RENEWABLE ENERGY
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2024
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IF 9
Xiangjun Guo,Yun Huang,Yunheng Tang,Ao Xia,Xianqing Zhu,Xun Zhu,Qiang Liao
Mixed bacterial syngas fermentation is a promising carbon-neutral method for producing acetic acid and ethanol. However, the bacterial community and metabolic pathways were different in the growth and ethanol production stages, whereas the activity of the bacterial community greatly depended on the pH of the culture. In this study, the effect of pH on syngas fermentation performance and microbial community composition under continuous gas supply was investigated. The mixed bacteria grew fastest at a pH of 7, while a constant pH of 6 led to the highest ethanol concentration of 5.15 g L −1 , which was 160 % higher than that at pH 7. Based on this, a two-step pH regulation method was proposed in this study to improve the ethanol production. Initially, the culture pH was maintained at 7 to create optimal growth conditions. Once bacterial density stabilized, it was then changed to a pH 6 to promote ethanol production. By doing this, compared with the control group, the maximum ethanol concentration (5.85 g L −1 ) increased by 148.9 %, the ethanol production rate (2.41 g L −1 d −1 ) increased by more than 8 times. This two-step pH regulation method ensured a high bacterial density and effectively stimulated ethanol production during syngas fermentation.
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高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2019
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IF 2.931
Kangming Xiong,Caixia Yin,Yongkang Yue,Fangjun Huo
The intracellular pH has a significant effect on several essential biological processes such as material transfer, enzymatic action, cell apoptosis et al. Thus, it is necessary to monitor pH fluctuation in living cells. Here, we designed a near-infrared ratiometric fluorescence probe for pH detection. The spectroscopic responses of probe to pH variations were investigated in CH 3 OH/PBS (v/v, 1:1) mixed solution at different pH values. The experimental results showed that the probe is sensitive to acidity, and the p K a of probe is calculated to be 4.85. When the pH was decreased from 9.0 to 1.0, the color of probe solution change from purple to yellow was found by naked eye. Moreover, the probe can be a practical tool for assessing cellular pH by cell imaging.
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
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IF 13.3
Yipeng Pang,Maofang Zhao,Yuhan Xie,Yanping Wang,Yuxin You,Yongding Ke,Chaoyi Zhang,Xiaohan Chen,Yijia Yang,Chunlei Zhang,Xi Chen,Yi Liu,Xingtang Fang
The development of non-antibiotic strategies for combating bacterial infections, particularly through reactive oxygen species (ROS) accumulation accompanying inflammation, has attracted much attention. Despite Allicin (Ac) emerges as a promising antimicrobial agent with wide and remarkable bioactivity, it still displays quite limited ROS scavenging and anti-inflammation capacity due to uncontrolled and poor bioavailability. Herein, a multifunctional nanoplatform with pH-dependent and ROS-scavenging antibacterial, anti-inflammatory and proangiogenic properties is introduced to promote infected wound healing by integrating Ac into silver nanoparticles (AgNPs)-loaded zeolite imidazole framework (ZIF-8), namely Ac@ZIF-8/AgNPs. Primarily, the nanoplatform is activated and controlled release in the infection microenvironment, with disrupting biofilms, scavenging ROS and antibacterial capacitys, outperforming conventional Ac. Moreover, in the mouse models induced by bacterial infection, Ac@ZIF-8/AgNPs can alleviate the inflammatory condition, scavenge ROS, facilitate the regeneration of collagen fiber and enhance vascular formation, collectively accelerating wound healing. Overall, this biocompatible nanoplatform is provided as a reliable approach to solve the long-standing problem of infected wound healing.
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高影响因子
PROGRESS IN ORGANIC COATINGS
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2025
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IF 7.3
Wenyan Zhou,Tong Wang,Yanan Pu,Lin Cao,Wen Li,Jiaxin Huang,Huimeng Feng,Shougang Chen
The research on intelligent corrosion inhibition and repair protective coatings is currently underway, with a particular focus on the intricate microstructure failure process of these coatings due to the inherent complexity of their fillers (functionality, interfacial compatibility, etc.). Herein, we developed corrosion inhibition nanocontainers with enhanced photothermal and pH-responsive properties. The incorporation of chitosan facilitated the acidic environment responsiveness of the nanocontainers, while MoS 2 nanocontainers enabled light-triggered release. The electrochemical results show that after 60 days, the impedance modulus of epoxy coating with 1 % nanocontainers is 4.35 × 10 8 Ω·cm 2 , while that of pure epoxy coating is 2.09 × 10 6 Ω·cm 2 . And it can achieve 300 h of salt spray resistance. In addition, the mechanical properties show that the adhesion and tensile properties of the coating are improved, and the saturated water absorption of the coating is decreased. In addition, the evolution of its electrochemical structure was comprehensively studied using relaxation time analysis. The research results indicate that the coating exhibits multiple electrochemical processes, and the controlled release and formation of a protective layer effectively hinder the formation of corrosion products and reduce internal electrochemical reactions. This study provides a potential method for studying the structural evolution of composite coatings.
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高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
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2025
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IF 4
Zhang Li,Li Xin-Rui,Xiao Xia-Hui,Zhou Li-Dan,Zhu Yu-Wei,Chen Jia-Yu,Jiang Hang,Han Jie,Liu Wei,Ngai To
In this study, a pair of dicarboxylic acids as cis-trans isomerism—citraconic acid (CA) and mesaconic acid (MA), was incorporated into polymeric networks of poly( N -isopropylacrylamide) (PNIPAM)-based core-shell microgels via semi-batch precipitation polymerization. We demonstrated that the pH-temperature dual responsiveness of the core-shell microgels is highly correlated with the structure and position of the acid isomers. Both the cis-trans molecular structure and the crosslinking position of the dicarboxylic acids significantly influenced the hydration capacity and surface charge density of the core-shell microgels. These diverse properties first influenced the swelling behavior, further affecting the interfacial behavior of the microgels, including the oil-water dynamic interfacial tension and air-water compression isotherms. Furthermore, the rheological behavior of the microgel suspensions also displayed distinct dependences on the frequency and temperature, illustrating that the cis-trans molecular structure and crosslinked position of the dicarboxylic acids also significantly influenced the interparticle clustering in the bulk solution. Our results suggest that the pH sensitivity of the cis-trans dicarboxylic acid isomer affects the ionization and surface charge distribution of the core or shell layers of individual microgels, which further determines the interparticle interaction and cooperative rearrangement at interfaces and in the bulk.
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高影响因子
Advanced Science
·
2025
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IF 14.1
Lei Lei,Wenbin Dai,Jinchao Zhao,Angfeng Jiang,Haisheng Peng,Qiao Jin,Xiaojing Li,Zhe Tang
Photodynamic therapy (PDT) is a promising cancer therapy modality by generating reactive oxygen species (ROS) and triggering immunogenic cell death. However, the therapeutic effect of PDT is strongly limited by tumor hypoxia and immunosuppressive landscape. Herein, a pH-sensitive nanosized covalent–organic polymer (COP), composed of the photosensitizer porphyrin and pyruvate kinase inhibitor vitamin K3 (VK3), is designed to overcome these issues. The signal transducer and activator of transcription 3 (STAT3) inhibitor WP1066 is further encapsulated into COPs to form a WP1066-loaded COP (TVW). As an inhibitor of pyruvate kinase, VK3 can reduce intracellular oxygen consumption by inhibiting the glycolytic pathway, leading to the alleviation of the tumor hypoxic microenvironment. The relief of tumor hypoxia by VK3 enhances photodynamic cytotoxicity by generating more ROS. Meanwhile, STAT3 acts as a major regulator of PD-L1, a key inhibitor that promotes immune escape. WP1066 effectively inhibits the expression of STAT3 and reduces PD-L1 expression, thereby significantly inhibiting tumor immune escape and enhancing antitumor efficacy in a synergistic manner. The antitumor capacity of photodynamic immunotherapy is extensively investigated in a murine subcutaneous hepatocellular carcinoma model. This photo-immunotherapy may provide an effective combination regimen for the efficient treatment of solid tumors such as hepatocellular carcinoma.
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Rimei Chen,Yonghui He,Lingli Tian,Yu Meng,Zhiping Chen,Nianfang Ma,Chunfang Wang,Hui He
Implementing differentiated photothermal temperatures in the infected area of the wound and adjacent normal tissue areas can achieve photothermal antibacterial effects while protecting adjacent healthy tissues from potential overheating damage associated with photothermal therapy. Here, a specific pH-induced photothermal temperature self-enhancing cellulose hydrogel was tailored using photothermal-responsive cellulose nanocrystals modified with polyaniline and pH-responsive cellulose nanocrystals loaded with taurine as the staggered network skeletons. The hydrogel possesses exceptional in-situ adaptability and tissue adhesion characteristics, enabling it to adhere to the irregular wound bed. Interestingly, polyaniline on cellulose nanocrystals can be converted from the form of adamantane base to the form of adamantane salt under acidic conditions, exhibiting enhanced photothermal effects. Consequently, the specific acidic microenvironment (pH 5.5–6.8) of infected wounds can elevate the photothermal temperature of hydrogel to 45–48 °C, significantly higher than that (42 °C) of adjacent healthy tissue with pH values of 6.8–7.4. Similarly, taurine grafted onto cellulose nanocrystals via dynamic imine bonding gets gradually released from the hydrogel into infected wounds under specific acidic conditions, thus providing an anti-inflammatory effect. This differential temperature regulation on the infected wound achieves effective photothermal antibacterial treatment while preventing overheating damage to normal tissue.
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高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2025
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IF 4.9
Ahmed M. Omer,Eman M. Abd El-Monaem,Heba S. Hassan,Mahmoud A. Elmeligy,Angela Kleinová,Abdelazeem S. Eltaweil,Abolfazl Heydari
pH-sensitive carriers have emerged as an optimal choice for the oral administration of anticancer drugs, exhibiting the desired release performance. This study aims to develop biocomposite beads for the sustained release of the anticancer drug 5-fluorouracil (5-FU). Here, 5-FU was encapsulated within a ZIF-8 metal-organic framework (MOF), which was subsequently impregnated into amino-chitosan beads. The resulting Am-CS@ZIF-8 biocomposite beads were characterized for their chemical structure, surface morphology, elemental composition, crystallinity, surface charges, and mechanical properties utilizing Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), zeta potential analysis, and a texture analyzer, respectively. The developed beads exhibited a textured surface, denser composition, and a positively charged surface with a maximum zeta potential of +12.4 at pH 7.4. In comparison to Am-CS beads, the Am-CS@ZIF-8 biocomposite beads demonstrated superior mechanical properties, achieving a maximum stress value of 5.668 MPa compared to the 1.874 MPa recorded for pure Am-CS beads. pH sensitivity was assessed through the investigation of water uptake behavior at pH 1.2 and pH 7.4. The Am-CS@ZIF-8 biocomposite beads demonstrated a high encapsulation efficiency of approximately 81.6 % for 5-FU. They exhibited pH-responsive release behavior, with only 17 % of the drug released at pH 1.2 after 2 h and a sustained release of 52 % at pH 7.4 over 24 h. The release mechanism was predominantly governed by Fickian diffusion, as closely fitted by the Peppas-Sahlin kinetic model. The formulated carrier confirmed its biodegradability under enzymatic physiological conditions, suggesting its potential applicability as an effective system for the oral delivery of anticancer drugs.
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高影响因子
MATERIALS CHEMISTRY AND PHYSICS
·
2025
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IF 4.7
Muhammad Umar Farooq,Rustem R. Zairov
A smart drug delivery system (DDs) based on PEGylated (polyethylene glycol) gold/zinc oxide (PEG-Au/ZnO) loaded with doxorubicin (DOX) and chlorine-e6 (Ce6) was successfully synthesized, characterized, and evaluated against breast malignancy. With and without laser exposure, the DOX-PEG-Au/ZnO–Ce6 nanoprobe bypassed the internal barriers and exhibited much higher synergistic therapeutic activity than Ce6 and DOX alone. The controlled release kinetics of DOX in combination with Ce6 could inhibit tumor growth and remarkably enhance the sensitivity of chemotherapy. Apart from the chemotherapeutic effect, the residual PEG-Au/ZnO could amplify the reactive oxygen species (ROS) generation through cascade reactions, which will benefit the release of free zinc ions in the lysosome of inflammatory cells. Taken together, the as-prepared DOX-PEG-Au/ZnO–Ce6 nanoprobe is expected to facilitate the management of chemo-photodynamic combination therapy as Trojan horses to eliminate cancer and improve the quality of life for the patient by reducing acute toxic side effects.
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高影响因子
Materials Today Communications
·
2025
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IF 4.5
Wenqiang Zhang,Hongjie Guo,Xiang Zhang,Hongliang Li
Wound infection remains a significant challenge in clinical medicine, impeding the healing process of wounds. Conventional therapeutic approaches, including antibiotics, surgical debridement, and conventional dressings, are often limited by issues such as antibiotic resistance, secondary tissue damage, and insufficient biocompatibility. Existing wound dressings exhibit poor mechanical properties and possess only single therapeutic functions, lacking the ability to effectively monitor wound healing status. To address these limitations, this study have developed a novel hydrogel dressing. This dressing utilizes microfibrillated cellulose (MFC) to stably encapsulate liquid metal (Ga) droplets, which also serve as a photothermal filler for the hydrogel. The addition of MXene stabilizes the colloidal system, and the resulting hydrogel is integrated with a pH-sensitive optical fiber to form a pH-sensitive optical fiber/ PMGa hydrogel. This composite hydrogel exhibits excellent mechanical properties (400 % elongation at break), antimicrobial activity, and pH sensitivity. Moreover, the hydrogel's tissue adhesion and stretchability enable it to conform to various skin surfaces and accommodate skin movement and stretching. The pH-sensitive optical fiber/PMGa hydrogel not only monitors the pH value of the wound through different light transmittance to judge the state of the wound environment， but also effectively inhibits bacterial growth through its photothermal effect. It provides an optimal temperature and humidity environment to promote cell proliferation and granulation tissue formation, thereby facilitating photothermal therapy. In summary, this work presents a novel hydrogel dressing that integrates monitoring and therapeutic functions. This comprehensive solution offers a new platform for the development of wound infection treatment materials.
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高影响因子
LANGMUIR
·
2025
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IF 3.9
Jun Zhang,Chao Hou,He Yu,Md All Amin Newton,Binjie Xin,Tingxiao Li
To address persistent challenges in wound care, including exudate management, infection prevention, and healing monitoring, this study developed a multifunctional fiber dressing using electrospinning technology. The system integrates a patterned hydrophobic polylactic acid/zinc oxide (PLA/ZnO) inner layer providing antimicrobial protection and exudate drainage; a polyacrylonitrile/polydopamine (PAN/PDA) intermediate water transport layer enabling unidirectional exudate transfer; and an outer PAN-based functional membrane incorporating sodium polyacrylate (SPA), phenol red (PSP), and tetracycline hydrochloride (TCH) for controlled drug release and visual wound status monitoring. The comprehensive evaluation revealed exceptional performance: rapid exudate removal within 3.35 s, 96 h sustained antibacterial drug release (68.6% cumulative release), pH-responsive chromatic transition (yellow-to-red at pH 5–9), and significant antimicrobial efficacy against Escherichia coli and Staphylococcus aureus (inhibition zone diameters of 10 and 18 mm, respectively). The dressing exhibited a balance of mechanical strength (6.1 MPa tensile strength) and breathability (13.4 mm/s air permeability rate). By integrating three core functions─efficient exudate management, antimicrobial regulation, and intelligent healing monitoring─this multifunctional architecture demonstrates clinical applicability in postoperative care and chronic wound therapy.
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PubMed
高影响因子
INORGANIC CHEMISTRY COMMUNICATIONS
·
2025
·
IF 5.4
Xiaokai Feng,Jing Zhao,Mingzhu Xie,Yangyang Guo,Haojin Xu,Yinglu Li,Fei Liang,Kaijin Hu
ZIF-8 NMOFs have been widely utilized in the field of nano-drug delivery system, due to the highly ordered porous structure, large specific surface area, and pH responsiveness. In this study, ZIF-8 NMOF was synthesized using 2-methylimidazole (H-MIM) as the ligand and zinc nitrate hexahydrate as the metal salt. Utilizing 5-fluorouracil (5-FU) as a drug model, mussel biomimetic chitosan (Cat-CS) modified NMOFs was constructed as a drug carrier through surface modification. The particle size, structure and morphology were characterized using DLS, SEM, XRD, FT-IR and TG, and the pH-responsive property of the NMOFs was investigated. The results showed that the average particle size of the NMOFs was 186.75 nm, and the drug loading capacity and encapsulation efficiency were 9.02 % and 64.79 %, respectively. In vitro controlled release studies showed that the sustained and controlled drug release can be achieved after surface modification, with maximum cumulative release rates of 63.80 %, 43.81 %, and 34.88 % at pH 1.4, 4.0 and 7.4, significantly increasing drug release under acidic conditions and demonstrating excellent pH responsiveness. In all, the prepared NMOFs exhibit excellent stability, pH-responsiveness and biocompatibility, further prolonging drug release time and improving bioavailability, which can be used as an ideal drug carrier to enhance the efficient drug delivery.
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高影响因子
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