Advanced Optical Materials
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2026
·Vol. 14
·期 17
·e71226
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IF 7.2
Jinwei Liu,Jiaxin Li,Guojun Zheng,Chuan Liao,Jianhong Wu,Jianrong Qiu,Wenge Xiao
Cr 3+ emission can well cover the NIR-I region (700–950 nm), while Ni 2+ emission typically extends across the NIR-II region (1000–1700 nm), making the Cr 3+ –Ni 2+ co-doped phosphors among the most promising ultrabroadband NIR emitters for phosphor-converted light-emitting diodes (pc-LEDs). However, a pronounced gap or even spectral discontinuity between the two emission bands results in a severely imbalanced photon flux across the spectrum, thereby degrading multicomponent spectral detection accuracy and significantly limiting the practical applications of such NIR pc-LED devices. Here, we report a superstoichiometric spinel MgO· n Ga 2 O 3 :Cr 3+ ,Ni 2+ ( n > 1) phosphor, in which the excess Ga 2 O 3 increases the degree of cation inversion to achieve a long-wavelength Cr 3+ emission at 895 nm, substantially elevating the spectral gap height to a state-of-the-art value of ≈36%. Moreover, efficient energy transfer from Cr 3+ to Ni 2+ enables the optimized MgO·1.2Ga 2 O 3 :Cr 3+ ,Ni 2+ phosphor to demonstrate a high internal quantum efficiency of 97% and excellent thermal stability. Finally, the as-fabricated NIR pc-LED delivers an exceptional photoelectric efficiency of 21% at 20 mA and a maximum NIR output power of 62 mW at 350 mA. This work establishes a new pathway toward next-generation compact ultrabroadband NIR pc-LEDs featuring unprecedented spectral flatness and superior optoelectronic performance.
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SENSORS AND ACTUATORS B-CHEMICAL
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2026
·
IF 8.3
Shixin Ma,Zhihua Zhao,Chen Chen,Zhuo Chen
1-Octen-3-ol is a characteristic volatile organic compound released from moldy wheat. Therefore, the development of high-performance gas sensors for 1-octen-3-ol detection is of great significance for ensuring grain safety by enabling real-time monitoring of wheat quality. However, substantial challenges remain, including poor selectivity and insufficient stability. To address these limitations, this study designed and successfully synthesized a three-dimensional nest-like Tungsten trioxide (WO 3 ) structure decorated with FeCo nanoalloys. By modulating the loading amount of the iron (Fe) cobalt (Co) alloy, we achieved precise tuning of surface oxygen vacancies and facilitated efficient electron transfer within the nanocomposite, resulting in a significantly enhanced gas response. The optimized 1.5FeCo@WO 3 sensor exhibited a high response value of 12.68 toward 100 ppm 1-octen-3-ol, along with superior selectivity and excellent long-term stability. Systematic material characterizations, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and Brunauer-Emmett-Teller (BET) analyses, confirmed that the composite possesses a high specific surface area, abundant oxygen vacancies, and a robust interfacial electronic interaction between the FeCo alloy and the WO 3 matrix. Furthermore, density functional theory calculations were integrated into the mechanistic analysis. Consequently, this work yields a promising sensor candidate for the early warning of wheat diseases and proposes a material design strategy for developing economical, high-sensitivity gas sensors for agricultural applications.
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Wenyan Hao,Nan Sun,Ruifen Xue,Junkai Chang,Xiaocong Pang,Ying Zhou,Chunsheng Gao
Secondary brain injury after traumatic brain injury (TBI) is driven largely by ferroptosis-induced neuronal death and maladaptive neuroinflammation. Current therapies are limited by poor drug delivery and the narrow scope of single-pathway interventions. Here, we report a biomimetic hybrid nanovesicle (hMLV) engineered to codeliver the ferroptosis inhibitor ferrostatin-1 (Fer-1) and M2 macrophage–derived exosomes, enabling simultaneous suppression of neuronal ferroptosis and reprogramming of the immune microenvironment. The liposomal core encapsulates hydrophobic Fer-1 to enhance solubility and stability, while the exosomal membrane promotes blood–brain barrier penetration, lesion targeting via chemokine receptors, and immune evasion through CD47 expression. Within injured brain tissue, released Fer-1 restores glutathione peroxidase 4 (GPX4) activity, reduces lipid peroxidation, and prevents ferroptotic neuronal death. Concurrently, exosomal cytokines such as interleukin-10 and transforming growth factor-β drive macrophage polarization toward a reparative M2 phenotype, mitigating neuroinflammation. This dual mechanism establishes a positive therapeutic cycle: ferroptosis inhibition dampens inflammatory triggers, while M2 polarization reduces oxidative stress. In a murine TBI model, hMLV treatment conferred superior neuroprotection and functional recovery compared with monotherapies. These findings highlight hMLV as a clinically translatable nanoplatform for synergistic, mechanism-guided intervention in secondary brain injury.
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JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
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2025
·
IF 2.5
Huiqian Zhang,Jiayi He,Xiuwei Shen,Congcong Wen,Yubin Xu,Feilu Wang,Shaowei Wang,Ren-shan Ge,Xiaoheng Li
The placenta contains 17β-hydroxysteroid dehydrogenase 1 (17β-HSD1), an enzyme critical for converting estrone to estradiol. Salicylates, widely used as preservatives, may inhibit 17β-HSD1, but their inhibitory strength and structure-activity relationships (SAR) remain unclear. This study evaluated 13 structurally diverse salicylates, identifying potent inhibitors of human and rat 17β-HSD1. Menthyl salicylate showed the strongest inhibition in humans (IC 50 : 5.23 μM) and rats (IC 50 : 14.85 μM). Inhibition correlated negatively with molecular weight, volume, carbon chain length, and LogP. Mechanistic studies revealed mixed/noncompetitive inhibition in both species. 3D-QSAR and molecular docking highlighted hydrophobic, van der Waals, and hydrogen-bonding interactions at the enzyme’s active site. Key structural features, including carbon chain length and substituent patterns, determined inhibitory potency. These findings clarify SAR and suggest salicylates' potential as endocrine disruptors.
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DYES AND PIGMENTS
·
2025
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IF 4.2
Shouqing Zhan,Xinyu Luan,Yan Feng,Xiuxiu Chen,Lisha Song,Xiangbo Han,Rongfei Zhang,Zhanli Liu
This study developed an innovative colorimetric film by incorporating 1-butyl-3-methylimidazolium chloride (BmimCl) in a composite matrix containing red cabbage anthocyanins extract (RCAE), ferulic acid (FA), gellan gum (GG), and potato starch (PS) for real-time grass carp freshness detection. A comprehensive analysis was conducted on the rheological characteristics of film-forming solutions, mechanical properties, hydrophobicity, opacity, characterization of structure, sensitivity, and color stability of smart film. Significantly, the introduction of BmimCl led to multifaceted enhancements in film performance. The findings indicated that the flexibility of films added with BmimCl was enhanced and the elongation at break (EAB) was increased from 20.34 % to 28.36 %. The surface of films was smoother and denser, and the surface roughness was reduced from 1.7 μm to 1.2 μm. The peak intensities of the XRD and FT-IR patterns of films changed, indicating the formation of hydrogen bonds between BmimCl and film substrates. The GGPS-R-FA-B4 film presented the most pronounced color change in different pH environments and the most sensitive response to the variation of ammonia concentration in the environment. The color of GGPS-R-FA-B4 film exhibited a strong correlation with the quality change of fish, which could be used to distinguish the freshness, sub-freshness, and spoilage of grass carp. This study provided an effective method to enhance the accuracy and sensitivity of smart films for monitoring food freshness.
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BIOMACROMOLECULES
·
2025
·
IF 5.4
Fen Zheng,Shanming Zhang,Dongxuan Liu,Yitong Chen,Long Xu
Suboptimal intratumoral penetration remains a major obstacle to the clinical translation of nanomedicines, underscoring the need for innovative nanoplatforms that enable precise tumor penetration. While tumor-penetrating peptides are commonly used to improve nanomedicine accumulation and permeability in tumors, their efficacy in hypoxic regions remains limited. Herein, four pH/ROS dual-responsive polymer prodrugs, modified with or without the tumor-penetrating peptide CRGDK and the CAIX ligand, were constructed. The stability, pH/ROS responsiveness, in vitro drug release properties, and cellular uptake of the resulting micelles were evaluated. Tumor penetration was investigated using multicellular tumor spheroids (MTSs) and the PANC-1 xenograft model. Antitumor efficacy was studied in normoxic and hyperoxic cells, MTSs, and the xenograft model. Results showed that the NRP-1/CAIX dual-targeted prodrug micelles (P1) achieved deep tumor penetration in hypoxic tumor regions. A sequential targeting strategy employing both a tumor-penetrating peptide and a CAIX ligand offers a promising approach for enhancing nanomedicine infiltration into deep tumor areas.
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ACS Applied Nano Materials
·
2023
·
IF 5.9
Yu Yang,Hao Cheng,Ruijue Chen,Qiying Chen,Si Gao,Li Chen,Wenyi Huang,Hongxing Kong,Lijun Li,Jun Feng
In this work, we have fabricated a surface-enhanced Raman scattering (SERS) magnetic immunosensor using a sandwich structure consisting of an SERS tag, a supporting substrate with magnetic properties, and a target. On the one hand, the SERS tag consists of AgNPs, a metal–organic framework called the zeolite imidazolate framework-67 (ZIF-67), and R6G, which acts as a Raman reporter. Due to the self-selective SERS-enhancing properties of ZIF-67 and better adsorption to analytes, SERS tags with this structure can further enhance the sensing capabilities. On the other hand, after surface functionalization with the human carboxylesterase 1 (hCE1) antibody, the nanostructure containing CoFe2O4 as the magnetic core and Ag NPs as the shell was used as the magnetic support substrate. The introduction of the CoFe2O4 magnetic core can not only realize the rapid separation of biological samples to simplify pre-treatment procedures but also stabilize and uniformly distribute the AgNPs and increase the Raman “hot spots”, thereby further enhancing the SERS intensity and improving the reproducibility. Not only that, the SERS signal can be further enhanced by the synergistic effect generated by the plasmonic coupling of the CoFe2O4 magnetic core–Ag satellite nanostructure (CoFe2O4/Ag). hCE1 in HepG-2 cell lysates and culture supernatants was rapidly determined using the constructed SERS magnetic immunosensor, and hCE1 released from acetaminophen-treated HepG-2 cells into the extracellular medium was also monitored in real time. The limit of detection was as low as 3.6 pg/mL, and the linear response covered a range of hCE1 concentrations (1.0 ng/mL–1.0 mg/mL) spanning 3 orders of magnitude. This strategy can be used for the quantitative detection of complex trace proteins or enzymes in biological samples.
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Frontiers in Pharmacology
·
2026
·
IF 5.4
Chenyang Jiang,Xinshu Feng,Mingyu Qi,Shaojuan Wu,Qiuyu Wang,Yawen Zhou,Xiaoshan Zheng,Zhuogui Liang,Jianhua Tan,Yudong Zhang,Qingquan Guo,Haishan Zhao
Licorice ( Glycyrrhiza genus ) is a traditional medicinal herb that has also been widely used in the food and cosmetic industries, leading to widespread human exposure. Currently, many components have been identified as active ingredients in licorice; however, the toxic impurities and quality markers still require further investigation. Glabrol has been identified as a potentially toxic component in glabridin (an extract from licorice). In this study, we sought to evaluate the toxicity of glabrol in commercial licorice extracts and investigated the toxicological mechanism. The content of glabrol and the acute toxicity in ten commercial licorice extracts from different vendors were quantified using HPLC. The toxicity was further verified in zebrafish, cells in vitro and mammals in vivo mouse models . For the in vivo experiments, C57BL/6 mice received daily oral gavage of licorice extracts with (Sample C: 319.23 μg/g) o low (Sample B: 1.54 μg/g) glabrol content for 7 days. Locomotion was assessed via Open Field Test and Elevated Plus Maze, followed by blood and organ collection for pathological and biochemical analyses. To investigate the toxicological mechanism of glabrol, RNA - seq was performed on zebrafish embryos exposed to glabrol. Morphological and histopathological evaluations in zebrafish treated with the glabrol standard were carried out using phalloidin staining, transmission electron microscopy, and alizarin red staining. Our results indicated that glabrol was detected in all tested commercial licorice extracts, and its content showed a significant positive correlation with toxicity in cells and zebrafish. In mice, licorice extracts with higher glabrol levels led to low survival rates, hypoactivity, acute liver and kidney injury, and significantly elevated plasma inflammatory cytokines. Transcriptomic and mechanistic studies revealed that glabrol disrupted AP-1 signaling pathways and may impair myo-fiber organization, osteoclast differentiation, and inflammatory responses. This study establishes glabrol as a prevalent risk-associated impurity in licorice extracts and reveals that its toxicity is mediated via the AP-1 signaling pathway.
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BMC MICROBIOLOGY
·
2026
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IF 5.4
Shi Le-Nan,Han Yang-gang,Liang Hai,Li Tiejun,Shi Hui,Jin Lei
Background The rapid expansion of the aquaculture industry has intensified the discharge of nitrogen-rich wastewater, posing significant ecological risks. Biological treatment with HN-AD bacteria is sustainable, but most conventional strains lack long-term environmental resilience. The key bottleneck is identifying novel, robustly adaptable strains, especially spore-forming Gram-positive bacteria. Moreover, the non-canonical metabolic mechanisms that distinguish such strains remain largely unexplored. This study isolated a novel HN-AD strain, Paenibacillus glycanilyticus DQ-1, from aquaculture sludge and investigated its nitrogen removal performance and genomic metabolic pathways. Methods Strain DQ-1 was isolated and identified through 16 S rRNA gene sequencing and morphological analysis. Its nitrogen removal efficiency was evaluated under aerobic conditions with different nitrogen sources, including ammonium nitrogen (NH₄ + -N), nitrate nitrogen (NO₃ − -N), total inorganic nitrogen (TIN) and hydroxylamine nitrogen (NH 2 OH-N). Whole-genome sequencing was conducted using the PacBio Sequel II platform to identify functional genes and reconstruct the nitrogen metabolic pathways. Results Strain DQ-1 achieved 93.26% NH₄⁺-N and 100% NO₃⁻-N removal within 36 h, with 95.92% TIN removal. Genomic analysis revealed a complete assimilatory nitrate reduction pathway ( nasAB and nirBD ). Notably, while the canonical hydroxylamine oxidoreductase gene ( hao ) is absent, the strain showed 74.67% NH 2 OH-N removal and harbors a putative ammonia monooxygenase gene ( amo ). These results suggest that DQ-1 employs a novel non-canonical pathway, distinct from known HN-AD models, for efficient nitrogen transformation. Conclusions P. glycanilyticus DQ-1 differs from typical HN-AD bacteria in its spore-forming ability and a novel hao -independent pathway. This study provides the first comprehensive genomic insight into the nitrogen removal capacity of P. glycanilyticus , expanding the microbial resource pool for sustainable environmental remediation.
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MOLECULAR MEDICINE
·
2023
·Vol. 29
·期 1
·1-17
·
IF 5.7
Feng Yuqing,Lu Jinfang,Peng Xujun,Ge Yanni,Zhang Ran,Li Huiling
Background Retinal ganglion cells (RGCs) apoptosis is a vital manifestation of retinal ischemia/reperfusion (I/R) injury, yet the underlying mechanisms are not well understood. The contribution of long noncoding RNAs (lncRNAs) to this cellular process is currently being explored. Based on a lncRNA chip assay, we aimed to investigate the role of lncRNA uc007nnj.1 in the pathological process of ischemia-induced RGCs apoptosis.Methods Hank’s balanced salt solution containing 10 µM antimycin A and 2 µM calcium ionophore for 2 h to construct an ischemic model in RGCs, and elevation of intraocular pressure to 120 mm Hg for 1 h was used to construct a mouse model of retinal I/R injury.Results In this study, lncRNA uc007nnj.1 was highly upregulated in response to I/R injury in RGCs and mouse retinas. In addition, lncRNA uc007nnj.1 knockdown reduced retinal neuronal cell apoptosis in vitro and in vivo and significantly improved retinal function.DiscussionMechanistically, the results demonstrated that lncRNA uc007nnj.1 acts as ceRNA competitively binding miR-155-5p, thereby enhancing the expression levels of Tle4, thus aggravating ischemia-related apoptosis in RGCs.Conclusion sFinally, our study identifies the lncRNA uc007nnj.1/miR-155-5p/Tle4 axis as a potential target for the prevention of I/R-induced retinal neuronal death.
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EUROPEAN JOURNAL OF PHARMACOLOGY
·
2022
·
IF 5.195
Yuzhen Lu,Cong Zhang,Yingying Song,Liang Chen,Xin Chen,Guohua Zheng,Yuan Yang,Peng Cao,Zhenpeng Qiu
Accumulating evidence suggests that de novo lipogenesis is a typical characteristic facilitating nonalcoholic fatty liver disease (NAFLD) progression. Gallic acid (GA) is a naturally occurring phenolic acid with metabolic disease-related clinical significance and preclinical benefits. This study aimed to evaluate the anti-steatotic potentials of GA in a fructose-induced NAFLD mouse model featuring a hepatic lipogenic phenotype. The results revealed that GA alleviated hepatic steatosis , oxidative stress , and inflammatory response in fructose-fed mice. Mechanistically, GA treatment restored AMP-activated protein kinase α (AMPKα) phosphorylation, resulting in downregulations of pro-lipogenic factors, including sterol regulatory element binding protein-1 (SREBP-1), fatty acid synthetase (FASN), and acetyl-CoA carboxylase (ACC), in hepatocytes of mice and in vitro . Furthermore, computational docking analysis indicated that GA could directly interact with AMPKα/β subunits to stabilize its activation. These results suggest that GA ameliorates fructose-induced hepatosteatosis by restraining hepatic lipogenesis via AMPK-dependent suppression of the SREBP-1/ACC/FASN cascade. Altogether, this study demonstrates that GA supplement may be a promising therapeutic strategy in NAFLD, especially in the subset with enhanced hepatic lipogenesis.
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CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Fei Long,Qixiang Zhang,Junjie Shi,Li Wen,Yonghui Wu,Ziqi Ren,Zunyu Liu,Yixin Hou,Ke Mao,Ke Niu,Nishuang Liu,Zhi Zhang,Luying Li,Jun Su,Fei Long,Yihua Gao
Aqueous zinc-ion batteries (AZIBs) are a green, low-cost and high-safety energy storage technology. Although MoS 2 is a promising electrode material, low conductivity and poor stability still limit their application in AZIBs. Constructing conductive heterostructures is an effective strategy to overcome these problems. Herein, metallic 1 T-MoS 2 nanosheets are innovatively combined with conductive Ti 3 C 2 MXene, resulting in enlarged 1 T-MoS 2 interlayers (from 9.5 to 9.9 Å) and enhanced hydrophilicity. This novel 1 T-MoS 2 /Ti 3 C 2 MXene heterostructure exhibits exceptional high-rate capability (284.3 mAh/g at 0.10 A/g with 105.2 mAh/g at 10.00 A/g) and long-term cycling stability (93.2 % capacity retention after 3000 cycles). High capacity comes from the expanded ion storage space caused by the extended layer spacing of the metallic 1 T-MoS 2 . Outstanding rate capability thanks to ultrafast electrons and ions transport from Ti 3 C 2 MXene. Prominent long-term cycling stability is attributed to the efficient synergistic effect of 1 T-MoS 2 and Ti 3 C 2 MXene in the 3D interconnected networks. As a proof of concept, the wearable quasi-solid-state Zn-ion battery employing the 1 T-MoS 2 /Ti 3 C 2 MXene cathode exhibits stable electrochemical performance under different bending conditions. This work explores a new route to design high-performance layered cathode materials for AZIBs.
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