Journal of Translational Medicine
·
2026
·Vol. 24
·期 1
·703
·
IF 9.7
Wang Fang,Ma Shuai,Liu Zhihui,Feng Mengzhao,Song Dengpan,Li Mengyuan,An Yuan,Zhang Kaiyuan,Du Yan,Hu Shaoshan,Guo Xinbin,Guo Fuyou,Liu Han
Background Glioma is a highly aggressive brain tumor with a poor prognosis. Photodynamic therapy (PDT) induces antitumor immunity, a key mechanism of its efficacy. Dendritic cell-derived exosomes (Dexs) are crucial for tumor antigen presentation and T-cell activation. Dexs represent a promising cell-free strategy for cancer immunotherapy. Understanding the role of Dexs in PDT-induced immunity may enhance PDT efficacy. Methods GL261 glioma cells were subjected to PDT, followed by co-culture with dendritic cells (DC) to obtain PDT-Dexs. Flow cytometry and ELISA were used to assess the effects of PDT-Dexs on DC maturation and T-cell activation. MicroRNA sequencing was performed on PDT-Dexs. The effect of PDT-Dexs on tumor growth and survival was evaluated in immune-competent and immune-deficient glioma model mice. Results Co-incubation with PDT-Dexs significantly increased DC maturation and T-cell activation. Sequencing revealed 156 up-regulated microRNAs, miR-152-3p was validated as a key functional miRNA that promotes DC maturation by targeting DNMT1 to upregulate MyD88 expression. PDT-Dexs entered the systemic circulation, increasing the serum IL-2, IFN-γ, and TNF-α levels. In immunocompetent mice, PDT-Dexs increased CD3 + CD4+ and CD3 + CD8+ T-cell percentages, slowed tumor growth, prolonged survival, and were associated with enhanced CD8 + T-cell infiltration and tumor cell apoptosis. Crucially, PDT-Dexs failed to inhibit tumor growth or improve survival in immunodeficient nude mice. Conclusions PDT-Dexs promote DC maturation and T-cell activation, improving antitumor immunity and PDT efficacy. Combining of PDT with PDT-Dexs further improves antitumor immunity and PDT efficacy. PDT-Dexs warrants further investigation as a potential strategy for enhancing antitumor immunity in glioma. Graphical The alternative text for this image may have been generated using AI.
✓ 已验证
DOI
高影响因子
Rice
·
2026
·
IF 5.8
Jianhui Liu,Zongqiong Zhang,Baoxuan Nong,Yu Zeng,Xiuzhong Xia,Yongcheng Li,Yunjie Zheng,Yaqian Wu,Shuangshuang Luo,Zuyu Liao,Hui Guo,Xinghai Yang,Danting Li
WRKY transcription factors are important plant regulators that participate in diverse biotic and abiotic stress responses. However, their roles in resistance to Southern rice black-streaked dwarf virus (SRBSDV) remain unknown. Previous work demonstrated that the histone deacetylase gene OsHDA706 (LOC_Os06g37420) enhances SRBSDV resistance by promoting jasmonic acid (JA) biosynthesis. In this study, we first confirmed that the rice line GR216 exhibits strong resistance to SRBSDV through artificial inoculation. Knockout of OsHDA706 in GR216 led to typical SRBSDV symptoms, including dwarfing, dark-green wrinkled leaves, and inverted fibrous roots, confirming its role in antiviral defense. Using the RiceTFtarget database and yeast one-hybrid experiments, we identified OsWRKY30 (LOC_Os08g38990) as a potential upstream regulator of OsHDA706. Co-expression analysis based on the CARFI-Rice database revealed that the expression pattern of OsWRKY30 closely resembles that of several disease-resistance-related WRKY genes under biotic stress and hormone treatments. CRISPR-Cas9 knockout of OsWRKY30 in GR216 resulted in strong symptoms after inoculation with SRBSDV, supporting its involvement in antiviral immunity. RNA sequence (RNA-seq) analysis further showed that OsWRKY30 expression was significantly down-regulated in mutants after SRBSDV infection, and that defense response, stress response, and salicylic acid signaling pathways were significantly enriched in both wild-type and mutant plants. Hormone quantification revealed that JA levels were markedly higher in wild-type than in oswrky30 mutants. Collectively, these results demonstrate that OsWRKY30 positively regulates rice resistance to SRBSDV, likely by modulating JA biosynthesis. This study provides new insights into the molecular mechanisms of rice antiviral defense and offers valuable genetic resources for breeding SRBSDV-resistant cultivars.
✓ 已验证
DOI
PubMed
高影响因子
NATURE
·
2026
·Vol. 654
·期 8118
·375-382
·
IF 56.1
Liu Shaocheng,Pols Mike,Zhang Zhongyang,Huang Xudan,Huang Zijian,Han Ying,Guo Zhenyu,Li Liang,Fan Rundong,Zhang De-Yi,Ping Du,Yu Wenjin,Gu Jiazhen,Men Luxuan,Dong Hao,Tao Shuxia,Wang Lifen,Chen Qi,Wang Huan,Xu Huaiyu,Sun Ling-Dong,Yan Chun-Hua,Zhou Huanping
Metal halide perovskites have emerged as promising semiconductors for light-emitting diodes (LEDs) owing to their excellent luminescence properties 1 . However, their performance remains limited, primarily owing to the inherent contradiction between ‘high crystallinity’ and ‘small size’ in the in situ synthesis of perovskite nanocrystals on substrates. Here we report efficient blue perovskite LEDs (PeLEDs) achieved via in situ polymerization-driven nanocrystal confinement to synthesize perovskite films composed of high-quality nanocrystals. The in situ-formed polymer network imposes nanoscale spatial constraints during perovskite nanocrystal growth, enabling nanocrystals with small sizes and a high photoluminescence quantum yield of 83%. Furthermore, polymerizable monomers with sufficient coordination sites allow a prolonged lattice rearrangement of perovskite clusters, promoting the crystallinity of the nanocrystals. The synthesized perovskite nanocrystals are utilized in the fabrication of PeLEDs, resulting in an external quantum efficiency of 21.8% at 491 nm, which is among the highest performances in blue PeLEDs. This work simultaneously controls the thermal dynamics of perovskite crystallization and organic ligand reactions, which helps to advance understanding of the effect of ligand engineering on nanocrystal synthesis, benefiting the development of efficient PeLEDs and other optoelectronic technologies.
✓ 已验证
DOI
PubMed
高影响因子
Nature Communications
·
2026
·
IF 18.1
Wu Fan,An Yanxin,Zhao Yuqing,Yu Jiazhi,Wu Gaoyi,Tay Franklin R.,Jiao Yang,Wang Jing
Reconstruction of large segmental bone defects remains challenging because current grafting strategies often fail to coordinate angiogenesis, neurogenesis, and osteogenesis. Here we developed a functional scaffold (peptide/Talin1 plasmid/PLA–HA/GelMA, PTPG) capable of simultaneously delivering peptides and Talin1 plasmids. We hypothesized that this scaffold enables neurovascularized bone regeneration through bidirectional activation of integrin β1 (ITGB1). The REDV–IKVAV (Arg-Glu-Asp-Val-Gly-Gly-Gly-Ile-Lys-Val-Ala-Val) peptide triggers “outside-in” ITGB1 signaling in endothelial and Schwann cells, while Talin1 plasmid-mediated “inside-out” activation. This PTPG scaffold synergistically enhances cell proliferation, migration and secretion, which are eliminated by ITGB1 silencing. In vivo, PTPG scaffold promotes aligned neurovascular networks guiding bone deposition. Single-cell RNA sequencing demonstrates enrichment of endothelial H-type signatures and repair-associated Schwann cell phenotypes, with activation of ITGB1–focal adhesion kinase–paxillin signaling. Collectively, this scaffold integrates structural support with peptide and genetic cues to promote coordinated angiogenesis, neurogenesis, and osteogenesis, offering a promising strategy for functional bone regeneration.
✓ 已验证
DOI
PubMed
高影响因子
Nature Communications
·
2026
·
IF 18.1
Liu Shujie,Zhao Sheng,Sun Qi,Liu Quanyi,Zhang Yihong,Li Yixuan,Jiang Lifeng,Li Tong,Cao Jianan,Wang Jiansen,Zhao Jingyuan,Cui Xiaomiao,Zhang Jingjing,Ren Xinkun,Du Yan,Zheng Liming,Jiang Qing,Wei Hui
Wear particle-induced osteolysis (WPO), primarily caused by particles generated from implants under mechanical loading, remains a major barrier to the long-term success of prosthetic implants. Traditional strategies to address WPO have largely focused on reducing wear generation, rather than mitigating the immunostimulatory effects elicited by wear particles. However, the limited scope of mechanical enhancement and the inevitable generation of wear particles shift increasing attention toward biological improvements. Herein, we propose a “proactive preventive” strategy for liner design, aiming to effectively prevent WPO by simultaneously reducing the generation of wear particles and minimizing their immunostimulatory effects. To validate the feasibility of this strategy, we synthesize a model system by incorporating ceria nanozyme into ultra-high molecular weight polyethylene (UHMWPE), referred to as CZPE. Mechanical assessments demonstrate an approximately 32% reduction in wear particle production of CZPE compared with pristine UHMWPE. Moreover, CZPE particles elicit a markedly attenuated immune response compared to PE particles in a male murine model of WPO, including reduced macrophage-mediated inflammation and diminished intramedullary plasma cell infiltration. These effects contribute to a reduction in osteoclastic bone resorption and foreign body reactions. Leveraging these mechanical and biological advantages, our approach offers a promising implant design strategy for WPO prevention.
✓ 已验证
DOI
PubMed
高影响因子
CELLULAR AND MOLECULAR LIFE SCIENCES
·
2026
·
IF 6.5
Siqi Nian,Lulu Zhao,Xiaokang He,Ping Xia,Yanqing Liu,Baotong Hua,Jun Li,Hongxing Zhang
Background: Patients with heart failure (HF) frequently develop atrial fibrillation, but the precise molecular mechanisms are unclear, leading to limited therapeutic strategies. Methods: Isoproterenol hydrochloride (ISO)-induced mouse HF model and ISO-treated HL-1 cardiomyocyte model were employed. A combination of qRT-PCR, Western blot, ChIP, dual-luciferase reporter assay, MeRIP-qPCR, RIP-qPCR, actinomycin D assay, and mitochondrial function assessments were used to systematically investigate the regulatory mechanism of the ALYREF/MZF1/HTRA1 axis and its role in cardiac remodeling and atrial fibrillation susceptibility. Results: HTRA1 expression was elevated in HF mice and human atrial fibrillation data. In cellular models, HTRA1 overexpression induced mitochondrial damage, cellular hypertrophy, and inflammation via the HIF-1α pathway. The transcription factor MZF1 directly bound to and activated the HTRA1 promoter. NSUN2-mediated m5C modification of MZF1 mRNA was required for its recognition and stabilization by the m5C reader protein ALYREF, thereby positively regulating the MZF1/HTRA1 axis. In the ISO-induced HF mouse model, knockdown of ALYREF effectively reduced MZF1 and HTRA1 expression, alleviated myocardial hypertrophy, fibrosis, cardiac dysfunction, and atrial fibrillation inducibility. Conclusion: This study elucidates a novel signaling axis wherein NSUN2-mediated m5C modification of MZF1 mRNA enables its stabilization by ALYREF, leading to transcriptional upregulation of HTRA1. This axis drives cardiomyocyte mitochondrial dysfunction, hypertrophy, and inflammation in the context of HF, ultimately increasing susceptibility to atrial fibrillation.
✓ 已验证
DOI
PubMed
高影响因子
Science China-Materials
·
2026
·
IF 7.7
Tan Jieke,Xu Dongfang,Li Yong,Fan Zihao,Cai Yan,Wang Zezhang,Li Gaofeng,Chen Haining,Li Yongzhe,Lei Hongjie,Liu Shengzhong,Liu Zhike
All-inorganic, hole-transport-material-free (HTM-free), carbon-based perovskite solar cells (C-PSCs) have garnered significant attention due to their exceptional stability and low cost. However, their performance and commercial potential are still constrained by issues such as poor interfacial contact, insufficient crystallinity, and energy level misalignment. In this work, we tackle these challenges via a molecular engineering strategy by introducing tetrakis(4-ethynylphenyl) methane (TEPM) as a multifunctional additive. The alkynyl moiety (C≡C) in TEPM coordinates with Pb 2+ ions in perovskite precursors, thereby synergistically slowing crystallization kinetics to regulate crystal growth and passivate deep-level defects. As a result, the CsPbI 3 films exhibit larger grain sizes, improved crystallinity, and lower defect densities. Devices modified with TEPM achieved a record power conversion efficiency (PCE) of 20.01% (certified 19.58%). Additionally, unencapsulated devices retained 87.6% of their initial efficiency after 1080 h under ambient conditions (25 °C, 30% relative humidity), and maintained 94.0% of their initial efficiency after 730 h of continuous AM 1.5G illumination in air. The alternative text for this image may have been generated using AI.
✓ 已验证
DOI
高影响因子
Scientific Reports
·
2026
·
IF 4.9
Cheng Shenghong,Chen Shizhe,Chen Guanghua,Liu Sanping,Jiang Kaixi,Guo Bao
Manganese is essential for zinc electrowinning but its recycling is challenging in oxide ore SX-EW circuits where P204 rejects Mn. This study proposes a novel manganese recycling strategy tailored for SX-EW streams involving the selective SO 2 reductive leaching of zinc anode slime followed by impurity removal. By controlling leaching pH at 5.0 with lime, Mn recovery > 92% while Fe, Ni, Co co-dissolution is suppressed to < 1%, 3%, 12% respectively. Residual impurities in the spent electrolyte are further removed by neutralization and DMDTC chelation. This integrated process effectively recovers manganese while simultaneously eliminating harmful impurities (Cu, Fe, Co, Ni), offering a sustainable solution for Mn management in complex oxide ore hydrometallurgy. The purified electrolyte enabled production of Grade #1 zinc with Pb < 0.005%.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2026
·
IF 18.1
Huang Zihao,Xu Chenchao,Que Yande,Liu Yi,Wang Yunhao,Zhu Shiyu,Shivajirao Ranjith,Tong Zheng Jue,Kumar Amit,Cao Chao,Cao Guang-Han,Gao Hong-Jun,Weber Bent
The interplay of charge and spin orders lies at the heart of correlated electron physics and plays a critical role in the emergence of unconventional quantum phases. Kagome magnets provide a particularly promising platform to investigate these phenomena, owing to their geometrically frustrated lattice structure. However, resolving spin and charge orders microscopically and establishing ways to control them remain fundamental challenges. Here, we demonstrate magnetic-field control of an altermagnetic spin density wave order intertwined with charge density wave order in kagome magnet CsCr 3 Sb 5 . Scanning tunneling microscopy down to deep cryogenic temperature of 50 mK reveals two previously unreported charge density wave orders. Density functional theory confirms that one of them, a 4 \({a}_{0}\times \sqrt{3}{a}_{0}\) charge order, is coupled to a spin density wave with an altermagnetic ground state. The charge density waves can be tuned in both amplitude and phase by an external magnetic field, reflected in domain switching and stripe sliding of the charge density wave. Our findings deepen the understanding of symmetry-breaking in kagome systems, providing a tunable platform to explore the interplay of electronic correlation with emergent quantum magnetism.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CATALYSIS LETTERS
·
2026
·Vol. 156
·期 6
·167
·
IF 2.5
Cao Dongyu,Gao Haitao,Wang Tianyi,Chen Jinbo
Developing efficient and stable electrocatalysts is key to converting 5-hydroxymethylfurfural (HMF) into the value-added product 2,5-furandicarboxylic acid (FDCA). Herein, a three-dimensional porous nanosheet-structured nickel-molybdenum-copper (NiMoCu) ternary catalyst was constructed on nickel foam via a two-step electrodeposition strategy coupled with alkaline heat treatment. Characterization (XRD, Raman, TEM, XPS) revealed the homogeneous integration of Ni, Mo, and Cu species at the nanoscale, forming multiple heterointerfaces (MoO 3 –CuO/NiOOH). Meanwhile, Cu incorporation refined the MoO 3 crystallite size to 8.2 nm and promoted the in situ formation of amorphous NiOOH containing Ni³⁺ species. Furthermore, the interfacial electron transfer effect optimized charge transport pathways, thereby promoting an efficient HMFOR process. At 1.47 V vs. RHE, this catalyst showed record HMF electrooxidation performance. The HMF conversion was 99%, FDCA selectivity was near 100%, FDCA yield was 98%, and Faradaic efficiency was 98%. After four cycles in a row, the yield dropped by less than 2%. The excellent performance of the NiMoCu catalyst comes from the synergy of its three metals. Ni³⁺ acts as the active center and drives the reaction. Mo 6+ keeps the Ni³⁺ state stable and speeds up charge movement. Cu stops the side oxygen evolution reaction (OER). The OER contribution is under 2%. This work offers a new way to design efficient and stable catalysts for the electrocatalytic conversion of HMF, a key biomass platform compound. Graphical The alternative text for this image may have been generated using AI.
✓ 已验证
DOI
高影响因子
JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
·
2026
·Vol. 41
·期 3
·612-622
·
IF 1.4
Zhu Liangliang,Yi Guoqiang,Chang Ying,Wei Zhishun,Xiong Yan,Chen Sha
Using (Na) 2 TiF 6 and CO(NH 2 ) 2 as raw materials, we proposed a simple one-pot hydrothermal method for synthesizing single-phase anatase TiO 2 across a broad pH range of the precursor solution. The results showed that, irrespective of whether the precursor solution was acidic (pH=1.43, 3.43, 5.37), neutral (pH= 7.23), or alkaline (pH=9.45, 11.18, 13.15) prior to the hydrothermal reaction, the post-reaction solution pH stabilized between 8 and 9, and all resultant TiO 2 materials were identified as single-phase anatase. This finding contrasted with previous reports where phase transformations among anatase, rutile, or brookite were observed under varying pH conditions of the precursor solution. This discrepancy was attributed to the continuous decomposition of urea during the hydrothermal process, which maintained the pH of the reaction solution within a relatively stable range. Comprehensive investigations revealed that anatase TiO 2 synthesized at pH 7.23 exhibited optimal light absorption ability, enhanced charge dynamics, and a larger electrochemically active surface area. As a result, TiO 2 (pH 7.23) showcased the highest photocatalytic activity toward tetracycline (TC), achieving a degradation efficiency of 97.7%. Mechanistic studies indicated that O 2 •− was the predominant reactive species accounting for TC degradation.
✓ 已验证
DOI
高影响因子
Plasmonics
·
2026
·
IF 5.6
Han Huibo,Singh Ragini,Niu Ben,Zhou Penglei,Zhang Bingyuan,Kumar Santosh
Ochratoxin A (OTA) is a potentially harmful mycotoxin that is widely found in agricultural products and animal by-products. In order to ensure our physical health, OTA testing is very important. Therefore, we chose to use an optical fiber biosensor based on the principle of local surface plasmon resonance (LSPR), and we designed an asymmetric optical fiber structure using single-mode optical fiber (SMF) to detect different concentrations of OTA. Gold nanoparticles (AuNPs) were applied to the sensing region to stimulate the LSPR effect, and then Nb 2 CTxMXene and CeO 2 -nanorods were sequentially fixed on the probe to change the dielectric environment around the sensing region to improve the performance of the sensor. The sensor has a linear range of 0.5 ng/mL to 60 ng/mL, a sensitivity of 0.0805 nm/(ng/mL), and a limit of detection (LOD) of 3.95 ng/mL. After that, we evaluated it through a series of tests, including repeatability, reproducibility, pH, stability, and selectivity. Finally, we also tested and verified the real samples. According to the experimental results, the sensor shows good performance in OTA detection, indicating that the sensor has good application potential and broad development prospects. This work designed an asymmetric optical fiber biosensor based on LSPR, achieving a broad detection range and a low LOD for OTA detection by coating with AuNPs, Nb 2 CTxMXene, and CeO 2 -nanorods. Its reliability and vast prospects in practical applications were validated through repeatability, stability, and real sample testing.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）