MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Tianwen Liu,Wei Yuan,Mengyao Si,Xiaoning Wang,Xiangping Liu,Xiaoying Wang
The concentration fluctuations of cellular-myelocytomatosis oncogene (c-Myc) protein may be related to a variety of tumors such as lymphoma, therefore, detection of abnormal trace-level changes is of great significance for early predictions. Conventional detection methods suffer from time-consuming analytical processes and insufficient sensitivity. Thus, the development of a sensitive detection method for c-Myc protein in blood is particularly crucial. We developed an electrochemical sensor for the sensitive detection of c-Myc protein based on gold–palladium alloy nanoparticles (AuPd NPs), leveraging its dual-function for both electrode modification and signal tag. Specifically, AuPd NPs were rapidly formed on the electrode surface by electrodeposition techniques to anchor the capture antibodies (Ab I ), which can increase the conductivity and load capacity of the electrode. Subsequently, using toluidine blue (TB) as a reducing agent, TB-AuPd was synthesized in one step, and further utilized to anchor the detection antibodies (Ab II ), which improved the load quantity and electrocatalytic activity of TB. When the target was present, the sandwich sensor was successfully constructed, benefiting from dual amplifications to achieve sensitive detection of c-Myc protein. Eventually, the proposed sensor exhibited a wider linear range (1–1000 pg mL −1 ) and a lower detection limit (0.5 pg mL −1 , S/N = 3). The developed method demonstrated strong concordance with commercially available ELISA kits, with no statistically significant difference observed in detection results. Thus, the proposed sensor realized sensitive detection of c-Myc protein, and can render valuable guidance for prospective clinical test applications.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Song-Yi Liao,Jing Chen,Dao-Ren Deng,Cai-Yun Wu,Selina X. Yao,Yi Wang,Yu-Ming Ru,Xiao-Yan Li,Xu-Gang Shu,Yong-Gang Min
In this study, a hybrid composite of MXene loaded with carbon-coated Ni 0.96 S hollow nanobox (shortened as HC-Ni 0.96 S@MXene/C) is successfully synthesized. The micro-structure of HC-Ni 0.96 S@MXene/C is further analyzed by transmission electron microscopy (TEM) and scanning electron microscopy (SEM) with EDS mappings. The results reveal that ∼550 nm Ni 0.96 S nanobox with ∼60 nm shell is effectively loaded on MXene nanosheets and encapsulated by a thin carbon layer. When evaluated as advanced anode for lithium-ion batteries (LIBs), HC-Ni 0.96 S@MXene/C achieves a specific capacity of 810.9 mAh g - 1 at 0.1 A g - 1 and remains 455.6 mAh g - 1 at 0.5 A g -1 after 200 cycles. Moreover, in sodium-ion batteries (SIBs), HC-Ni 0.96 S@MXene/C anode delivers 416.5 mAh g - 1 at 0.05 A g - 1 and maintains 201.4 mAh g - 1 at 0.5 A g - 1 after 400 cycles. Additionally, the HC-Ni 0.96 S@MXene/C anode demonstrates higher pseudo-capacitance effects of 81.6 and 92.5 % at a scanning rate of 1 mV s - 1 in LIBs and SIBs respectively. Moreover, the higher pseudo-capacitance effects in SIBs are according with the facts that the ionic diffusion coefficients of Na ions ( D Na + = 4.6 ∼ 40.6 × 10 -11 (discharge) and 1.7 ∼ 127.8 × 10 -11 (charge) cm 2 /s) are larger than those of Li ions ( D Li + = 1.1 ∼ 19.6 × 10 -11 (discharge) and 0.82 ∼ 32.6 × 10 -11 (charge) cm 2 /s) for HC-Ni 0.96 S@MXene/C anode. The excellent electrochemical performances of HC-Ni 0.96 S@MXene/C should be assigned to hollow Ni 0.96 S structure, carbon coating and conductive MXene nanosheets, which collectively alleviate volume changes during cycling, enhance electronic conductivity and accelerate ion diffusion respectively. This strategy of synthesizing HC-Ni 0.96 S@MXene/C may provide a guidance for designing advanced LIBs/SIBs anodes in the near future.
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JOURNAL OF ORGANIC CHEMISTRY
·
2025
·
IF 3.6
Jiapeng Sun,Hanxiao Luo,Junyong Wang,Hongliang Li,Raorao Zheng,Dingru Qiao,Jiaji Zhao,Yue Yu,Hua Cao
A simple and practical method has been developed for the carbonylative esterification of imidazo[1,2-a]pyridines via C(sp2)–H bond functionalization using alkyl alcohols under mild reaction conditions. The carbonyl fragment is sourced from radical-mediated C–C cleavage of the alcohols, providing a green, safe, and economic alternative to traditional carbonyl sources like carbon monoxide. Through this strategy, a number of imidazo[1,2-a]pyridine-3-carboxylates were obtained from simple substrates by a single step.
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PubMed
高影响因子
WATER RESEARCH
·
2025
·
IF 12.4
Bobo Xing,Ji Li,Linlin Li,Nigel J.D. Graham,Xian Li,Wenzheng Yu
Excessive accumulation of nitrate in natural ecosystems can lead to eutrophication of water bodies, resulting in environmental impacts such as algal blooms and red tides that pose serious threats to environmental and human health. Autotrophic denitrification is a resource-efficient biological nitrogen removal technology, but the slow growth and low electron transfer efficiency of autotrophic denitrifiers limit their practical application. In this study, the heterotrophic denitrifying bacterium Pseudomonas sp. JM-7 ( P. JM-7) was used in mixed culture with the autotrophic denitrifying Thiobacillus denitrificans ATCC 25259 to form a heterotrophic-autotrophic synergistic denitrification process (mixPT) to enhance electron transfer and improve the denitrification efficiency. Our results for an initial nitrate concentration of 430 mg/L showed that P. JM-7 reduced approximately 210 mg/L nitrate (48.8 %) in 90 h, with 1 g/L yeast extract powder (YEP) as the electron donor, while Thiobacillus denitrificans barely removed nitrate. In contrast, the mixPT system reduced approximately 360 mg/L nitrate (83.3 %), nearly 1.7 times greater than P. JM-7 alone. The mixPT culture also exhibited excellent denitrification in low carbon waters (10 mg/L), and removed 40 mg/L nitrate completely within 120 h. Cytochrome c produced by Pseudomonas sp. JM-7, which is an excellent electron transfer mediator for denitrification by Thiobacillus denitrificans , played a crucial role in the heterotrophic-autotrophic syntrophic denitrification. The adsorption effect of Pseudomonas sp. JM-7 shortened the contact distance between the autotrophic denitrifying bacteria and cytochrome c, which made it easy for cytochrome c to transfer the electrons to the autotrophic bacteria directly, thereby reducing the loss of electrons in the process of transfer, and improved the electron utilization efficiency. These findings have demonstrated the potential applications of mixPT system in controlling eutrophic waters and propose cytochrome c of Pseudomonas sp. JM-7 could serve as a novel and high-quality electron transfer mediator. Furthermore, this study have overcome the restriction of low denitrification efficiency exhibited by heterotrophic denitrifying bacteria Pseudomonas sp. JM-7 in low-carbon environments and expanded the utilisation of Pseudomonas sp. JM-7 in low carbon environments.
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高影响因子
Journal of Environmental Chemical Engineering
·
2024
·
IF 7.4
Yanyan Ji,Wenjing Li,Weiping Cao,Zhen Yang,Chunming Zheng,Wu Zhang
In this work, Cu-Fe bimetal-embedded carbonaceous CuFe@C materials were prepared by high-temperature pyrolysis of CuFe-MOFs precursors synthesized through a facile two-step feeding approach. Through adjusting the reaction time of each feeding step, CuFe-MOFs of uniform dispersed crystals with controlled sizes were obtained. The carbonized composites were then applied to activate persulfate (PMS) for Reactive Brilliant Red X-3B (RBRX-3B) degradation in water. The removal rate of RBRX-3B was up to 98% in 40 min in the CuFe@C 600 /PMS system, indicating that the CuFe@C 600 catalyst showed excellent sulfate radical-based oxidation (SR-AO) activity in the degradation process. The effects of PMS dosage, initial pH, RBRX-3B concentration on the degradation efficiency were investigated in detail. Based on quenching experiments, a possible mechanism for the CuFe@C 600 /PMS system was proposed. The catalyst had good reusability, in which the removal rate of RBRX-3B could attain 82% after 5 times of repeated recycling. It also showed satisfactory removal effect on other organic pollutants, i.e. Congo red, Methyl orange, Reactive blue and p-nitrophenol. This study provided a valuable strategy for the treatment of wastewater containing organic pollutants using MOFs-derived materials.
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CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Feng Jiang,Wen Li,Tao Wang,Junling Yu,Junxiong Zhang,Qian Wu,Quan Zhang,Xiaojun Zhang,Qing Hu,Guo Feng,Jianmin Liu,Yun Yu
Novel pressure field assisted non-hydrolytic sol-gel method is developed for the in-situ synthesis of novel seed-pulp-structured C@ZrSiO 4 pigments. The obtained pigments, which are composed of in-situ carbon derived from leaving organic groups as core and zircon as shell, were characterized via DSC-TG, XRD , FT-IR, Raman, XPS , SEM , TEM, UV–Vis, and automatic colorimeters. It was found that the pressure field promotes the non-hydrolytic sol-gel heterogeneous polycondensation reaction and the direct transformation of reaction groups into in-situ spherical carbon. Meanwhile, the in-situ spherical carbon was enclosed by heterogeneous condensation bonds wrap and formed a dense structure. The as-prepared pigments exhibited excellent color rendering performance ( L* = 21.07, a* = 0.48, b* = 0.75) and thermal stability.
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高影响因子
ACS Applied Polymer Materials
·
2024
·
IF 4.4
Haifeng Yu,Yanting Du,Jiayu Li,Songhao Zhao,Cheng Wang,Shuhong Wang,Haiyang Chang
Donor–acceptor (D–A) conjugated polymers have exhibited their utility in the fabrication of memory devices with high information storage capacity. The device performance can be effectively regulated through the appropriate pairing of the acceptor and donor moieties. Six different D–A conjugated polymers, featuring varied structures, were synthesized by using the Suzuki coupling reaction. Donor molecules such as fluorene, carbazole, and 4′-methoxytriphenylamine, as well as the acceptor molecule dipyrido[3,2-a:2′,3′-c]phenazine (dppz), were employed in this process. Interestingly, it was observed that simply increasing the ratio of donor groups did not yield improvements in device performance. On the other hand, the memory devices fabricated using these polymers as the active layers exhibited favorable ternary resistance memory behavior. Specifically, the first and second threshold voltages were impressively low, at −0.40 and −0.75 V, respectively. The OFF: ON1: ON2 current ratio reached an outstanding ratio of 1:102.90:105.47. Moreover, these devices demonstrated excellent stability with a retention time of 104 s and an endurance of 103 cycles. In conclusion, this study successfully synthesized D–A conjugated polymer with dppz as an acceptor and proved the great potential of constructing ternary memory devices using the dppz structure.
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高影响因子
MOLECULAR THERAPY
·
2025
·
IF 12
Di Wang,Xiao-ya Wang,Wen-jing Li,Cheng-hui Liang,Yu-xin Zou,Jin-wei Xiao,Qing-mei Kang,Jun-han Wang,Ling Mao,Jun-jie Chen,Xue-jia Zhai,Ji-tao Zhuang,Xian-Yan Yang,Hong-ying Jiang,Tian-hua Shen,Jie Liu,Qian Wen,Jiang-jie Duan,Jun Wang,Shi-cang Yu
The oncoprotein c-Myc is a prominent target in cancer therapy and modulating its stability is a promising potential treatment strategy. Phosphorylation at Ser62 is the primary mechanism by which c-Myc degradation is suppressed, which extends its half-life. Consequently, identifying kinases that regulate the phosphorylation of c-Myc at Ser62 may pave the way for novel intervention strategies. In this study, we revealed that acetaldehyde dehydrogenase 18A1 (ALDH18A1), a key enzyme in glutamate-proline metabolism, acts as a protein kinase through its γ-glutamate kinase (γ-GK) domain, which mediates the phosphorylation of the Ser62 site of c-Myc and suppresses its degradation. In turn, stabilized c-Myc directly increases the transcription of ALDH18A1 . This positive feedback loop sustains the mutual high expression of both proteins, which promotes the development of various tumors. Thonzonium bromide (TB), a small-molecule inhibitor screened from a Food and Drug Administration-approved drug library, was found to block ALDH18A1-mediated phosphorylation of c-Myc at Ser62 and attenuate tumor progression in preclinical models. Overall, these findings reveal the therapeutic potential of inhibiting the ALDH18A1 - MYC regulatory circuit in human cancers.
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高影响因子
Catalysts
·
2025
·Vol. 15
·期 5
·504
·
IF 4
Xiyuan Gao,Pengnian Shan,Weilong Shi,Feng Guo
The development of photothermal-assisted photocatalytic systems with broad-spectrum solar utilization and high charge separation efficiency remains a critical challenge for antibiotic degradation. Herein, we report novel black g-C3N4(BCN) materials synthesized via a one-step thermal copolymerization strategy using C/N precursors and tetrachlorofluorescein. After the introduction of tetrachlorofluorescein, the color of the sample changes, which gives BCN enhanced light absorption and a significant photothermal effect for poorly heating-assisted photocatalysis. The synergistic coupling of photothermal and photocatalytic processes enabled the optimal BCN-U sample to achieve exceptional degradation efficiency (89% within 120 min) for a typical antibiotic (e.g., tetracycline) under an LED lamp as the visible light source, outperforming conventional yellow g-C3N4(YCN-U) by a factor of 1.37. Mechanistic studies revealed that the photothermal effect facilitates carrier separation via thermal-driven electron excitation while accelerating reactive oxygen species (•OH and •O2−) generation. The synergistic interplay between photocatalysis and photothermal effects, which improved mass transfer, ensures robust stability, which provides new insights into designing dual-functional carbon nitride-based materials for sustainable environmental remediation.
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Scientific Reports
·
2015
·Vol. 5
·期 1
·1-6
·
IF 5.578
Xiong Xiaoqin,Luo Wei,Hu Xianluo,Chen Chaoji,Qie Long,Hou Dongfang,Huang Yunhui
A flexible membrane consisting of MoS 2 /carbon nanofibers has been fabricated by a simple electrospinning method. MoS 2 nanosheets are uniformly encapsulated in the inter-connected carbon nanofibers with diameters of ~150 nm. When evaluated as a binder-free electrode for sodium-ion batteries, the as-obtained electrode demonstrates high performances, including high reversible capacity of 381.7 mA h g −1 at 100 mA g −1 and superior rate capability (283.3, 246.5 and 186.3 mA h g −1 at 0.5, 1 and 2 A g −1 , respectively). Most importantly, the binder-free electrode made of MoS 2 and carbon nanofibers can still deliver a charge capacity of 283.9 mA h g −1 after 600 cycles at a current density of 100 m A g −1 , indicating a very promising anode for long-life SIBs.
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高影响因子
Experimental and Therapeutic Medicine
·
2022
·Vol. 24
·期 1
·1-8
·
IF 2.751
Maoshun Tang,Yi Zheng,Jianping Li,Yuanlang Hu
Venous endothelial cell apoptosis can be induced by endoplasmic reticulum (ER) stress, thus serving an important role in the formation of deep venous thrombosis. X‑box binding protein 1 (XBP1) is a protein associated with ER. The present study aimed to explore the function of XBP1/C/EBP homologous protein (CHOP) pathway in the process of endothelial cell apoptosis under hyperglycemia. Small interfering (si)RNAs targeting XBP1 and CHOP were designed to downregulate the expression of XBP1 and CHOP in human umbilical vein endothelial cell, respectively. Flow cytometry was used to determine cell apoptosis. The expression of XBP1, glucose‑regulated protein 78 (GRP78), CHOP, Puma, cleaved caspase‑3 and Cytochrome c was evaluated by western blotting. There were seven groups of cells that were used in the present study: i) Control (5.5 mM D‑glucose); ii) hypertonic (hypertonic control, 27.8 mM mannitol and 5.5 mM D‑glucose); iii) 16.7 mM D‑glucose; iv) 33.3 mM D‑glucose; v) 33.3 mM + NC (33.3 mM D‑glucose incubated with NC); vi) 33.3 mM + si‑XBP1 (33.3 mM D‑glucose incubated with siRNA against XBP1); and vii) 33.3 mM + si‑CHOP (33.3 mM D‑glucose incubated with siRNA against CHOP). Compared with the control, the apoptosis rate of human umbilical vein endothelial cells (HUVECs) increased greatly with the increase in the concentration of D‑glucose. Compared with the 33.3 mM D‑glucose group, the HUVECs incubated with 33.3 mM D‑glucose and si‑XBP1 or 33.3 mM D‑glucose and si‑CHOP demonstrated a significantly lower apoptosis rate. Compared with the control, XBP1, GRP78, CHOP, Puma, cleaved caspase‑3 and cytochrome c were significantly upregulated in the hypertonic, 16.7 mM D‑glucose, 33.3 mM D‑glucose and 33.3 mM + negative control (NC) groups. Compared with the 33.3 mM D‑glucose group, the expression levels of XBP1, GRP78, CHOP, Puma, cleaved caspase‑3 and cytochrome c in the 33.3 mM + si‑XBP1 or 33.3 mM + si‑CHOP groups significantly decreased. High dosage of glucose induced endothelial cell apoptosis by promoting the expression of apoptotic proteins by activating endoplasmic reticulum stress. XBP1/CHOP may be a potential target for the treatment of deep vein thrombosis as one of the key pathways regulating ERS by regulating apoptosis of endothelial cells.
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高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2025
·Vol. 109
·期 1
·e70416
·
IF 3.8
Junjie Shi,Sheng Li,Chenglin Kang,Futong Li,Min Chen,Shizhuo Yin,Jianzhong Li
This study presents the first systematic experimental determination of phase equilibria in the Er 2 O 3 –Al 2 O 3 –SiO 2 system at 1600°C in air, employing the high-temperature isothermal equilibration method followed by rapid drop-quenching to preserve high-temperature phase assemblages. The mineralogy and chemical compositions of the equilibrated samples were analyzed by x-ray diffraction (XRD), scanning electron microscopy (SEM), and electron probe x-ray microanalysis (EPMA). One single liquid equilibria, five two-phase equilibria (liquid–SiO 2 , liquid–Er 2 Si 2 O 7 , liquid–Er 3 Al 5 O 12 , liquid–Al 2 O 3 , and liquid–mullite) and seven three-phase equilibria (liquid–SiO 2 –Er 2 Si 2 O 7 , liquid–Er 2 Si 2 O 7 –Er 2 SiO 5 , liquid–Er 2 SiO 5 –Er 3 Al 5 O 12 , liquid–Er 3 Al 5 O 12 –Al 2 O 3 , liquid–Al 2 O 3 –mullite, Er 2 O 3 –Er 2 SiO 5 –Er 4 Al 2 O 9 , Er 3 Al 5 O 12 –Er 2 SiO 5 –Er 4 Al 2 O 9 ) were observed in the equilibrium ternary system. The 1600°C isothermal section of the Er 2 O 3 –Al 2 O 3 –SiO 2 phase diagram in air ( p O 2 = 0.21 atm) was constructed based on the present experimentally determined equilibrium phase compositions. The liquid area and the primary fields of SiO 2 , Er 2 Si 2 O 7 , Er 3 Al 5 O 12 , Al 2 O 3 , and mullite were constructed. The comparison of the present experimental results deviate significantly from the modelling by FactSage (version 8.3) using its “ FactPS ” and “ FToxid ” databases, suggesting that FactSage underestimated the stability of the liquid phase under the present experimental conductions.
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