FOOD CHEMISTRY
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2022
·
IF 9.231
Jia Cheng Qian,Dan Liu,Li Ping Lin,Wen Jing Zhu,Ren Xiang Tan
Kimchi is a globally consumed food with diverse health-benefits, but the low-abundance bioactive compounds in kimchi remain largely neglected. Here we show that kimchi contains a family of low-abundance (0.5–1.6 μg/g, dried weight) high-order indole oligomers derived from indole-3-carbinol (I3C), a breakdown product released from cruciferous vegetables used for producing the traditional subsidiary food. The structure determination of such complex molecules was accomplished by synthesizing linear indole oligomers as standard materials followed by the LC–HR–MS analysis. One indole tetramer (LTe2) is substantially toxic to tumor MV4-11 (IC 50 = 1.94 μM) and THP-1 cells (IC 50 = 7.12 μM). Collectively, the work adds valuable information to the knowledge package about kimchi, and may inspire the generation of indole-based molecules, to which many drugs belong.
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高影响因子
ACS Applied Energy Materials
·
2022
·
IF 6.959
Hui Peng,Faqiang Wang,Danyang Wang,Shuzhen Cui,Wenbo Hou,Guofu Ma
Aqueous Zn–MnO2 batteries have received much attention due to their low cost, safety, reliability, and large storage capacity. However, the sluggish ion/electron transport kinetics of bulk MnO2 inevitably decreases the rate capability and cycle stability of Zn–MnO2 batteries. Herein, hierarchical MnO2 nanosheet arrays self-anchored and grown in polyaniline-derived carbon nanotubes (PCNT@MnO2, denoted as PCMO) with enhanced stability are prepared by employing PCNT as both a substrate and a sacrificial reductant. The hollow PCNT conductive skeleton feature and robust integrated MnO2 nanosheet arrays in PCMO are not only favorable for enhancing electronic conductivity and accelerating electronic migration but also provide effective nucleation sites for the growth of MnO2 nanosheets and unimpeded ion channels, resulting in high specific capacity, rapid ion-diffusion kinetics, and long-term cycle stability. Specifically, the optimized PCMO material (PCMO-2) can deliver 264 mAh g–1 at 0.2 A g–1 after 120 cycles without obvious capacity decay, superior to the bare MnO2 material. Moreover, the as-fabricated PCMO//Zn battery can exhibit a high energy density of 320.2 Wh kg–1 at a power density of 120 W kg–1. The rational design of low-cost and integrated core–shell architecture with robust contact between MnO2 nanosheet arrays and a hollow conductive skeleton is expected to achieve cost-effective and high-performance Zn–MnO2 batteries.
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FOOD CHEMISTRY
·
2022
·
IF 9.231
Jiaodi Li,Chenxi Wang,Xiaoling Chen,Minghui Huang,Qian Fu,Rongjie Li,Yilin Wang,Chunyan Li,Pengcheng Zhao,Yixi Xie,Junjie Fei
Gallic acid (GA) is found in a wide range of natural plants and is relevant to the health of human beings. Here, a photoelectrochemical sensing platform based on g-C 3 N 4 @CNT heterojunction has been prepared for the highly sensitive and selective detection of GA. Under the light of xenon lamp, the photocurrent of g-C 3 N 4 @CNT is 7 times higher than that of g-C 3 N 4 . And the sensor generates 4 times more photocurrent in the presence of GA than without GA. This sensor has a wide linear range from 10 nM to 10 μM with a limit of detection as low as 2 nM. Also, the abundant amino groups of g-C 3 N 4 provide excellent selectivity for the sensor. Furthermore, the sensor can be used for the analysis of GA in black tea samples, which provides a novel and rapid method for the detection of GA in food samples.
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ACS Applied Bio Materials
·
2022
·
IF 0
Tianran Lin,Gaoyan Jiang,Danxuan Lin,Yunping Lai,Li Hou,Shulin Zhao
Bacitracin (an antimicrobial peptide, AMP)-modified dextran-MoSe2 nanosheets (AMP/dex-MoSe2 NSs) were constructed and applied for low-temperature and synergetic antibacterial applications. The near-infrared (NIR) photothermal and peroxidase-like activities of dex-MoSe2 were combined with the bacterial membrane-binding ability of AMP through electrostatic adsorption, and a multimode antibacterial method was realized. H2O2 was converted into a hydroxyl radical (·OH) by AMP/dex-MoSe2, which exhibits a higher antibacterial activity and can avoid the toxicity of a high concentration of H2O2. Importantly, the production of ·OH and the antibacterial efficiency of AMP/dex-MoSe2 were accelerated by low-temperature heat sterilization with NIR irradiation. Owing to the AMP-guided binding and destruction effect to the bacterial membrane, AMP/dex-MoSe2 shows a better antibacterial effect on Gram-negative Escherichia coli under NIR irradiation as compared to catalytic treatment or NIR photothermal sterilization alone. Furthermore, the cytotoxicity and hemolysis of AMP/dex-MoSe2 were weak and in a relatively safe range. This multimode antibacterial strategy based on the AMP/dex-MoSe2 nanozyme will pave a way for the development of more safe and efficient antibacterial applications.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2022
·
IF 9.136
Meng Wu,Minghao Xu,Jiaojiao Yang,Yun Wang,Bin Lu,Hui Liu,Rufen Chen
The elimination of pharmaceutical wastewater has aroused great attention because of its environmental and ecological significance. In this work, an efficient photo-assisted FeP/peroxodisulfate (PDS) system was constructed and applied to the degradation of antibiotic. About 98.47 % Metronidazole (MNZ) could be removed by FeP/PDS after 20 min at its natural pH under the irradiation of 10 W fluorescent. The SO 4 •− , HO • and O 2 •− radicals were involved in MNZ degradation, in which SO 4 •− played the major role. Both Fe δ+ and P δ– in FeP as well as surface oxidized ≡Fe 2+ could be used as activity sites to activate PDS. The rate-determining step of Fenton-like reaction (M (n+1)+ → M n+ ) can be accelerated through internal electron transfer of FeP. Moreover, the Fe 2 O 3 /FeP hetero-structure on the surface of FeP particles also took part in PDS activation under light irradiation. This finding illustrates a potential utilization of metal phosphide as a photo-assisted Fenton-like catalyst to remove organic pollutants in the environment.
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JOURNAL OF MOLECULAR STRUCTURE
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2022
·
IF 3.841
Aihong Yang,Wenjing Liu,Xiangyu Li,Wanru Wu,Xiaodi Kou,Rui Shen
More and more evidence suggested that bio-metals including iron, zinc and copper play an important role in Alzheimer's disease (AD). Metal chelation agents may play an important role through promoting the metal homeostasis for AD treatment. In this study, UA (usnic acid), a natural product with antioxidant activity and metal chelation sites was selected as a lead compound. Different types of tertiary amine groups were introduced to synthesize four UA derivatives 1–4 as metal chelators and cholinesterase inhibitors since tertiary amine moiety was the key pharmacophore to inhibit cholinesterase. And the related activities such as antioxidant, anti-cholinesterase and metal chelation were evaluated. Results showed that 1–4 displayed excellent anti-oxidant activity, with lowest IC 50 of 0.433 µM for ·OH scavenging ability and 8.808 µM for ·O 2 − scavenging ability. The mechanisms of anti-oxidant activities were furtherly studied by cyclic voltammetry. Besides, 1–4 also showed good anti-cholinesterase activities with lowest IC 50 of 0.269 µM for acetylcholinesterase (AChE) and 0.361 µM for butyrylcholinesterase (BuChE). The results of molecular docking with AChE and BuChE were consistent with the experimental results. 1–4 displayed obvious chelating abilities with Cu(II) and Fe(III) by UV–vis spectra analysis and the metal complexes also showed good anti-AD activities. Interestingly, single crystal of Cu(II) complex of the hydrolyzed mono-substituted ligand was obtained which further substantiated the metal binding ability and provided clues to the anti-AD activities of the metal complex. Meanwhile, hydrolysis ratio of 4 was also tested by HPLC. Finally, BBB permeability of 1–4 was acceptable by ADMET prediction. Overall, these findings demonstrated that compounds 1–4 might be considered as potential candidates in the anti-AD therapy.
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Nutrients
·
2022
·Vol. 14
·期 8
·1564
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IF 6.706
Hongbo Jiang,Pei Ma,Zhiguang Duan,Yannan Liu,Shihong Shen,Yu Mi,Daidi Fan
Gastric cancer (GC) is the leading causes of cancer-related death worldwide. Surgery remains the cornerstone of gastric cancer treatment, and new strategies with adjuvant chemotherapy are currently gaining more and more acceptance. Ginsenoside Rh4 has excellent antitumor activity. Conversely, the mechanisms involved in treatment of GC are not completely understood. In this study, we certified that Rh4 showed strong anti-GC efficiency in vitro and in vivo. MTT and colony formation assays were performed to exhibit that Rh4 significantly inhibited cellular proliferation and colony formation. Results from the wound healing assay, transwell assays, and Western blotting indicated that Rh4 restrained GC cell migration and invasion by reversing epithelial–mesenchymal transition (EMT). Further validation by proteomic screening, co-treatment with disitertide, and SIX1 signal silencing revealed that SIX1, a target of Rh4, induced EMT by activating the TGF-β/Smad2/3 signaling pathway. In summary, our discoveries demonstrated the essential basis of the anti-GC metastatic effects of Rh4 via suppressing the SIX1–TGF-β/Smad2/3 signaling axis, which delivers a new idea for the clinical treatment of GC.Keywords:ginsenoside Rh4;SIX1;TGF-β/Smad2/3 pathway;gastric cancer
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Journal of Water Process Engineering
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2022
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IF 7.34
Tang Zhou,Lei Zhao,Dingsheng Wu,Quan Feng,Baobao Zhao
As an emerging and promising technology , photocatalytic technology can effectively remove trace organic pollutants such as tetracycline hydrochloride (TC-H, an antibiotic) in water. However, the research on photocatalysis is mainly focused on the powder photocatalyst, which is difficult to separate from the water body after use. Generally, fixing the photocatalytic material on a specific carrier can effectively avoid the above problems. In this article, we uniformly assembled g-C 3 N 4 on bacterial cellulose (BC) with 3D nanofiber network and enhance its catalytic activity by polypyrrole (PPy). Different from the modification of the photocatalyst in most studies, we have effectively improved the catalytic activity through the design of the support material and reactor in this work. The PPy@(BC/g-C 3 N 4 ) flexible membrane prepared has high-efficiency catalytic performance (64.28%, 2 h, TC-H) under a low-power xenon lamp (λ > 420 nm) in the reactor designed, which is 5.27 times the catalytic efficiency of the original BC/g-C 3 N 4 (12.20%, 2 h, TC-H). After 10 times of repeated use, it can stably retain more than 80% of the initial catalytic activity. Specifically, we propose to introduce oxygen in the active substrate generation stage and construct a photoelectrocatalytic reaction cell. This study can be used as a general strategy to prepare flexible membrane materials with high-efficiency catalytic properties.
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MOLECULES
·
2022
·Vol. 27
·期 7
·2097
·
IF 4.927
Pu Li,Xiaoxiao Chen,Gaojun Wu,Zhe Wang,Chaobiao Huang
An ascorbic acid (AA) sensor was constructed based on the fluorescence resonance energy transfer (FRET) between CdS quantum dots (CdS QDs) and polydopamine (PDA) to detect trace AA sensitively. FRET occurred due to the broad absorption spectrum of PDA completely overlapped with the narrow emission spectrum of CdS QDs. The fluorescence of CdS QDs was quenched and in the “off” state. When AA was present, the conversion of DA to PDA was hindered and the FRET disappeared, resulting in the fluorescence of CdS QDs in an “on” state. Importantly, the degree of fluorescence recovery of CdS QDs displayed a desirable linear correlation with the concentration of AA in the range of 5.0–100.0 μmol/L, the linear equation isy=0.0119cAA+0.3113, and the detection limit is 1.16 μmol/L (S/N = 3,n= 9). There was almost no interference with common amino acid, glucose and biological sulfhydryl small molecules to AA. Trace amount of AA in vitamin C tablets were determined and satisfactory results were obtained; the recoveries were observed to be 98.01–100.7%.Keywords:CdS quantum dots;PDA;fluorescence resonance energy transfer;ascorbic acid
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Frontiers in Cellular and Infection Microbiology
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2022
·
IF 6.073
Yi Yan-ling,Li Yao,Guo Sheng,Yan Hui,Ma Xin-fei,Tao Wei-wei,Shang Er-xin,Niu Yang,Qian Da-wei,Duan Jin-ao
Jujube (Ziziphus jujuba Mill.) fruit (JF) is widely consumed as food in Asian countries due to its potential effects for human health. As a traditional Chinese medicine, JF is often used to treat anorexia, fatigue and loose stools caused by spleen deficiency syndromes in China, but the mechanism underlying this effect has not been thoroughly elucidated. In this study, a rat model of spleen deficiency syndromes was adopted to investigate the therapeutic effect of JF extract and its possible mechanism by metabolomics analyses of plasma and urine as well as the intestinal flora analysis. The results showed that the changes in plasma and urine metabolites caused by spleen deficiency were reversed after administration of JF, and these changed endogenous metabolites were mainly involved in retinol metabolism, pentose and glucuronate interconversions, nicotinate and niacinamide metabolism pathways. The 16S rDNA sequencing results showed that JF could regulate intestinal flora imbalance caused by spleen deficiency. The covariance analysis of intestinal flora structure and metabolome indicated that Aerococcus may be a candidate strain for predicting and treating the metabolic pathways of spleen deficiency and related disorders. In summary, it can be revealed that spleen deficiency, which alters metabolic profiles and the intestinal flora, could be alleviated effectively by JF extract.
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Journal of Environmental Chemical Engineering
·
2022
·
IF 7.968
Xiurong Zhu,Lei Ge,Wei Yan,Shengjiong Yang,Gen Wang,Delu Miao,Pengkang Jin
Heterogeneous activation of peroxymonosulfate (PMS) has been frequently proposed for the degradation of organic pollutants via the generation of reactive oxygen species (ROS). Spinel ferrite such as CoFe 2 O 4 shows great advantage for PMS activation but suffers from aggregation problem and lack of microstructure. Herein, network-like CoFe 2 O 4 immobilized on volcanic rock was synthesized for PMS activation for degrading sulfamethoxazole (SMX). The immobilized CoFe 2 O 4 network exhibited good catalytic performance for SMX removal. Systematic investigations, including in situ ATR-FTIR and Raman spectroscopy analysis, chemical quenching experiments and electron paramagnetic resonance (EPR) tests, revealed that a redox cycle of Co 2+ /Co 3+ induced the generation of ROS (SO 4 •− , OH • and 1 O 2 ) that participated in the degradation of SMX. Background constituents (e.g., inorganic ions and natural organic matters) exhibited limited influence on SMX removal. A continuous flow-through reaction in a fixed-bed column revealed the immobilized CoFe 2 O 4 network could efficient degrade SMX with long-term durability, which therefore can be a promising catalyst for PMS activation for the degradation of SMX.
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OPTICAL MATERIALS
·
2022
·
IF 3.754
Wenkun Zhang,Rong Ma,Shuo Gu,Liting Zhang,Ningbo Li,Jie Qiao
Nitrogen and phosphorus co-doped carbon dots (NPCDs) with bright blue fluorescence were established by a hydrothermal method using alanine and diammonium phosphate as raw materials. The NPCDs were characterized by transmitted electron microscopy , X-ray photoelectron spectroscopy, Fourier transform infrared spectrometry , ultraviolet–visible absorption (UV–vis), and fluorescence spectroscopy to investigate the morphology, elemental composition, and optical properties . The NPCDs had good water solubility, high dispersibility with an average diameter of only 2.77 nm, and satisfactory optical properties with a fluorescence quantum yield of 17.2%. The NPCDs were employed for the detection of doxorubicin (DOX). A good linear response of the NPCDs in the range 0.5–6.5 μM was obtained for DOX with a detection limit of 12 nM. The NPCDs were also applied to the analysis of real samples, urine and serum, with a recovery of 92.0–109.3%. The low cytotoxicity and good biocompatibility of the NPCDs were indicated by an MTT assay and cell imaging of HeLa cells. Compared with other detection systems, using NPCDs for DOX detection was a facile and efficient method with good selectivity and sensitivity.
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