JOURNAL OF MATERIALS RESEARCH
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2026
·
IF 2.9
Jia Changlong,Fu Jieni,Zhao Jin,Yuan Xubo
Bacterial infection of biomedical devices presents a significant challenge in modern clinical medicine. Therefore, manufacturing surfaces with antibacterial and anti-adhesion properties is crucial to reduce the risk of infection. In this study, we created a copper-zinc antibacterial coating on stainless steel by electrochemical deposition. A superhydrophobic coating made of Cu 5 Zn 8 with a micro-nano structure was formed on the steel surface. The coating exhibits a water contact angle of 154°, effectively reducing bacterial adhesion by over 99%. The ions and reactive oxygen species released from the coating can kill more than 99% of bacteria and provide a static antibacterial effect lasting over 24 h. Additionally, the coating exhibits notable antibacterial and photothermal properties under near-infrared light irradiation, reaching temperatures of 60 °C within 2 min. This work successfully constructs a copper-zinc antibacterial coating with anti-adhesion, antibacterial, and NIR-responsive photothermal antibacterial properties, providing a dynamic and static combined antibacterial strategy for medical device surfaces. Graphical abstract
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2026
·
IF 4.1
Chen Hongze,Wan Yuebing,Li Kangcong,Li Xiuqin,Li Xiaomin,Chu Hongtao,Zhang Qinghe
Organophosphorus flame retardants (OPFRs) are widespread environmental contaminants with bioaccumulative potential and associated human health risks. The lack of commercial reference standards for many OPFRs limits the accuracy of their quantification. In this study, a compound-independent calibration (CIC) method using gas chromatography-inductively coupled plasma mass spectrometry (GC-ICP-MS) was developed for the simultaneous quantification of seven alkyl OPFRs, with tripropyl phosphate (TnPP) as a single universal calibrant. Key parameters were optimized: a DB-5MS column (15 m × 0.25 mm × 0.10 μm) with pulsed splitless injection (70 psi, 280 °C), and ICP-MS settings including an RF power of 1600 W, sampling depth of 7.5 mm, dilution gas flow rate of 0.5 mL/min, and octopole voltage of − 5 V. The method exhibited excellent linearity ( R 2 = 0.9994 to 0.9999) over the range of 0.01–1.0 μg/mL. Limits of detection and quantification were 0.22 to 0.91 ng/mL and 0.75 to 3.02 ng/mL, respectively. For six of the seven OPFRs (excluding TEHP), the relative P response ratios compared to TnPP ranged from 0.91 to 1.01, confirming effective structure-independent calibration. The matrix effect in rice was moderate (enhancement factors 1.13–1.35). Quantitative results obtained by the CIC method agreed well with those from an external standard approach, with relative deviations within −8.54% to +7.78%. This work demonstrates that CIC-GC-ICP-MS using a single, readily available calibrant provides a reliable, practical solution for quantifying alkyl OPFRs in complex food matrices, effectively overcoming the challenge posed by the scarcity of compound-specific reference standards. Graphical
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Cell Death & Disease
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2026
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IF 12.2
Qiu Quanpeng,Ding Yi,Han Jing,Guo Xiaolong,Zhang Jiaqi,Chen Yue,Xue Xinzhu,Hu Xiake,Yu Tianyu,Liu Gaixia,Zhang Haowei,Li Qixin,Li Xiang,She Junjun,Chen Yinnan
The malignant transition of colorectal cancer (CRC) is caused by the combined action of epigenetic dysregulation and genomic instability. It is well known that EZH2-directed H3K27me3 modification is one of the main contributors to tumorigenesis; however, how it affects the DNA mismatch repair (MMR) system and the genesis of extrachromosomal circular DNA (eccDNA) remains unknown. Here, we demonstrate that EZH2 epigenetically represses critical MMR genes, which results in genomic instability and abnormal eccDNA accumulation, ultimately accelerating CRC progression. On the molecular level, the H3K27me3 mark catalyzed by EZH2 is the main cause of the downregulation of MMR genes, which affects the stability of the genome and leads to an increase in eccDNA that makes the tumor more aggressive. Our study reveals an unprecedented role of EZH2 in controlling chromosomal instability and eccDNA production through the MMR pathway and offers a conceptual framework for the development of CRC-targeted epigenetic therapies.
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Stem Cell Research & Therapy
·
2026
·Vol. 17
·期 1
·200
·
IF 7.8
Chen Qi,Chen Xiaolong,Yang Qu,Miao Xinxin,Yuan Jinghong,Ding Shuihua,Ding Rui,Cai Shenghao,Li Bin,Cheng Xigao
Background Intervertebral disc degeneration (IVDD) is characterized by progressive nucleus pulposus cell loss and extracellular matrix degradation, in which persistent oxidative stress plays a critical pathogenic role. Transplantation of nucleus pulposus–derived stem cells (NPSCs) is a promising therapeutic strategy, yet the hostile oxidative microenvironment severely compromises cell survival. Although cellular quiescence has been suggested to enhance stress tolerance, its regulatory mechanisms and relevance in NPSCs remain largely unexplored. Methods Oxidative stress was evaluated in human degenerated disc tissues, a rat needle-puncture degeneration model, and tert-butyl hydroperoxide–treated NPSCs in vitro. Proliferating and quiescent NPSCs were compared for reactive oxygen species (ROS) levels, apoptosis, viability, and transcriptomic profiles. Pathway enrichment analyses were performed to identify critical signaling mechanisms. Recombinant transforming growth factor-beta 3 (rhTGF-β3) was used to activate the pathway, while small interfering RNA targeting the transforming growth factor-beta receptor type 2 ( Tgfbr2 ) and the pharmacological inhibitor SB431542 were applied for pathway suppression. Functional assays, organ culture, and in vivo transplantation were conducted to assess cell survival and regenerative effects. Results Elevated oxidative stress was consistently observed across clinical, animal, and cellular models of disc degeneration. Quiescent NPSCs demonstrated enhanced resistance to oxidative injury, with reduced ROS accumulation, decreased apoptosis, and improved survival. Transcriptomic analyses revealed suppression of metabolic and P53-mediated apoptotic pathways, alongside marked activation of TGF-β/SMAD signaling. Activation of this pathway induced quiescence, reduced ROS levels, inhibited mitochondrial apoptotic signaling, and protected NPSCs from oxidative injury, whereas pathway inhibition abolished these protective effects. In both organ culture and in vivo transplantation models, quiescent and TGF-β–activated NPSCs exhibited superior survival and significantly improved disc structural preservation compared with proliferating or pathway-blocked cells. Conclusion Activation of the TGF-β/SMAD pathway induces NPSC quiescence and enhances oxidative stress tolerance by suppressing P53-dependent mitochondrial apoptosis. Pharmacological induction of quiescence represents a potential strategy to improve stem cell–based therapies for intervertebral disc degeneration.
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APOPTOSIS
·
2026
·Vol. 31
·期 6
·158
·
IF 9
Zhen Shuman,Gao Yifan,Wang Jiaqi,Ren Jingyi,Pei Huanting,Yin Danjing,Deng Yandong
Acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) remains a major clinical challenge in non-small cell lung cancer. Emerging evidence indicates that metabolic reprogramming and epigenetic alterations contribute to drug resistance, particularly through the evasion of ferroptosis, a regulated form of cell death characterised by lipid peroxidation. This study investigated the role of lactate-associated histone modifications in driving EGFR-TKI resistance. Resistant lung adenocarcinoma tissues and cell lines were analysed using transcriptomics, Cleavage Under Targets and Tagmentation (CUT&Tag) profiling, and biochemical assays. Glycolytic activity, lactate accumulation, and ferroptosis-related lipid peroxidation were assessed, followed by genetic and pharmacological interventions and in vivo xenograft validation. Resistant cells exhibited enhanced glycolysis and lactate accumulation, with pathway analyses highlighting ferroptosis evasion as a key resistance-associated process. Consequently, histone H4 lysine 8 lactylation (H4K8la) was significantly elevated in resistant tissues and cells. Mechanistically, H4K8la was enriched at transcription start sites, particularly at the promoter of aldo-keto reductase family 1 member C1 (AKR1C1). This epigenetic modification profoundly suppressed ferroptosis and promoted drug resistance. Disrupting this H4K8la-AKR1C1 defence axis restored lipid peroxidation, increased ferroptotic sensitivity, and resensitised resistant cells to EGFR-TKIs, as confirmed in vivo. These findings reveal a novel lactate-driven epigenetic mechanism that orchestrates ferroptosis escape and EGFR-TKI resistance, offering a promising therapeutic strategy to overcome treatment failure.
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ARCHIVES OF TOXICOLOGY
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2026
·
IF 10.9
Huang Fang-Fang,Luo Ying,Chen Hao,Meng Yu-Huan,Li Wei,Liang Hong,Ai Chun-Zhi
Pregnane X receptor (PXR), a nuclear receptor superfamily member, maintains bile acid homeostasis by regulating metabolic enzymes [e.g., cytochrome P450 3A4 (CYP3A4), uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1)] and multidrug resistance protein 1 transporter, and alleviates liver/intestinal inflammation via inhibiting the nuclear factor kappa-B pathway, serving as a critical therapeutic target for cholestatic liver diseases and inflammatory bowel disease. In this study, we established a novel structure-based machine learning strategy to identify PXR agonists from a natural product database. With generated bioactive conformations binding with PXR, we integrated ligand-based and structure-based features to construct a comprehensive machine learning model using light gradient boosting machine. This model illustrated an R 2 of 0.874 for the internal validation set and an R 2 of 0.845 for the external test set, superior to the performance of other machine learning models, e.g. random forest regression, support vector regression, gradient boosting regression, K-nearest neighbors, and extreme gradient boosting. The model was used to predict the PXR agonistic activity of the candidate molecules screened out by the pharmacophore model. Promising candidates were selected out for further assay with HepG2 cell culture combined with a dual-luciferase reporter. Ultimately, natural products like schisantherin A, rhynchophylline, and irigenin were identified as potent PXR agonists, with half-maximal effective concentrations (EC 50 ) of 1.58 μM, 2.57 μM, and 20.67 μM, respectively. These PXR agonists act as potential candidates for targeted therapies against PXR-related diseases. We anticipate that this work will provide support for the design and discovery of PXR modulators.
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Nature Communications
·
2026
·
IF 18.1
Deng Canbin,Xie Yizhan,Tang Jiayue,Lu Xibin,Li Yiqing,Weng Lu-Tao,Li Biao,Li Kaikai,Huang Jiaqiang
Electrochemical reactions are generally accompanied by mechanical evolutions, which, in turn, play a critical role in the performance of the electrochemical system. In aqueous Zn||MnO 2 batteries, the intrinsically structural instability of MnO 2 and rampant side reactions create considerable strain/stress changes in operation. However, the electrochemistry-mechanics-performance relationship of the Zn||MnO 2 cell is still missing. Herein, we decode the electrochemomechanical interplay of Zn||β-MnO 2 pouch cells with different electrolytes via optical fiber sensors. The operando stress monitoring provides proof of the prevailing proton intercalation and Mn dissolution/deposition mechanisms in the system, where the basic zinc salts play a dominant role in stress evolution. Additionally, the non-monotonic stress variation during discharge implies Zn-compensated reaction. For cycling ageing, a negative correlation is found between early stress amplitudes and capacity retention in long cycles. For calendar ageing, greater stress variation during open-circuit ageing is linked with more severe self-discharge. Altogether, this work provides a deep understanding of the electrochemistry-mechanics-performance correlation in aqueous Zn||MnO 2 batteries, offering additional tools for electrolyte screening and battery design.
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Nano-Micro Letters
·
2026
·Vol. 18
·期 1
·197
·
IF 36.3
Ma Yuqiang,Li Meng,Zhang Dandan,Wang Cihang,Li Yu,Zhao Zihang,Mu Xiaogang,Hu Jun,Hu Xiang,Li Jiachen,Ma Haixia,Wen Zhenhai
Replacing anodic oxygen evolution reaction with 3,5-diamino-1,2,4-triazole oxidative coupling enables ultra-low-voltage (0.96 V @10 mA cm − 2 ) dual-electrode H 2 production and simultaneous synthesis of energetic 5,5′-diamino-3,3′-azido-1H-1,2,4-triazole (DAAT), achieving 35.8% energy savings.
A Pt single-atom/nanoparticle hybrid on NiS 2 nanosheets (Pt s,n @NiS 2 @CC) exhibits exceptional alkaline hydrogen evolution reaction performance and stability via optimized H* adsorption.
Anodic DAAT formation proceeds via an OH*-mediated N–N coupling pathway, enabling stable (> 300 h @500 mA cm − 2 ), industrial-scale bipolar H 2 production coupled with green DAAT synthesis in an anion-exchange membrane water electrolyzer.
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EUROPEAN FOOD RESEARCH AND TECHNOLOGY
·
2026
·Vol. 252
·期 2
·50
·
IF 3.2
Zhang Wen,Zhu Yongqiang,Jin Zhiqiang,Sun Yao,Meng Yan,Cao Fuliang,Su Erzheng
Fresh Ginkgo biloba seed kernels are nutritious but contain toxic ginkgotoxin (MPN) and its 5′-glucoside (MPNG), limiting their safe consumption. Existing detoxification methods mostly target powdered/homogenized kernels, which are unsuitable for whole-kernel food products. In this study, ultrasound-assisted, microwave-assisted, and static water bath methods were compared and evaluated for the removal of MPN and MPNG from fresh whole Ginkgo biloba seed kernels. Among the three methods, the static water bath method exhibited higher detoxification efficiency (i.e., higher removal rates of MPNG, MPN, and TMPN (the sum of MPN and MPNG)) while better maintaining the integrity of whole seed kernels. Under the selected conditions of the static water bath method (material-to-liquid ratio of 1:20, temperature of 60 °C, duration of 27 h), the removal of MPNG, MPN, and TMPN of ‘Da Fozhi’ variety reached 87.51 ± 1.62%, 91.73 ± 4.69% and 87.87 ± 1.14%, respectively. Additionally, under the same selected conditions, the TMPN removal rates in two other varieties (‘Fo Shou’ and ‘Da Maling’) reached 79.01 ± 3.10% and 70.57 ± 5.67%, respectively. The static water bath method is convenient and low-complexity, achieving a relatively satisfactory detoxification effect for whole Ginkgo biloba seed kernels. This method lays the foundation for the detoxification of Ginkgo biloba seed whole kernels and also provides low-toxic Ginkgo biloba seed whole kernel raw materials for the food processing industry.
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Nano-Micro Letters
·
2026
·Vol. 18
·期 1
·127
·
IF 36.3
Wei Xiyan,Guan Jinpeng,Mu Yongbiao,Zou Yuhan,Wei Xianbin,Yang Lin,Man Quanyan,Yang Chao,Zang Limin,Sun Jingyu,Zeng Lin
Aqueous zinc-ion batteries (AZIBs) hold great promise for next-generation energy storage but face challenges such as Zn dendrite growth, side reactions, and limited performance at low temperatures. Here, we propose an electrolyte design strategy that reconstructs the hydrogen-bond network through the synergistic effect of glycerol (GL) and methylsulfonamide (MSA), enabling the formation of a (100)-oriented Zn anode. This design significantly broadens the operating current and temperature windows of AZIBs. As a result, Zn||Zn symmetric cells exhibit remarkable cycling stability, achieving 4,000 h at 1 mA cm −2 and 600 h at 40 mA cm −2 (both at 1 mAh cm −2 capacity); even at −20 °C, Zn||Zn symmetric cells deliver ultra-stable cycling for over 5,400 h. Furthermore, Zn||VO 2 full cells retain 77.3% of their capacity after 2,000 cycles at 30 °C with a current density of 0.5 A g −1 and 85.4% capacity retention after 2,000 cycles at −20 °C and 0.25 A g −1 . These results demonstrate a robust pathway for enhancing the practicality and low-temperature adaptability of AZIBs.
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COLLOID AND POLYMER SCIENCE
·
2023
·Vol. 301
·期 3
·175-187
·
IF 2.4
Meng Rui,Liu Liqin,Guo Weihong
A novel Al 2 O 3 –PDA–MoS 2 nanohybrid was synthesized by depositing Al 2 O 3 nanoparticles on the surface of molybdenum disulfide (MoS 2 ) sheets covered with polydopamine (PDA). Many characterizations demonstrated that the Al 2 O 3 was successfully deposited on the surface of MoS 2 . It was found that when the mass ratio of PDA–MoS 2 to Al 2 O 3 was 1.5:1, the nano-hybrid filler showed good dispersion performance. Then, the composite coating samples were prepared by adding Al 2 O 3 –PDA–MoS 2 (1.5:1) hybrid to waterborne epoxy resin. The effects of Al 2 O 3 , MoS 2 , and PDA–MoS 2 on the corrosion resistance of epoxy coating were also investigated. The potentiodynamic polarization test demonstrated that Al 2 O 3 –PDA–MoS 2 nanohybrids had excellent corrosion inhibition properties. The results of electrochemical impedance spectroscopy also revealed that the impedance modulus of Al 2 O 3 –PDA–MoS 2 /EP composite coating was nearly two orders of magnitude higher than that of pure epoxy resin after immersion in saline for 21 days. This study confirmed that Al 2 O 3 –PDA–MoS 2 nanosheets had better barrier properties and corrosion inhibition properties, and provided a new idea for the wide application of nanofillers in the field of anticorrosion.
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Nanoscale Research Letters
·
2016
·Vol. 11
·期 1
·1-8
·
IF 2.584
Han Shuai,Tang Yu,Guo Haijun,Qin Shenjun,Wu Jiang
The lanthanide-functionalized multifunctional hybrid nanoparticles combining the superparamagnetic core and the luminescent europium complex were successfully designed and assembled via layer-by-layer strategy in this work. It is noted that the hybrid nanoparticles were modified by a hydrophilic polymer polyethyleneimine (PEI) through hydrogen bonding which bestowed excellent hydrophilicity and biocompatibility on this material. A bright-red luminescence was observed by fluorescence microscopy, revealing that these magnetic-luminescent nanoparticles were both colloidally and chemically stable in PBS solution. Therefore, the nanocomposite with magnetic resonance response and fluorescence probe property is considered to be of great potential in multi-modal bioimaging and diagnostic applications.
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