Nature Biomedical Engineering
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2022
·Vol. 6
·期 7
·867-881
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IF 29.234
Zhang Guorong,Wang Qin,Tao Wanyin,Jiang Wei,Elinav Eran,Wang Yucai,Zhu Shu
Orally delivered antibiotics can reach the caecum and colon, and induce gut dysbiosis. Here we show that the encapsulation of antibiotics in orally administered positively charged polymeric nanoparticles with a glucosylated surface enhances absorption by the proximal small intestine through specific interactions of glucose and the abundantly expressed sodium-dependent glucose transporter 1. This improves bioavailability of the antibiotics, and limits their exposure to flora in the large intestine and their accumulation in caecal and faecal contents. Compared with the standard administration of the same antibiotics, the oral administration of nanoparticle-encapsulated ampicillin, chloramphenicol or vancomycin in mice with bacterial infections in the lungs effectively eliminated the infections, decreased adverse effects on the intestinal microbiota by protecting the animals from dysbiosis-associated metabolic syndromes and from opportunistic pathogen infections, and reduced the accumulation of known antibiotic-resistance genes in commensal bacteria. Glucosylated nanocarriers may be suitable for the oral delivery of other drugs causing gut dysbiosis.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2022
·Vol. 414
·期 21
·6393-6402
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IF 4.478
Guo Zhi-Yong,Yao Qiu-Hong,Zheng Wen-Hui,Jiao Rui-wen,Zhang Chen,Zhang Li,Ye Ting-Xiu,Chen Xi
New approaches for the engineering of well-defined, pore modality, and multi-chemical functionality nanocomposites are crucial to generate the next generation of functional materials with recoverable and easy preparation properties. Here, a catalyst and heat free polymerization reaction is exploited and fabricated zwitterionic system around magnetic nanoparticles. N-aminoethyl piperazine propane sulfonate (AEPPS) and dopamine (DA) are introduced as the zwitterionic system, which provided abundant zwitterionic groups (NH 2 , SO 3 − , N + ) and strong adhesion and various oxidation state properties. And that, the zwitterionic engineering will assemble between AEPPS and DA whereby Schiff base formation or Michael type addition. Whereafter, a series of sophisticated array of microscopic, spectroscopic, and structure techniques verify the formation of highly crosslinking internal zwitterionic architectures, well-defined core–shell structure, and better porosity. The zwitterionic structure–function relationships and striking porous structure are explored in a multi-interaction adsorption assay. The adsorption capacity of the magnetic nanocomposites was 1065.8 mg/g. And that, the system exhibited with hydrophilic-hydrophobic activity towards glycoprotein and better performance to bioactive protein (Ig-G) isolation form human whole blood sample. The synergistic enhancement interaction in hydrophilic target enrichment, easy preparation, and soft substrate properties of the AEPPS-DA zwitterionic materials make them intriguing candidates for sustainable biomedical loading and chromatographic separation.
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CELLULOSE
·
2022
·Vol. 29
·期 13
·7263-7276
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IF 6.123
Qiao Liangzhi,Liao Yuxin,Wang Xiawen,Wang Shanshan,Du Kaifeng
Cellulose microspheres are commonly chromatographic media yet seriously limited in biomacromolecules separation and purification due to the slow mass transfer kinetics resulting from their narrow nanopores. Herein, a macroporous cellulose microsphere (MCM) with enhanced mass transfer ability has been successfully developed by an oil-in-water-in-oil (O 1 /W/O 2 ) double emulsion strategy. The evolution profile of the double emulsion was tracked and achieved the optimization of interconnected macroporous structure. The macroporous structure not only provide fast mass transfer pathways for proteins but also increase the accessibility of meso/micropores. Benefitting from the macropores, the obtained diethylaminoethyl-modified MCM (DEAE-MCM) exhibits high permeability (3.81 × 10 –13 m 2 ), and fast adsorption rate (reaching equilibrium within 40 min) and high adsorption capacity (334.21 mg/g) for bovine serum albumin, far superior to commercially DEAE Sepharose Fast Flow. More importantly, under the high flow rate, DEAE-MCM remains a high dynamic adsorption capacity, promising it for fast protein chromatography.
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CATALYSIS LETTERS
·
2022
·Vol. 153
·期 5
·1319-1332
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IF 2.936
Amin Bilal Ul,Yu Haojie,Wang Li,Fahad Shah,Nazir Ahsan,Haq Fazal,Mehmood Sahid,Uddin Md Alim,Liang Ruixue,Liu Jinyi,Li Xuefei,Ding Lei
This study focus on hetero cyclic ferrocene-based furan and triazole (FT-Fcs) organometallic compounds with their burning rate catalytic and anti-migration application for rocket propellant system. FT-Fcs (Fc-FAM, Fc-AMT, and Fc-FAO) were successfully prepared by the coupling reaction from the corresponding unit monomers. The structures of the targeted FT-Fcs were characterized by 1 H NMR, 13 C NMR, FT-IR, XPS and ESI-MS. Reversible or quasi-reversible redox waves were observed in the current work using CV analysis of FT-Fcs and electrochemical behaviors were discussed. From the TGA data it was observed that with the addition of 5 wt% of Fc-AMT thermal decomposition temperature of pure AP was significantly decreased to 353.58 °C from 426.15 °C and proposed decomposition mechanism were discussed. Because of the presence of electronegative elements in the hetero cyclic ring, which are responsible for the establishment of interaction with AP and binding agent, FT-Fcs had better anti-migration performance than Fc. Graphical Abstract
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2022
·Vol. 29
·期 56
·85454-85464
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IF 5.19
Wang Wenfeng,Yuan Shu,Kwon Jung-Hwan
The prevalence of per- and polyfluoroalkyl substances (PFASs) in agricultural soils has raised concerns regarding the health risks associated with the consumption of PFAS-contaminated agricultural products. The present study investigated the uptake and translocation of nine PFASs in lettuce using a hydroponic setting. During the uptake experiments, long-chain PFASs (≥ C8) exhibited greater accumulations in lettuce roots, while short-chain PFASs (≤ C7) manifested preferential transport to the shoots. The average root concentration factors of PFASs were positively correlated with their log K ow values. A significantly negative relationship was found between the average translocation factors of PFASs and their molecular volume. Sorption of long-chain PFASs by lettuce roots was enhanced after heating the roots to increase the cell membrane permeability. The accumulation of perfluorododecanoic acid increased significantly in shoots of lettuce plants without roots as compared to whole lettuce plants. Results of the present study indicate that sorption to root surface tissues and efficiency in passing through the root Casparian strip are two important factors that affect the uptake and distribution of PFASs within plants.
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CELLULOSE
·
2022
·Vol. 29
·期 13
·7225-7249
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IF 6.123
Tang Rui,Zhang Hanbing,Muhammad Yaseen,Lu Caimei,Liu Kun,Yu Sishan,Tong Zhangfa
Magnetic bentonite (MB) is a cheap, effective and recyclable adsorbent for the removal of many pollutants. However, further enhancing the adsorption performance of pristine MB and eliminating the instability of Fe 3 O 4 magnetic particles in MB are vital and urgent for practical applications. Based on the principles of washing mesh bag and octopus tentacle, mesh-bag-like modifiers with tentacle-like structure of octopus were synthesized via grafted reaction of polyethylenimine (PEI) and carboxymethyl cellulose (CMC) to cover MB. As compared with the pristine MB, CMC-MB and PEI-MB, the magnetic bentonite adsorbent co-modified by PEI and CMC (CMC/PEI-MB) exhibited more multi-adsorption sites, stronger capture effects of tentacle for heavy metals and more effective mesh-bag-protection for Fe 3 O 4 . Attributed to these fascinating properties, CMC/PEI-MB achieved faster adsorption rates (the values of k 2 of Pb(II) and Cd(II) were 73.0 g mg ‒1 min ‒1 and 17.4 g mg ‒1 min ‒1 ) and elevated adsorption capacities (760 mg g ‒1 and 470 mg g ‒1 ) for 1500 mg L ‒1 Pb(II) and 1000 mg L ‒1 Cd(II) in a wider pH range (3–7). Moreover, the reutilization rate of Pb(II) and Cd(II) over CMC/PEI-MB still remained 90% after five successive recycles. XRD and FT-IR results indicated that the structure of CMC/PEI-MB was well persevered after desorption, and the corresponding maximum desorption capacities of Pb(II) and Cd(II) from CMC/PEI-MB were 624 mg g ‒1 and 362 mg g ‒1 within 1 h, respectively. The findings of this study provide an interesting and effective approach for the construction of superior adsorbents basing on customary phenomena for the remediation of heavy metals from wastewater. Graphical Abstract
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Science China-Materials
·
2022
·Vol. 65
·期 12
·3452-3461
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IF 8.64
Yang Lin,Yu Jinxing,Chang Shufang,Xu Xiaoxiang
LaTaON 2 is an attractive visible-light-active photocatalyst for water splitting due to its broad visible light absorption as far as 650 nm and proper band edge positions. Notwithstanding these promising properties, LaTaON 2 generally exhibits poor photocatalytic activity because of its high defect concentration that severely hinders charge separation. Here, LaTaON 2 has been modified by doping Al into the Ta sublattice, i.e., LaTa 1− x Al x O 1− y N 2− y (0 ≤ x ≤ 0.20). Al doping not only inhibits the defect concentration and increases surface hydrophilicity but also maintains the desired visible light absorption of LaTaON 2 . These important modifications substantially ameliorate the charge separation conditions within LaTaON 2 and are responsible for a much enhanced photocatalytic performance for water redox reactions under visible light illumination. Under optimal conditions, the Al-doped LaTaON 2 delivers an apparent quantum efficiency of 1.17% at 420 ± 20 nm for water oxidation into O 2 , outperforming most LaTaON 2 -based photocatalysts. These findings highlight Al as a useful dopant to open up the photocatalytic potential of metal oxynitrides whose activity is often undermined by a high defect concentration.
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Plasmonics
·
2022
·Vol. 17
·期 4
·1743-1750
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IF 2.726
Wang Tongtong,Zhang Qijia,Li Jia,Xu Guangda,Guo Na,Song Peng,Xia Lixin
Thiram is used as a fungicide and insecticide in agriculture to prevent white rot and anthracnose, but it also produces certain pesticide residues that endanger human health. Polydopamine (PDA) is an adhesive polymer that functionalizes almost all chemical materials, having been inspired by the adhesive properties of catechol and amines in mussel adhesive protein. In this work, we have fabricated a highly sensitive face mask (FM)–based surface-enhanced Raman scattering (SERS) substrate by depositing silver nanoparticles (AgNPs), using a PDA layer as an interface to promote adhesion. Face masks are currently ubiquitous, and are simple and easy to obtain, and this approach can be regarded as waste utilization. FM/PDA/AgNPs can detect Nile blue A (NBA) probe molecules at concentrations as low as 1.0 × 10 −9 M, and permit measurements with sensitivity and uniformity. The Raman substrate can be used to swab the surface of fruit to detect thiram at concentrations as low as 1.0 × 10 −7 M, and the reproducibility has been assessed. The simple utilization of this flexible SERS substrate holds promise for its practical application in the field of pesticide control.
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Chinese Medicine
·
2022
·Vol. 17
·期 1
·1-20
·
IF 4.546
Yu Hui,Shao Shumin,Xu Junnan,Guo Haibiao,Zhong Zhangfeng,Xu Jiangping
Background Fresh or dried Persimmon leaves (Diospyros kaki Thunb.) exhibit preventive effects on cardiovascular and cerebrovascular diseases. However, their antidepressant effects and underlying mechanisms are unclear. Thus, we investigated mechanisms responsible for Persimmon leaf extract (PLE) activity on chronic social defeat stress (CSDS)-induced depressive-like behaviors in mice.Methods CSDS was used as a mouse model of depression. We performed the sucrose preference test (SPT), forced swim test (FST), and tail suspension test (TST) to identify depressive-like behavior. Spine density and dendritic morphology were assessed using Golgi staining. Neurochemicals were quantified by microdialysis, doublecortin by immunofluorescence, and cAMP using an ELISA kit. Finally, the levels of cortical proteins of phosphorylated cAMP-response element binding protein (CREB), brain-derived neurotrophic factor (BDNF), postsynaptic density synapsin-1 and protein 95 (PSD95) were quantified by western blot. 16S rRNA gene sequencing was used to detect fecal microbiota.Results Treatment of CSDS-subjected mice with PLE (30.0–60.0 mg/kg, i.g.) enhanced sucrose preference, decreased immobility times in the TST and FST but did not affect locomotor activity. Furthermore, persistent social defeat stress decreased dendritic spine density and dendritic length in the brain, as well as decreased PSD95 and synapsin-1 expression. PLE, interestingly, inhibited dendritic spine loss and increased synaptic protein levels. PLE also increased brain levels of 5-HT, cAMP, phosphorylated (p)-CREB, BDNF, PSD95, and synapsin-1 in mice subjected to CSDS. Furthermore, PLE increased their doublecortin-positive cell count in the hippocampal dentate gyrus. CSDS mice represented a distinct fecal microbiota cluster which differed compared with normal C57BL/6J mice, and the phenotype was rescued by PLE.Conclusion sPLE alleviated CSDS-induced depressive behaviors and spinal damage by suppressing serotonin reuptake and activating the cAMP/CREB/BDNF signaling pathway. Simultaneously, PLE influenced the composition of the fecal microbiota in CSDS-subjected mice.
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JOURNAL OF MATERIALS SCIENCE
·
2022
·Vol. 57
·期 25
·12138-12146
·
IF 4.682
Liu Yupeng,Jian Junyu,Xie Yitong,Gao Shishuai,Zhang Daihui,Shi Hao,Xu Yuzhi,Lai Chenhuan,Wang Chunpeng,Chu Fuxiang
Magnetic hydrogels have been widely utilized in the fields of biomedical devices, flexible electronics, and soft robotics. Unfortunately, current strategies to synthesize magnetic hydrogels are difficult to achieve high mechanical properties. Herein, we have presented a biomimetic strategy to synthesize a strong, tough and elastic cellulose enhanced magnetic hydrogel (CEMH). The cellulose skeleton containing magnetic nanoparticles was first generated by self-assembly of cellulose chains as the enhancement filler, while elastic polyacrylamide formed by in situ polymerization functioned as the elastic matrix. The mechanical and physicochemical properties of CEMH, as well as the effect of Fe 3 O 4 and acrylamide concentration on the performance, were systematically investigated. The highest tensile strength and toughness of CEMH could reach 1.1 MPa and 2.9 MJ/m 3 , respectively. Furthermore, CEMH showed a high elastic recovery of 94.5% (10th cycle), accompanies by a certain swelling resistance ability. All these advantages were accomplished mainly owing to the synergetic contribution of biomimetic design and enhanced non-covalent interactions.
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CATALYSIS LETTERS
·
2022
·Vol. 153
·期 4
·1096-1108
·
IF 2.936
Tang Lingqian,Fan Mingxuan,Pan Zhiquan,Cheng Qingrong,Feng Lu,Wu Hanjun,Zhou Hong
Low-molecular weight solid acid, [(DETA-(SO 3 H) 2 ], was synthesized and fully characterized by FTIR, XRD, TGA, XPS, 1 H-NMR and elemental analysis. The prepared solid acid exhibited high strong acid density (7.6 mmol H + /g), much higher than most of other solid acids. The solid acid was used for the extraction of diosgenin from the saponins in Dioscorea zingiberensis C. H. Wright. Diosgenin is a very medical intermediate for the synthesis of various kinds of steroidal drugs. To improve the diosgenin yield, the optimal conditions of the extraction reaction were investigated by single-factor experiments. Under the optimized conditions, the diosgenin yield catalyzed by the solid acid was much higher than those obtained by the catalysis of other solid acids or conventional sulfuric acid. Importantly, no waste liquid was discharged in the approach as the reaction medium can be recycled. The alcoholysis approach for the production of diosgenin has a great potential application in the industry. Graphical Abstract A novel low-molecular weight solid acid was synthesized and fully characterized. The solid acid showed excellent catalytic activity for the catalytic alcoholysis of saponins from D. zingiberensis C. H. Wright (DZW), the catalyst can be recycled and the whole extraction process is green and efficient.
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APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
·
2022
·Vol. 106
·期 18
·6277-6287
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IF 5.56
Yin Ru,Zhang Xue,Wang Beijia,Jia Jianbo,Wang Nana,Xie Chunyan,Su Peiyang,Xiao Pengfei,Wang Jianqiao,Xiao Tangfu,Yan Bing,Hirai Hirofumi
Abstract Environmental bisphenol F (BPF) has a cyclic endocrine disruption effect, seriously threatening animal and human health. It is frequently detected in environmental samples worldwide. For BPF remediation, biological methods are more environmentally friendly than physicochemical methods. White-rot fungi have been increasingly studied due to their potential capability to degrade environmental pollutants. Phanerochaete sordida YK-624 has been shown to degrade BPF by ligninolytic enzymes under ligninolytic conditions. In the present study, degradation of BPF under non-ligninolytic conditions (no production of ligninolytic enzymes) was investigated. Our results showed that BPF could be completely removed after 7-d incubation. A metabolite of BPF, 4,4’-dihydroxybenzophenone (DHBP) was identified by mass spectrometry and nuclear magnetic resonance, and DHBP was further degraded by this fungus to form 4-hydroxyphenyl 4-hydroxybenzoate (HPHB). DHBP and HPHB were the intermediate metabolites of BPF and would be further degraded by P. sordida YK-624. We also found that cytochrome P450s played an important role in BPF degradation. Additionally, transcriptomic analysis further supported the involvement of these enzymes in the action of BPF degradation. Therefore, BPF is transformed to DHBP and then to HPHB likely oxidized by cytochrome P450s in P. sordida YK-624. Furthermore, the toxicological studies demonstrated that the order of endocrine-disrupting activity for BPF and its metabolites was HPHB > BPF > DHBP. Key points
• White-rot fungus Phanerochaete sordida YK-624 could degrade BPF.
• Cytochrome P450s were involved in the BPF degradation.
• The order of endocrine disrupting activity was: HPHB > BPF > DHBP.
Graphical abstract
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危险品化学品经营许可证（带存储）