ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
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2019
·Vol. 41
·期 3
·1545-1557
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IF 3.252
Ye Bin,Cang Yan,Li Ji,Zhang Xiaolei
Chlorine dioxide (ClO 2 ) has been widely used in the process of preoxidation and disinfection as an excellent water treatment reagent. However, the inorganic by-products produced by ClO 2 , such as chlorite (ClO 2 − ) and chlorate (ClO 3 − ) are harmful to human health, and this has become a potential problem when using ClO 2 in drinking water treatment. In this study, ClO 2 alone and a ClO 2 /NaClO combination process were carried out to evaluate the algae removal efficiency of the treatment and the formation of disinfection by-products (DBPs: chlorite, chlorate, trihalomethanes and haloacetic acids) for high algae-laden water with 124.16 µg L −1 chlorophyll a (Chl.a) content. The results show that disinfection with 1.5 mg L −1 ClO 2 alone results in a ClO 2 − concentration exceeding 0.7 mg L −1 . ClO 2 preoxidation/ClO 2 disinfection is applicable for the control of effluent quality, but the ClO 2 − concentration still has an excessive risk when using 0.8 mg L −1 and 0.6 mg L −1 ClO 2 for the two process, respectively. In the ClO 2 /NaClO combination process, the ClO 2 − concentration is below 0.6 mg L −1 , and trihalomethane (THM) and haloacetic acid (HAA) concentrations are lower than 60% of the maximum contaminant levels (MCLs) set by the World Health Organization (WHO). Further, the formation of ClO 2 − is more effectively controlled by NaClO preoxidation/ClO 2 disinfection than ClO 2 preoxidation/NaClO disinfection.
研究领域:
环境科学
·
水处理工程
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Chemistry Central Journal
·
2016
·Vol. 10
·期 1
·1-11
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IF 2.552
Guo Wenbo,Yan Mengmeng,Xu Bing,Chu Fuhao,Wang Wei,Zhang Chenze,Jia Xiaohui,Han Yaotian,Xiang Hongjun,Zhang Yuzhong,Wang Penglong,Lei Haimin
Background Glycyrrhetinic acid (GA) derivatives had shown not only cytotoxicity but also could trigger apoptosis in various human cancer cell lines. Moreover, cinnamic acid (CA) and its phenolic analogues as potent antitumor agents were employed in the design of anti-tumor drugs. To further improve the anti-tumor activity of GA and CA derivatives, a series of novel compounds were designed and synthesized using GA and CA derivatives fragments.Results The result showed that all the novel glycyrrhetinic acid-cinnamoyl (GA–CA) hybrids presented higher antitumor activity on the tumor cell lines of HepG2, HT-29, Hela and lower cytotoxicity on three non-tumor cells lines MDCK, HY926, H9C2 than the parent compounds (IC50 > 50 μM). It was worth noting that 8a had a superior cytotoxicity effect on Hela cells (IC50 = 8.54 μM) than on other cancer cell lines (IC50 > 15 μM). And it also indicated that 8a showed lower cytotoxicity (IC50 > 27 μM) towards MDCK, HY926 and H9C2 cells than cisplatin (DDP, IC50 < 10 μM). Moreover, according to the acute toxicity, it could be indicated that the LD50 of 8a exceeded 3.0 g/kg by oral administration in mice. The further research using Giemsa, H33342 staining, flow cytometric analysis and caspase-3 assay showed that 8a could cause Hela cell damage, nuclei lysis and apoptosis. In addition, the structure–activity relationships of these hybrids were briefly discussed.Conclusion sCompared with GA, target compounds demonstrated better anti-tumor activity, among which 8a was the most active one. What’s more, structure–activity relationship analysis also revealed that hybrids with trans olefinic bond group show higher antitumor activity than those without olefinic bond, such as 1a > 1b, 6a > 2b, 8a > 3b, 9a > 4b. In addition, it was found that the methoxy substituent might enhance selectivity of GA–CA hybrids towards regular non-cancerous cells MDCK, HY926 and H9C2, such as 4a, 6a, 7a, 8a. However, there might be less relationship between the cytotoxicity and the quantity, position of methoxy moiety. Hence, it is urgent need to synthesize efficient, low toxicity and multi-target anti-tumor compounds based on the structure combination principle.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2022
·Vol. 33
·期 13
·9845-9857
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IF 2.779
Hu Ke,Wang Ruoheng,Maimaitituersun Mieralimu,Sun Huajun,Liu Xiaofang,Zhang Yong
In this work, ultrathin Bi 2 WO 6 nanosheets (BWO NS) was synthesized by two-step hydrothermal process, which exhibited a lamellar structure with a thickness of about 10 nm and a transverse length of 100–400 nm. The piezoelectric properties and photocatalytic properties of BWO NS were coupled successfully, and the piezo-photocatalytic activity was studied through the decomposition of 10 mg L − 1 Rhodamine B (Rh B). The results showed that the degradation ratio of BWO NS for Rh B was about 98.39% within 70 min, which was higher than that of sole piezocatalysis (48.98%) and photocatalysis (61.84%). There was no significant degradation of the catalytic performance observed after being recycled four times. Moreover, piezo-photocatalysis of BWO NS efficiently produced active radicals that the major reactive oxidative species (ROS) such as superoxide radicals (·O 2 − ) and hydroxyl radicals (·OH) were confirmed by radical capture experiment. The excellent piezo-photocatalysis of BWO NS endows it the potential application for decomposing organic dye via making full advantage of the vibration and solar energy present in natural environments.
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ANALYTICAL SCIENCES
·
2023
·Vol. 39
·期 10
·1669-1679
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IF 1.6
Lin Xiaorong,Wang Changting,You Liuxia,Fu Fanrui,Liu Qiaoling
In this work, PtCo bimetallic nanoparticles supported on multi-walled carbon nanotubes (PtCo@MWCNTs) nanohybrid was prepared simply and used for the first time as a novel nanozyme in the colorimetric sensing of L-cysteine (L-Cys) and Cu 2+ . Due to its strong enzyme-like catalytic activity, the prepared PtCo@MWCNTs nanohybrid can catalyze the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) to form ox-TMB without H 2 O 2 . Interestingly, the oxidase-like active of PtCo@MWCNTs was effectively suppressed by L-Cys, which could reduce ox-TMB to colorless TMB and lead to a pronounced blue fading, and the absorbance at 652 nm gradually decreased with increasing L-Cys concentration. On the other hand, the nanozyme activity of PtCo@MWCNTs can be recovered due to the complexation between L-Cys and Cu 2+ . Therefore, a colorimetric method based on PtCo@MWCNTs nanozyme was established to detect L-Cys and Cu 2+ . The results show that the assay platform has simple, rapid, sensitive performance and good selectivity. The detection limits for L-Cys and Cu 2+ are 0.041 μM and 0.056 μM, respectively, coupled with the linearities of 0.01 ~ 60.0 μM and 0.05 ~ 80.0 μM. The successful first application of PtCo bimetal-based nanozyme in colorimetric sensing herein opens a new direction for nanozyme and colorimetric analysis, showing great potential applications. Graphical Abstract
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RARE METALS
·
2023
·Vol. 42
·期 10
·3443-3454
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IF 8.8
Zhou Ming-Jie,Zhang Wen-Tao,Li Zhun,Feng Tao,Lan Si,Peng Zhen,Chen Shuang-Qin
Metallic glasses (MGs) are promising heterogeneous catalysts in water remediation, due to their superior efficiency, selectivity, reusability and corrosion resistance. However, few works are focused on the influence of inorganic anions that are abundant in wastewater. Herein, four common inorganic anions were added in a heterogeneous Fenton-like system (Fe–MG/H 2 O 2 ) to study inorganic anions’ influence on MGs’ catalytic performance during methylene blue (MB) degradation. Evidence demonstrated that chloride ions and dihydrogen phosphate ions had an adverse effect on the catalytic performance of Fe–MG, whereas Fe–MG/H 2 O 2 system sustained high efficiency in the presence of sulfate ions and nitrate ions during the Fenton-like process. By studying the structure, surface morphology, and evolution of active species, it was found that inorganic anions had a significant effect on the surface morphology of Fe–MG and the generation of active species. This work will provide essential references for MGs as heterogeneous catalysts in practical applications. Graphical abstract
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Nature Communications
·
2026
·
IF 18.1
Dai Ziliang,Zhang Lili,Yu Juan,Zhu Enqing,Wang Rui,Meng Jiao,Ullah Muhammad Wajid,Khan Khalid Ali,He Wen,Fan Yimin,Wang Zhiguo
Sustainable structural fibers are highly desirable because many conventional high-performance fibers are neither renewable nor biodegradable. Bamboo original fibers, which possess a natural hollow vascular bundle architecture, represent a promising biomass-derived reinforcement but are difficult to isolate without damaging their structure. Here, we develop a mild “top-down” strategy to efficiently dissociate intact bamboo original fibers (B p OFs) from pretreated natural bamboo using a deep eutectic solvent (ChCl/OA-DES) treatment at 110 °C for 1 h. The treatment selectively weakens parenchyma cell cohesion (elastic modulus reduced from 6.24 to 3.14 GPa) while preserving fiber cell stiffness (15.04 to 15.92 GPa), enabling rapid separation of vascular bundles through subsequent CH₃COOH/H₂O₂ delignification and simple roller compaction. Controlled hydrogen-bond reconstruction during drying enhances mechanical performance, yielding fibers with an apparent tensile strength of 1947 ± 217 MPa while retaining the native hollow structure. Analysis of the load-bearing cell wall further reveals an intrinsic cell-wall stress of 2636 ± 197 MPa, indicating highly efficient stress transfer within the cellulose framework. The preserved tubular architecture provides low density, flexibility, and favorable interfacial interactions with polymer matrices. When incorporated into epoxy resin, B p OFs enhance bending strength and impact resistance, demonstrating their potential as lightweight, renewable reinforcement for high-performance composites.
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Chinese Journal of Integrative Medicine
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2026
·
IF 3.1
Zhang Di,Zhuang Zi-feng,Lin Shao-zi,Chen Zen-ni,Chen Hong-ling,Gu Jun-yan,Hao Yu-ting,Li Yi-xuan,Chen Jia-xu,Zhao Guo-ping
Objective To elucidate whether Danggui Sini Decoction (DGSD) relieves sciatica by downregulating transient receptor potential (TRP) channels involved in peripheral sensitization. Methods After conducting chronic constriction injury of sciatic nerve (CCI) operation, 32 SD rats, randomly assigned to the sham, CCI 7d, CCI 14d, and CCI 21d groups ( n =8 per group), were used to observe the course of sciatica. mRNA sequencing of dorsal root ganglia (DRG) was conducted on rats in the sham and CCI 21d groups. Another 32 rats were divided into the sham, CCI, mecobalamin, and DGSD groups, 8 in each group. mRNA sequencing analysis and single-cell RNA-sequencing (scRNA-seq) data analysis were conducted. Behavioural tests were conducted to evaluate the therapeutic effects of DGSD. The levels of TRP vanilloid (TRPV)1–4, TRP ankyrin 1 (TRPA1), TRP melastatin 8 (TRPM8), Ras homolog family member A (RhoA), and phosphorylated p38 mitogen-activated protein kinase (p-p38MAPK) were measured via Western blot, and the serum levels of C-C motif chemokine ligand 2 and 5 (CCL2, CCL5), substance P (SP), and prostaglandin E2 (PGE2) were conducted via ELISA. Results scRNA-seq and mRNA sequencing analysis revealed that inflammatory mediator regulation of TRP channels played a role in the development of sciatica. CCI rats exhibited cold hyperalgesia from day 4 to 21, increased the DRG protein expression levels of TRP channels, including TRPV1–4, TRPA1, TRPM8, RhoA, p-p38MAPK, CCL2, CCL5, SP, and PGE2. Treatment with DGSD decreased the serum levels of CCL2, CCL5, SP, and PGE2, and reduced the levels of RhoA, p-p38MAPK, TRPV1–4, TRPA1, and TRPM8 in DRG ( P <0.05). Conclusion CCI increased the levels of TRP channels and inflammatory factors, inducing cold hyperalgesia, whereas DGSD relieved pain via inhibiting peripheral sensitization to relieve cold hyperalgesia by reducing the inflammatory factors and TRP.
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Cell Communication and Signaling
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2026
·
IF 11.6
Liu Fang,Han Chao,Xiao Yi
Histone lactylation is a recently identified epigenetic modification that directly couples cellular metabolic state with gene expression. Whether lactate affects host resistance to pathogens via histone lactylation remains unclear. Here, we found that infection with Pseudomonas aeruginosa PA14 significantly increased lactate levels in Caenorhabditis elegans . Exogenous sodium lactate (NAL) also raised lactate levels and reduced worm resistance to the extracellular bacteria P. aeruginosa and Enterococcus faecalis , but had no detectable effect on the intracellular bacteria Salmonella and Listeria monocytogenes . Lowering lactate levels with the lactate dehydrogenase inhibitor Oxamate enhanced worm resistance to infection. Genetic screening showed that the regulatory effects of NAL and Oxamate on immunity were dependent on SKN-1. Similar results were also observed with pyruvate and the pyruvate dehydrogenase kinase inhibitor dichloroacetate (DCA) treatment. Mechanistic studies showed that, among the histone lactylation sites examined, elevated lactate promoted lactylation most strongly at H4K16 (H4K16la). ChIP‑qPCR results showed increased H4K16la enrichment at the skn-1 promoter upon lactate elevation. This led to increased activity of the transcription factor SKN-1, as evidenced by increased SKN-1 nuclear translocation, upregulation of downstream genes ( skn-1 , gst-4 , gst-7 , gst-10 , gcs-1 ), and enhanced GST-4::GFP fluorescence. However, the addition of NAL caused excessive GST-4::GFP fluorescence, indicating SKN-1 overactivation. This also led to suppression of the antimicrobial peptide IRG-1 and increased bacterial accumulation in the gut. In summary, this study provides evidence that lactate suppresses innate immunity in C. elegans , likely through H4K16 lactylation-mediated overactivation of SKN-1. These findings suggest that lactate may act as a negative regulator of innate immunity in an invertebrate model and provide a basis for future studies on targeting lactate metabolism or histone lactylation in infectious diseases.
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CELLULOSE
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2023
·
IF 5.7
Tang Peixin,Si Yang,Song Xiyu,Sun Gang
Volatile carboxylic acids (VCAs) are intensively generated via bioengineering and widely used in food, textile, and cosmetic industries, but the efficient separation, collection, and regeneration of VCAs still face challenges. Here, we report a design and application of novel hierarchically porous structures built on bacterial cellulose nanofibrous membrane to effectively adsorb VCAs and to reveal the adsorptive status of the material at the same time. By in situ growing a triazine-based porous organic polymer on the nanofibers, the composite achieved integrated features of the co-existence of micro/meso/macropores, high specific surface area (255 m 2 /g), good flexibility, and selective affinity to VCAs, resulting in record-high adsorption capacities toward formic acid (815.36 mg/g) and acetic acid (754.21 mg/g). Moreover, the introduction of colorimetric probes onto the composite allows a visual indication of the adsorption-desorption process, i.e., the working status of the material, in real time. The successful fabrication of a bifunctional, hierarchical porous cellulose-based nanofibrous membrane could inspire the development of green adsorbents with improved efficacy and flexibility for gas capture and filtration. Graphical abstract
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RARE METALS
·
2023
·
IF 8.8
Zhang Chen-Chen,Wei Sheng,Sun Li-Xian,Ouyang Yi-Fang,Xu Fen,Chu Hai-Liang,Pan Hong-Ge,Chen Li-Xin,Xiao Xue-Zhang
Electrocatalytic water splitting coupled with sustainable energies is identified as an environmentally friendly and renewable strategy to generate high-quality hydrogen for the fuel cells. However, the main challenge is to develop high performance, low cost and chemically stable electrocatalysts to decline the energy barriers and enhance the sluggish kinetics of hydrogen evolution reaction (HER). Herein, a three-dimensional hierarchically ordered macroporous Ru-CoP@NC electrocatalyst (3DOM Ru-CoP@NC) derived from ordered macro-microporous metal–organic frameworks has been prepared using the precursor@template and double-solvent methods. The prepared 3DOM Ru-CoP@NC catalyst exhibits an overpotential of 15 mV ( j = 10 mA·cm −2 ) and a reaction Tafel slope of 38 mV·dec −1 in alkaline electrolyte, which are superior to commercial Pt@C catalyst. Additionally, the overpotential and reaction Tafel slope of this catalyst in acidic media are 45 mV and 50 mV·dec −1 , respectively. The outstanding HER activities of 3DOM Ru-CoP@NC catalysts are ascribed to the 3D highly interconnected-reticular nanospaces that can increase effective reaction active sites. The N doped carbon framework improves the electronic properties and conductivity. Moreover, the strong interaction of Ru and CoP nanoparticles also boosts the HER process. These results indicate that 3DOM Ru-CoP@NC catalysts with high catalytic activities have a broad application prospect in the future. Graphic abstract
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Biotechnology for Biofuels and Bioproducts
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2023
·Vol. 16
·期 1
·1-13
·
IF 0
Zhang Xiaoling,Miao Qin,Tang Bingling,Mijakovic Ivan,Ji Xiao-Jun,Qu Lingbo,Wei Yongjun
Xylo-oligosaccharides (XOS) are considered as a promising type of prebiotics that can be used in foods, feeds, and healthcare products. Xylanases play a key role in the production of XOS from xylan. In this study, we conducted a metagenomic analysis of the fecal microbiota from dairy cows fed with different types of fodders. Despite the diversity in their diets, the main phyla observed in all fecal microbiota were Firmicutes and Bacteroidetes. At the genus level, one group of dairy cows that were fed probiotic fermented herbal mixture-containing fodders displayed decreased abundance of Methanobrevibacter and increased growth of beneficial Akkermansia bacteria. Additionally, this group exhibited a high microbial richness and diversity. Through our analysis, we obtained a comprehensive dataset comprising over 280,000 carbohydrate-active enzyme genes. Among these, we identified a total of 163 potential xylanase genes and subsequently expressed 34 of them in Escherichia coli . Out of the 34 expressed genes, two alkaline xylanases with excellent temperature stability and pH tolerance were obtained. Notably, CDW-xyl-8 exhibited xylanase activity of 96.1 ± 7.5 U/mg protein, with an optimal working temperature of 55 ℃ and optimal pH of 8.0. CDW-xyl-16 displayed an activity of 427.3 ± 9.1 U/mg protein with an optimal pH of 8.5 and an optimal temperature at 40 ℃. Bioinformatic analyses and structural modeling suggest that CDW-xyl-8 belongs to GH10 family xylanase, and CDW-xyl-16 is a GH11 family xylanase. Both enzymes have the ability to hydrolyze beechwood xylan and produce XOS. In conclusion, this metagenomic study provides valuable insights into the fecal microbiota composition of dairy cows fed different fodder types, revealing main microbial groups and demonstrating the abundance of xylanases. Furthermore, the characterization of two novel xylanases highlights their potential application in XOS production.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
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2023
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IF 5.8
Dong Lulu,Yao Zhenxing,Sun Shaohua,Wang Mingquan,Jia Ruibao
UV/peroxymonosulfate (UV/PMS) is a promising advanced oxidation technology in water treatment. This study aimed to investigate the impact of UV/PMS on humic acid (HA) and the influence of PMS dosage, pretreatment time, pH pretreatment, nitrate, nitrite, ammonium, and bicarbonate influencing factors on disinfection byproduct (DBP) formation during post-chlorination. With increased PMS dosage or pretreatment time, the UV/PMS treatment significantly reduced ultraviolet absorbance and increased mineralization. It altered the fractional constituent as humic substances were gradually transformed into building blocks and low-molecular-weight acids. However, most DBP formation increased initially and then decreased after subsequent chlorination. Rising nitrate or nitrite concentrations markedly promoted halonitromethane (HNM) formation. The presence of ammonia had a more significant impact on dichloroacetonitrile (DCAN) formation. Bicarbonate in UV/PMS pretreatment increased carbonated disinfection byproduct (C-DBP) formation, whereas it had a negligible impact on nitrogenous disinfection byproduct (N-DBP) formation. The present study revealed the impact of a series of influencing factors on DBP formation in UV/PMS reaction systems, providing comprehensive insights on applying UV/PMS in actual practice.
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