JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2023
·Vol. 332
·期 1
·23-32
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IF 1.6
Ou Minrui,Li Wanying,Zhang Zihui,Xu Xiaoping
In this work, we synthesized a novel β -cyclodextrin/poly(2-acrylamide-2-methylpropionic acid)/attapulgite (CAMA) hydrogel for uranium(VI) adsorption. Various instrumental techniques such as FTIR, SEM, EDX, and TGA were utilized for characterization of the CAMA. Simultaneously, different important parameters, in specific pH, time, initial uranyl ion concentration and temperature were investigated to evaluate the optimal conditions of the adsorption process. The experiments proofs that the adsorption follows the pseudo-second-order kinetic model so as the Langmuir model, and revealed the maximum adsorption capacity of 434.78 mg g −1 at 298.15 K. Regeneration studies further sighted out the good reusability of the synthesized CAMA hydrogel.
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CELLULOSE
·
2022
·Vol. 30
·期 4
·2279-2288
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IF 6.123
Duan Xia,Zhang Shouwei,Liu Qingtao,Yu Zhicai,Cui Yongming,Tang Bin,Zhang Qian,Wang Jinfeng
The nanostructure of materials plays a key role in interfacial solar vapor generation. Traditional approaches for optimizing interfacial evaporation rely on the external devices to enable floating on water. However, how to unlock the self-floating ability of absorbers for solar interfacial evaporation have not been taken into account. Here, we propose a self-floating absorber based on kapok fibers, which possess large hollow structure and hydrophobicity to enable this absorber float on water without assistance. Gold nanoparticles (AuNPs) were loaded on kapok fibres by in-situ synthesis and showed an extended adsorption (74.7%) wavelength ranging from 280 to 2500 nm. Both the hollow structure of kapok fibres and the thermal localization effect of AuNPs sustaintially enhance the solar interfere vapor generation effect (4 kW m −2 , up to 89%). Also, Each cycle test was carried out under 1 h irradiation. The AuNPs/kapok membrane exhibited stable cycling performance, which maintained an evaporation rate of 6.98 kg m −2 h −1 over 10 times without performance decrease. These results provide new insights for design of advanced photothermal conversion materials with biomass as supporting material, We expect this as-prepared membrane can be used for a range of applications, such as solar interference steam generation, desalination and disinfection, to name a few.
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JOURNAL OF ELECTRONIC MATERIALS
·
2023
·Vol. 52
·期 5
·3008-3017
·
IF 2.1
Yu Hongquan,Deng Yutian,Chen Baojiu,Zhang Yong,Zhao Hong
BiFeO 3 , GdFeO 3 and GdFeO 3 /graphene nanofibers were successfully fabricated by using an electrospinning technique with a simple single needle. Their structure, size and morphology were investigated by x-ray diffraction, scanning electron microscopy, transmission electron microscopy, energy-dispersive spectroscopy, and selected area electron diffraction. The diameters of the BiFeO 3 and GdFeO 3 are 60–70 and 80–170 nm, respectively. The electrochemical properties of the BiFeO 3 , GdFeO 3 , and GdFeO 3 /graphene nanofibers for lithium-ion battery applications were evaluated. The results indicate that the GdFeO 3 /graphene composite shows better electrochemical performance than BiFeO 3 and GdFeO 3 nanofibers.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2023
·Vol. 21
·期 1
·1-19
·
IF 10.2
Zhu Ting-ting,Wang He,Gu Han-wen,Ju Ling-sha,Wu Xin-miao,Pan Wei-tong,Zhao Ming-ming,Yang Jian-jun,Liu Pan-miao
Inflammatory depression is closely related to neuroinflammation. However, current anti-inflammatory drugs have low permeability to cross blood–brain barrier with difficulties reaching the central nervous system to provide therapeutic effectiveness. To overcome this limitation, the nano-based drug delivery technology was used to synthesize melanin-like polydopamine nanoparticles (PDA NPs) (~ 250 nm) which can cross the blood–brain barrier. Importantly, PDA NPs with abundant phenolic hydroxyl groups function as excellent free radical scavengers to attenuate cell damage caused by reactive oxygen species or acute inflammation. In vitro experiments revealed that PDA NPs exhibited excellent antioxidative properties. Next, we aimed to investigate the therapeutic effect of PDA NPs on inflammatory depression through intraperitoneal injection to the lipopolysaccharide-induced inflammatory depression model in mice. PDA NPs significantly reversed the depression-like behavior. PDA NPs was also found to reduce the peripheral and central inflammation induced by LPS, showing that alleviated splenomegaly, reduced serum inflammatory cytokines, inhibited microglial activation and restored synaptic loss. Various experiments also showed that PDA NPs had good biocompatibility both in vivo and in vitro. Our work suggested that PDA NPs may be biocompatible nano-drugs in treating inflammatory depression but their clinical application requires further study. Graphical Abstract
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2023
·Vol. 415
·期 9
·1687-1698
·
IF 4.3
Liu Cheng,Zheng Jingtian,Zhang Benxing,Zhong Xianhua,Wang Wei,Li Zhangyong
The Fenton reaction is one of the most effective methods for treating organic wastewater, which is extremely harmful to humans but difficult to treat. However, finding simple, low-cost, and efficient catalysts for the Fenton reaction remains a challenge. In this study, a BSA-Cu 3 (PO 4 ) 2 hybrid nanoflower (NF) was synthesized to investigate its peroxidase-like activity for the treatment of organic wastewater. Its morphology, composition, and crystallization had been fully studied and the results confirmed that the NFs were successfully prepared. Subsequently, the origin of the peroxidase-like activity of the NFs was further analyzed, with the results suggesting two reasons: (i) the transformation between Cu(I) and Cu(II) and (ii) nano-effects. Additionally, Congo red was selected as the organic pollutant to simulate the decolorization of wastewater. After 3 h, the decolorization efficiency reached 96%. Furthermore, the NFs exhibited good storage performance, maintaining approximately 90% relative activity after storage for 30 days. In summary, the NFs have great application prospects in the treatment of organic wastewater. Graphical abstract
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CELLULOSE
·
2023
·Vol. 30
·期 4
·2399-2412
·
IF 5.7
Li XiaoJuan,Zhang Ying,Chen Junfeng,Wang Yanan,Cheng Zhuoying,Chen Xueqi,Guo Minghui
Solid flexible electrolyte plays important roles in flexible supercapacitors. However, their low ionic conductivity and mechanical stability restrict their applications. Therefore, the development of flexible solid electrolytes with excellent mechanical properties and electrochemical performance is highly desirable. In this work, a cellulose-polyacrylamide double network hydrogel electrolyte was prepared by a simple method, with cellulose as the first network layer and polyacrylamide as the second network layer. The ionic conductivity of the resulting material reached 131.4 mS cm −1 . The dual network endowed the hydrogel electrolyte with abundant ion channels and excellent mechanical stability, effectively reducing the interfacial contact resistance with the electrode. The activated carbon-based supercapacitor with cellulose-Polyacrylamide interpenetrating network hydrogel electrolyte delivered high specific capacitance of 989 mF cm −2 at 2 mA cm −2 . Besides, the electrochemical behavior of the supercapacitor showed no obvious differences from supercapacitors assembled with aqueous electrolytes. The excellent adhesion and flexibility of hydrogels allowed the supercapacitors to cope with deformation and compression at various angles while maintaining stable electrochemical behavior. In summary, the proposed approach is promising for the development of flexible energy storage devices with good electrochemical and mechanical stability.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-9
·
IF 16.6
Guan Lijiang,Guo Zhaoqi,Zhou Qi,Zhang Jin,Cheng Cheng,Wang Shengyao,Zhu Xiang,Dai Sheng,Jin Shangbin
Proton-conducting materials are essential to the emerging hydrogen economy. Covalent triazine frameworks (CTFs) are promising proton-conducting materials at high temperatures but need more effective sites to strengthen interaction for proton carriers. However, their construction and design in a concise condition are still challenges. Herein, we show a low temperature approach to synthesize CTFs via a direct cyclotrimerization of aromatic aldehyde using ammonium iodide as facile nitrogen source. Among the CTFs, the perfluorinated CTF (CTF-TF) was successfully synthesized with much lower temperature ( ≤ 160 °C) and open-air atmosphere. Due to the additional hydrogen-bonding interaction between fluorine atoms and proton carriers (H 3 PO 4 ), the CTF-TF achieves a proton conductivity of 1.82 × 10 −1 S cm −1 at 150 °C after H 3 PO 4 loading. Moreover, the CTF-TF can be readily integrated into mixed matrix membranes, displaying high proton conduction abilities and good mechanical strength. This work provides an alternative strategy for rational design of proton conducting media.
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BMC Complementary Medicine and Therapies
·
2023
·Vol. 23
·期 1
·1-16
·
IF 3.9
Ma Jianping,Zheng Miao,Zhang Xinyue,Lu Jiaqi,Gu Lili
Background Alzheimer’s disease (AD) is the most prevalent neurodegenerative and remains incurable. Aluminum is a potent neurotoxin associated with AD. The main pathological features of AD are extracellular amyloid-β protein deposition and intracellular hyperphosphorylated Tau protein. A body of evidence suggest that oxidative stress and autophagy are involved in the pathogenesis of AD. Andrographis paniculata (AP) is a native plant with anti-inflammatory, anti-oxidative stress, and regulation of autophagy properties. AP significantly alleviated cognitive impairments, reduced Aβ deposition and has neuroprotective effect. However, its effects on aluminum-induced AD model have not been studied much. In this study, we investigated whether AP protect against aluminum-induced neurotoxicity through regulation of p62-Kelch-like ECH-associated protein 1(Keap1)-Nuclear factor E2 related factor 2 (Nrf2) pathway and activation autophagy in vivo and in vitro.Methods UPLC-ESI-qTOF-MS/MS was used to identify the chemical constituents of AP ethanol extract. The mice with cognitive deficit were established by injecting aluminum chloride and D-galactose, and treated with either AP extract (200, 400, or 600 mg/kg/d) or andrographolide (2 mg/kg/2d).The spatial memory ability was detected by Morris water maze, HE staining were used to detect in brain tissue,Oxidative stress indexs and SOD activity in both serum and brain tissue were detected by kit.The expression of p62-Nrf2 pathway proteins were measured via western blotting. Furthermore, the neurotoxicity model was induced by aluminum maltolate (700 µM) in PC12 cells. Following AP and andrographolide treatment, the cell viability was detected. The relevant mRNA and protein expressions were detected in cells transfected with the p62 siRNA.Results The main active components of AP included andrographolide, neoandrographolide and deoxyandrographolide as identified. AP and andrographolide significantly improved the spatial memory ability of mice, attenuated pathological changes of hippocampal cells, reduced the level of malondialdehyde, and increased superoxide dismutase activity in serum or brain tissue as compared to model control. In addition, the Nrf2, p62 and LC3B-II proteins expression were increased, and p-Tau and Keap1 proteins were decreased in the hippocampus after AP and andrographolide treatment.Furthermore, AP increased aluminum maltolate-induced cell viability in PC12 cells. Silencing p62 could reverse the upregulation expression of Nrf2 and downregulation of Keap1 and Tau proteins induced by AP in aluminum maltolate-treated cells.Conclusion sAP had neuroprotective effects against aluminum -induced cognitive dysfunction or cytotoxicity, which was involved in the activation of the p62-keap1-Nrf2 pathway and may develop as therapeutic drugs for the treatment of AD. However, this study has certain limitations, further optimize the protocol or model and study the molecular mechanism of AP improving AD.
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KOREAN JOURNAL OF CHEMICAL ENGINEERING
·
2023
·Vol. 40
·期 12
·3059-3067
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IF 2.7
Yin Zihang,He Ruibo,Nie Fei,Wei Zhen,Jia Bo,Feng Qing,Fu Xiaolong,Zhang Wenyan
The oxygen evolution kinetics of industrial copper electrodeposition is slow, resulting in low electrocatalytic activity and high energy consumption. In this work, a quaternary composite of carbon coated active particles containing Mn, Co and Ce were prepared (Mn-Co 3 O 4 /CeO 2 @C), and Ti/Sb-SnO 2 /PbO 2 electrode doped with these active particles was prepared by co-electrodeposition. The microstructure and chemical composition of the electrode was characterized by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and X-ray diffractometry (XRD). Linear sweep voltammetry (LSV), electrochemical impedance spectroscopy (EIS) and Tafel polarization curve (Tafel) were used to study the electrochemical properties of anode materials. The results showed that the doping of Mn-Co 3 O 4 /CeO 2 @C active particles promoted the crystal transition of PbO 2 , decreased the average grain size, and the doping of Ce increases the average valence state of Co. The modified titanium electrode showed excellent catalytic activity of the oxygen evolution reaction (OER) characteristics. The overpotential of the doped Ti/Sb-SnO 2 /PbO 2 anode was only 453 mV when the current density was 20 mA cm −2 in 0.5 M H 2 SO 4 solution, which is 508 mV lower than that of the undoped Ti/Sb-SnO 2 /PbO 2 anode. In simulated copper electro-deposition experiments, the cell voltage was reduced by about 400 mV, compared to the undoped Ti/Sb-SnO 2 /PbO 2 electrode.
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Nano Research
·
2023
·
IF 9.9
Li Guanting,Xia Fengli,Xiao Hongying,Zheng Shunzhe,Fu Shuwen,Qiao Han,Jin Qianhui,Zhang Xuanbo,Zhou Dun,Tian Chutong,Sun Jin,He Zhonggui,Sun Bingjun
Small-molecule prodrug nanoassemblies have emerged as efficient antitumor drug delivery systems. However, in the case of camptothecins-based prodrug nanoassemblies, linear aliphatic side chain modification often results in rod-shaped or irregularly shaped nanoassemblies, which are highly unfavorable for sterilization through filtration, and may cause capillary blockage upon intravenous injection. The rational design of camptothecins-based prodrug nanoassemblies remains a challenge. Herein, we propose that branched aliphatic alcohol (BAA) functionalization could fine-tune the structure-tolerance-antitumor efficacy axis of prodrug nanoassemblies. Correspondingly, four SN38-BAA prodrugs were synthesized by conjugating 7-ethyl-10-hydroxycamptothecin (SN38) with BAAs of varying lengths via a tumor redox-responsive disulfide bond, which self-assemble into uniform spherical nanoparticles. The length of BAA was found to significant impact the multiple drug delivery process, including colloidal stability, drug release profiles and pharmacokinetics. Overall, SN38-C21 NPs (SN38-11-heneicosanol nanoparticles), featuring the longest BAA, showcased multiple therapeutic advantages, ultimately culminating the optimal antitumor efficacy and tolerance. The findings underscore the potential of BAA functionalization in strengthening the therapeutic outcomes of prodrug nanoassemblies, and provide valuable insights for developing translational camptothecins-based nanomedicines.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2023
·Vol. 415
·期 20
·5011-5021
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IF 4.3
He Jingbo,Xie Chenchen,Meng Chen,Chen Xiaolin,Liu Huilin,Sun Baoguo
A thermal-sensitive molecularly imprinted optosensing probe based on fluorescent advanced glycation end products (AGEs) was prepared by one-pot hydrothermal synthesis. Carbon dots (CDs) derived from fluorescent AGEs were used as the luminous centers, while molecularly imprinted polymers (MIPs) were wrapped outside of the CDs to form specific target recognition sites to highly selectively adsorb the intermediate product of AGEs of 3-deoxyglucosone (3-DG). Thermosensitive N-isopropylacrylamide (NIPAM) was combined with acrylamide (AM) as co-functional monomers, and ethylene glycol dimethacrylate (EGDMA) was chosen as a cross-linker for targeting identification and detection of 3-DG. Under optimal conditions, the fluorescence of MIPs could be gradually quenched with the adsorption of 3-DG on the surface of MIPs in the linear range of 1–160 μg/L, and the detection limit was 0.31 μg/L. The spiked recoveries of MIPs ranged from 82.97 to 109.94% in two milk samples, and the relative standard deviations were all less than 1.8%. In addition, the inhibition rate for non-fluorescent AGEs of pyrraline (PRL) was 23% by adsorbing 3-DG in the simulated milk system of casein and d -glucose, indicating that temperature-responsive MIPs not only could detect the dicarbonyl compound 3-DG quickly and sensitively, but also had an excellent inhibitory effect on AGEs. Graphical abstract
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Signal Transduction and Targeted Therapy
·
2023
·Vol. 8
·期 1
·1-12
·
IF 39.3
Gu Yangzhuo,Yang Jingyun,He Cai,Zhao Tingmei,Lu Ran,Liu Jian,Mo Xianming,Wen Fuqiang,Shi Huashan
mRNA vaccines have emerged rapidly in recent years as a prophylactic and therapeutic agent against various diseases including cancer and infectious diseases. Improvements of mRNA vaccines have been underway, among which boosting of efficacy is of great importance. Pam2Cys, a simple synthetic metabolizable lipoamino acid that signals through Toll-like receptor (TLR) 2/6 pathway, eliciting both humoral and cellular adaptive immune responses, is an interesting candidate adjuvant. To investigate the enhancement of the efficacies of mRNA vaccines by Pam2Cys, the adjuvant was incorporated into mRNA-lipid nanoparticles (LNPs) to achieve co-delivery with mRNA. Immunization with the resulting mRNA-LNPs (Pam2Cys) shaped up the immune milieu in the draining lymph nodes (dLNs) through the induction of IL-12 and IL-17, among other cytokines. Antigen presentation was carried out mainly by migratory and dLN-resident conventional type 2 DCs (cDC2s) and significantly more potent antitumor responses were triggered in both prophylactic and therapeutic tumor models in a CD4 + and CD8 + T cell-dependent fashion. Accompanying memory antitumor immunity was also established. Moreover, the vaccine also stimulated much more robust humoral and cellular immunity in a surrogate COVID-19 prophylactic model. Last but not the least, the new vaccines exhibited good preliminary safety profiles in murine models. These facts warrant future development of Pam2Cys-incorporated mRNA vaccines or relevant mRNA therapeutics for clinical application.
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