JOURNAL OF NANOBIOTECHNOLOGY
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2026
·Vol. 24
·期 1
·360
·
IF 15
Liao Tao,Wu Xiaomei,Wang Jinyu,Guo Yuhao,Wang Wang,Hu Weikang,Kuang Ying,Li Cao,Liu Jia
Diabetic wounds are a critical clinical challenge due to chronic inflammation, impaired tissue regeneration, and bacterial infection. The absence of multifunctional therapeutic systems that can address these pathological barriers simultaneously is a major obstacle in managing diabetic wounds. In this study, we developed a versatile photothermal-responsive hydrogel (HPCT) by incorporating Ti 3 C 2 MXene nanosheets and Cur-Cu nanoparticles (NPs) into a dual-network polymer matrix. This hydrogel exhibits robust physicochemical stability, efficient photothermal conversion, and on-demand release properties. Due to the synergistic effects of its components, HPCT effectively scavenges ROS/RNS, reprograms macrophages, and promotes fibroblast and endothelial proliferation and migration. Additionally, it exhibits potent antibacterial activity. Transcriptomic analysis reveals that the bioactive material activates the PI3K-AKT and Wnt signaling pathways, providing a mechanistic basis for its regenerative potential. In vivo, HPCT significantly accelerates wound closure in diabetic mice by reducing inflammation and oxidative stress, enhancing angiogenesis, and improving collagen deposition while maintaining good biocompatibility. Overall, this multifunctional hydrogel is a promising therapeutic strategy for treating diabetic and other chronic wounds.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2026
·
IF 4.4
Han Qian,Wang Huili,Wang Yantao,Shen Zhenpeng,Wang He,Song Zhaoping,Liu Wenxia,Cao Lepan
Aerogels remain a focal point for researchers seeking to tackle environmental and energy challenges through innovative thermal insulation solutions. Designing and acquiring lightweight biobased aerogels that possess flexibility and thermal insulation represent a key future direction. Herein, taking advantage of synergistic assembly of xanthan gum (XG) and konjac glucomannan (KGM), and a novel biobased aerogel (XG/KGM@F) was fabricated and scaffolded by multiscale cellulose fibers (MCFs) through vacuum freeze-drying technology. The structural characterization demonstrates that the synergy of MCFs and polysaccharides forms a robust hierarchical network within the aerogels, significantly enhancing their mechanical resilience. The XG/KGM@F aerogels exhibit remarkable thermal insulation properties with a temperature difference (Δ T ) exceeding 60 °C for a long time between the top and bottom surfaces of the aerogels. With an ultra-low density of 3.97 mg cm −3 and a thermal conductivity of 0.0288 W m −1 K −1 , the XG/KGM@F demonstrates its potential for applications necessitating lightweight and sustainable thermal insulation. This study not only advances the design of biobased aerogels but also provides a scalable and eco-friendly strategy for developing high-performance insulation materials, aligning with global sustainability goals in packaging, construction, and energy conservation. Graphical The alternative text for this image may have been generated using AI.
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JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
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2026
·Vol. 41
·期 2
·353-363
·
IF 1.4
Yan Ming,Deng Yuxiao,Yan Zhuanlong,Li Hongyu,Cao Mengyang
This study reported the synthesis of magnetic solid solutions V 2 (A x B y Sn 1− x − y )C (where A and B are Mn, Fe, or Co) MAX phases. These materials were prepared by incorporating magnetic elements into the V 2 SnC MAX phase via pressure-less sintering at 1 000 °C for 3 hours. XRD analysis reveals that the composition with x = y = 0.2 exhibits a shift of diffraction peaks to higher angles, indicating lattice parameter changes, and achieves the highest phase purity with the maximum solid solution limit, further increases in the dopant content led to the formation of impurities. While the solid solution of magnetic elements preserves the characteristic layered structure of the MAX phase, it successfully induces magnetic properties. The magnetic transition temperatures for these solid solutions ranges from 61 to 200 K. Specifically, V 2 (Mn x Co y Sn 1− x − y )C demonstrated hard magnetic characteristics, with a high saturation magnetization (6.536 emu/g) and large remanence (4.236 emu/g). In contrast, V 2 (Mn x Fe y Sn 1− x − y )C and V 2 (Fe x Co y Sn 1− x − y )C exhibits soft magnetic behavior, evidenced by their narrow hysteresis loops and low coercivity. Their saturation magnetization values are 3.80 and 1.784 emu/g, respectively. The distinctly “S”-shaped hysteresis loop of V 2 (Fe x Co y Sn 1− x − y )C further confirms its soft magnetic nature.
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Nature Communications
·
2026
·
IF 18.1
Mao Qiqi,Wang Wenxin,Yang Ruidong,Deng Kai,Yu Hongjie,Li Wenzhen,Wang Liang,Wang Hongjing,Guo Shaojun
Industrial-level alkynols electrocatalytic semi-hydrogenation using seawater as hydrogen source offers a sustainable alternative to conventional thermocatalytic routes, yet remains limited by the lack of efficient and robust electrocatalysts. Here, we report the synthesis of Nd 1 Gd 1 dual atomic site on metallene for co-production of alkenol and magnesium hydroxide in the seawater system. Nd 1 Gd 1 Pd metallene achieves a selectivity of ≈96.7% and a Faradaic efficiency of ≈87.3% for the conversion of 2-methyl-3-butyn-2-ol to 2-methyl-3-buten-2-ol at −150 mA cm -2 in a flow-cell system, and maintains ≈98.0% selectivity at 1.2 A for over 300 h of continuous operation, achieving the long-term stable co-electrosynthesis of alkenols and magnesium hydroxide in natural seawater at industrial-scale currents. Techno-economic analysis reveals a projected product revenue of at least $8,499 per ton of 2-methyl-3-buten-2-ol, underlining the industrial viability of this process. Mechanism investigations illustrate dual hydrogen-spillover and co-catalytic effects on Nd 1 Gd 1 Pd, promoting migration-reaction coupling mechanism of reactive *H to synergize hydrogenation. This work provides a seawater electrocatalytic semi-hydrogenation system and proposes an optimization strategy by atomically engineered dual hydrogen-spillover effect.
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EUROPEAN JOURNAL OF NUTRITION
·
2026
·Vol. 65
·期 3
·117
·
IF 4.5
Peng Yongmiao,Guan Yuting,Zhang Ao,Fu Yuchong,Shen Xiaofeng,Yu Bowen,Zhao Shuhui,Feng Xing,Wang Yijia,Zhang Bing,Ji Weiping,Wu Lianpin,Guo Xiaoling
Purpose Kawasaki disease (KD) is an acute, self-limiting artery vasculitis, especially involving the coronary arteries. Chlorogenic acid (CGA) is a plant-derived polyphenolic compound with anti-inflammatory, anti-apoptotic, and anti-oxidative pharmacological effects. The purpose of this study was to explore the protective effects of CGA on KD and elucidate its mechanisms. Methods Candida albicans water-soluble fraction (CAWS) was used to establish a KD mouse model with coronary arteritis, and tumor necrosis factor α (TNF-α) was employed to induce human umbilical vein endothelial cell (HUVEC) injury of KD cell model, which was administrated in different ways and analyzed by hematoxylin–eosin (HE) staining, Masson trichrome staining, TdT-mediated dUTP Nick-End Labeling (TUNEL) staining, immunofluorescence staining, western blotting immunohistochemistry staining, real-time quantitative polymerase chain reaction (RT-qPCR), and so on. Results In vivo results showed that CGA could exert protective effects on KD mice through alleviating inflammation and fibrosis around the coronary arteries, and relieving vascular endothelial cell apoptosis. In vitro studies confirmed that CGA could inhibit TNF-α induced inflammation of HUVECs, similar to the NF-κB inhibitor QNZ. Additionally, it can also inhibit TNF-α induced HUVEC apoptosis by increasing BCL-2 expression as well as reducing TUNEL positive cells, the rates of flow cytometric apoptotic cells, and BAX expression. These effects could be reversed by the AMPK inhibitor compound c (CC). Further mechanistic study based on bioinformatics analysis and western blotting revealed that CGA could protect against vascular inflammation and cell apoptosis of KD through regulating the AMPK/mTOR/NF-κB pathway. Conclusion CGA may have the potentially protective effects on KD through inhibition endothelial cell inflammation and apoptosis, suggesting that CGA may serve as an adjuvant for KD therapy in the future.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
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2026
·
IF 1.7
Cui Yiqun,Ma Fuqiu,Jia Fengyan,Wang Guixiang
With the growing application of 177 Lu-based radiopharmaceuticals, efficient separation of no-carrier-added (NCA) 177 Lu from its isotopic precursor ytterbium has become an urgent need in radiochemistry. However, the adjacent positions of lutetium and ytterbium in the lanthanide series lead to highly similar physicochemical properties, rendering conventional separation methods ineffective. In this study, P507@PS-DVB resin was synthesized via a facile one-pot method by reacting the extractant P507 with polymerizable monomers, exhibiting an optimized microstructure and functional group distribution conducive to the selective adsorption of Lu(III) over Yb(III). Key factors affecting adsorption and separation performance were systematically evaluated. Under optimized conditions, the resin demonstrated a Lu(III) adsorption capacity of 55.4 mg/g. Furthermore, a two-step separation process consisting of primary enrichment and secondary purification was developed, achieving a Lu(III) recovery exceeding 60% alongside an 82% removal rate of Yb(III). This work presents both a promising material for NCA 177 Lu production and a viable strategy for lanthanide separation.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Yao Yaqi,Xu Zhenna,Ding Haoran,Zhu Yehan,Yang Shen shen,Wang Shuo,Fan Simiao,Hu Jingwen,Zhou Mengjiao,Wu Hongfei,Xu Zihang,Xia Jingyao,Li Yubo
Acute liver injury (ALI) represented a significant clinical challenge due to its high mortality rate and the absence of specific therapeutic interventions. Plant-derived exosome-like nanoparticles (ELNs) had recently garnered increasing attention in the field of disease prevention and treatment, owing to their favorable biocompatibility and potential for targeted delivery. In this study, we isolated and systematically characterized ELNs from the medicinal plant yam (Yam ELNs). Structural analysis revealed that Yam ELNs possess a homogeneous bilayer membrane structure with an average particle size of 214.7 nm and demonstrated considerable stability in gastrointestinal fluids. These nanoparticles were found to be enriched with lipids (primarily phosphatidylcholine, PC), functional proteins (including GPX1 and GSTP1), and microRNAs (such as the miR159 family). In vivo imaging and cellular uptake assays indicated that Yam ELNs were efficiently internalized by the liver and HepG2 cells. Using a carbon tetrachloride (CCl₄)-induced ALI model, we demonstrated that oral administration of Yam ELNs significantly reduced serum markers of liver injury (ALT and AST), ameliorated oxidative stress imbalance (as evidenced by decreased MDA and increased GSH levels), and attenuated histopathological damage in the liver. Furthermore, in vitro experiments confirmed that Yam ELNs modulate cellular oxidative stress through their cargo of endogenous functional RNA molecules, thereby exerting a prophylactic protective effect. Desorption electrospray ionization mass spectrometry imaging (DESI-MSI) visually demonstrated that Yam ELNs remodel the spatial distribution of glycerophospholipid metabolism and suppress lipid peroxidation and the propagation of inflammation. Targeted lipidomics analysis further revealed that disturbances in several core metabolic pathways, including glycerophospholipid metabolism and linoleic acid metabolism, were corrected by Yam ELNs. As a result, the homeostasis of key phospholipid species, such as PE, PI, and PS, was maintained, and the propagation of inflammatory responses was limited. Notably, Yam ELNs pretreatment significantly reduced serum levels of lipopolysaccharide (LPS) and downregulated hepatic Toll-like receptor 4 (TLR4) expression, indicating preservation of intestinal barrier integrity and attenuation of endotoxin-triggered hepatic inflammation. Furthermore, an integrated correlation analysis based on gut microbiota 16S rRNA sequencing, fecal metabolomics, and untargeted serum metabolomics clarified the relationships between differential serum metabolites, fecal metabolites, and microbial community structure. Following treatment with Yam ELNs, modulation of gut microbiota composition was observed, marked by the enrichment of Lactobacillus spp. These microbial shifts correlated with concurrent improvements in both serum lipid profiles and fecal metabolite profiles. Collectively, these effects were associated with enhanced hepatoprotective efficacy, suggesting a gut-initiated and metabolism-mediated mechanism underlying the prophylactic protection against ALI. In summary, this study systematically establishes the substantial potential of Yam ELNs in the prevention and treatment of liver injury, offering a novel strategy for the development of natural vesicle-based liver-targeted therapies. Graphical abstract
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Communications Chemistry
·
2026
·
IF 6.9
Xu Yiming,Zou Yun,Zhang Junfei,Li Fujun,Tao Shengyang
Calorimetry data for continuous-flow photochemistry are scarce, hindering kinetic model development and safe scale-up. Here we show that in situ calorimetry combined with designed experiments enables a quantitative, heat-consistent kinetic description for the continuous-flow photobromination of ( E )-methyl 2-(methoxyimino)-2-( o -tolyl) acetate (EMMA). We record total heat release, conversion, and selectivity over defined windows of residence time and light intensity, and fit a two-step kinetic scheme constrained by the calorimetric heat-release data. The model predicts total heat with R 2 = 0.957 and conversion with R 2 = 0.894, while the second bromination step shows negligible dependence on light intensity within the explored window, indicating thermally driven behaviour. We translate these parameters into a real-time visual digital model that maps the spatial distributions of conversion, selectivity, and heat-release rate and provides thermal-management guidance in real time. This approach extends the calorimetric dimension of process analytics for photochemistry and supports safer, more efficient process development.
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Nano-Micro Letters
·
2026
·Vol. 18
·期 1
·325
·
IF 38.5
Ali Muhammad,Ali Moazzam,Hussain Hamid,Aman Samia,Naseer Ufra,Mahmood Asif,Ahsan Muhammad Tayyab,Jiang Yinzhu,Yousaf Muhammad
A multifunctional melamine cyanurate hydrogen-bonded framework separator provides intrinsic flame retardancy, high-temperature dimensional stability, and dendrite suppression, offering a practical alternative to commercial polyolefin separators for sodium metal batteries.
Polar N–H/C=O motifs preferentially interact with PF 6 − , suppressing anion migration and boosting Na + transference number, enabling uniform Na + flux and lower polarization.
Separator-driven interphase regulation forms an inorganic, NaF-rich solid electrolyte interphase confirmed by X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry 3D mapping, improving Na plating/stripping reversibility and long-term full-cell durability at elevated temperature.
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 5
·301
·
IF 5.4
Wang Junbo,Holman Joseph Benjamin,Chen Xiangyu,Sun Jiaying,Qiu Bensheng,Zhang Anqing,Ding Weiping,Li Chengpan
In gout progression, uric acid (UA) accumulation triggers crystal deposition, while interleukin-6 (IL-6) drives the subsequent inflammatory flares. Therefore, monitoring both UA and IL-6 is important for gout management. In this study, for the first time a microfluidic electrochemical system (MES) has been developed to simultaneously detect UA and IL-6 levels in blood. The MES consists of a multilayer microfluidic chip that incorporates a plasma separation module and two screen-printed electrochemical (SPE) sensors, integrated with a wireless potentiostat for real-time data analysis. The working electrode (WE) of one SPE was modified with uricase and hydrophilic fumed nano-silica (FSiO₂) for UA sensing, and the WE of the other SPE was modified with gold nanoparticle-reduced graphene oxide (Au NPs/rGO) composites and antibodies for IL-6 sensing. The MES demonstrated excellent analytical performance for the simultaneous detection of UA and IL-6 in human blood, featuring high selectivity, broad linear ranges (10-1000 µM for UA and 0.001-100 ng/mL for IL-6), robust stability, and strong concordance with reference methods (R² > 0.95). This study provides a proof-of-concept platform for gout-related biomarker determination and offers a new strategy for the development of multi-biomarker electroanalytical devices.
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JOURNAL OF SOLUTION CHEMISTRY
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2026
·
IF 1.3
Zhuo Chen,He Zhu,Junlei Shi,Chengxin Shen,Shun Yan,Huanxin Li,Xueguo Liu
The dissolution behavior of 6-methylcoumarin in eleven mono-solvents, namely methanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, isobutanol, 2-methyl-2-butanol, methyl acetate, ethyl acetate, n-propyl acetate and isopropyl acetate, was investigated with the static equilibrium method. The studied temperature ranged from 278.15 to 318.15 K at p = 100 kPa. The results demonstrated that the solubility of 6-methylcoumarin increased with the temperature increasing. Among the selected solvents, methyl acetate exhibited the highest solubility for 6-methylcoumarin, whereas 2-propanol had the lowest. At the same time, the experimental solubility data were fitted with van’t Hoff, λh , Wilson, and NRTL models, with the NRTL model providing the most accurate predicted results. Additionally, the mixing thermodynamics were calculated by using the NRTL model, which revealed that the mixing process is spontaneous, endothermic and entropy-driven. Finally, the dissolution mechanism of 6-methylcoumarin in the selected solvents was preliminarily analyzed from the perspectives of the molecular structural characteristics of the solute, the solute–solvent intermolecular interactions, and the physicochemical properties of the solvent.
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npj Science of Food
·
2026
·
IF 9.7
Peng Ya-lin,Wang Yong-zhan,Li Yu-cong,Zeng Li-ting,Song Xin-yi,Li Xue-qing,Lv Ao-jing,Dong Rui-ling,Gao Wen-hao,Feng Lu,Li He-shuai,Qi Jun,Xiong Guo-yuan,Zhang Chun-hui
This study developed a novel gelatin-stabilized nano-silver particle/agar hydrogel (AgNP hydrogel) and investigated its color rendering mechanism for monitoring the freshness of braised chicken. The results showed that the color of AgNP hydrogel shifted from brown to gray-white within 3 days of storage of braised chicken, and its application extended the shelf life of unpackaged braised chicken meat from 4 d to 6 d at 4 °C ( P < 0.05). The results of circular dichroism (CD), particle size, zeta potential, and UV indicated that Cl - on the surface of braised chicken could react with Ag + on the surface of AgNP, resulting in the formation of AgCl particles during storage. These AgCl particles were subsequently transformed into black Ag 2 S particles, causing the visual color shift of AgNP to gray-white. Overall, the AgNP hydrogel could provide a new method for the freshness assessment of cooked meat products.
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