JOURNAL OF FLUORESCENCE
·
2024
·
IF 2.6
Wang Wenxiang,Gan Yudie,Jiang Huaqin,Fang Min,Wu Zhenyu,Zhu Weiju,Li Cun
Hydrogen sulfide (H 2 S) plays a key role in the physiology and pathology of organisms, and H 2 S in the environment is easily absorbed and harmful to health. It is of great significance to develop a probe with good selectivity, high sensitivity and good stability that can detect hydrogen sulfide inside and outside organisms. In this work, we designed a novel “turn-on” fluorescent probe CIM-SDB for the detection of H 2 S. The probe CIM-SDB used indene-carbazole as the fluorophore and 2,4-dinitrobenzenesulfonyl as the recognition site. The probe CIM-SDB exhibited high selectivity and sensitivity to H 2 S (detection limit as low as 123 nM). Moreover, the probe CIM-SDB was successfully applied to the detection of intracellular exogenous and endogenous H 2 S, and the test strips prepared by the probe CIM-SDB could realize the convenient and rapid detection of H 2 S.
✓ 已验证
DOI
高影响因子
CELLULOSE
·
2019
·Vol. 27
·期 3
·1113-1126
·
IF 3.917
Chen Wei,Li Delin,Bu Yunhao,Chen Guangxue,Wan Xiaofang,Li Nan
Abstract Design of strong and tough hydrogels had made significant progress recently. However, most of the cellulose-based hydrogels are soft and brittle. In this work, we fabricate a class of strong and tough hydrogels by simply soaking poly (acrylamide) (PAM)/methylcellulose (MC) hydrogels in kosmotropic solutions. The kosmotropic ions could notably enhance the hydrophobic interactions and chain bundlings of MC. As a consequence, the obtained optimal ammonium sulfate [(NH 4 ) 2 SO 4 ] treated PAM/MC gel with a water content of approximately 30 wt% exhibit predominant mechanical properties, with the fracture tensile strength of 4.4 MPa, fracture elongation of 690%, elastic modulus of 3.8 MPa, and toughness of 19.3 MJ/m 3 , superior to that of the most existing cellulose-based hydrogels. The enhancement of mechanical properties could be ascribed to the formation of more hydrophobic associations in methylcellulose network. Additionally, the mechanical properties of the methylcellulose-based hydrogels could be facile and finely tuned by varying the post soaking time and the kind of Hofmeister salts. We expect that this work may enrich the avenue in the preparation and regulation of MC-hydrogels for promising applications in biomedical and load-bearing fields. Graphic abstract The obtained PAM/MC-A s gels possessed eminent mechanical performances. Additionally, the mechanical properties of MC-based hydrogels could be facile and finely tuned by soaking in different kosmotropic anions solution.
✓ 已验证
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-15
·
IF 10.6
Cheng Jinmei,Li Jiaxin,Yu Qilin,Li Peishan,Huang Junyi,Li Jinhui,Guan Leyang,Xu Zhiyong,Xiao Jisheng,Duan Xiaopin
Chemotherapy, as a conventional strategy for tumor therapy, often leads to unsatisfied therapeutic effect due to the multi-drug resistance and the serious side effects. Herein, we genetically engineered a thermal-responsive murine Ferritin (mHFn) to specifically deliver mitoxantrone (MTO, a chemotherapeutic and photothermal agent) to tumor tissue for the chemotherapy and photothermal combined therapy of colorectal cancer, thanks to the high affinity of mHFn to transferrin receptor that highly expressed on tumor cells. The thermal-sensitive channels on mHFn allowed the effective encapsulation of MTO in vitro and the laser-controlled release of MTO in vivo. Upon irradiation with a 660 nm laser, the raised temperature triggered the opening of the thermal-sensitive channel in mHFn nanocage, resulting in the controlled and rapid release of MTO. Consequently, a significant amount of reactive oxygen species was generated, causing mitochondrial collapse and tumor cell death. The photothermal-sensitive controlled release, low systemic cytotoxicity, and excellent synergistic tumor eradication ability in vivo made mHFn@MTO a promising candidate for chemo-photothermal combination therapy against colorectal cancer. Graphical Abstract
✓ 已验证
DOI
PubMed
高影响因子
Chinese Journal of Integrative Medicine
·
2024
·
IF 2.2
Li Gang-gang,Chu Xiu-feng,Xing Ya-min,Xue Xia,Ihtisham Bukhari,Liang Xin-feng,Xu Ji-xuan,Mi Yang,Zheng Peng-yuan
Objective To observe the therapeutic effects and underlying mechanism of baicalin against colon cancer. Methods The effects of baicalin on the proliferation and growth of colon cancer cells MC38 and CT26. WT were observed and predicted potential molecular targets of baicalin for colon cancer therapy were studied by network pharmacology. Furthermore, molecular docking and drug affinity responsive target stability (DARTS) analysis were performed to confirm the interaction between potential targets and baicalin. Finally, the mechanisms predicted by in silico analyses were experimentally verified in-vitro and in-vivo . Results Baicalin significantly inhibited proliferation, invasion, migration, and induced apoptosis in MC38 and CT26 cells (all P <0.01). Additionally, baicalin caused cell cycle arrest at the S phase, while the G 0 /G 1 phase was detected in the tiny portion of the cells. Subsequent network pharmacology analysis identified 6 therapeutic targets associated with baicalin, which potentially affect various pathways including 39 biological processes and 99 signaling pathways. In addition, molecular docking and DARTS predicted the potential binding of baicalin with cyclin dependent kinase inhibitor 2A (CDKN2A), protein kinase B (AKT), caspase 3, and mitogen-activated protein kinase (MAPK). In vitro , the expressions of CDKN2A, MAPK, and p-AKT were suppressed by baicalin in MC38 and CT26 cells. In vivo , baicalin significantly reduced the tumor size and weight (all P <0.01) in the colon cancer mouse model via inactivating p-AKT, CDKN2A, cyclin dependent kinase 4, cyclin dependent kinase 2, interleukin-1, tumor necrosis factor α , and activating caspase 3 and mouse double minute 2 homolog signaling (all P <0.05). Conclusion Baicalin suppressed the CDKN2A protein level to prevent colon cancer and could be used as a therapeutic target for colon cancer.
✓ 已验证
DOI
PubMed
高影响因子
Nuclear Science and Techniques
·
2020
·Vol. 31
·期 4
·1-13
·
IF 1.556
Zhang Shi-Chang,Ning Shun-Yan,Zhou Jie,Wang Si-Yi,Zhang Wei,Wang Xin-Peng,Wei Yue-Zhou
A porous silica-polymer-based adsorbent, iso Bu-BTP/SiO 2 -P, was prepared by a vacuum impregnation method and used for the recovery of ruthenium, rhodium, and palladium from nitric acid solution. The experimental results revealed that iso Bu-BTP/SiO 2 -P exhibited unique adsorption properties such as high saturation adsorption capacity (Ru: 0.35 mmol g −1 , Rh: 0.32 mmol g −1 , Pd: 1.05 mmol g −1 ) and excellent selectivity over other metal ions, such as lanthanides (SF PGM/ M > 40) in 1 M HNO 3 solution. The adsorption process conformed to the pseudo-second-order model and Langmuir model. From the UV, FTIR, and XPS analyses, it can be concluded that the strong affinity between functional groups (C–N=C) and metal ions as well as NO 3 − played a role in coordination during the adsorption process. Furthermore, the desorption behavior was studied, and it was found that the adsorbed Pd, Rh, and Ru could be eluted with a 0.01 M nitric acid–0.1 M thiocarbamide solution, 5 M hydrochloric acid, and sodium hypochlorite (CP) solution, respectively. Finally, based on those findings, a simple process for the separation and recovery of Pd, Rh, and Ru from high-level liquid waste using iso Bu-BTP/SiO 2 -P was designed and proposed.
✓ 已验证
DOI
高影响因子
IONICS
·
2023
·Vol. 29
·期 11
·4841-4849
·
IF 2.8
Yue Xing,Huang Xiqiang,Zhang Yaohui,Wei Bo,Lv Zhe
Ca 3 Co 4 O 9+δ (CCO) cathode has been extensively studied for its excellent thermal expansion matching with commonly used electrolytes. CCO composite cathode with different concentrations of La 0.9 Sr 0.1 Ga 0.8 Mg 0.2 O 3 (LSGM) was prepared to evaluate its performance on LSGM electrolyte in this work. The appropriate amount of LaCoO 3 generated by the in-situ reaction of CCO and LSGM under operating conditions significantly enhances the oxygen exchange ability of CCO cathodes. The composite cathode containing 60 wt. % CCO and 40 wt. % LSGM (C-LGM60) exhibits the best electrochemical performance and the lowest polarization impedance among the C-LGM series cathodes. The area-specific resistance (ASR) of C-LGM60 is 0.06 Ωcm 2 at 750 °C. The maximal power density of the electrolyte-supported cell with C-LGM60 cathode reaches 489 mWcm -2 at 800 °C. After a 10 h stabilizing, there is no observable decline of the cell during the next 40 h of discharge. These results encourage the research of using CCO cathode on LSGM electrolytes and make valuable improvements on the development of SOFC cathode.
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2023
·Vol. 34
·期 17
·1-11
·
IF 2.8
Mei Xiang,Xiang Zhiwei,Mo Dingdiao,Fu Weihai,Jin Peixuan,Huang Xiaocong,Yang Yuanzheng,Cai Weitong
CsPbBr 3 perovskite solar cells (PSCs) have attracted a lot of attention due to their excellent long-term stability and easy fabrication in humid air. The preparation of the light-absorbing layer is crucial for achieving high efficiency in CsPbBr 3 perovskite solar cells. In this study, methylammonium iodide (CH 3 NH 3 I, MAI) was introduced into the PbBr 2 precursor solution to improve the quality of perovskite films and the photovoltaic performance of PSCs. The spin-coating method was employed to prepare CsPbBr 3 films in ambient air. Firstly, a layer of PbBr 2 film was spin-coated, followed by two spin-coatings of CsBr solution on top of it. By adjusting the content of MAI additives, a PbBr 2 film with a microporous structure was obtained. These porous structures acted as channels for CsBr molecules, enabling them to react fully with PbBr 2 and more favorable for the crystallization of CsPbBr 3 . As a result, we achieved the high-purity, high-crystallinity, and continuous CsPbBr 3 films. Furthermore, we utilized CsPbBr 3 films as the light-absorbing layer in PSCs with a structure of FTO/c-TiO 2 /m-TiO 2 /CsPbBr 3 /carbon, a champion power conversion efficiency of 8.02% was achieved, and the unencapsulated device showed excellent long-term stability.
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2022
·Vol. 57
·期 25
·11537-11545
·
IF 4.682
Chen Chuan,Zhang Qiang,Yao Tianhao,Wang Hongkang
Nickel-copper-zinc (NiCuZn) ferrites are widely used in high-frequency fields due to their low eddy current losses as well as high resistivity, but which are greatly affected by their microstructures, such as porosity, grain size. Herein, we report a novel synthesis of shuttle-shaped NiCuZn ferrites through electrospinning and subsequent sintering. The microstructural evolution and its effect on magnetic properties upon annealing at temperatures ranging from 500 to 1000 °C are systematically investigated through X-ray diffraction, Raman spectroscopy, scanning electron microscopy, and vibrating sample magnetometry. The results demonstrate that the average crystallite size of NiCuZn ferrites decreases and the grain size rises with increasing the sintering temperature. Meanwhile, the saturation magnetization shows an upward trend upon increasing the sintering temperature and reaches the highest value of 68.07 emu g −1 at 900 °C. However, when further increasing the sintering temperature to 1000 °C, the crystalline structure, as well as the morphology of the NiCuZn ferrite, change a lot with coarse particle growth/aggregation, thus resulting in lowered saturation magnetization. Inductively coupled plasma mass spectrometer analysis shows that the stoichiometric ratios of NiCuZn ferrite change with the sintering temperature, which also affects the magnetic properties. More importantly, this study demonstrates that electrospinning is promising to fabricate well-defined nanostructured ferrites with tunable components, morphologies, and magnetic properties.
✓ 已验证
DOI
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2023
·Vol. 41
·期 11
·1786-1795
·
IF 4.3
Yu Tian-Xin,Liu Ya-Yuan,Tian Fu-Yue,Ning Nan-Ying,Yu Bing,Tian Ming
3D printing silicone elastomer has demonstrated great potential in diverse areas such as medical devices, flexible electronics and soft robotics. It is of great value to investigate how to improve the mechanical properties, including tensile strength and elongation at break of printed parts. In this work, a light curing system that can be applied in silicone elastomer 3D printing is explored, which is composed of vinyl terminated polysiloxane as the macromer and thiol containing polysiloxane as the crosslinking agent, and a chain extension reaction is also introduced into this light curing system via the addition of the chain extender dithiol molecules, and a light curing system accompanied with chain extension is designed and realized based on the thiol-ene click reaction mechanism. After reinforced with silica fillers, the obtained light curing system can endow the light curing silicone elastomer with better mechanical properties under the condition of a lower viscosity of the precursor, the tensile strength and elongation at break can reach 525.5 kPa and 601%, respectively. This light curing system provides a feasible method to solve the contradiction between the viscosity of the precursor and the mechanical properties of the light curing elastomer in the digital light processing (DLP) 3D printing field.
✓ 已验证
DOI
高影响因子
Nature Communications
·
2023
·Vol. 14
·期 1
·1-13
·
IF 16.6
Chen Shiyi,Zhang Shishi,Guo Lei,Pan Lun,Shi Chengxiang,Zhang Xiangwen,Huang Zhen-Feng,Yang Guidong,Zou Ji-Jun
Surface reconstruction generates real active species in electrochemical conditions; rational regulating reconstruction in a targeted manner is the key for constructing highly active catalyst. Herein, we use the high-valence Mo modulated orthorhombic Pr 3 Ir 1− x Mo x O 7 as model to activate lattice oxygen and cations, achieving directional and accelerated surface reconstruction to produce self-terminated Ir‒O bri ‒Mo (O bri represents the bridge oxygen) active species that is highly active for acidic water oxidation. The doped Mo not only contributes to accelerated surface reconstruction due to optimized Ir‒O covalency and more prone dissolution of Pr, but also affords the improved durability resulted from Mo-buffered charge compensation, thereby preventing fierce Ir dissolution and excessive lattice oxygen loss. As such, Ir‒O bri ‒Mo species could be directionally generated, in which the strong Brønsted acidity of O bri induced by remaining Mo assists with the facilitated deprotonation of oxo intermediates, following bridging-oxygen-assisted deprotonation pathway. Consequently, the optimal catalyst exhibits the best activity with an overpotential of 259 mV to reach 10 mA cm geo −2 , 50 mV lower than undoped counterpart, and shows improved stability for over 200 h. This work provides a strategy of directional surface reconstruction to constructing strong Brønsted acid sites in IrO x species, demonstrating the perspective of targeted electrocatalyst fabrication under in situ realistic reaction conditions.
✓ 已验证
DOI
高影响因子
Frontiers of Chemical Science and Engineering
·
2024
·Vol. 18
·期 10
·1-10
·
IF 4.3
Jia Hongwei,Yue Xiaoyang,Hou Yuying,Huang Fei,Cao Cuiyao,Jia Feifei,Liu Guanhua,Zheng Xiaobing,Liu Yunting,Jiang Yanjun
Unspecific peroxygenases exhibit high activity for the selective oxyfunctionalization of inert C(sp 3 )-H bonds using only H 2 O 2 as a clean oxidant, while also exhibiting sensitivity to H 2 O 2 concentration. CdS-based semiconductors are promising for the photosynthesis of H 2 O 2 owing to their adequately negative potential for oxygen reduction reaction via a proton-coupled electron transfer process, however, they suffer from fast H 2 O 2 decomposition on the surface of pristine CdS. Therefore, [Cp*Rh(bpy)H 2 O] 2+ , a highly selective proton-coupled electron transfer catalyst, was anchored onto a supramolecular polymer-grafted CdS nanoflower to construct an efficient integrated photocatalyst for generating H 2 O 2 , mitigating the surface issue of pristine CdS, increasing light absorption, accelerating photonic carrier separation, and enhancing oxygen reduction reaction selectivity to H 2 O 2 . This photocatalyst promoted the light driven H 2 O 2 generation rate up to 1345 µmol·L −1 ·g −1 ·h −1 , which was 2.4 times that of pristine CdS. The constructed heterojunction photocatalyst could supply H 2 O 2 in situ for nonspecific peroxygenases to catalyze the C-H oxyfunctionalization of ethylbenzene, achieving a yield of 81% and an ee value of 99% under optimum conditions. A wide range of substrates were converted to the corresponding chiral alcohols using this photo-enzyme catalytic system, achieving the corresponding chiral alcohols in good yield (51%–88%) and excellent enantioselectivity (90%–99% ee).
✓ 已验证
DOI
高影响因子
Advanced Composites and Hybrid Materials
·
2021
·Vol. 4
·期 3
·478-491
·
IF 5.693
Hu Xinpeng,Wu Hao,Lu Xiang,Liu Shuang,Qu Jinping
For thermal management of phase change materials (PCMs), the main concerns are liquid leakage and low thermal conductivity. Here, via a green steam explosion method with the assistance of pure water, we fabricated a series of ethylene propylene diene monomer/paraffin wax/expanded graphite (EPDM/PW/EG) shape-stabilized PCMs (SSPCMs) with enhanced thermal conductivity resulting from better EG dispersion. Specifically, the steam explosion processed EPDM/PW/EG SSPCM with 9.0 wt.% EG obtains 448.2% thermal conductivity to that of EPDM/PW; the single steam explosion process enhanced the thermal conductivity by 27.4% compared the steam explosion processed and unprocessed EPDM/PW/EG SSPCM with same EG fraction (9.0 wt.%). With improved thermal conductivity, the obtained SSPCMs could absorb the heat faster in heating process and dissipate the heat quicker in the cooling process, exhibiting enhanced thermal management properties. In addition, steam explosion processed SSPCMs simultaneously exhibit improved shape recovery properties, revealing more possibility to fit into the installation space. Coupled with reusability, shape stability, flexibility, and excellent thermal properties, the obtained SSPCMs were proved to be promising candidates for thermal management. Graphical abstract The SSPCMs with enhanced thermal conductivity were developed by steam explosion method and possessed excellent thermal management properties.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）