JOURNAL OF POWER SOURCES
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2025
·
IF 7.9
Shilong Su,Yajin Shi,Jinlian Zhang,Xin Zhong,Die He,Qiuyan Li,Junkai Wang,Lianfeng Duan
Polyethylene oxide (PEO) is widely considered to be a highly promising solid polymer electrolyte (SPE) owing to its flexibility, excellent mechanical and chemical stability, and safety. However, PEO still faces challenges in the application of all-solid-state lithium-sulfur batteries (ASSLSBs), such as low ion transport efficiency, lithium dendrite formation, and complex polysulfide shuttle effects. Herein, a unique ring-funnel β-cyclodextrin (β-CD) is introduced as a functional additive into the PEO matrix for structural reconfiguration as a composite solid electrolyte (CSE). The strong non-covalent interactions between β-CD and PEO reveals that the ordered arrangement of the PEO chains is disrupted because the dihedral and torsional angles are disturbed. These interactions significantly expand the amorphous regions of PEO, which increases the ion transport pathways and enhances the chain flexibility to improve ionic conductivity and electrochemical performance. Additionally, β-CD could strengthen the immobilization of TFSI⁻, further promoting Li⁺ dissociation and rapid migration, while effectively suppressing lithium dendrite growth and the polysulfide shuttle effect. As a result, the discharge capacity of ASSLSBs with PEO-LiTFSI-β-CD retain at 650.5 mAh·g⁻ 1 after 200 cycles, exhibiting a coulombic efficiency close to 98 %, which provide a novel design strategy for preparing high-performance and durable SPE for ASSLSBs.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Lukai Ma,Zijian Li,Linjing Li,Xianhong Bi,Gengsheng Xiao,Linlin Li
This study developed nanostructured lipid carriers (NLCs) using edible beeswax and flaxseed oil to encapsulate β-sitosterol. Structural analysis revealed the formation of a less ordered lipid matrix with reduced crystallinity compared to pure beeswax, contributing to a high encapsulation efficiency of 92 %. Optimal formulation (beeswax: flaxseed oil 3:2, Tween 80: Polyglycerol fatty acid(PGE) 4:1 totaling 7 % emulsifier) and processing parameters (10 min homogenization, 200 W ultrasonic power for 4 min) yielded stable nanoparticles maintaining physical stability for 40 days across varying pH and temperature. In vitro digestion demonstrated that the NLCs effectively protected β-sitosterol from gastric degradation and enabled controlled intestinal release, achieving significantly higher bioaccessibility (43.9 %) compared to free β-sitosterol (12.1 %). These results highlight beeswax-flaxseed oil NLCs as a promising delivery system for enhancing the bioaccessibility of hydrophobic bioactive in functional foods.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Yongmei Lyu,Fengxiang Chen,Wanjie Mao,Zhihan Ge,Yaoyao Zhang,Yue Hu,Wenbin Jin,Jinbin Liu,Jia Chen,Xiaohong Yu,Xiaoyang Zhang
Lactose intolerance has been a significant global health concern, as it is caused by the absence of lactase, leading to the inability of the human body to absorb lactose. This study investigated two genes encoding maltose O -acetyltransferase with β-galactosidase activity from Aeromonas caviae to evaluate their potential application value for lactose degradation in bovine and human milk. The two novel β-galactosidases (AcGal25: 22.0 kDa and AcGal31: 21.3 kDa) were heterologously expressed and biochemically characterized. The optimal pH of both enzymes was 8.0, and the optimal temperature of AcGal25 and AcGal31 were 45 and 42 °C, respectively. Fe 2+ and Mn 2+ significantly promoted the activity of both enzymes. The two enzymes kept over 75 % activity after incubation for 30 days at 45 °C. HPLC results showed that lactose in bovine milk was completely hydrolyzed by AcGal31 when reacted for 6 h, and about 5 % lactose in human milk was left. The docking results showed that AcGal31 has a more vital lactose-binding ability than AcGal25. LYS129 and ARG165 are highly likely catalytic sites of AcGal31. AcGal31 demonstrated excellent commercial value in making lactose-free milk.
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ENERGY & FUELS
·
2025
·
IF 5.3
Jing Li,Suxia Ma,Nuo Xu
Fly ash, a solid waste rich in silicon (Si) and aluminum (Al), offers significant potential for valorization through the high-value synthesis of zeolites, exemplifying the waste-to-wealth approach. We determined the optimal synthesis conditions for FA-β zeolite using the alkali fusion hydrothermal synthesis method, with fly ash as the primary raw material. The conditions included a NaOH/FA ratio of 1.2, a SiO2/Al2O3 ratio of 30, an H2O/Al2O3 ratio of 1200, a TEAOH/Al2O3 ratio of 14, a β-seed addition of 7.5%, and hydrothermal conditions of 140 °C for 72 h. XRD and FTIR analyses confirmed that the diffraction peaks of the synthesized fly ash-based zeolite align well with the standard pattern of commercial β zeolite. Removal experiments indicated that the efficiency of nitrogen oxides removal hinges on the adequate oxidation of NO. Under optimized conditions, the FA-β zeolite demonstrated a removal efficiency of 83%. ESR analysis revealed that the removal mechanism involves the oxidative elimination of NO, catalyzed by FA-β zeolite through the decomposition of H2O2 to OH radicals. This novel synthesis method, which utilizes fly ash as the raw material to prepare β zeolite, offers advantages in terms of cost-effectiveness and environmental protection. It holds significant potential for applications in environmental conservation.
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FOOD CHEMISTRY
·
2024
·
IF 8.5
Linna Guo,Qianqian Wang,Qiuhua Wu,Chun Wang,Baojiang Chen
High efficiency enrichment and trace analysis of triazine herbicide residues are crucial for ensuring environmental and food safety. Herein, a series of magnetic hyper-crosslinked polymers (CD-gs-MHCPs) were synthesized with different crosslinkers, which might possess different pore structure and surface area, so they might dispay variable adsorption performance. CD-gs-MHCP2 with dichloroxylene as crosslinker delivered superior adsorption ability for triazine herbicides (THs). The synergistic effect of hydrogen bonds, hydrophobic interaction, π-π stacking interaction and pore adsorption were proved to be the main adsorption mechanism. Combined CD-gs-MHCP2 based magnetic solid-phase extraction (MSPE) with high-performance liquid chromatography, the quantitative analysis of THs in river water and vegetable samples (zucchini, pakchoi) was achieved. Under the optimal conditions, the enrichment factors for three different samples ranged from 94 to 244 and low detection limit (S/N = 3) of the four THs were obtained from 0.05 to 0.15 ng mL −1 for river water and 0.31–3.10 ng g −1 for vegetable samples. The method recoveries were in the range of 86.2 %–120 % with relative standard deviations lower than 7.4 %. This work not only offers a new strategy for fabrication β-CD-based HCPs, but also provided a practical and effective method for efficient isolation and sensitive detection of trace THs residues in complex samples.
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International Journal of Pharmaceutics-X
·
2024
·
IF 5.2
Dan Yang,Min Zhao,Yihe Huang,Liwen Chen,Jiqin Fang,Jiaonan Liu,Miao Wang,Chunjie Zhao
The incidence of acetaminophen-induced liver injury has increased, but effective prevention methods are limited. Although luteolin has hepatoprotective activity, its low solubility and bioavailability limit its applications. Cyclodextrin metal-organic frameworks (CD-MOFs) possess 3D-network structures and large inner cavities, which make them excellent carriers of poorly soluble drugs. In this study, we used CD-MOFs as carriers to improve the dissolution of luteolin and assessed their antioxidant activity, bioavailability, and hepatoprotective effects. Luteolin was loaded into β-CD-MOF, γ-CD-MOF, β-CD, and γ-CD, and characterized by powder X-ray diffractometry (PXRD) and thermogravimetric analysis (TGA). Our results showed that luteolin-β-CD-MOF was the most stable. The main driving forces were hydrogen bonds and van der Waals forces, as determined by molecular simulation. The loading capacity of luteolin-β-CD-MOF was 14.67 wt%. Compared to raw luteolin, luteolin-β-CD-MOF exhibited a 4.50-fold increase in dissolution and increased antioxidant activity in vitro . Luteolin-β-CD-MOF increased the bioavailability of luteolin by approximately 4.04- and 11.07-fold in healthy rats and liver injured rats induced by acetaminophen in vivo , respectively. As determined by biochemical analysis, luteolin-β-CD-MOF exhibited a better hepatoprotective effect than raw luteolin in rats with acetaminophen-induced liver injury. This study provides a new approach for preventing acetaminophen-mediated liver damage.
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CHEMISTRY & BIODIVERSITY
·
2026
·Vol. 23
·期 10
·e71871
·
IF 2.9
Dan Zhang,Qianru Jiang,Min Li,Hongyuan Yan,Haiyan Liu
Ficus tikoua Bur., a perennial creeping woody liana belonging to the genus Ficus (Moraceae), has been traditionally used in combination therapies for rheumatoid arthritis (RA). This study aimed to screen active components from F. tikoua Bur. against RA. Prior to activity testing, compounds with appropriate polarity and size were enriched by a homemade β‐cyclodextrin‐based monolithic material when adjusting the polarity of the enrichment mobile phase. Anti‐inflammatory activity evaluations of different fractions were conducted using Cell Counting Kit‐8 (CCK‐8) assay and enzyme‐linked immunosorbent assay (ELISA). Results showed that the compounds in F. tikoua Bur. had no significant effect on RAW264.7 cell viability while effectively reducing secretion levels of inflammatory cytokines IL‐6 and TNF‐α. When a mixture of methanol and water (30:70, v / v ) was used as the enrichment mobile phase, those components adsorbed on the monolith exhibited optimal inhibition effects on IL‐6 and TNF‐α production. Further separation and LC–MS analysis of the most active fraction, combined with literature data, 4‐hydroxy‐3,5‐bis(3′‐methyl‐2‐butenyl) benzoic acid‐O‐β‐D‐glucopyranoside may be the primary anti‐inflammatory constituent. Optimization of enrichment conditions revealed that the monolithic material achieved an enrichment factor of 15.352 for the screened compound. A β‐CD‐based monolith was prepared and used as solid‐phase extraction adsorbent for on‐line enrichment of compounds from Ficus tikoua Bur. Various fractions with different molecular sizes and polarities were obtained and anti‐inflammatory activity evaluations were conducted. The active ingredient against rheumatoid arthritis was screened out by further separation of the most active fraction.
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CHEMISTRY-A EUROPEAN JOURNAL
·
2023
·Vol. 29
·期 60
·e202301827
·
IF 4.3
Mengyan Zeng,Xin Chen,Jie Zhang
Hierarchical chiral structures have broad applications in optical devices, asymmetric catalysis, and biological systems. The delicate balance of various interactions are key to the self-assembly of chiral structures. Herein, a ternary co-assembly consisting of cationic pillar[5]arenes (P5As), anionic β- glucopyranoside ( β GlcD/ β GlcL), and Anderson-type polyoxometalates (POMs) were constructed. Through adjusting the stoichiometry of β GlcD, the assemblies were effectively controlled to form hierarchical nano-leaf assemblies with twisted nanoribbons in a homochiral direction. The co-assemblies exhibit strong Cotton effects, and successfully induced the chirality of Anderson-type POMs. More interestingly, by changing the central metal in Anderson-type POMs (XMo 6 O 24 3− (X=Cr, Al, and Ga)), even though the three clusters have the same numbers of charge and size, the hierarchical chirality of the related assemblies varied in the morphology of the assemblies and the Cotton effect in the CD spectra. Results in theoretical calculations and ITC titration indicates that the tiny difference in long-range electrostatic interaction would result in the anion recognition of POMs, modulated by β GlcD through host–guest inclusion and hydrogen bonding in the assembly process. Graphical β -Glucopyranoside, as a modulator, successfully induced the chirality of Anderson-type polyoxometalates and modulated the ternary co-assembly to form hierarchically chiral leaves. By substituting highly similar polyoxometalates, the accurate balance between short- and long-range interactions is demonstrated to be the key to the formation of chiral hierarchical microstructures.
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Nano Energy
·
2012
·
IF 0
Junfeng Xie,Xu Sun,Ning Zhang,Kun Xu,Min Zhou,Yi Xie
With the dramatic development of portable electronics, power sources with ultrathin geometries and ultraflexibility have become an important prerequisite. In this rising field, all-solid-state thin-film supercapacitors (ASSTFSs) have received tremendous attentions due to their ultraflexibility and high safety, which are considered as competitive candidates for energy supplies in flexible electronics. However, state of the art for ASSTFSs based on carbonaceous materials and conducting polymers exhibits relatively low capacitance, which restricts their practical applications. In this study, we demonstrate the first successful application of pseudocapacitive transition metal hydroxides in all-solid-state thin-film supercapacitor (ASSTFS), exhibiting high capacitance, remarkable high-rate capability and long-term cycling stability. The free-standing thin-film electrode was fabricated by β-Ni(OH) 2 /graphene nanohybrids with unique layer-by-layer characteristics. The nanohybrids can be easily exfoliated into ultrathin hybrid nanoflakes with thickness of ∼10 nm and reassembled into free-standing thin-film electrode with ultraflexibility. The novel layer-by-layer structure could efficiently integrate both merits of pseudocapacitive β-Ni(OH) 2 and conducting graphene, resulting in extraordinary electrochemical performance in ASSTFSs. The highest specific capacitance of 660.8 F cm −3 for ASSTFSs was achieved with negligible degradation even after 2000 charge–discharge cycles, demonstrating the high-performance electrochemical property and superior cycling stability. And the all-solid-state nature combined with superior electrochemical performance and ultraflexibility makes our device an outstanding candidate for power sources in portable electronics.
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ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
·
2026
·
IF 3.5
Margarita A. Arbuzova,Olga Yu Selyutina,Nikolay E. Polyakov
Cholesterol drives E-protein depth redistribution via a matrix-mediated helix tilt adjustment. • Escin-induced peptide localization shifts strictly require the presence of charged DMPS lipids. • Escin is hypothesized to modulate the viroporin conformation via localized helix kinking rather than matrix disruption. • Escin is able to extract cholesterol from lipid membrane. β-Escin is a well-known saponin derived from the horse chestnut tree. Saponins, including escin, exhibit a wide range of biological activities, among which membrane-modifying activity is particularly notable. The latter is key to understanding the molecular mechanisms underlying escin's biological effects, including its antiviral properties. For example, altering membrane properties can strongly influence the life cycle of enveloped viruses such as SARS-CoV-2 by modulating the activity of its envelope protein (E protein). In the present paper, we studied the localization of both escin and the E protein transmembrane domain (ETM) in model membranes with different lipid compositions. We demonstrated that escin can alter ETM localization in membranes containing the negatively charged lipid DMPS, and that escin is also capable of extracting cholesterol from model lipid membranes. Download: Download high-res image (423KB) Download: Download full-size image
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Biomedicines
·
2026
·Vol. 14
·期 7
·1586
·
IF 4.5
Xiaofei Tong,Meina Sun,Xin Gan,Xin Chen,Shiyang Liu,Ieong Sun,Lin Zhang,Weihong Zheng
Background: Capsular contracture is driven by self-amplifying foreign body response (FBR) where inflammatory and fibrotic signals from fibroblasts and macrophages reinforce each other. We hypothesized that cogradient simultaneous blockade of NF-κB as an inflammatory node and TGF-β/Smad as fibrotic node could attenuate the FBR. Emodin has dual inhibitory activity but suffers from poor delivery.Methods: Emodin liposomes (Emo-Lip) were characterized and tested on TGF-β1-stimulated NIH/3T3 fibroblasts and LPS-stimulated RAW264.7 macrophages. In a rat silicone implant model, periprosthetic injections were given for four weeks. Fibrous capsule formation was evaluated by histology, immunofluorescence, and FAPI-PET/CT. Transcriptomic analyses were performed to verify and predict relevant pathways.Results: Emo-Lip had uniform size and high encapsulation efficiency. In vitro, Emo-Lip inhibited fibroblast migration, ROS production, myofibroblast differentiation (α-SMA+) as well asCtgfexpression, while suppressing M1 polarization and reduced IL-12/IL-6 secretion in macrophages. In vivo, Emo-Lip reduced capsule thickness, collagen area, and α-SMA/Col I expression, comparable to dexamethasone. Transcriptomics showed coordinated downregulation of inflammatory/fibrotic genes, and Western blot confirmed suppressed phosphorylation of Smad3.Conclusions: Coordinated two-node blockade of NF-κB and TGF-β/Smad by liposomal emodin reprograms the FBR and effectively prevents capsular contracture in rats, offering a translational strategy for implant-associated fibrosis.
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JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
·
2026
·
IF 4.1
Zheng Chen,Yang Yu-Ma,Xiao Jian-Wu,He Jun-Jie,Lin Bo,He Fu-An
In this work, the novel multifunctional electrospun trimethoxy (1H,1H,2H,2H-heptadecafluorodecyl)silane (TMHFDS)/Ag-TiO 2 /polyvinylidene fluoride (PVDF) mats were prepared. In the preparation process, the AgNO 3 was reduced to be the Ag nanoparticle and then in situ deposited on the TiO 2 nanoparticle to form the Ag-TiO 2 hybrid, which was used as the filler to fabricate the electrospun Ag-TiO 2 /PVDF mats followed by the TMHFDS modification. The successful preparation of the electrospun TMHFDS/Ag-TiO 2 /PVDF mats were proved by the characterizations of scanning electron microscopy, two-dimension energy-dispersive X-ray spectroscopy mapping, Fourier transform infrared spectroscopy, differential scanning calorimeter, and wide-angle X-ray diffraction. The electrospun TMHFDS/Ag-TiO 2 /PVDF mats possessed not only the enhanced crystallinity degree and useful piezoelectric β-crystal content of PVDF than those of the PVDF solid film and the electrospun PVDF mat but also the photocatalytic degradation ability for the oil red O dye. Moreover, for the electrospun TMHFDS(3%)/Ag-TiO 2 (30%)/PVDF mat, its water contact angle reached as high as 156.4° which was 24.6° higher than that of the electrospun PVDF mat before the TMHFDS modification, and its oil absorption capacities for valorous oils ranged between 16.3 g g −1 and 25.1 g g −1 , exhibiting the well oil–water separation ability.
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