C-NPs was 233.1 ± 5.7 nm, and the encapsulation rate of RH was 93.67 ± 1.60%. And it could maintain gastric stability and release RH in the colon with the designed pH/ROS sensitivity contributed by the polysaccharide-based structures. Cellular uptake experiments showed that both NCM 460 cells and RAW 264.7 cells had a good uptake of RH-F/C-NPs. Importantly, the effects of RH were highlighted in in vivo experiments, the results of which showed that RH-F/C-NPs could significantly reduce DSS-induced inflammation by inhibiting the TLR4/NF-κB-mediated anti-inflammatory pathway, the Nrf2/HO-1-mediated antioxidant pathway, colonic mucosal barrier repair, and intestinal microflora regulation. In addition, pharmacokinetic studies have shown that F/C-NPs contribute to the increase in the plasma concentration and the accumulation of RH in the colon to some extent. In short, this study is the first to develop an oral multiple polysaccharide-based nanosystem with pH/ROS dual sensitivity to study the “one stone four birds” therapeutic effect of RH on UC.
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RSC Advances
·
2015
·Vol. 5
·期 95
·77986-77995
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IF 3.84
Nuannuan Li,Pei Zhang,Chunzhi Huang,Yunmei Song,Sanjay Garg,Yuxia Luan
In this paper, we synthesized the pH-sensitive and biodegradable amphiphilic polypeptide-based block copolymer methoxy-poly(ethylene glycol)2K-poly(ε-caprolactone)4K-poly(glutamic acid)1K (mPEG2K-PCL4K-PGA1K). mPEG2K-PCL4K-PGA1K had low critical aggregation concentration and could self-assemble into polymersomes in aqueous solution revealed by transmission electron microscopy. Therefore, two hydrophilic drug doxorubicin hydrochloride (DOX) and verapamil hydrochloride (VER) were encapsulated into the mPEG2K-PCL4K-PGA1K polymersomes to form poly(DOX + VER) co-delivery system to reverse the multidrug resistance by inhibiting the expression of P-glycoprotein and improve the anti-cancer effect of DOX. The in vitro cytotoxicity experiments indicated the obviously higher inhibition ratio to MCF-7/ADR resistant cells of poly(DOX + VER) compared with that of free DOX solution and polyDOX. The release rate of the two drugs from poly(DOX + VER) were much slower than that from the free drug solutions, and their release behaviors exhibited high pH-sensitive character. Furthermore, the low hemolysis ratio of mPEG2K-PCL4K-PGA1K confirmed that the copolymer could be applied for intravenous injection safely. Therefore, all these findings indicated that the co-delivery of DOX and VER by mPEG2K-PCL4K-PGA1K polymersomes is very promising for cancer therapy.
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