CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Lin Deng,Zhihui Xia,Ting Peng,Zhou Shi,Haojie Zhang
Sulfadiazine (SDZ), a widely used antibiotic, poses significant environmental risks due to its persistence and potential to induce bacterial resistance. This study presents a novel FeOOH-modified iron foam (FeOOH/IF) catalyst for efficient peroxymonosulfate (PMS) activation to degrade SDZ. The catalyst was synthesized via a simple NaBH₄-induced surface modification, forming FeOOH nanoflakes with abundant oxygen vacancies. Comprehensive characterization (SEM, TEM, XRD, XPS, EPR) confirmed the successful formation of FeOOH/IF with enhanced catalytic properties. The FeOOH/IF/PMS system achieved nearly complete SDZ removal (100 %) within 20 min, exhibiting 4.7 times higher k obs value (0.18 min −1 ) than unmodified IF (0.038 min −1 ). Mechanistic studies revealed a dual radicals ( • OH and SO 4 • − ) and non-radicals ( 1 O 2 , Fe IV O, electron transfer) oxidation pathway, with non-radical processes dominating (53.12 % contribution). DFT calculations and LC-MS identified four primary degradation pathways, demonstrating effective detoxification of SDZ. Moreover, the as-synthesized exhibited excellent recyclability (over 90 % removal in the four repeated cycles) and versatility, efficiently degrading various organic pollutants (tetracycline, carbamazepine, etc.). This work provides a highly efficient, stable, and eco-friendly PMS-activating catalyst for antibiotic wastewater treatment, with insights into reaction mechanisms and practical applicability.
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ADVANCED MATERIALS
·
2024
·
IF 27.4
Lina Wang,Ruofei Du,Xiao Liang,Yongcun Zou,Xiao Zhao,Hui Chen,Xiaoxin Zou
Improving catalytic activity of surface iridium sites without compromising catalytic stability is the core task of designing more efficient electrocatalysts for oxygen evolution reaction (OER) in acid. This work presents phase transition of a bulk layered iridate Na 2 IrO 3 in acid solution at room temperature, and subsequent exfoliation to produce 2D iridium oxide nanosheets with around 4 nm thickness. The nanosheets consist of OH-terminated, honeycomb-type layers of edge-sharing IrO 6 octahedral framework with intrinsic in-plane iridium deficiency. The nanosheet material is among the most active Ir-based catalysts reported for acidic OER and gives an iridium mass activity improvement up to a factor of 16.5 over rutile IrO 2 nanoparticles. The material also exhibits good catalytic and structural stability and retains the catalytic activity for more than 1300 h. The combined experimental and theoretical results demonstrate that edge Ir sites of the layer are active centers for OER, with structural hydroxyl groups participating in the catalytic cycle of OER via a non-traditional adsorbate evolution mechanism. The existence of intrinsic in-plane iridium deficiency is the key to building a unique local environment of edge active sites that have optimal surface oxygen adsorption properties and thereby high catalytic activity.
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Advanced Energy Materials
·
2019
·Vol. 9
·期 17
·1804004
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IF 24.884
Hanyu Huo,Yue Chen,Jing Luo,Xiaofei Yang,Xiangxin Guo,Xueliang Sun
Solid polymer electrolytes as one of the promising solid-state electrolytes have received extensive attention due to their excellent flexibility. However, the issues of lithium (Li) dendrite growth still hinder their practical applications in solid-state batteries (SSBs). Herein, composite electrolytes from “ceramic-in-polymer” (CIP) to “polymer-in-ceramic” (PIC) with different sizes of garnet particles are investigated for their effectiveness in dendrite suppression. While the CIP electrolyte with 20 vol% 200 nm Li 6.4 La 3 Zr 1.4 Ta 0.6 O 12 (LLZTO) particles (CIP-200 nm) exhibits the highest ionic conductivity of 1.6 × 10 −4 S cm −1 at 30 °C and excellent flexibility, the PIC electrolyte with 80 vol% 5 µm LLZTO (PIC-5 µm) shows the highest tensile strength of 12.7 MPa. A sandwich-type composite electrolyte (SCE) with hierarchical garnet particles (a PIC-5 µm interlayer sandwiched between two CIP-200 nm thin layers) is constructed to simultaneously achieve dendrite suppression and excellent interfacial contact with Li metal. The SCE enables highly stable Li plating/stripping cycling for over 400 h at 0.2 mA cm −2 at 30 °C. The LiFePO 4 /SCE/Li cells also demonstrate excellent cycle performance at room temperature. Fabricating sandwich-type composite electrolytes with hierarchical filler designs can be an effective strategy to achieve dendrite-free SSBs with high performance and high safety at room temperature.
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Energy Storage Materials
·
2022
·
IF 20.831
Qiao Wang,Chuang Yu,Liping Li,Xiaoqing Liu,Xin Zhang,Guichen Gao,Yaowen Wang,Guangshe Li
Solid-state sodium batteries (SSSBs) display great potential in scale energy storage for their safety, cost and sustainability. However, it is a great challenge to achieve high ionic conductivity and temperature adaptability for most sodium-ion solid electrolytes. Here, we first demonstrate that Sc 3+ -doped Na 3 Zr 2 Si 2 PO 12 (NASICON) is a promising electrolyte for a wide temperature range utilizing in SSSBs from 0 to 80 °C. Optimal Na 3.4 Zr 1.6 Sc 0.4 Si 2 PO 12 shows a superior Na-ion conductivity, up to 1.77 × 10 −3 S cm −1 at room temperature, and excellent Na metal compatibility, as confirmed by a symmetrical cell test. Furthermore, the solid-state sodium battery with the configuration of Na 3 V 2 (PO 4 ) 3 /Na 3.4 Zr 1.6 Sc 0.4 Si 2 PO 12 /Na maintains a discharge capacity of 98.7 mAh g −1 at 1C after 300 cycles at room temperature. Even at 0 °C, the battery still displays a reversible capacity of 99.2 mAh g −1 at 0.1C after 100 cycles. Through the structure analysis and ex-situ and in-situ electrochemical characterizations, the reasons that dominate the excellent performance of the assembled all-solid-state sodium battery with NASICON electrolytes are initially revealed.
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MOLECULAR THERAPY
·
2025
·
IF 12
Qian Yu,Ke Jiang,Siyu Ma,Quan Zheng,Serena Tondi,Chiara Reina,Berina Šabanović,Chenlei Wen,Baiyong Shen,Alexandra Aicher,Haiyun Song,Yinxing Ma,Christopher Heeschen
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor prognosis, partly due to cancer stem cells (CSCs) that drive progression and treatment resistance. We explored the therapeutic potential of inducing cuproptosis, a copper-dependent regulated cell death, in CSC-enriched PDAC models. Using human and murine PDAC models, we evaluated elesclomol, a copper transport enhancer. Elesclomol alone had minimal effects; combined with copper chloride (CuCl 2 ), it significantly and irreversibly reduced CSC phenotypes without affecting non-transformed cells. Mechanistically, only the combination raised intracellular copper ions 2–4-fold, decreased iron–sulfur cluster proteins, and caused fatty acylated DLAT accumulation in mitochondria, triggering cuproptosis, particularly in CSCs. It also selectively inhibited copper-dependent antioxidant SOD1 in PDAC cells, impairing oxidative stress defense and sensitizing them to copper-induced death. To enhance clinical relevance, CuCl 2 was replaced with hollow mesoporous copper sulfide nanoparticles releasing copper ions. Either combined with or loaded with elesclomol, these nanoparticles similarly increased copper levels and inhibited PDAC spheroid formation. In vivo , in aggressive immunocompetent murine PDAC models, this nanoparticle-based treatment significantly improved gemcitabine response. These findings identify nanoparticle-mediated cuproptosis induction, combined with standard chemotherapy, as an innovative CSC-targeting strategy to improve PDAC outcomes, offering new hope for PDAC patients.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Ziyi Zhang,Huiqing Dong,Dongxu Zhou,Kexin Tang,Yidi Ma,Tao Han,Jianqiu Lei,Shoushuang Huang,Xiaodong Zhang,Liang Tang,Ning Liu
Photocatalytic CO 2 reduction is a promising strategy to address both environmental issues and energy crisis. Defect engineering offers great potential for improving the photocatalytic performance. Herein, we report an innovative approach to introduce defects in MIL-68(In) via electron beam irradiation for the photoreduction of CO 2 into CH 4 . The irradiated X-MIL-68(In) (X mean the irradiation dose) retained the crystal structure and morphology of pristine MIL-68(In), while generating novel organic framework defects. These defects significantly improved the CO 2 photoreduction activity, with 300-MIL-68(In) achieving the highest CH 4 rate of 87.5 μmol g −1 h −1 and a CH 4 selectivity of 74.8 %. Comprehensive ex situ and in situ characterizations, combined with DFT calculations, demonstrated that defects formation in 300-MIL-68(In) accelerated the separation and transfer of photoexcited carriers, thereby driving its superior photocatalytic performance. Furthermore, In situ DRIFTS along with DFT calculations confirmed that ⁎ COOH, ⁎ CHO and ⁎ CH 2 O were key intermediates during CO 2 reduction process. This work highlights electron beam irradiation as an effective strategy for defect engineering, offering new opportunities for tuning the performance of photocatalysts.
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INFLAMMOPHARMACOLOGY
·
2025
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IF 5.3
Xu Wenxiu,Wang Hongbo,Sun Zhenyu,Zhang Hui,Zhang Zhijun,Sun Xiangrong,Gu Jiayu,Gong Yanling
Limonene, a monoterpene naturally abundant in various Citrus fruits, is widely used as a fragrance component and dietary supplement. Ulcerative colitis (UC), a representative inflammatory bowel disease, is characterized by an arising incidence and considerable impact on human health. Although several reports have demonstrated the beneficial effects of limonene on UC, detailed mechanisms remain incompletely understood. In this study, we employed a dextran sulfate sodium (DSS)-induced UC murine model and a lipopolysaccharide (LPS)-stimulated Caco-2 cell model to explore the mechanisms of limonene on UC. The results revealed that limonene significantly decreased disease activity index (DAI) score and alleviated pathological damage in UC mice, exhibiting therapeutic potential for UC. Limonene significantly inhibited interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and malondialdehyde (MDA) while increased superoxide dismutase (SOD) in both DSS-induced UC mice and LPS-induced Caco-2 cells. Furthermore, limonene significantly increased expressions of Zonula occludens-1 (ZO-1), occludin, and claudin-1, thereby enhancing intestinal barrier integrity. Limonene mitigated UC-associated dysbiosis by shifting the gut microbial composition toward that of healthy controls. Specifically, it modulated the microbiota at the phylum, family, genus and species levels, increasing the abundance of anti-inflammatory bacteria while decreasing inflammatory related taxa. Collectively, our in vivo and in vitro results demonstrate that limonene alleviates UC involving in anti-inflammation, anti-oxidation, restoration of intestinal barrier integrity and regulation of the gut microbiota. Future studies are warranted to explore whether gut microbial metabolites contribute to the protective effects of limonene in UC. Graphical abstract
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JOURNAL OF POROUS MATERIALS
·
2025
·
IF 3.2
Qian Yi,Jiang Qingqing,Xiang Shimeng,Lu Zhenhao,Xu Xiaowen,Yang Jing,Dai Guoliang,Song Ruifeng,Jiang Ji
Separating CO 2 and N 2 from CH 4 is crucial for energy production and environmental protection. This study showed the rapid synthesis of CHA zeolites with different morphologies using an in situ growth method, without the assistance of organic structure directing agents (OSDA) or fluoride media. The crystallization behavior of CHA zeolites was studied in terms of synthesis gel composition (including water content, silicon and aluminum content, alkalinity and Sr 2+ concentration), synthesis temperature and duration. The results suggested that pure phase CHA zeolite nano-aggregates could be synthesized with broad precursor conditions at 150 °C for only 4 h. Then, K-CHA zeolite was ion-exchanged to Na-CHA and Ca-CHA and the adsorption properties of CHA zeolites with different morphologies and ions were studied. The results suggested that Na-CHA exhibited highest CH 4 , CO 2 and N 2 adsorption capacity and showed higher ideal selectivity for N 2 /H 2 ; Although Ca-CHA zeolites exhibited relative lower CO 2 and CH 4 adsorption capacity, it exhibited the highest ideal selectivity for CO 2 /CH 4 ; Simultaneously, K-CHA zeolite exhibited high CH 4 adsorption capacity and high adsorption separation ability of CH 4 /N 2 . Furthermore, breakthrough experiments have confirmed the practical feasibility of separating CO 2 from CH 4 .
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ADVANCED FUNCTIONAL MATERIALS
·
2025
·Vol. 35
·期 36
·2424114
·
IF 19
Song He,Wenkang Zhong,Mufan Zhu,Shuaidi Wu,Wenju Xie,Zhiyong Ouyang,Baochang Cheng,Jie Zhao
Although memristor-based in-memory computing (IMC) prototypes demonstrate great progress and performance, integrating high flexibility and programmability into large-scale, high-density crossbar arrays remain a major hurdle for advanced computing systems. Herein, the execution of 12 distinct algorithms is successfully implemented in a single halide perovskite based IMC, leading to the construction of a halide perovskite memory with reconfigurable logic operation capabilities. Moreover, the device exhibits robust anti-crosstalk performance, paving the way for its potential application in crossbar integrated arrays. The work differs from common resistive switching, which needs electro-forming to shift from high-resistance state (HRS) to low-resistance state (LRS). Instead, it begins with LRS driven by ionic conduction, and the switching is controlled by reversible barriers due to ion migration and accumulation, enabling voltage magnitude and polarity to independently regulate various resistive behaviors. Additionally, mappings between environmental parameters and behavioral patterns are systematically established, providing an approach for adapting reconfigurable computing architectures to evolving conditions. This 1R-IMC device provides self-rectification and multiple reconfigurable functions, vital for flexible, programmable high-density crossbar arrays in advanced computing.
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ADVANCED FUNCTIONAL MATERIALS
·
2021
·Vol. 31
·期 30
·2102827
·
IF 18.808
Bo Wang,Jianping Yan,Yufei Zhang,Minghui Ye,Yang Yang,Cheng Chao Li
Aqueous zinc-ion batteries (ZIBs) have attracted significant attention due to their intrinsic safety, cost-effectiveness, and environmental friendliness. However, the common zinc metal anode suffers from zinc dendrite formation, self-corrosion, and surface passivation, which impede the further application of aqueous ZIBs. Herein, carbon-inserted molybdenum dioxide (MoO 2 ) materials with laminated structure are designed as novel intercalation-type anodes for ZIBs by combination of interlayer engineering and in situ carbonization of aniline guest in molybdenum trioxide interlayers. The uniform dispersion of carbon layers in laminated MoO 2 not only provide fast transportation paths for electron but also strengthen the framework of MoO 2 , leading to high structural integration during high-rate cycling. Benefiting from the unique structural design, the carbon-inserted MoO 2 electrode exhibits high initial Coulombic efficiency, excellent cycling stability, and outstanding rate capability. Multiple ex situ characterizations reveal its excellent electrochemical stability is derived from reversible intercalation mechanism and ultrastable structural framework. Furthermore, the rocking-chair zinc-ion full battery assembled with the zinc pre-intercalated Na 3 V 2 (PO 4 ) 2 O 2 F cathode presents excellent stability and ultralong lifespan with a high capacity retention of 91% over 8000 cycles.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Qi Zhang,Xue Zou,Wei Xu,Yueting Ding,Jie Jin,Yulan Song,Ziyi Wang,Huihui Wang,Zhou Liu,Qiangling Zhang,Xun Bao,Qu Liang,Chaoqun Huang,Chengyin Shen,Yannan Chu
The speed of bacterial identification is crucial for the treatment efficiency of patients with infections. However, the clinical method typically requires more than 24 h to obtain identification results. Recent studies have revealed that bacteria can emit or absorb characteristic volatile organic compounds (VOCs) in the early stage of cultivation. Based on this discovery, our study tried to develop a rapid identification method using these bacteria-derived VOCs. The studied subjects are five common urinary tract infection (UTI) bacteria: Klebsiella pneumoniae ( Kpn ), Escherichia coli ( Eco ), Pseudomonas aeruginosa ( Pae ), Enterococcus faecalis ( Efs ) and Enterococcus faecium ( Efm ). Within six hours of cultivation, characteristic VOCs specific to these bacteria emerged and were detected by a proton transfer reaction mass spectrometry (PTR-MS). Using a hierarchical classification tree method, we constructed several discriminant models based on different combinations of these VOCs, all achieving 100 % accuracy. To validate the clinical applicability of this method, we collected and analyzed 119 actual urine samples. A classification model utilizing VOCs with m/z values of 63, 65, and 71 achieved 95.0 % accuracy. These three VOCs were identified as dimethyl sulfide, ethanol, and 3-methyl-1-butanol, respectively, using gas chromatography-proton transfer reaction mass spectrometry (GC-PTR-MS). Our results demonstrate that this novel method can rapidly and accurately identify UTI bacteria, requiring only one-fourth of the time compared to clinical method. This method has the potential to help promptly formulate antibiotic treatment plans, which could shorten the treatment process and enhance therapeutic effects.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2025
·
IF 4.6
Shuqin Chen,Miaowei Jiang,Hangbiao Wei,Fangkun Yang,Kai Wang,Li Li,Jinhui Shang
Copper ions (Cu 2+ ) play a critical role in physiological and pathological processes, including diabetes. However, detecting Cu 2+ with high sensitivity and specificity in diabetes remains challenging. In this study, we developed a hemicyanine-based copper ion probe (CUP) encapsulated in mPEG-DSPE nanoparticles (CUNP) for dual-modality fluorescence and photoacoustic (PA) imaging of Cu 2+ . CUNP exhibited excellent aqueous solubility, biocompatibility, and a turn-on response to Cu 2+ , with activate signals. In vivo studies in streptozotocin (STZ)-induced diabetic mice revealed elevated hepatic Cu 2+ levels, which were attenuated by metformin treatment, as confirmed by PA and fluorescence imaging. Urine analysis further revealed elevated Cu 2+ in diabetic patients. These findings highlight CUNP as a promising tool for non-invasive Cu 2+ monitoring in diabetes, with potential clinical applications in disease diagnosis and therapeutic evaluation.
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