Nature Communications
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2026
·Vol. 17
·期 1
·1699
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IF 15.7
Sui Huiting,Lou Wenhua,Xiao Shibing,He Jia,Wu Fuling,Liu Ying,Wei Jianbiao,Lu Haijie,Sun Huajun,Ma Xiaoguang,Zhang Shujun
Defect microstructures, particularly dislocations, are pivotal in determining the functional properties of ferroelectric thin films. While their density is routinely considered, the critical role of their spatial configuration has remained largely unexplored and difficult to control. Here, we develop a controlled self-assembly strategy for dislocations in Bi(Fe,Mn)O 3 thin films on Ni-Cr that directly addresses this challenge. By employing a LaNiO 3 buffer layer, we template a discontinuous-columnar grain structure and guide the self-assembly of edge dislocations along grain boundaries in a topologically-protected configuration. The resulting ordered microstructure promotes a more uniform strain field and more coherent FeO 6 octahedral tilting, significantly enhances polarization homogeneity, leading to a lower domain-switching barrier and a more uniform domain pinning effect. Consequently, the BFMO thin film exhibits dramatically superior aging stability after 60 days at 60 °C, exhibiting far smaller reductions in remanent polarization (~20%) and coercive field (~35%) compared to the BFMO thin film grown directly on Ni-Cr. These findings establish a defect engineering paradigm wherein the deliberate dislocation rearrangement is leveraged to unlock superior ferroelectric performance.
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 3
·145
·
IF 5.4
Jia Bao-Zhu,Zhang Wen-Feng,Yin Qing-Chun,Rui Xue-Ying,Luo Lin,Xu Zhen-Lin
A dual-mode immunosensor based on polydopamine@Prussian blue nanoparticles (PDA@PB NPs) was developed for rapid and sensitive detection of benzocaine (BZC) in aquatic food. PDA@PB NPs possess excellent peroxidase-like activity, photothermal conversion efficiency, and antibody-binding capacity, enabling simple, crosslinker-free antibody immobilization. Upon target recognition, the sensor produces a distinct blue color via TMB–H 2 O 2 oxidation and a robust near-infrared photothermal signal, allowing dual-mode quantitative determination. Under optimized conditions, the sensor showed a linear range of 0.01–1000 ng/mL, with detection limits of 0.33 ng/mL (colorimetric) and 0.82 ng/mL (photothermal). The integration of colorimetric and photothermal outputs improves detection accuracy, reduces matrix interference, and eliminates the need for complex instrumentation. Validation with spiked real samples confirmed its reliability and applicability. This portable, cost-effective immunosensor offers a promising tool for on-site monitoring of BZC residues in aquatic products, contributing to enhanced food safety surveillance. Graphical abstract
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EUROPEAN JOURNAL OF NUTRITION
·
2026
·Vol. 65
·期 2
·52
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IF 4.5
Liu Kaiyue,Li Na,Fan Jiayi,He Siliang,Tang Weixiang,Cao Yaxin,Shen Liang,Sun Shuyang,Du Chengcheng,Du Chao
Purpose This study investigated the basic composition, in vitro digestibility, biological activities, and potential bioactive peptides of Pacific oyster (PO), Mytilus edulis (ME), Argopecten irradians (AIS), and Meretrix meretri x L. (MML) after simulated gastrointestinal digestion (SGD). Methods SGD products were prepared using the INFOGEST 2.0 model, and their nutritional properties and biological activities were analyzed. A comprehensive peptidomic profiling of the digested samples was conducted using nano-liquid chromatography-tandem mass spectrometry (nano-LC MS/MS) analysis. Results All four shellfish exhibited a nutritional profile characterized by high protein and low-fat content. The digestibility of shellfish increased progressively, while the average molecular weight (MW) of the hydrolysates gradually decreased during SGD, with the intestinal hydrolysates showing the highest overall digestibility. Biological activity analysis demonstrated that intestinal digestion products from all four species exhibited notable ABTS radical scavenging activity and α-glucosidase inhibition activity, with PO and ME exhibiting the strongest effects. A total of 349, 99, 314 and 105peptides were identified from the digestion products of PO, ME, AIS, and MML, respectively. Among these, PO and AIS showed the highest sequence similarity, sharing 69 identical peptides. By contrast, MML displayed distinct peptidomic characteristics, including a higher proportion of large MW peptides. Conclusion This study provides a comprehensive peptide catalog of shellfish digestion products and offers new insights into the biological activities of shellfish-derived peptides, supporting their potential as functional food resources.
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Nature Communications
·
2026
·
IF 15.7
Hongyu Cao,Fengnian Zhuang,Yanfei Wang,Tang Sheng,Wenyuan Liu,Zhiwen Bai,Mengdie Lan,Zhaoqi Li,Wenshan Yu,Shengping Shen
The challenge of dendrite growth limiting metal battery lifespan, despite extensive chemical composition optimizations for artificial solid electrolyte interphases (ASEIs), necessitates the development of ASEI design routes. Regulating the ASEI crystallographic microstructure offers a promising yet underexplored solution with efficacy uncertainty. Critical issue lies in what is the optimal crystallographic microstructure state. Using the ZnS ASEI in aqueous Zn batteries as a case study, here we report the effects of grain orientation and grain boundary density on the performance of Zn negative electrode. The results reveal the existence of an optimal microstructure state—predominant in-plane (111) orientation coupled with a critical grain boundary density of ~55 μm/μm 2 —which delivers an 18-fold lifespan extension, and over 3400 cycles with a Coulombic efficiency of 99.92% at 5 mA cm -2 , surpassing the efficacy of most chemical composition manipulations. Mechanistically, the (111) orientation integrates higher electrochemical kinetics and mechanical strength. As grain boundary density increases to tens of μm/μm 2 , the enhancement in electrochemical kinetics coincides with compromised mechanical strength, with their trade-off delineating the critical density that maximizes electrode cycling stability. Our findings exemplify an efficient ASEI design route—crystallographic microstructure engineering. Dendrite growth compromises the cycling life of metal batteries. Here, authors propose a crystallographic microstructure engineering approach to the artificial solid electrolyte interphase, demonstrating a high efficacy in stabilizing the zinc metal electrode during plating/stripping.
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APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
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2018
·Vol. 102
·期 13
·5695-5705
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IF 3.34
Qiao Ying,Cai Hao-Liang,Yang Xi,Zang Yuan-Yuan,Chen Zhi-Gang
In this study, a new method of cryopreservation of lactic acid bacteria (LAB) using natural deep eutectic solvents (NADESs) was developed. Survival rates of LAB during 24-h short-term and 180-day long-term cryostorage at − 20 °C were investigated. The results revealed that survival of Streptococcus thermophilus ( S. thermophilus ) in NADESs after 24 h of cryostorage was superior to survival of two other tested LAB. Moreover, survival was higher at a ratio of NADESs to S. thermophilus of 1:1 ( v / v ) than observed using a 4:1 ( v / v ) ratio. Representative freezing characteristics of five NADESs were elucidated, including thermodynamic properties and hydrogen bonding interactions after addition of water. In order to identify the protective mechanism of NADESs on cell structure and vital metabolic enzymes of S. thermophilus during cryostorage, transmission electron microscopy (TEM) and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) were employed and enzyme activities of both lactate dehydrogenase (LDH) and β -galactosidase were determined. Subsequently, NADES GlyP prepared from glycerol and L-proline was demonstrated to maintain cell membrane structural integrity and significantly ( p < 0.05) maintain activities of both intracellular enzymes of S. thermophilus . Moreover, NADESs could efficiently penetrate S. thermophilus cells and intracellular β -galactosidase activity could be used to demonstrate NADESs effectiveness in maintaining S. thermophilus survival after long-term cryostorage. These results demonstrate that NADESs can be used as green cryoprotective chemical agents (CPAs) that can efficiently increase LAB viability during cryostorage. These results should have great value in the food production and probiotics industries.
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CELLULOSE
·
2019
·Vol. 26
·期 11
·6755-6768
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IF 3.917
Zhou Ying,Fu Jing-Jing,Wang Lin-Xiang,Lu Zhisong,Wang Feng,Xia Qingyou,Kang Yuejun,Li Chang Ming,Yu Ling
Abstract A novel free-standing gelatin-impregnated polypropylene nonwoven (gelatin @PP nonwoven hybrid sheet) was prepared by loading gelatin hydrogel on nonwoven fabric, followed by a freeze-drying procedure. Formation of gelatin in the gaps between the PP fibers significantly increased the pore ratio of the scaffolds. In addition, the freeze-drying prepared gelatin enabled fast liquid absorption and rapid swelling. The cell adhesion and cell proliferation assays showed that the gelatin @PP nonwoven hybrid is a ready-to-use substrate for cell-based assays. Cell immunoassay was conducted to measure the protein expression on cells which were cultured on gelatin @PP nonwoven hybrid sheet. In addition, the freeze-drying prepared gelatin @PP nonwoven hybrid sheet was applied for assembling multilayer stacking for 3D cell culture. The ready-to-use convenience of the gelatin @PP nonwoven hybrid was ensured, as the physicochemical properties (chemical group, pore ratio, and swelling rate) and cell compatibility were well preserved after 90 days of storage. Graphic abstract A novel free-standing gelatin-impregnated polypropylene nonwoven (gelatin @PP nonwoven hybrid) was prepared as a ready-to-use substrate for cell culture.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2026
·Vol. 37
·期 13
·962
·
IF 3.2
Xu Xiaoying,Liu Ming,Zhou Hang,Guo Yangfan,Pei Xuanxu,Li Pengcheng,Yu Shihui
Considering its excellent film-forming properties and biodegradability, chitosan was expected to become one of the new raw materials for green electronic components. However, pure chitosan film was difficult to achieve satisfactory application in the field of ultra-flexible electronic devices due to its insufficient flexibility and poor high-temperature resistance. In this study, citric acid and glycerol were used to modify chitosan to enhance its overall performance. Based on this, a conductive film composed of silver nanowires (AgNWs) embedded into citric acid cross-linked chitosan was fabricated via a transfer method. During the preparation process, the optoelectronic properties of the composite film were improved by the method of heat treatment. The results showed that the composite film exhibited low surface roughness ( RMS = 5.48 ± 1.16), excellent transmittance (the sheet resistance is 15 Ω/sq and the transmittance at 550 nm is 73.7%), good thermal stability (no observable alteration in sheet resistivity and appearance features after being maintained at 180 0 C for 30 min), and outstanding flexibility. When tested as a heater, the film displayed favorable heating performance. The composite film prepared in this study showed the promising development value in the field of flexible electronic devices.
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Experimental Hematology & Oncology
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2026
·Vol. 15
·期 1
·36
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IF 17.5
Xiong Shumin,Zhou Ren,Wei Chuijin,Wang Xiaomin,Tang Yunhan,Dong Liaoliao,Yu Ping,Pei Duanqing,Chen Zhu,Chen Sai-Juan,Cheng Lin
Background The clinical supply of hematopoietic cells is severely constrained by the limitations of donor donation and inefficient in vitro generation. While generating these cells within interspecies chimeras presents a groundbreaking alternative, the fundamental biological properties and therapeutic potential of the resulting xenogeneic hematopoietic cells remain poorly characterized. Methods We generated xenogeneic hematopoietic cells in rodent models via blastocyst complementation and bone marrow transplantation. A comprehensive comparative analysis of these cells was conducted using single-cell RNA sequencing and proteomics. Their functional efficacy was rigorously evaluated through reverse transplantation into a series of donor-species disease models, including hemorrhagic anemia, thalassemia, thrombocytopenia, and leukemia. Results Bone marrow transplantation yielded significantly higher chimeric efficiency than blastocyst complementation. Xenogeneic hematopoietic cells, including red blood cells, platelets, and white blood cells, exhibited a transcriptional and proteomic profile that was dominantly donor-specific. Crucially, these cells did not elicit significant immune rejection upon reverse transfusion. Functionally, xenogeneic red blood cells rescued models of hemorrhagic anemia and thalassemia, platelets alleviated thrombocytopenia, and xenogeneic T cells engineered with a chimeric antigen receptor effectively suppressed leukemia progression. Furthermore, the implantation of xenogeneic hematopoietic cells partially reconstituted splenic morphology and function in immunodeficient recipients. Conclusion Our study provides the first comprehensive functional validation of xenogeneic hematopoietic cells generated in interspecies bioreactors. We definitively show that these cells possess donor-like molecular identities, evade immune rejection, and serve as effective “seed cells” to rescue a wide spectrum of hematologic diseases. This work establishes a transformative paradigm for utilizing interspecies chimeras to overcome critical shortages in transfusion and cellular therapies.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
·
IF 15
Nannan Wang,Ke Wang,Yuepeng Cao,Guoqing Su,Jinghang Qian,Jingru Shen,Jiayuan Jiang,Zian Chen,Xing Huang,Chengshuai Si,Jun Bao,Lei Ding,Liu Yang
The clinical efficacy of immune checkpoint inhibitors (ICIs) in colorectal cancer (CRC) is restricted by a dense, rigid extracellular matrix (ECM) that acts as a physical barrier to immune infiltration. To address this resistance, a biomimetic nanoplatform (MDPAs) was developed, comprising Defactinib-loaded mesoporous silica nanoparticles encapsulated in PD-L1 antibody-conjugated platelet membranes. Leveraging platelet-mimetic adhesion for tumor accumulation, MDPAs were shown to inhibit the Integrin-FAK-YAP mechanotransduction axis, leading to YAP cytoplasmic sequestration and attenuated cytoskeletal tension. This alleviation of the mechanical niche is associated with enhanced cytotoxic T cell infiltration, which synergizes with co-delivered PD-L1 antibodies to activate antitumor immunity. Single-cell RNA sequencing reveals that MDPAs remodel immune-epithelial-stromal crosstalk, driving tumor cells from a mesenchymal-like phenotype toward an immunologically susceptible, antigen-presenting state. In orthotopic, liver metastasis, and post-surgical recurrence models, MDPA treatment elicited tumor regression and extended survival with a favorable biosafety profile. These findings suggest that modulating tumor mechanics may represent an effective strategy to sensitize refractory CRC to immunotherapy.
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Food Analytical Methods
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2026
·Vol. 19
·期 7
·209
·
IF 3
Xie Mingmeng,Sun Xiaodong,Wen Zijun,Jiang Xinhui,Mao Qiu,Li Siqiao,Wang Wei,Zhang Zhengwei
The widespread use of acetamiprid (ACE) poses increasing threats to food safety and human health due to its environmental persistence and potential toxicity. Herein, a fluorescent europium-based metal–organic framework (Eu-MOF) was synthesized via a facile room-temperature direct mixing strategy, which serves as a rapid and selective fluorescent probe for ACE detection. The dual-ligand Eu-MOF exhibited intrinsic multi-emission properties, with a dominant red fluorescence at 616 nm that is selectively quenched upon ACE exposure. Under optimized conditions, the sensor showed two linear response ranges (0.01–6 and 6–20 µg/mL) with a detection limit as low as 3.03 ng/mL. Mechanistic investigations reveal that the quenching is primarily governed by the inner filter effect (IFE), supported by spectral overlap and unaltered fluorescence lifetime. The probe demonstrates high specificity against common interfering substances and enables accurate quantification of ACE in complex matrices such as apples and oranges, with satisfactory recovery rates (94.35–100.6%) and low relative standard deviations (≤ 1.96%). This work provides a promising platform for rapid, low-cost, and highly sensitive monitoring of pesticide residues in food safety surveillance.
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Scientific Reports
·
2026
·
IF 4.9
Xiang Qingqing,Yu Rong,Huang Li,Liu Qingqing,Qin Nuo,Wang Li,Wu Yan,Fu Hang
Due to a lack of complete mechanistic understanding, there are no specific therapeutics for necrotizing enterocolitis (NEC), a deadly gastrointestinal disease affecting premature newborns. While sodium butyrate offers intestinal protection, its efficacy is strictly dose-dependent, and the underlying mechanisms regulating intestinal epithelial cell (IEC) survival remain elusive. Here, using neonatal murine NEC models and human IECs, we demonstrate that moderate-dose butyrate (50 mg/kg) significantly attenuates mucosal injury and improves survival, whereas high-dose butyrate (250 mg/kg) exacerbates mortality by inducing complex cell death pathways including necroptosis and ferroptosis. Mechanistically, moderate butyrate suppresses glycolysis and intracellular lactate production, which restores expression of the translational regulator PABPC1; PABPC1 then binds to YB-1 mRNA to enhance YB-1 protein synthesis without altering transcription. Elevated YB-1 subsequently binds BCL-2 mRNA, increasing BCL-2 protein levels to inhibit intrinsic mitochondrial apoptosis. Functional validation shows that YB-1 knockdown abolishes butyrate-mediated protection and exacerbates TNF-α-induced apoptosis, while YB-1 overexpression rescues cell viability, and exogenous lactate supplementation reverses these effects by suppressing the PABPC1-YB-1 axis. These findings elucidate a novel Lactate-PABPC1-YB-1-BCL-2 signaling axis through which butyrate safeguards the intestinal epithelium, highlighting precise dosing and the modulation of epithelial translational control as promising therapeutic strategies for NEC.
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Light-Science & Applications
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2026
·Vol. 15
·期 1
·216
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IF 24
Li Zesen,Li Zhuoran,Cheng Zhongyuan,Borri Claudia,Giannetti Ambra,Lan Ni,Long Junqiu,Chen Wenwei,Cai Xiangran,Yang Jingge,Guan Bai-Ou,Chiavaioli Francesco,Ran Yang
The combination of optical fiber and phototheranostic agents has emerged as a promising strategy to address the challenges of limited light penetration depth and systemic toxicity of nanomaterials. However, the multiplexing potential of fiber-optic probes remains underrated, resulting in enlarged incisions, repeated invasive procedures, and a lack of real-time therapeutic feedback. Herein, we propose a scheme for single‑fiber multifunctional integration leveraging wavelength division multiplexing technology. As a proof-of-concept, by co-immobilizing pH indicator, temperature indicator, and photothermal agent with non-overlapped excitation bands onto tapered optical fiber surface, a fiber-optic theranostic probe enabling closed-loop tumor photothermal therapy was developed. Pre-treatment, the probe can achieve tumor edge identification through revealing the tumor pH gradient. Intra-treatment, the photothermal agent can convert optical energy into heat for photothermal therapy, while simultaneous temperature monitoring enables precise thermal dose control. Post-treatment, rapid efficacy assessment can be achieved via real-time monitoring of the reversal of acidic tumor microenvironment. Animal experiments validate the excellent therapeutic efficacy and biocompatibility of the probe. This research opens new avenues for multifunctional fiber-optic theranostic platforms, where modular wavelength assignment enables customizable minimally invasive interventions and feedback monitoring, holding significant promise for both clinical practice and mechanistic exploration.
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